Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila

subsp. ( ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, belongs to the group, some strains o...

Full description

Saved in:
Bibliographic Details
Published ineLife Vol. 12
Main Authors Jneid, Rouba, Loudhaief, Rihab, Zucchini-Pascal, Nathalie, Nawrot-Esposito, Marie-Paule, Fichant, Arnaud, Rousset, Raphael, Bonis, Mathilde, Osman, Dani, Gallet, Armel
Format Journal Article
LanguageEnglish
Published England eLife Sciences Publication 27.02.2023
eLife Sciences Publications, Ltd
eLife Sciences Publications Ltd
Subjects
Animals
bacillus thurigiensis
Bacillus thuringiensis
Bacillus thuringiensis Toxins - adverse effects
Bacteriology
Cell Adhesion
Cell Biology
Crops, Agricultural
Cry1A toxins
Drosophila melanogaster
E-Cadherins
enteroendocrine cells
intestinal stem cells
Life Sciences
Microbiology and Parasitology
Plants, Genetically Modified
Stem Cells - drug effects
Toxicology
Toxicology and food chain
enteroendocrine cells
bacillus thurigiensis
cell biology
E-Cadherins
intestinal stem cells
Cry1A toxins
D. melanogaster
Drosophila melanogaster
Online AccessGet full text

Cover

Abstract subsp. ( ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, belongs to the group, some strains of which are well known human opportunistic pathogens. Therefore, ingestion of along with food may threaten organisms not susceptible to infection. Here we show that Cry1A toxins induce enterocyte death and intestinal stem cell (ISC) proliferation in the midgut of , an organism non-susceptible to . Surprisingly, a high proportion of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyte destiny. We show that Cry1A toxins weaken the E-Cadherin-dependent adherens junction between the ISC and its immediate daughter progenitor, leading the latter to adopt an enteroendocrine fate. Hence, although not lethal to non-susceptible organisms, Cry toxins can interfere with conserved cell adhesion mechanisms, thereby disrupting intestinal homeostasis and endocrine functions.
AbstractList Bacillus thuringiensis subsp. kurstaki (Btk) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, Btk belongs to the B. cereus group, some strains of which are well known human opportunistic pathogens. Therefore, ingestion of Btk along with food may threaten organisms not susceptible to Btk infection. Here we show that Cry1A toxins induce enterocyte death and intestinal stem cell (ISC) proliferation in the midgut of Drosophila melanogaster, an organism non-susceptible to Btk. Surprisingly, a high proportion of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyte destiny. We show that Cry1A toxins weaken the E-Cadherin-dependent adherens junction between the ISC and its immediate daughter progenitor, leading the latter to adopt an enteroendocrine fate. Hence, although not lethal to non-susceptible organisms, Cry toxins can interfere with conserved cell adhesion mechanisms, thereby disrupting intestinal homeostasis and endocrine functions.Bacillus thuringiensis subsp. kurstaki (Btk) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, Btk belongs to the B. cereus group, some strains of which are well known human opportunistic pathogens. Therefore, ingestion of Btk along with food may threaten organisms not susceptible to Btk infection. Here we show that Cry1A toxins induce enterocyte death and intestinal stem cell (ISC) proliferation in the midgut of Drosophila melanogaster, an organism non-susceptible to Btk. Surprisingly, a high proportion of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyte destiny. We show that Cry1A toxins weaken the E-Cadherin-dependent adherens junction between the ISC and its immediate daughter progenitor, leading the latter to adopt an enteroendocrine fate. Hence, although not lethal to non-susceptible organisms, Cry toxins can interfere with conserved cell adhesion mechanisms, thereby disrupting intestinal homeostasis and endocrine functions.
Bacillus thuringiensis subsp. kurstaki ( Btk ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, Btk belongs to the B. cereus group, some strains of which are well known human opportunistic pathogens. Therefore, ingestion of Btk along with food may threaten organisms not susceptible to Btk infection. Here we show that Cry1A toxins induce enterocyte death and intestinal stem cell (ISC) proliferation in the midgut of Drosophila melanogaster , an organism non-susceptible to Btk . Surprisingly, a high proportion of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyte destiny. We show that Cry1A toxins weaken the E-Cadherin-dependent adherens junction between the ISC and its immediate daughter progenitor, leading the latter to adopt an enteroendocrine fate. Hence, although not lethal to non-susceptible organisms, Cry toxins can interfere with conserved cell adhesion mechanisms, thereby disrupting intestinal homeostasis and endocrine functions.
Bacillus thuringiensis subsp. kurstaki ( Btk ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, Btk belongs to the B. cereus group, some strains of which are well known human opportunistic pathogens. Therefore, ingestion of Btk along with food may threaten organisms not susceptible to Btk infection. Here we show that Cry1A toxins induce enterocyte death and intestinal stem cell (ISC) proliferation in the midgut of Drosophila melanogaster , an organism non-susceptible to Btk . Surprisingly, a high proportion of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyte destiny. We show that Cry1A toxins weaken the E-Cadherin-dependent adherens junction between the ISC and its immediate daughter progenitor, leading the latter to adopt an enteroendocrine fate. Hence, although not lethal to non-susceptible organisms, Cry toxins can interfere with conserved cell adhesion mechanisms, thereby disrupting intestinal homeostasis and endocrine functions.
subsp. ( ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests. However, belongs to the group, some strains of which are well known human opportunistic pathogens. Therefore, ingestion of along with food may threaten organisms not susceptible to infection. Here we show that Cry1A toxins induce enterocyte death and intestinal stem cell (ISC) proliferation in the midgut of , an organism non-susceptible to . Surprisingly, a high proportion of the ISC daughter cells differentiate into enteroendocrine cells instead of their initial enterocyte destiny. We show that Cry1A toxins weaken the E-Cadherin-dependent adherens junction between the ISC and its immediate daughter progenitor, leading the latter to adopt an enteroendocrine fate. Hence, although not lethal to non-susceptible organisms, Cry toxins can interfere with conserved cell adhesion mechanisms, thereby disrupting intestinal homeostasis and endocrine functions.
