Bim establishes the B-cell repertoire from early to late in the immune response

• Published in: International immunology Vol. 33; no. 2; pp. 79 - 90
• Main Authors: Sugimoto-Ishige, Akiko, Harada, Michishige, Tanaka, Miho, Terooatea, Tommy, Adachi, Yu, Takahashi, Yoshimasa, Tanaka, Takashi, Burrows, Peter D, Hikida, Masaki, Takemori, Toshitada
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 01.02.2021
• Subjects: extrafollicular plasma cells; GC-independent response; niche; GC-dependent response; affinity selection

Abstract In T cell-dependent antibody responses, some of the activated B cells differentiate along extrafollicular pathways into low-affinity memory and plasma cells, whereas others are involved in subsequent germinal center (GC) formation in follicular pathways, in which somatic hypermutation and a...