Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment

Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurrence. CSCs exhibit enhanced iron uptake and altered lipid metab...

Full description

Saved in:
Bibliographic Details
Published inGenes & diseases Vol. 12; no. 6; p. 101678
Main Authors Wang, Luyao, Zhu, Ye, Huang, Chengying, Pan, Qiuming, Wang, Junxi, Li, Hongrui, Huang, Yudi, Yi, Guozhong, Li, Zhiyong, Qi, Songtao, Huang, Guanglong, Qu, Shanqiang
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2025
Chongqing Medical University
KeAi Communications Co., Ltd
Subjects
Cancer stemcells (CSCs)
Cell signaling
Drug target
Ferroptosis
Iron metabolism
Review
Drug target
Ferroptosis
Iron metabolism
Cancer stemcells (CSCs)
Cell signaling
Online AccessGet full text

Cover

Abstract Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurrence. CSCs exhibit enhanced iron uptake and altered lipid metabolism, allowing them to evade conventional therapies and persist within the cancer microenvironment. Their resilience is linked to low reactive oxygen species levels, aiding survival under oxidative stress. Key regulatory pathways, including the cystine/glutathione axis, significantly modulate CSCs' sensitivity to ferroptosis by maintaining a balance between antioxidant defenses and pro-oxidative stressors. Targeting ferroptosis in CSCs offers promising therapeutic avenues for enhancing treatment efficacy and overcoming resistance. Strategies such as pharmacological inhibition of the SLC7A11 transporter, which reduces cysteine availability and glutathione levels, can potentiate ferroptosis in CSCs. Additionally, inducing dysregulation of iron metabolism or lipid peroxidation can selectively compromise CSCs' survival. Nanoparticle drug delivery systems that increase intracellular iron and reactive oxygen species levels are proving effective in targeting CSCs with minimal impact on normal cells. Ultimately, a comprehensive understanding of the interplay between ferroptosis and CSCs' biology is essential for developing innovative strategies aimed at eradicating these elusive cells, thereby improving cancer treatment outcomes and reducing recurrence rates.
AbstractList Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurrence. CSCs exhibit enhanced iron uptake and altered lipid metabolism, allowing them to evade conventional therapies and persist within the cancer microenvironment. Their resilience is linked to low reactive oxygen species levels, aiding survival under oxidative stress. Key regulatory pathways, including the cystine/glutathione axis, significantly modulate CSCs' sensitivity to ferroptosis by maintaining a balance between antioxidant defenses and pro-oxidative stressors. Targeting ferroptosis in CSCs offers promising therapeutic avenues for enhancing treatment efficacy and overcoming resistance. Strategies such as pharmacological inhibition of the SLC7A11 transporter, which reduces cysteine availability and glutathione levels, can potentiate ferroptosis in CSCs. Additionally, inducing dysregulation of iron metabolism or lipid peroxidation can selectively compromise CSCs' survival. Nanoparticle drug delivery systems that increase intracellular iron and reactive oxygen species levels are proving effective in targeting CSCs with minimal impact on normal cells. Ultimately, a comprehensive understanding of the interplay between ferroptosis and CSCs' biology is essential for developing innovative strategies aimed at eradicating these elusive cells, thereby improving cancer treatment outcomes and reducing recurrence rates.
Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurrence. CSCs exhibit enhanced iron uptake and altered lipid metabolism, allowing them to evade conventional therapies and persist within the cancer microenvironment. Their resilience is linked to low reactive oxygen species levels, aiding survival under oxidative stress. Key regulatory pathways, including the cystine/glutathione axis, significantly modulate CSCs' sensitivity to ferroptosis by maintaining a balance between antioxidant defenses and pro-oxidative stressors. Targeting ferroptosis in CSCs offers promising therapeutic avenues for enhancing treatment efficacy and overcoming resistance. Strategies such as pharmacological inhibition of the SLC7A11 transporter, which reduces cysteine availability and glutathione levels, can potentiate ferroptosis in CSCs. Additionally, inducing dysregulation of iron metabolism or lipid peroxidation can selectively compromise CSCs' survival. Nanoparticle drug delivery systems that increase intracellular iron and reactive oxygen species levels are proving effective in targeting CSCs with minimal impact on normal cells. Ultimately, a comprehensive understanding of the interplay between ferroptosis and CSCs' biology is essential for developing innovative strategies aimed at eradicating these elusive cells, thereby improving cancer treatment outcomes and reducing recurrence rates.Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurrence. CSCs exhibit enhanced iron uptake and altered lipid metabolism, allowing them to evade conventional therapies and persist within the cancer microenvironment. Their resilience is linked to low reactive oxygen species levels, aiding survival under oxidative stress. Key regulatory pathways, including the cystine/glutathione axis, significantly modulate CSCs' sensitivity to ferroptosis by maintaining a balance between antioxidant defenses and pro-oxidative stressors. Targeting ferroptosis in CSCs offers promising therapeutic avenues for enhancing treatment efficacy and overcoming resistance. Strategies such as pharmacological inhibition of the SLC7A11 transporter, which reduces cysteine availability and glutathione levels, can potentiate ferroptosis in CSCs. Additionally, inducing dysregulation of iron metabolism or lipid peroxidation can selectively compromise CSCs' survival. Nanoparticle drug delivery systems that increase intracellular iron and reactive oxygen species levels are proving effective in targeting CSCs with minimal impact on normal cells. Ultimately, a comprehensive understanding of the interplay between ferroptosis and CSCs' biology is essential for developing innovative strategies aimed at eradicating these elusive cells, thereby improving cancer treatment outcomes and reducing recurrence rates.
ArticleNumber 101678
Author Li, Hongrui
Qi, Songtao
Huang, Yudi
Yi, Guozhong
Wang, Luyao
Zhu, Ye
Wang, Junxi
Huang, Guanglong
Huang, Chengying
Pan, Qiuming
Li, Zhiyong
Qu, Shanqiang
Author_xml – sequence: 1
  givenname: Luyao
  surname: Wang
  fullname: Wang, Luyao
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 2
  givenname: Ye
  surname: Zhu
  fullname: Zhu, Ye
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 3
  givenname: Chengying
  surname: Huang
  fullname: Huang, Chengying
  organization: Department of Obstetrics and Gynecology, Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510440, China
– sequence: 4
  givenname: Qiuming
  surname: Pan
  fullname: Pan, Qiuming
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 5