Author Fichant, Arnaud
Jneid, Rouba
Nawrot-Esposito, Marie-Paule
Zucchini-Pascal, Nathalie
Loudhaief, Rihab
Bonis, Mathilde
Gallet, Armel
Rousset, Raphael
Osman, Dani
Author_xml – sequence: 1
  givenname: Rouba
  surname: Jneid
  fullname: Jneid, Rouba
  organization: Faculty of Sciences III and Azm Center for Research in Biotechnology and its Applications, LBA3B, EDST, Lebanese University, Tripoli, Lebanon
– sequence: 2
  givenname: Rihab
  surname: Loudhaief
  fullname: Loudhaief, Rihab
  organization: Universite Cote d'Azur, CNRS, INRAE, Sophia Antipolis, France
– sequence: 3
  givenname: Nathalie
  surname: Zucchini-Pascal
  fullname: Zucchini-Pascal, Nathalie
  organization: Universite Cote d'Azur, CNRS, INRAE, Sophia Antipolis, France
– sequence: 4
  givenname: Marie-Paule
  surname: Nawrot-Esposito
  fullname: Nawrot-Esposito, Marie-Paule
  organization: Universite Cote d'Azur, CNRS, INRAE, Sophia Antipolis, France
– sequence: 5
  givenname: Arnaud
  surname: Fichant
  fullname: Fichant, Arnaud
  organization: Laboratory for Food Safety, University Paris-Est, French Agency for Food, Environmental and Occupational Health & Safety, Maisons-Alfort, France
– sequence: 6
  givenname: Raphael
  surname: Rousset
  fullname: Rousset, Raphael
  organization: Universite Cote d'Azur, CNRS, INRAE, Sophia Antipolis, France
– sequence: 7
  givenname: Mathilde
  surname: Bonis
  fullname: Bonis, Mathilde
  organization: Laboratory for Food Safety, University Paris-Est, French Agency for Food, Environmental and Occupational Health & Safety, Maisons-Alfort, France
– sequence: 8
  givenname: Dani
  surname: Osman
  fullname: Osman, Dani
  organization: Faculty of Sciences III and Azm Center for Research in Biotechnology and its Applications, LBA3B, EDST, Lebanese University, Tripoli, Lebanon
– sequence: 9
  givenname: Armel
  orcidid: 0000-0002-2054-4780
  surname: Gallet
  fullname: Gallet, Armel
  organization: Universite Cote d'Azur, CNRS, INRAE, Sophia Antipolis, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36847614$$D View this record in MEDLINE/PubMed
https://hal.science/hal-04043393$$DView record in HAL
BookMark eNpdkl1vFCEUhiemxtbaK-8NlxqzFQZmgBuTtn60ySbeaOIdOQtndmhmYYWZrf0j_l7ZD5tWboDDe54T3rwvq6MQA1bVa0bPZdOIDzj3HZ4ryqR-Vp3UtKEzqsTPo0fn4-os51talhRKMf2iOuatErJl4qT6cwnWD8OUydhPyYelx5B9ucXfPmTi_AbTSNYpLjH4MSZicRi2z3eQHMEwYooYXLSlF0kHI5LFPXFoE0IuuJ2egOsx-xjInR974ktXHn2AgeQRVwekD-RTijmuez_Aq-p5B0PGs8N-Wv348vn71fVs_u3rzdXFfGa5bvXMtlgv0Da1trLVXOvOSquwZa3QEi1IiY6rZtHVmkJNnQQHSgAqYNbxuuGn1c2e6yLcmnXyK0j3JoI3u0JMSwNp9HZAg1o22lLdUcEFMLaw2gHrUDjaUoG0sD7uWetpsUJnizkJhifQpy_B92YZN0ZrKWvdFsC7PaD_r-36Ym62NSrKbK75hhXt28OwFH9NxU6z8nlrJASMUza1VFSouuaySN_vpbbYmxN2D2xGzTZEZhciswtRUb95_IsH7b_I8L9B8MmC
CitedBy_id crossref_primary_10_1098_rsos_230565
crossref_primary_10_1016_j_pestbp_2023_105596
crossref_primary_10_3390_foods13081140
crossref_primary_10_1016_j_resmic_2023_104089
Cites_doi 10.1186/s12915-015-0160-2
10.1016/j.mrgentox.2008.10.017
10.4172/0974-276X.1000487
10.1042/bj0810225
10.1016/B978-0-12-800197-4.00002-6
10.1242/dev.142539
10.1242/bio.037085
10.3390/toxins12020104
10.1002/ps.4262
10.1242/dev.114959
10.1126/science.1136606
10.1006/jmbi.2000.4361
10.1002/jat.3252
10.1038/nature04333
10.1038/nmeth.2019
10.1073/pnas.0911797106
10.15252/embj.201695622
10.1046/j.1365-2583.2002.00373.x
10.3389/fcimb.2013.00116
10.1242/dev.02212
10.1111/j.1365-2443.2008.01239.x
10.1073/pnas.1109348108
10.14670/HH-30.277
10.3389/fmicb.2018.01915
10.1128/jb.177.21.6027-6032.1995
10.1002/dvg.20661
10.1242/dev.189472
10.1016/j.dci.2016.02.008
10.1016/j.stem.2008.10.016
10.3389/fmicb.2021.775669
10.1242/jcs.113100
10.15252/embj.201591517
10.1016/j.celrep.2014.05.024
10.1016/0167-7012(94)90041-8
10.1016/j.jip.2013.09.001
10.1006/dbio.1999.9494
10.1021/jacs.8b01710
10.1038/nature04371
10.1016/j.bbagen.2012.08.009
10.1016/j.it.2018.04.002
10.1126/science.aab0988
10.1111/febs.16067
10.1242/dev.149807
10.1371/journal.pbio.3000041
10.1128/AEM.00476-20
10.1016/j.cois.2016.04.008
10.1152/ajpgi.00353.2018
10.1111/j.1574-6976.2012.00341.x
10.1073/pnas.79.22.6951
10.1371/journal.pone.0068164
10.1016/j.pneurobio.2019.02.003
10.1242/dev.118.2.401
10.1128/microbiolspec.GPP3-0032-2018
10.1093/jisesa/iex102
10.1371/journal.pone.0246885
10.1016/j.ydbio.2009.10.045
10.1111/1541-4337.12785
10.3390/toxins12050301
10.3390/insects11100697
10.1093/jee/tow062
10.1111/1744-7917.12961
10.1016/j.devcel.2014.09.012
10.1083/jcb.201306082
10.1038/emboj.2012.106
10.1016/j.cell.2010.05.011
10.1242/dev.113357
10.7554/eLife.00886
10.1039/c7tx00198c
10.1016/j.ymeth.2014.03.022
10.1371/journal.pgen.1006854
10.1242/dev.065292
10.1021/acs.jafc.9b04563
10.1016/j.stem.2012.06.017
10.1007/978-3-319-56678-8
10.7554/eLife.01857
10.1186/s12859-018-2336-6
10.1242/dev.052506
10.3389/fcell.2022.886773
10.1016/j.jip.2012.05.001
10.1242/dev.199831
10.1016/j.tim.2019.09.005
10.1016/j.celrep.2013.04.001
10.1016/j.stem.2008.07.024
10.1073/pnas.0707177104
10.1038/s41598-020-73145-6
10.1002/jcp.21808
10.1016/j.dci.2016.01.001
10.1016/j.ibmb.2016.11.008
10.1016/j.cell.2009.05.014
10.1016/j.cell.2011.08.048
10.1016/j.devcel.2017.02.009
10.3390/ijms21176362
10.1242/dev.137950
10.1016/B978-0-12-391498-9.00002-4
10.1007/s00018-008-8330-9
ContentType Journal Article
Copyright 2023, Jneid et al.
Attribution
2023, Jneid et al 2023 Jneid et al
Copyright_xml – notice: 2023, Jneid et al.
– notice: Attribution
– notice: 2023, Jneid et al 2023 Jneid et al
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
1XC
VOOES
5PM
DOA
DOI 10.7554/eLife.80179
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic



MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
EISSN 2050-084X
ExternalDocumentID oai_doaj_org_article_e9759c09f0434a11bc9da1fe4d0604e0
oai_HAL_hal_04043393v1
10_7554_eLife_80179
36847614
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: ANR-15-IDEX-01
– fundername: ;
  grantid: ANR-13-CESA-0003-01
GroupedDBID 3V.
