Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship With Obesity and Type 2 Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 100; no. 4; pp. E591 - E595
• Main Authors: Clemente-Postigo, Mercedes, Muñoz-Garach, Araceli, Serrano, Marta, Garrido-Sánchez, Lourdes, Bernal-López, M. Rosa, Fernández-García, Diego, Moreno-Santos, Inmaculada, Garriga, Nuria, Castellano-Castillo, Daniel, Camargo, Antonio, Fernández-Real, Jose M., Cardona, Fernando, Tinahones, Francisco J., Macías-González, Manuel
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2015; Copyright by The Endocrine Society
• Subjects: 25-Hydroxyvitamin D; Adipose tissue; Adipose Tissue - metabolism; Adult; Aged; Body fat; Body Mass Index; Calcitriol; Carbohydrate metabolism; Cells, Cultured; Cohort Studies; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Explants; Female; Gene Expression; Glucose metabolism; Homeostasis; Humans; Insulin resistance; Male; Metabolism; Middle Aged; Obesity; Obesity - blood; Obesity - genetics; Overweight - blood; Overweight - genetics; Parathyroid hormone; Prediabetic State - blood; Prediabetic State - genetics; Receptors, Calcitriol - genetics; Receptors, Calcitriol - metabolism; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - genetics; Vitamin D receptors; Vitamin D3; Vitamin deficiency

Context:The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].Objective:To analyze serum 25...