Daclatasvir and asunaprevir in hemodialysis patients with hepatitis C virus infection: a nationwide retrospective study in Japan

• Published in: Journal of gastroenterology Vol. 53; no. 1; pp. 119 - 128
• Main Authors: Suda, Goki, Furusyo, Norihiro, Toyoda, Hidenori, Kawakami, Yoshiiku, Ikeda, Hiroki, Suzuki, Michihiro, Arataki, Keiko, Mori, Nami, Tsuji, Keiji, Katamura, Yoshio, Takaguchi, Koichi, Ishikawa, Toru, Tsuji, Kunihiko, Shimada, Noritomo, Hiraoka, Atsushi, Yamsaki, Sho, Nakai, Masato, Sho, Takuya, Morikawa, Kenichi, Ogawa, Koji, Kudo, Mineo, Nagasaka, Atsushi, Furuya, Ken, Yamamoto, Yoshiya, Kato, Kanji, Ueno, Yoshiyuki, Iio, Etsuko, Tanaka, Yasuhito, Kurosaki, Masayuki, Kumada, Takashi, Chayama, Kazuaki, Sakamoto, Naoya
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.01.2018; Springer Nature B.V
• Subjects: Abdominal Surgery; Adult; Aged; Aged, 80 and over; Alanine; Alanine transaminase; Antiviral agents; Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Antiviral Agents - pharmacology; Antiviral drugs; Biliary Tract; Clinical trials; Colorectal Surgery; Data processing; Drug Therapy, Combination; Exanthema; Female; Fibrosis; Gastroenterology; Genotype; Genotype & phenotype; Hemodialysis; Hepacivirus - genetics; Hepatitis; Hepatitis C; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - virology; Hepatocellular carcinoma; Hepatology; Humans; Imidazoles - administration & dosage; Imidazoles - adverse effects; Imidazoles - pharmacology; Infections; Isoquinolines - administration & dosage; Isoquinolines - adverse effects; Isoquinolines - pharmacology; Japan; Kidney transplantation; Liver; Liver cancer; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article—Liver; Pancreas; Renal Dialysis; Retrospective Studies; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - pharmacology; Surgical Oncology; Sustained Virologic Response; Transaminase; Treatment Outcome; UMIN; UMIN000024227; Japan; DAAs; HCV; Hemodialysis; CKD

Background Hepatitis C virus (HCV) infection is common in hemodialysis patients and worsens their prognosis, while antiviral therapy options are limited. Recently, clinical trial and real-world, small-scale studies have reported excellent responses to direct-acting antivirals in patients with advanc...