53G
5VS
7X7
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAKDD
ABUWG
ACGFO
ACGOD
ACPRK
ADBBV
ADRAZ
AENEX
AFKRA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CGR
CUY
CVF
DIK
DWQXO
ECM
EIF
EMOBN
FRP
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
IEA
IHR
INH
INR
ISR
ITC
KQ8
LK8
M1P
M2P
M48
M7P
M~E
NPM
NQS
OK1
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RHF
RHI
RNS
RPM
UKHRP
AAYXX
AFPKN
CITATION
7X8
1XC
H13
VOOES
5PM
ID FETCH-LOGICAL-c3969-c6e2bec529c769399fc7c8e616497eca77ed385bf290a20d7ada84ae8a1cd3253
IEDL.DBID RPM
ISSN 2050-084X
IngestDate Tue Oct 22 15:11:58 EDT 2024
Tue Sep 17 21:31:46 EDT 2024
Thu Nov 07 06:51:29 EST 2024
Sat Oct 26 04:04:34 EDT 2024
Fri Aug 23 04:04:03 EDT 2024
Sat Nov 02 12:15:35 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords enteroendocrine cells
bacillus thurigiensis
cell biology
E-Cadherins
intestinal stem cells
Cry1A toxins
D. melanogaster
Drosophila melanogaster
Language English
License 2023, Jneid et al.
Attribution: http://creativecommons.org/licenses/by
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3969-c6e2bec529c769399fc7c8e616497eca77ed385bf290a20d7ada84ae8a1cd3253
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC9977296
Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
UMR PIMIT (Processus Infectieux en Milieu Insulaire Tropical) CNRS 9192- INSERM 1187-IRD 249-Université de La Réunion, île de La Réunion, France.
K8520 IWK Health Centre 8th Floor East Research 5850/5980 University Avenue Halifax, Nova Scotia, Canada.
ORCID 0000-0002-2054-4780
0000-0002-4999-403X
0000-0003-4659-2788
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9977296/
PMID 36847614
PQID 2780482237
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_e9759c09f0434a11bc9da1fe4d0604e0
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9977296
hal_primary_oai_HAL_hal_04043393v1
proquest_miscellaneous_2780482237
crossref_primary_10_7554_eLife_80179
pubmed_primary_36847614
PublicationCentury 2000
PublicationDate 20230227
PublicationDateYYYYMMDD 2023-02-27
PublicationDate_xml – month: 2
  year: 2023
  text: 20230227
  day: 27
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle eLife
PublicationTitleAlternate Elife
PublicationYear 2023
Publisher eLife Sciences Publication
eLife Sciences Publications, Ltd
eLife Sciences Publications Ltd
Publisher_xml – name: eLife Sciences Publication
– name: eLife Sciences Publications, Ltd
– name: eLife Sciences Publications Ltd
References Jovanovic (bib48) 2021; 20
Apidianakis (bib6) 2009; 106
Joly (bib47) 2020; 21
Gallet (bib32) 2006; 133
Biteau (bib11) 2008; 3
Brand (bib15) 1993; 118
González (bib35) 1982; 79
Vachon (bib91) 2012; 111
Schindelin (bib79) 2012; 9
Rosi-Marshall (bib76) 2007; 104
Beebe (bib8) 2010; 338
Toret (bib90) 2014; 204
Castella (bib21) 2019; 8
Tamamouna (bib88) 2020; 147
Choi (bib25) 2011; 108
Cossentine (bib27) 2016; 22
Ohlstein (bib69) 2007; 315
Shao (bib81) 2013; 114
Schott (bib80) 2017; 144
Li (bib52) 2021; 29
Zhai (bib96) 2017; 13
Biteau (bib12) 2014; 7
Micchelli (bib59) 2006; 439
Jiang (bib45) 2009; 137
Caballero (bib17) 2020; 86
Nawrot-Esposito (bib64) 2020; 11
Sallé (bib78) 2017; 36
Guisoni (bib38) 2017; 144
Allaire (bib3) 2018; 39
Clausen (bib26) 2018; 19
Watnick (bib93) 2019; 4
Hernández-Rodríguez (bib41) 2013; 8
Soberón (bib85) 2009; 66
Li (bib50) 2014; 31
Amcheslavsky (bib4) 2009; 4
Hung (bib43) 2016; 72
Biggel (bib10) 2021; 12
Adang (bib1) 2014; 47
Tian (bib89) 2014; 3
Antonello (bib5) 2015; 34
Goulas (bib36) 2012; 11
Stevens (bib86) 2017; 80
Babin (bib7) 2020; 10
Nässel (bib63) 2019; 179
Zeng (bib94) 2010; 48
Marianes (bib57) 2013; 2
Shao (bib82) 2018; 18
Castagnola (bib20) 2016; 15
Obata (bib65) 2015; 13
Agaisse (bib2) 1995; 177
Ohlstein (bib68) 2006; 439
Micchelli (bib60) 2014; 68
Chatterjee (bib22) 2009; 220
Pasco (bib72) 2015; 30
ISAAA (bib44) 2017
Bonis (bib14) 2021; 16
Shaya (bib84) 2017; 40
Hill (bib42) 2001; 305
Vriz (bib92) 2014; 108
Gao (bib33) 2019; 67
Oda (bib67) 1999; 216
Johler (bib46) 2018; 9
Mendoza-Almanza (bib58) 2020; 12
Loudhaief (bib55) 2017; 144
St Johnston (bib87) 2010; 141
Chen (bib23) 2018; 16
Gill (bib34) 2002; 11
Maeda (bib56) 2008; 13
Fiuza (bib31) 2017
Capo (bib18) 2016; 64
Liu (bib54) 2018; 140
Bonfini (bib13) 2016; 64
Rubio-Infante (bib77) 2016; 36
O’Brien (bib66) 2011; 147
de Navascués (bib28) 2012; 31
Grisolia (bib37) 2009; 672
Guo (bib39) 2015; 350
Perdigoto (bib73) 2011; 138
Kim (bib49) 2014; 3
Chen (bib24) 2022; 10
Liu (bib53) 2018; 11
Ehling-Schulz (bib29) 2019; 7
Monro (bib61) 1961; 81
Perdigoto (bib74) 2013; 1830
Zeng (bib95) 2015; 142
Pardo-López (bib71) 2013; 37
Murty (bib62) 1994; 19
Rabinovitch (bib75) 2017
Beehler-Evans (bib9) 2015; 142
Li (bib51) 2020; 12
Falo-Sanjuan (bib30) 2021; 148
Guo (bib40) 2021; 289
Buchon (bib16) 2013; 3
Osman (bib70) 2012; 125
Casida (bib19) 2017; 6
Shaw (bib83) 2010; 137
Zwick (bib97) 2019; 316
References_xml – volume: 13
  year: 2015
  ident: bib65
  article-title: Induction of rapid and selective cell necrosis in Drosophila using bacillus thuringiensis cry toxin and its silkworm receptor
  publication-title: BMC Biology
  doi: 10.1186/s12915-015-0160-2
  contributor:
    fullname: Obata
– volume: 672
  start-page: 119
  year: 2009
  ident: bib37
  article-title: Genotoxic evaluation of different delta-endotoxins from Bacillus thuringiensis on zebrafish adults and development in early life stages
  publication-title: Mutation Research
  doi: 10.1016/j.mrgentox.2008.10.017
  contributor:
    fullname: Grisolia
– volume: 11
  start-page: 201
  year: 2018
  ident: bib53
  article-title: The defined toxin-binding region of the cadherin G-protein coupled receptor, BT-R1, for the active cry1ab toxin of bacillus thuringiensis
  publication-title: Journal of Proteomics & Bioinformatics
  doi: 10.4172/0974-276X.1000487
  contributor:
    fullname: Liu
– volume: 81
  start-page: 225
  year: 1961
  ident: bib61
