Additive effects of orthokeratology and atropine 0.01% ophthalmic solution in slowing axial elongation in children with myopia: first year results

Purpose To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia. Study design Prospective randomized clinical trial. Methods Japanese children aged 8–12 years with a sp...

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Published inJapanese journal of ophthalmology Vol. 62; no. 5; pp. 544 - 553
Main Authors Kinoshita, Nozomi, Konno, Yasuhiro, Hamada, Naoki, Kanda, Yoshinobu, Shimmura-Tomita, Machiko, Kakehashi, Akihiro
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.09.2018
Springer Nature B.V
Subjects
Atropine
Atropine - administration & dosage
Axial Length, Eye - diagnostic imaging
Child
Children
Clinical Investigation
Cornea - diagnostic imaging
Corneal Topography
Disease Progression
Dose-Response Relationship, Drug
Elongation
Female
Follow-Up Studies
Humans
Interferometry
Laser interferometry
Male
Medicine
Medicine & Public Health
Mydriatics - administration & dosage
Myopia
Myopia - diagnosis
Myopia - physiopathology
Myopia - therapy
Ophthalmic Solutions
Ophthalmology
Orthokeratologic Procedures - methods
Prospective Studies
Refraction, Ocular - physiology
Time Factors
Treatment Outcome
Axial length
Orthokeratology
Atropine 0.01% ophthalmic solution
Additive effects
Myopia
Online AccessGet full text
ISSN0021-5155
1613-2246
1613-2246
DOI10.1007/s10384-018-0608-3

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Abstract Purpose To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia. Study design Prospective randomized clinical trial. Methods Japanese children aged 8–12 years with a spherical equivalent refractive error of − 1.00 to − 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups. Results A total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group ( P  = 0.0356, unpaired t test). Conclusion During the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.
AbstractList Purpose To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia. Study design Prospective randomized clinical trial. Methods Japanese children aged 8–12 years with a spherical equivalent refractive error of − 1.00 to − 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups. Results A total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group ( P  = 0.0356, unpaired t test). Conclusion During the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.
To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia. Prospective randomized clinical trial. Japanese children aged 8-12 years with a spherical equivalent refractive error of - 1.00 to - 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups. A total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group (P = 0.0356, unpaired t test). During the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.
To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia.PURPOSETo investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia.Prospective randomized clinical trial.STUDY DESIGNProspective randomized clinical trial.Japanese children aged 8-12 years with a spherical equivalent refractive error of - 1.00 to - 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups.METHODSJapanese children aged 8-12 years with a spherical equivalent refractive error of - 1.00 to - 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups.A total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group (P = 0.0356, unpaired t test).RESULTSA total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group (P = 0.0356, unpaired t test).During the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.CONCLUSIONDuring the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.
PurposeTo investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia.Study designProspective randomized clinical trial.MethodsJapanese children aged 8–12 years with a spherical equivalent refractive error of − 1.00 to − 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups.ResultsA total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group (P = 0.0356, unpaired t test).ConclusionDuring the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.
Author Konno, Yasuhiro
Shimmura-Tomita, Machiko
Kanda, Yoshinobu
Kakehashi, Akihiro
Hamada, Naoki
Kinoshita, Nozomi
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  surname: Kinoshita
  fullname: Kinoshita, Nozomi
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  organization: Department of Ophthalmology, Saitama Medical Center, Jichi Medical University
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  surname: Konno
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  organization: Omiya Hamada Eye Clinic
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  surname: Kakehashi
  fullname: Kakehashi, Akihiro
  organization: Department of Ophthalmology, Saitama Medical Center, Jichi Medical University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29974278$$D View this record in MEDLINE/PubMed
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Copyright Japanese Ophthalmological Society 2018
Japanese Journal of Ophthalmology is a copyright of Springer, (2018). All Rights Reserved.
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Wed Feb 19 02:43:36 EST 2025
Thu Apr 24 22:56:41 EDT 2025
Tue Jul 01 03:57:47 EDT 2025
Fri Feb 21 02:35:01 EST 2025
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Issue 5
Keywords Axial length
Orthokeratology
Atropine 0.01% ophthalmic solution
Additive effects
Myopia
Language English
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Springer Nature B.V
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Snippet Purpose To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow...
To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial...
PurposeTo investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial...
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SubjectTerms Atropine
Atropine - administration & dosage
Axial Length, Eye - diagnostic imaging
Child
Children
Clinical Investigation
Cornea - diagnostic imaging
Corneal Topography
Disease Progression
Dose-Response Relationship, Drug
Elongation
Female
Follow-Up Studies
Humans
Interferometry
Laser interferometry
Male
Medicine
Medicine & Public Health
Mydriatics - administration & dosage
Myopia
Myopia - diagnosis
Myopia - physiopathology
Myopia - therapy
Ophthalmic Solutions
Ophthalmology
Orthokeratologic Procedures - methods
Prospective Studies
Refraction, Ocular - physiology
Time Factors
Treatment Outcome
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Title Additive effects of orthokeratology and atropine 0.01% ophthalmic solution in slowing axial elongation in children with myopia: first year results
URI https://link.springer.com/article/10.1007/s10384-018-0608-3
https://www.ncbi.nlm.nih.gov/pubmed/29974278
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