Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment

• Published in: Genes & diseases Vol. 12; no. 6; p. 101678
• Main Authors: Wang, Luyao, Zhu, Ye, Huang, Chengying, Pan, Qiuming, Wang, Junxi, Li, Hongrui, Huang, Yudi, Yi, Guozhong, Li, Zhiyong, Qi, Songtao, Huang, Guanglong, Qu, Shanqiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2025; Chongqing Medical University; KeAi Communications Co., Ltd
• Subjects: Cancer stemcells (CSCs); Cell signaling; Drug target; Ferroptosis; Iron metabolism; Review; Drug target; Ferroptosis; Iron metabolism; Cancer stemcells (CSCs); Cell signaling

Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurrence. CSCs exhibit enhanced iron uptake and altered lipid metab...