  article-title: Protein turnover and the formation of protein inclusions during sporulation of bacillus thuringiensis
  publication-title: The Biochemical Journal
  doi: 10.1042/bj0810225
  contributor:
    fullname: Monro
– volume: 47
  start-page: 39
  year: 2014
  ident: bib1
  article-title: Chapter two – diversity of bacillus thuringiensis crystal toxins and mechanism of action
  publication-title: Advances in Insect Physiology
  doi: 10.1016/B978-0-12-800197-4.00002-6
  contributor:
    fullname: Adang
– volume: 144
  start-page: 808
  year: 2017
  ident: bib55
  article-title: Apoptosis restores cellular density by eliminating a physiologically or genetically induced excess of enterocytes in the Drosophila midgut
  publication-title: Development
  doi: 10.1242/dev.142539
  contributor:
    fullname: Loudhaief
– volume: 8
  year: 2019
  ident: bib21
  article-title: Transcriptomic analysis of spodoptera frugiperda sf9 cells resistant to bacillus thuringiensis cry1ca toxin, reveals that extracellular ca2+, mg2+ and production of camp are involved in toxicity
  publication-title: Biology Open
  doi: 10.1242/bio.037085
  contributor:
    fullname: Castella
– volume: 12
  year: 2020
  ident: bib51
  article-title: Atp-binding cassette subfamily a member 2 is a functional receptor for bacillus thuringiensis cry2a toxins in bombyx mori, but not for cry1a, cry1c, cry1d, cry1f, or cry9a toxins
  publication-title: Toxins
  doi: 10.3390/toxins12020104
  contributor:
    fullname: Li
– volume: 72
  start-page: 2247
  year: 2016
  ident: bib43
  article-title: Fate of insecticidal Bacillus thuringiensis Cry protein in soil: differences between purified toxin and biopesticide formulation
  publication-title: Pest Management Science
  doi: 10.1002/ps.4262
  contributor:
    fullname: Hung
– volume: 142
  start-page: 654
  year: 2015
  ident: bib9
  article-title: Generation of enteroendocrine cell diversity in midgut stem cell lineages
  publication-title: Development
  doi: 10.1242/dev.114959
  contributor:
    fullname: Beehler-Evans
– volume: 315
  start-page: 988
  year: 2007
  ident: bib69
  article-title: Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential Notch signaling
  publication-title: Science
  doi: 10.1126/science.1136606
  contributor:
    fullname: Ohlstein
– volume: 305
  start-page: 1011
  year: 2001
  ident: bib42
  article-title: Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster
  publication-title: Journal of Molecular Biology
  doi: 10.1006/jmbi.2000.4361
  contributor:
    fullname: Hill
– volume: 36
  start-page: 630
  year: 2016
  ident: bib77
  article-title: An overview of the safety and biological effects of Bacillus thuringiensis Cry toxins in mammals
  publication-title: Journal of Applied Toxicology
  doi: 10.1002/jat.3252
  contributor:
    fullname: Rubio-Infante
– volume: 439
  start-page: 470
  year: 2006
  ident: bib68
  article-title: The adult Drosophila posterior midgut is maintained by pluripotent stem cells
  publication-title: Nature
  doi: 10.1038/nature04333
  contributor:
    fullname: Ohlstein
– volume: 9
  start-page: 676
  year: 2012
  ident: bib79
  article-title: Fiji: an open-source platform for biological-image analysis
  publication-title: Nature Methods
  doi: 10.1038/nmeth.2019
  contributor:
    fullname: Schindelin
– volume: 106
  start-page: 20883
  year: 2009
  ident: bib6
  article-title: Synergy between bacterial infection and genetic predisposition in intestinal dysplasia
  publication-title: PNAS
  doi: 10.1073/pnas.0911797106
  contributor:
    fullname: Apidianakis
– volume: 36
  start-page: 1928
  year: 2017
  ident: bib78
  article-title: Intrinsic regulation of enteroendocrine fate by Numb
  publication-title: The EMBO Journal
  doi: 10.15252/embj.201695622
  contributor:
    fullname: Sallé
– volume: 11
  start-page: 619
  year: 2002
  ident: bib34
  article-title: Transgenic Drosophila reveals a functional in vivo receptor for the Bacillus thuringiensis toxin cry1ac1
  publication-title: Insect Molecular Biology
  doi: 10.1046/j.1365-2583.2002.00373.x
  contributor:
    fullname: Gill
– volume: 3
  year: 2014
  ident: bib49
  article-title: Role of duox in gut inflammation: lessons from Drosophila model of gut-microbiota interactions
  publication-title: Frontiers in Cellular and Infection Microbiology
  doi: 10.3389/fcimb.2013.00116
  contributor:
    fullname: Kim
– volume: 133
  start-page: 407
  year: 2006
  ident: bib32
  article-title: Cholesterol modification is necessary for controlled planar long-range activity of hedgehog in Drosophila epithelia
  publication-title: Development
  doi: 10.1242/dev.02212
  contributor:
    fullname: Gallet
– volume: 13
  start-page: 1219
  year: 2008
  ident: bib56
  article-title: E-Cadherin prolongs the moment for interaction between intestinal stem cell and its progenitor cell to ensure Notch signaling in adult Drosophila midgut
  publication-title: Genes to Cells
  doi: 10.1111/j.1365-2443.2008.01239.x
  contributor:
    fullname: Maeda
– volume: 108
  start-page: 18702
  year: 2011
  ident: bib25
  article-title: Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway
  publication-title: PNAS
  doi: 10.1073/pnas.1109348108
  contributor:
    fullname: Choi
– volume: 30
  start-page: 277
  year: 2015
  ident: bib72
  article-title: The cellular homeostasis of the gut: what the Drosophila model points out
  publication-title: Histology and Histopathology
  doi: 10.14670/HH-30.277
  contributor:
    fullname: Pasco
– volume: 9
  year: 2018
  ident: bib46
  article-title: Enterotoxin production of Bacillus thuringiensis isolates from biopesticides, foods, and outbreaks
  publication-title: Frontiers in Microbiology
  doi: 10.3389/fmicb.2018.01915
  contributor:
    fullname: Johler
– volume: 177
  start-page: 6027
  year: 1995
  ident: bib2
  article-title: How does bacillus thuringiensis produce so much insecticidal crystal protein?