  givenname: Junxi
  surname: Wang
  fullname: Wang, Junxi
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 6
  givenname: Hongrui
  surname: Li
  fullname: Li, Hongrui
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 7
  givenname: Yudi
  surname: Huang
  fullname: Huang, Yudi
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 8
  givenname: Guozhong
  surname: Yi
  fullname: Yi, Guozhong
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 9
  givenname: Zhiyong
  surname: Li
  fullname: Li, Zhiyong
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 10
  givenname: Songtao
  surname: Qi
  fullname: Qi, Songtao
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 11
  givenname: Guanglong
  surname: Huang
  fullname: Huang, Guanglong
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
– sequence: 12
  givenname: Shanqiang
  orcidid: 0000-0002-2709-0101
  surname: Qu
  fullname: Qu, Shanqiang
  email: qushq3@163.com
  organization: Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40821110$$D View this record in MEDLINE/PubMed
BookMark eNp9kk1r3DAQhkVJadJt_kEpPvay29GXLffQEkI_AoFeUuhNyPLY1WJLW0m7kH8fbZyE5NKTxKtXzzDvzFty4oNHQt5T2FCg9aftZkTfu7RhwOS91KhX5IxxydYcBDt5dj8l5yltAYByDlK0b8ipAMUopXBG_tyYOGJ2fqwGjDHsckguVc5X1niLsUoZ58riNKXP1UXlwwGnokWTcbytcqjcvItFfLTniCbP6PM78nowU8Lzh3NFfn__dnP5c33968fV5cX12vK2VuuasUFg3aBquaSm4V0NVjQS2x5BtD03TNR900GtupaCrK0YDBjFetkIOhi-IlcLtw9mq3fRzSbe6mCcvhdCHLWJ2dkJdYe0o7WVFiUXVkpVyKYZ5MB623S0K6yvC2u372bsbWkjmukF9OWLd3_1GA6alrCFYlAIHx8IMfzbY8p6dumYnvEY9klzJkAoUKXbFfnwvNhTlcfZFINYDDaGlCIOTxYK-jhyvdXLFujjFuhlC8q3L8s3LKkfHEadrMMynN5FtLnE4v4PuAPVcbxP
Cites_doi 10.3390/cells9030527
10.1186/s43556-023-00165-9
10.1016/j.cell.2017.09.021
10.7150/jca.30318
10.7150/jca.84363
10.1016/j.scr.2015.08.006
10.1016/j.actbio.2023.02.015
10.1080/15548627.2017.1327104
10.1152/ajpcell.00322.2015
10.3390/cancers14153642
10.1002/stem.3101
10.3389/fonc.2020.01332
10.1016/j.jconrel.2023.03.001
10.1089/scd.2017.0123
10.1016/j.biocel.2018.12.008
10.1016/j.stem.2012.12.013
10.1002/iub.1756
10.1002/bmm2.12010
10.1038/s41598-020-66471-2
10.1007/s13238-021-00841-y
10.1002/advs.202004320
10.1158/1541-7786.MCR-19-0691
10.1038/nm0797-730
10.1038/s41388-023-02744-0
10.1038/s41419-021-04406-z
10.7150/jca.81027
10.1002/pmic.201800311
10.1136/gutjnl-2021-324994
10.3390/cells10010083
10.1038/s41586-021-03539-7
10.1186/s40591-015-0045-3
10.7150/thno.14848
10.1038/s41467-021-25354-4
10.1111/j.1478-3231.2006.01316.x
10.1073/pnas.95.7.3483
10.1155/2015/750798
10.1016/j.ccr.2011.01.038
10.1007/s12031-022-02017-7
10.1038/s41586-019-1707-0
10.1016/j.redox.2023.102632
10.1038/s41586-019-1426-6
10.1053/j.gastro.2023.09.021
10.1038/s41418-019-0352-3
10.1074/jbc.M109.032839
10.1155/2023/4772134
10.1084/jem.20091046
10.1158/0008-5472.CAN-13-1224
10.1016/j.cell.2012.03.042
10.3390/cells11193053
10.1074/jbc.M305327200
10.1002/hep.29778
10.1016/j.cmet.2020.06.019
10.1016/j.fmre.2021.07.008
10.1016/j.freeradbiomed.2024.09.033
10.1073/pnas.1331931100
10.1093/carcin/bgn095
10.1002/bmm2.12022
10.1111/j.1541-4337.2011.00156.x
10.1002/ctm2.1028
10.1016/j.fmre.2022.10.001
10.1007/s10238-022-00955-5
10.1038/nrc3495
10.3390/antiox13010070
10.1002/mco2.298
10.1371/journal.pone.0235747
10.18632/oncoscience.160
10.1038/s41418-022-01096-8
10.1186/s12876-022-02637-8
10.1586/era.11.82
10.4252/wjsc.v12.i11.1307
10.3389/fgene.2022.904536
10.1002/advs.202105222
10.1042/BCJ20170164
10.3390/ijms24054487
10.1186/s43556-023-00142-2
10.1038/nchem.2778
10.1089/ars.2019.7905
10.1111/1759-7714.14835
10.1016/j.addr.2014.06.004
