Valence-dependent dopaminergic modulation during reversal learning in Parkinson’s disease: A neurocomputational approach

• Published in: Neurobiology of learning and memory Vol. 215; p. 107985
• Main Authors: Ursino, Mauro, Pelle, Silvana, Nekka, Fahima, Robaey, Philippe, Schirru, Miriam
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2024
• Subjects: Basal Ganglia - metabolism; Basal Ganglia - physiopathology; Cognitive Flexibility; Computer Simulation; Dopamine; Dopamine - metabolism; Go NoGo pathways; Hebb rule; Humans; Models, Neurological; Parkinson Disease - metabolism; Parkinson Disease - physiopathology; Punishment; Reinforcement learning; Reversal Learning - drug effects; Reversal Learning - physiology; Reward; Punishment; Go NoGo pathways; Dopamine; Hebb rule; Reinforcement learning; Cognitive Flexibility; Reward

•Action valence (wins/losses) significantly affects the learning process and outcomes.•Dopamine (DA) modulation varies with action valence, impacting cognitive flexibility.•Reversal learning processes are driven by dynamic changes in DA levels.•A Hebbian-trained Basal Ganglia model simulates diverse...