  publication-title: Journal of Bacteriology
  doi: 10.1128/jb.177.21.6027-6032.1995
  contributor:
    fullname: Agaisse
– volume: 48
  start-page: 607
  year: 2010
  ident: bib94
  article-title: Characterization of midgut stem cell- and enteroblast-specific GAL4 lines in Drosophila
  publication-title: Genesis
  doi: 10.1002/dvg.20661
  contributor:
    fullname: Zeng
– volume: 147
  year: 2020
  ident: bib88
  article-title: Evidence of two types of balance between stem cell mitosis and enterocyte nucleus growth in the Drosophila midgut
  publication-title: Development
  doi: 10.1242/dev.189472
  contributor:
    fullname: Tamamouna
– volume: 64
  start-page: 22
  year: 2016
  ident: bib13
  article-title: From pathogens to microbiota: how Drosophila intestinal stem cells react to gut microbes
  publication-title: Developmental & Comparative Immunology
  doi: 10.1016/j.dci.2016.02.008
  contributor:
    fullname: Bonfini
– volume: 4
  start-page: 49
  year: 2009
  ident: bib4
  article-title: Tissue damage-induced intestinal stem cell division in Drosophila
  publication-title: Stem Cell
  doi: 10.1016/j.stem.2008.10.016
  contributor:
    fullname: Amcheslavsky
– volume: 12
  year: 2021
  ident: bib10
  article-title: Whole genome sequencing reveals biopesticidal origin of bacillus thuringiensis in foods
  publication-title: Frontiers in Microbiology
  doi: 10.3389/fmicb.2021.775669
  contributor:
    fullname: Biggel
– volume: 125
  start-page: 5944
  year: 2012
  ident: bib70
  article-title: Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division
  publication-title: Journal of Cell Science
  doi: 10.1242/jcs.113100
  contributor:
    fullname: Osman
– volume: 34
  start-page: 2025
  year: 2015
  ident: bib5
  article-title: Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by mir‐8–escargot switch
  publication-title: The EMBO Journal
  doi: 10.15252/embj.201591517
  contributor:
    fullname: Antonello
– volume: 7
  start-page: 1867
  year: 2014
  ident: bib12
  article-title: Slit/robo signaling regulates cell fate decisions in the intestinal stem cell lineage of Drosophila
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2014.05.024
  contributor:
    fullname: Biteau
– volume: 19
  start-page: 103
  year: 1994
  ident: bib62
  article-title: A simple method for separation of the protein crystal from bacillus thuringiensis using carboxymethyl cellulose column chromatography
  publication-title: Journal of Microbiological Methods
  doi: 10.1016/0167-7012(94)90041-8
  contributor:
    fullname: Murty
– volume: 114
  start-page: 255
  year: 2013
  ident: bib81
  article-title: Proteolytic processing of Bacillus thuringiensis toxin Cry1Ab in rice brown planthopper, Nilaparvata lugens (Stål)
  publication-title: Journal of Invertebrate Pathology
  doi: 10.1016/j.jip.2013.09.001
  contributor:
    fullname: Shao
– start-page: 1
  volume-title: Bacillus thuringiensis and Lysinibacillus sphaericus
  year: 2017
  ident: bib75
  contributor:
    fullname: Rabinovitch
– volume: 216
  start-page: 406
  year: 1999
  ident: bib67
  article-title: Nonchordate classic cadherins have a structurally and functionally unique domain that is absent from chordate classic cadherins
  publication-title: Developmental Biology
  doi: 10.1006/dbio.1999.9494
  contributor:
    fullname: Oda
– volume: 140
  start-page: 6853
  year: 2018
  ident: bib54
  article-title: Synthetic polymer affinity ligand for bacillus thuringiensis (bt) cry1ab/ac protein: the use of biomimicry based on the bt protein-insect receptor binding mechanism
  publication-title: Journal of the American Chemical Society
  doi: 10.1021/jacs.8b01710
  contributor:
    fullname: Liu
– volume: 439
  start-page: 475
  year: 2006
  ident: bib59
  article-title: Evidence that stem cells reside in the adult Drosophila midgut epithelium
  publication-title: Nature
  doi: 10.1038/nature04371
  contributor:
    fullname: Micchelli
– volume: 1830
  start-page: 2307
  year: 2013
  ident: bib74
  article-title: Sending the right signal: Notch and stem cells
  publication-title: Biochimica et Biophysica Acta
  doi: 10.1016/j.bbagen.2012.08.009
  contributor:
    fullname: Perdigoto
– volume: 39
  start-page: 677
  year: 2018
  ident: bib3
  article-title: The intestinal epithelium: central coordinator of mucosal immunity
  publication-title: Trends in Immunology
  doi: 10.1016/j.it.2018.04.002
  contributor:
    fullname: Allaire
– volume: 350
  year: 2015
  ident: bib39
  article-title: Stem cell regulation: bidirectional notch signaling regulates Drosophila intestinal stem cell multipotency
  publication-title: Science
  doi: 10.1126/science.aab0988
  contributor:
    fullname: Guo
– volume: 289
  start-page: 4773
  year: 2021
  ident: bib40
  article-title: The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review
  publication-title: The FEBS Journal
  doi: 10.1111/febs.16067
  contributor:
    fullname: Guo
– volume: 144
  start-page: 3840
  year: 2017
  ident: bib80
  article-title: A fluorescent toolkit for spatiotemporal tracking of apoptotic cells in living Drosophila tissues
  publication-title: Development
  doi: 10.1242/dev.149807
  contributor:
    fullname: Schott
– volume: 16
  year: 2018
  ident: bib23
  article-title: An alternative mode of epithelial polarity in the Drosophila midgut
  publication-title: PLOS Biology
  doi: 10.1371/journal.pbio.3000041
  contributor:
    fullname: Chen
– volume: 86
  start-page: e00476
  year: 2020
  ident: bib17
  article-title: Unraveling the composition of insecticidal crystal proteins in bacillus thuringiensis: a proteomics approach
  publication-title: Applied and Environmental Microbiology
  doi: 10.1128/AEM.00476-20
  contributor:
    fullname: Caballero
– volume: 15
  start-page: 104
  year: 2016
  ident: bib20
  article-title: Intestinal regeneration as an insect resistance mechanism to entomopathogenic bacteria
  publication-title: Current Opinion in Insect Science
  doi: 10.1016/j.cois.2016.04.008
  contributor:
    fullname: Castagnola
– volume: 316
  start-page: G313
  year: 2019
  ident: bib97
  article-title: Intestinal renewal across the animal Kingdom: comparing stem cell activity in mouse and Drosophila
  publication-title: American Journal of Physiology. Gastrointestinal and Liver Physiology
