Bone Turnover, Bone Mineral Density, and Fracture Risk in Acromegaly: A Meta-Analysis

• Published in: The journal of clinical endocrinology and metabolism Vol. 100; no. 2; pp. 384 - 394
• Main Authors: Mazziotti, Gherardo, Biagioli, Elena, Maffezzoni, Filippo, Spinello, Maurizio, Serra, Vincenza, Maroldi, Roberto, Floriani, Irene, Giustina, Andrea
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2015; Copyright by The Endocrine Society
• Subjects: Acromegaly; Acromegaly - complications; Acromegaly - diagnostic imaging; Acromegaly - physiopathology; Bone density; Bone Density - physiology; Bone growth; Bone mineral density; Bone Remodeling - physiology; Bone resorption; Bone strength; Bone turnover; Femur Neck - diagnostic imaging; Fractures; Fractures, Bone - diagnostic imaging; Fractures, Bone - etiology; Fractures, Bone - physiopathology; Humans; Hypogonadism; Long bone; Lumbar Vertebrae - diagnostic imaging; Meta-analysis; Osteogenesis; Radiography; Risk; Spine (lumbar); Vertebrae

Context:GH excess causes an increase in bone turnover, but the consequences in terms of skeletal fragility have long been uncertain due to the heterogeneity of studies dealing with this topic.Objective:We conducted a meta-analysis of studies examining the effects of acromegaly on bone turnover, bone...