  doi: 10.1152/ajpgi.00353.2018
  contributor:
    fullname: Zwick
– volume: 37
  start-page: 3
  year: 2013
  ident: bib71
  article-title: Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection
  publication-title: FEMS Microbiology Reviews
  doi: 10.1111/j.1574-6976.2012.00341.x
  contributor:
    fullname: Pardo-López
– volume: 79
  start-page: 6951
  year: 1982
  ident: bib35
  article-title: Transfer of bacillus thuringiensis plasmids coding for delta-endotoxin among strains of B. thuringiensis and B. cereus
  publication-title: PNAS
  doi: 10.1073/pnas.79.22.6951
  contributor:
    fullname: González
– volume: 8
  year: 2013
  ident: bib41
  article-title: Shared midgut binding sites for cry1a.105, Cry1Aa, Cry1Ab, Cry1Ac and CRY1Fa proteins from Bacillus thuringiensis in two important corn pests, Ostrinia nubilalis and Spodoptera frugiperda
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0068164
  contributor:
    fullname: Hernández-Rodríguez
– volume: 179
  year: 2019
  ident: bib63
  article-title: Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
  publication-title: Progress in Neurobiology
  doi: 10.1016/j.pneurobio.2019.02.003
  contributor:
    fullname: Nässel
– volume: 118
  start-page: 401
  year: 1993
  ident: bib15
  article-title: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
  publication-title: Development
  doi: 10.1242/dev.118.2.401
  contributor:
    fullname: Brand
– volume: 7
  year: 2019
  ident: bib29
  article-title: The bacillus cereus group: bacillus species with pathogenic potential
  publication-title: Microbiology Spectrum
  doi: 10.1128/microbiolspec.GPP3-0032-2018
  contributor:
    fullname: Ehling-Schulz
– volume: 18
  year: 2018
  ident: bib82
  article-title: Analysis of homologs of cry-toxin receptor-related proteins in the midgut of a non-bt target, nilaparvata lugens (stål) (hemiptera: delphacidae)
  publication-title: Journal of Insect Science
  doi: 10.1093/jisesa/iex102
  contributor:
    fullname: Shao
– volume: 16
  year: 2021
  ident: bib14
  article-title: Comparative phenotypic, genotypic and genomic analyses of Bacillus thuringiensis associated with foodborne outbreaks in France
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0246885
  contributor:
    fullname: Bonis
– volume: 338
  start-page: 28
  year: 2010
  ident: bib8
  article-title: Jak/Stat signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage
  publication-title: Developmental Biology
  doi: 10.1016/j.ydbio.2009.10.045
  contributor:
    fullname: Beebe
– volume: 20
  start-page: 3719
  year: 2021
  ident: bib48
  article-title: Bacillus cereus food intoxication and toxicoinfection
  publication-title: Comprehensive Reviews in Food Science and Food Safety
  doi: 10.1111/1541-4337.12785
  contributor:
    fullname: Jovanovic
– volume: 12
  year: 2020
  ident: bib58
  article-title: The cytocidal spectrum of bacillus thuringiensis toxins: from insects to human cancer cells
  publication-title: Toxins
  doi: 10.3390/toxins12050301
  contributor:
    fullname: Mendoza-Almanza
– volume: 11
  year: 2020
  ident: bib64
  article-title: Bacillus thuringiensis bioinsecticides induce developmental defects in non-target Drosophila melanogaster larvae
  publication-title: Insects
  doi: 10.3390/insects11100697
  contributor:
    fullname: Nawrot-Esposito
– volume: 22
  start-page: 1071
  year: 2016
  ident: bib27
  article-title: Biological activity of bacillus thuringiensis in Drosophila suzukii (diptera: drosophilidae)
  publication-title: Journal of Economic Entomology
  doi: 10.1093/jee/tow062
  contributor:
    fullname: Cossentine
– volume: 29
  start-page: 783
  year: 2021
  ident: bib52
  article-title: Genome-wide identification and comparative analysis of cry toxin receptor families in 7 insect species with a focus on spodoptera litura
  publication-title: Insect Science
  doi: 10.1111/1744-7917.12961
  contributor:
    fullname: Li
– volume: 31
  start-page: 291
  year: 2014
  ident: bib50
  article-title: The conserved misshapen-warts-yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila
  publication-title: Developmental Cell
  doi: 10.1016/j.devcel.2014.09.012
  contributor:
    fullname: Li
– volume: 204
  start-page: 265
  year: 2014
  ident: bib90
  article-title: A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.201306082
  contributor:
    fullname: Toret
– volume: 31
  start-page: 2473
  year: 2012
  ident: bib28
  article-title: Drosophila midgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells
  publication-title: The EMBO Journal
  doi: 10.1038/emboj.2012.106
  contributor:
    fullname: de Navascués
– volume: 141
  start-page: 757
  year: 2010
  ident: bib87
  article-title: Cell polarity in eggs and epithelia: parallels and diversity
  publication-title: Cell
  doi: 10.1016/j.cell.2010.05.011
  contributor:
    fullname: St Johnston
– volume: 142
  start-page: 644
  year: 2015
  ident: bib95
  article-title: Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut
  publication-title: Development
  doi: 10.1242/dev.113357
  contributor:
    fullname: Zeng
– volume: 2
  year: 2013
  ident: bib57
  article-title: Physiological and stem cell compartmentalization within the Drosophila midgut
  publication-title: eLife
  doi: 10.7554/eLife.00886
  contributor:
    fullname: Marianes
– volume: 6
  start-page: 755
  year: 2017
  ident: bib19
  article-title: The ABCs of pesticide toxicology: amounts, biology, and chemistry
  publication-title: Toxicology Research
  doi: 10.1039/c7tx00198c
  contributor:
    fullname: Casida
– volume: 68
  start-page: 273
  year: 2014
  ident: bib60
  article-title: Whole-mount immunostaining of the adult Drosophila gastrointestinal tract
  publication-title: Methods
  doi: 10.1016/j.ymeth.2014.03.022
  contributor:
    fullname: Micchelli
– volume-title: Global Status of Commercialized Biotech/GM Crops in 2017: Biotech Crop Adoption Surges as Economic Benefits Accumulate in 22 Years
  year: 2017
  ident: bib44
  contributor:
    fullname: ISAAA
– volume: 13
  year: 2017
  ident: bib96
  article-title: A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila
  publication-title: PLOS Genetics
  doi: 10.1371/journal.pgen.1006854
  contributor:
    fullname: Zhai
– volume: 138
  start-page: 4585
  year: 2011
  ident: bib73
  article-title: Distinct levels of notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine
  publication-title: Development
  doi: 10.1242/dev.065292
  contributor:
    fullname: Perdigoto
– volume: 67
  start-page: 13237
  year: 2019
  ident: bib33
  article-title: Roles of midgut cadherin from two moths in different Bacillus thuringiensis action mechanisms: correlation among toxin binding, cellular toxicity, and synergism
  publication-title: Journal of Agricultural and Food Chemistry
  doi: 10.1021/acs.jafc.9b04563
  contributor:
    fullname: Gao
– volume: 11
  start-page: 529
  year: 2012
  ident: bib36
  article-title: The PAR complex and integrins direct asymmetric cell division in adult intestinal stem cells
  publication-title: Stem Cell
  doi: 10.1016/j.stem.2012.06.017
  contributor:
    fullname: Goulas
– volume-title: Bacillus Thuringiensis and Lysinibacillus Sphaericus: Characterization and Use in the Field of Biocontrol
  year: 2017
  ident: bib31
  doi: 10.1007/978-3-319-56678-8
  contributor:
    fullname: Fiuza
– volume: 3
  year: 2014
  ident: bib89
  article-title: Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut
  publication-title: eLife
  doi: 10.7554/eLife.01857
  contributor:
    fullname: Tian
– volume: 19
  year: 2018
  ident: bib26
  article-title: Rapid and precise alignment of raw reads against redundant databases with KMA
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-018-2336-6
  contributor:
    fullname: Clausen
– volume: 137
  start-page: 4147
  year: 2010
  ident: bib83
  article-title: The hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
  publication-title: Development
  doi: 10.1242/dev.052506
  contributor:
    fullname: Shaw
– volume: 10
  year: 2022
  ident: bib24
  article-title: Epithelial cell polarity during Drosophila midgut development
  publication-title: Frontiers in Cell and Developmental Biology
  doi: 10.3389/fcell.2022.886773
  contributor:
    fullname: Chen
– volume: 111
  start-page: 1
  year: 2012
  ident: bib91
  article-title: Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review
  publication-title: Journal of Invertebrate Pathology
  doi: 10.1016/j.jip.2012.05.001
  contributor:
    fullname: Vachon
– volume: 148
  year: 2021
  ident: bib30
  article-title: Membrane architecture and adherens junctions contribute to strong notch pathway activation
  publication-title: Development
  doi: 10.1242/dev.199831
  contributor:
    fullname: Falo-Sanjuan
– volume: 4
  start-page: 30240
  year: 2019
  ident: bib93
  article-title: Microbial control of intestinal homeostasis via enteroendocrine cell innate immune signaling
  publication-title: Trends in Microbiology
  doi: 10.1016/j.tim.2019.09.005
  contributor:
    fullname: Watnick
– volume: 3
  start-page: 1725
  year: 2013
  ident: bib16
  article-title: Morphological and molecular characterization of adult midgut compartmentalization in Drosophila
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2013.04.001
  contributor:
    fullname: Buchon
– volume: 3
  start-page: 442
  year: 2008
  ident: bib11
  article-title: Jnk activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut
  publication-title: Stem Cell
  doi: 10.1016/j.stem.2008.07.024
  contributor:
    fullname: Biteau
– volume: 104
  start-page: 16204
  year: 2007
  ident: bib76
  article-title: Toxins in transgenic crop byproducts may affect headwater stream ecosystems
  publication-title: PNAS
  doi: 10.1073/pnas.0707177104
  contributor:
    fullname: Rosi-Marshall
– volume: 10
  year: 2020
  ident: bib7
  article-title: Differential side-effects of Bacillus thuringiensis bioinsecticide on non-target Drosophila flies
  publication-title: Scientific Reports
  doi: 10.1038/s41598-020-73145-6
  contributor:
    fullname: Babin
– volume: 220
  start-page: 664
  year: 2009
  ident: bib22
  article-title: Pathogenic stimulation of intestinal stem cell response in Drosophila
  publication-title: Journal of Cellular Physiology
  doi: 10.1002/jcp.21808
  contributor:
    fullname: Chatterjee
– volume: 64
  start-page: 11
  year: 2016
  ident: bib18
  article-title: Bacteria sensing mechanisms in Drosophila gut: local and systemic consequences
  publication-title: Developmental and Comparative Immunology
  doi: 10.1016/j.dci.2016.01.001
  contributor:
    fullname: Capo
– volume: 80
  start-page: 61
  year: 2017
  ident: bib86
  article-title: Expressing a moth ABCC2 gene in transgenic Drosophila causes susceptibility to bt cry1ac without requiring a cadherin-like protein receptor
  publication-title: Insect Biochemistry and Molecular Biology
  doi: 10.1016/j.ibmb.2016.11.008
  contributor:
    fullname: Stevens
– volume: 137
  start-page: 1343
  year: 2009
  ident: bib45
  article-title: Cytokine/jak/stat signaling mediates regeneration and homeostasis in the Drosophila midgut
  publication-title: Cell
  doi: 10.1016/j.cell.2009.05.014
  contributor:
    fullname: Jiang
– volume: 147
  start-page: 603
  year: 2011
  ident: bib66
  article-title: Altered modes of stem cell division drive adaptive intestinal growth
  publication-title: Cell
  doi: 10.1016/j.cell.2011.08.048
  contributor:
    fullname: O’Brien
– volume: 40
  start-page: 505
  year: 2017
  ident: bib84
  article-title: Cell-Cell contact area affects Notch signaling and Notch-dependent patterning
  publication-title: Developmental Cell
  doi: 10.1016/j.devcel.2017.02.009
  contributor:
    fullname: Shaya
– volume: 21
  year: 2020
  ident: bib47
  article-title: Tissue adaptation to environmental cues by symmetric and asymmetric division modes of intestinal stem cells
  publication-title: International Journal of Molecular Sciences
  doi: 10.3390/ijms21176362
  contributor:
    fullname: Joly
– volume: 144
  start-page: 1177
  year: 2017
  ident: bib38
  article-title: Diversity of fate outcomes in cell pairs under lateral inhibition
  publication-title: Development
  doi: 10.1242/dev.137950
  contributor:
    fullname: Guisoni
– volume: 108
  start-page: 121
  year: 2014
  ident: bib92
  article-title: Cell death: a program to regenerate
  publication-title: Current Topics in Developmental Biology
  doi: 10.1016/B978-0-12-391498-9.00002-4
  contributor:
    fullname: Vriz
– volume: 66
  start-page: 1337
  year: 2009
  ident: bib85
  article-title: Signaling versus punching hole: how do Bacillus thuringiensis toxins kill insect midgut cells?
  publication-title: Cellular and Molecular Life Sciences
  doi: 10.1007/s00018-008-8330-9
  contributor:
    fullname: Soberón
SSID ssj0000748819
Score 2.4104733
Snippet subsp. ( ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, and its toxins are used worldwide...
Bacillus thuringiensis subsp. kurstaki ( Btk ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes....
Bacillus thuringiensis subsp. kurstaki (Btk) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence,...
Bacillus thuringiensis subsp. kurstaki ( Btk ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes....
SourceID doaj
pubmedcentral
hal
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
SubjectTerms Animals
bacillus thurigiensis
Bacillus thuringiensis
Bacillus thuringiensis Toxins - adverse effects
Bacteriology
Cell Adhesion
Cell Biology
Crops, Agricultural
Cry1A toxins
Drosophila melanogaster
E-Cadherins
enteroendocrine cells
intestinal stem cells
Life Sciences
Microbiology and Parasitology
Plants, Genetically Modified
Stem Cells - drug effects
Toxicology
Toxicology and food chain
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQiFeAIoN6XerYSZw5ttBqhQonKvUW-THRRlolaB8V_SP9vZ1xttUGDr1wiRTbchzP2PPwzGchjrQCHVuyVAOZF7PC08NXtB75UIvEdSAuYNfAj5_V_LL4flVe7V31xTFhIzzwOHHHCLaEoKBVhSlcnvsA0eUtFpFhX3C01hXsGVNpD7bEmDmMCXmWROYxXnQtfqmZASciKCH1k2BZcBzkv0rm37GSe8Ln_Ll4ttMa5ck42hfiCfYvxe2pC91yuV3LzSIlG3YcjE5vw5-uX8vIERcbyQFYyOt2JdlJz9UcKCsZi3M1YB-HwAmAsiWlU_obGZMeyR6E1F66uED2qEn22EpGl6BNgQfDCNC7LrteflulCxG6pXslLs_Pfn2dz3bXLMyCgQpmoUJNlCw1BL4YEaANNtRYkSEFFoOzFqOpS99qUE6raF10deGwdnmIRpfmtTjohx7fCpkjhBhUNN6bonQBrPM1qLqNgU946kwc3c9883tE02jICmECNYlATSJQJk6ZKg9NGAI7FRBjNDvGaB5jjEx8JppO-pifXDRcphhSyIC5zjPx6Z7kDa0rnjTX47BdN5qRmUh7MjYTb0YWeOjLVCTTSa_JhJ0wx-Rj05q-WyTsbgA2Z6p3_-MP34unmlSulGBvP4iDzWqLh6QibfzHtBruAHp1FKM
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1Lb9QwEB6VIqFeUBGvQIsM6nWXxE7izAm1hWqFCidW6i1ybIeNtEpKdhe1f4Tfy4w3W5ECl0iJHSfyzHgeHn8DcCJjlK4mT9WSezFJK7pUOckjb2qRurbEBRwa-PI1n83Tz1fZ1R7sinEOE7j6p2vH9aTm_XJ68-P2Awk82a9TTdrwvb9saj8tmLcewEOZkovOOXyDnR-WZE18muD2fN79dw7gkcppkc6TdKScAoY_qZwFZ0j-bX7ez6L8Qy1dHMLjwZ4Up1sGeAJ7vn0Kv86MbZbLzUqsF-EYYsNp6nTX3TTtSjjOxVgLTs3yLNG94PA9N3MKrWCUzr7zressHw0UNZmjoroVLliYHFsI_YVxC8-xNsGxXMG4E7Rc8M8wNvQwZNOKj30oldAszTOYX3z6dj6bDAUYJlZhjhObe0k0ziRaLpmIWFttC5-Ti4XaW6O1d6rIqlpibGTstHGmSI0vTGKdkpl6Dvtt1_qXIBKP1tnYqapSaWYsalMVGBe1s7z3U0Rwspv58nqLs1GSf8K0KgOtykCrCM6YKnddGBw7POj67-Uga6VHnaGNsY5TlZokqSw6k9Q-dYwU5OMI3hFNR2PMTi9LfhYz2JBC9TOJ4O2O5CVJHE-aaX23WZWSMZvIrlI6ghdbFrgba8dIEegRc4w-Nm5pm0VA9UZkRyd_9d8xX8MB17oP5-n1Eeyv-40_JotoXb0J3P4bFkgOeA
  priority: 102
  providerName: Scholars Portal
Title Bacillus thuringiensis toxins divert progenitor cells toward enteroendocrine fate by decreasing cell adhesion with intestinal stem cells in Drosophila
URI https://www.ncbi.nlm.nih.gov/pubmed/36847614
https://www.proquest.com/docview/2780482237
https://hal.science/hal-04043393
https://pubmed.ncbi.nlm.nih.gov/PMC9977296
https://doaj.org/article/e9759c09f0434a11bc9da1fe4d0604e0
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEB6SFEoupaUvpa3ZllxtS1pJqz3GaYIpcQilAd_EvlQLHCnIdmn_SH9vZ9ZSiNpbLwK9VkLzzc5DM98CnMahjG2JkarB8GKcaNzoDPWRfmqhuTaIAkoNLK6z-W3yZZkuDyDte2F80b7R1aRe303qauVrK-_vzLSvE5veLM6lJJ8wmx7CIQL0UYjup1-BmIzkvhdPoLWcuquqdJOcsHcMT3mGE3IWJQND5Pn60bysqBryX1fz74rJRybo8jk863xHdrZ_xxdw4OqX8HumTLVe7zZsu_IthxWVpONe87OqN8xS3cWWURmWI-1tGaXq6TSVyzJi5GwbV9vGUBsgK9H1ZPoXs96bpDyCv54pu3KUV2OUt2XEMYFTA70M8UB3Q1Y1-9z6ZRGqtXoFt5cX387n426xhbHhMpNjk7kY5ZnG0tDyiFKWRpjcZRhOSeGMEsJZnqe6jGWo4tAKZVWeKJeryFgep_w1HNVN7d4Ci5w01oSWa82TVBkplM5lmJfW0H-ePIDT_ssX93tOjQJjEZJV4WVVeFkFMCOpPFxCRNj-QNN-Lzo4FE6KVJpQlmHCExVF2kirotIllliBXBjAJ5TpYIz52VVBx0IiFuKS_4gC-NiLvEDtoo-matfsNkVM_EzoQ3ERwJs9BB7G6oEUgBiAY_Cw4RkEtGfw7gB88t93voNjWvfe99aL93C0bXfuA3pHWz1CnViKETyZXVzffB35HANuF0k-8nryB7R0GYc
link.rule.ids 230,315,730,783,787,867,888,2109,24330,27936,27937,31732,33757,53804,53806
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VIkEvCMTLPBfUaxLba3u9x7ZQBUgqDq3U22pfbiylduUkCP4Iv5eZjVPVcONiya-15flm5-GZbwEO01imrsJI1WJ4McoMbkyB-kg_tdBcW0QBpQbmZ8X0Ivt6mV_uQb7rhQlF-9bU42Z5PW7qRaitvLm2k12d2OT7_ERK8gmLyT24j_oaZ3eC9DABC0RlIrfdeALt5cTP6sqPS0LfATzgBU7JRZINTFFg7EcDs6B6yH-dzb9rJu8YodPH8Kj3HtnR9i2fwJ5vnsLvY23r5XKzYutFaDqsqSgd99qfdbNijiov1owKsTzpb8coWU-nqWCWESdn1_rGtZYaAVmFziczv5gL_iRlEsL1TLuFp8wao8wtI5YJnBzoZYgJuh-ybtinLiyMUC_1M7g4_Xx-Mh31yy2MLJeFHNnCpyjRPJWWFkiUsrLClr7AgEoKb7UQ3vEyN1UqY53GTminy0z7UifW8TTnz2G_aRv_EljipXU2dtwYnuXaSqFNKeOycpb-9JQRHO6-vLrZsmoojEZIVirISgVZRXBMUrm9hKiww4G2u1I9IJSXIpc2llWc8UwnibHS6aTymSNeIB9H8BFlOhhjejRTdCwmaiEu-Y8kgg87kSvUL_pouvHtZqVSYmhCL4qLCF5sIXA71g5IEYgBOAYPG55BSAcO7x7Cr_77zvfwcHo-n6nZl7Nvr-EgRd8rdNqLN7C_7jb-LfpKa_MuaMYfBEcYjQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSNNeEIhbuBq01zZOnMTx4y5UBbppD0zam-Vb1khdUqUtgj_C7-UcN50aeOOlUpPUjXK-43PJ58-EHKdMpq6CStVCeTHKDHyYAvwRX2pBuLaAAmwNXFwW0-vs601-s7fVVyDtW1OPm8XduKnngVu5vLPxjicWX12cSYk5YREvXRU_JI_AZ1mxV6iHSVgAMhO5XZEnIGbGflZXflwiAo_IIS9gWi6SbBCOgmo_BJk5ciL_TTj_5k3uBaLJE_K4zyDpyfZOn5IHvnlGfp9qWy8WmxVdz8PCwxqJ6fCt_Vk3K-qQfbGmSMby6MMdxYY9nkbSLEVdzq71jWstLgakFSSg1PyiLuSU2E0I11Pt5h67axS7txSVJmCCwJtBNeh-yLqh513YHKFe6OfkevL5-9l01G-5MLJcFnJkC5-CVfNUWtwkUcrKClv6AooqKbzVQnjHy9xUqWQ6ZU5op8tM-1In1vE05y_IQdM2_hWhiZfWWea4MTzLtZVCm1KysnIW3_aUETnePXm13CprKKhI0FYq2EoFW0XkFK1yfwnKYYcDbXerelAoL0UuLZMVy3imk8RY6XRS-cyhNpBnEfkENh2MMT2ZKTzGUF6IS_4jicjHnckV-Bg-NN34drNSKao0QSbFRURebiFwP9YOSBERA3AM_mx4BmAddLx7GL_-719-IIdX5xM1-3L57Q05SiH9CovtxVtysO42_h2kS2vzPjjGH-ZOGaA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bacillus+thuringiensis+toxins+divert+progenitor+cells+toward+enteroendocrine+fate+by+decreasing+cell+adhesion+with+intestinal+stem+cells+in+Drosophila&rft.jtitle=eLife&rft.au=Jneid%2C+Rouba&rft.au=Loudhaief%2C+Rihab&rft.au=Zucchini-Pascal%2C+Nathalie&rft.au=Nawrot-Esposito%2C+Marie-Paule&rft.date=2023-02-27&rft.eissn=2050-084X&rft.volume=12&rft_id=info:doi/10.7554%2FeLife.80179&rft_id=info%3Apmid%2F36847614&rft.externalDocID=36847614
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2050-084X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2050-084X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2050-084X&client=summon