10.1002/advs.202101848
10.1038/s41586-022-05475-6
10.1016/j.sjbs.2021.04.005
10.1158/0008-5472.CAN-21-0567
10.1080/07315724.2001.10719159
10.1126/science.aaw9872
10.1002/j.2040-4603.2013.tb00518.x
10.1089/ars.2012.5014
10.1002/mco2.262
10.3390/ijms20020273
10.1158/0008-5472.CAN-18-3855
10.1042/BSR20120097
10.1158/1078-0432.CCR-08-2822
10.1038/s43018-023-00653-5
10.1007/s10555-012-9382-8
10.1186/s43556-023-00140-4
10.18632/oncotarget.7598
10.1517/17425247.2015.998648
10.1056/NEJMra1804280
10.1021/jacs.3c08032
10.1038/nm.4409
10.1016/j.ccell.2024.11.007
10.1002/emmm.201302654
10.1016/j.stem.2016.11.004
10.1002/hep4.2031
10.1038/s41589-024-01612-6
10.1074/jbc.M109.016139
10.1002/ctm2.1147
10.1186/s43556-022-00105-z
10.3390/molecules21030325
10.1016/j.freeradbiomed.2018.07.015
10.1006/geno.1998.5268
10.18632/oncotarget.21846
10.1128/MCB.26.9.3514-3526.2006
10.1002/bmm2.12043
10.1186/s13046-024-03169-7
10.1158/1078-0432.CCR-09-3352
10.1158/1078-0432.CCR-10-0799
10.1172/JCI72931
10.1002/ijc.25944
10.1186/1471-2407-14-722
10.1038/s41586-019-1705-2
10.1002/cai2.7
10.1167/iovs.07-1472
10.1038/s41422-022-00642-w
10.3164/jcbn.11-009FR
10.1096/fj.09-132795
10.1172/JCI171166
10.1371/journal.pone.0041942
10.1038/s41467-022-29018-9
10.1186/s13045-021-01194-z
10.1016/j.cell.2010.06.028
10.1038/s41392-020-0110-5
10.1111/nyas.13008
10.1016/j.cell.2019.03.010
10.1038/s41598-019-52837-8
10.1038/s41467-021-27365-7
10.1002/mco2.606
10.1038/nature07733
10.1186/s13046-023-02843-6
10.1016/j.prostaglandins.2019.106363
10.1053/j.gastro.2013.08.018
10.1016/j.jhep.2019.08.025
10.1016/S0891-5849(99)00177-X
10.1016/j.canlet.2015.02.002
10.1038/s41419-022-05121-z
10.1128/AEM.01503-18
10.1186/s13046-022-02567-z
10.1136/gutjnl-2016-313264
10.1021/acscentsci.9b01063
10.1126/sciimmunol.adh1306
10.1021/acs.nanolett.4c02192
10.1002/cai2.77
10.1038/s41418-021-00859-z
10.1158/0008-5472.CAN-10-0713
10.1002/advs.202302953
10.1038/s41589-020-0613-y
10.1245/s10434-009-0617-z
10.1158/0008-5472.CAN-10-0184
10.1053/j.gastro.2013.01.046
10.1016/j.lfs.2019.116986
10.1515/BC.2003.070
10.1021/acsnano.3c08485
10.1080/15548627.2023.2165323
10.1016/j.biopha.2022.114134
10.1016/j.chembiol.2020.03.012
10.1038/nm.4336
10.1016/j.freeradbiomed.2018.09.014
10.1016/0005-2760(82)90150-3
10.1186/s13046-023-02816-9
10.1016/j.redox.2021.101928
10.3389/fimmu.2022.903859
10.1002/mco2.337
10.1016/j.addr.2014.03.001
10.1016/j.devcel.2017.11.020
10.1158/0008-5472.CAN-07-5003
10.1038/s41467-019-14046-9
10.1038/s41392-024-01851-y
10.3390/cells9061511
10.1002/anie.202218407
10.18632/oncotarget.6004
10.1038/s41392-024-01772-w
10.1186/s13046-022-02518-8
10.1016/j.canlet.2022.215783
10.1016/j.fmre.2023.08.015
10.1038/s41419-022-05462-9
10.1016/j.ejps.2020.105450
10.1126/science.1226929
10.1021/ja411006a
10.3389/fphar.2014.00196
10.1038/s41419-024-06667-w
10.18632/oncotarget.28488
10.1016/j.stem.2023.05.007
10.1002/adhm.201900160
10.1186/s12885-016-2372-4
10.1016/j.ccell.2023.07.012
10.1016/j.ccell.2015.09.002
10.1016/j.redox.2021.102006
10.1038/s41416-019-0660-x
10.1186/s13046-022-02493-0
10.1016/j.molcel.2023.05.011
10.1002/advs.202203357
10.1074/jbc.M111.315705
10.1038/s41586-020-2623-z
ContentType Journal Article
Copyright 2025 Chongqing Medical University
2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltdé.
2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltdé. 2025 Chongqing Medical University
Copyright_xml – notice: 2025 Chongqing Medical University
– notice: 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltdé.
– notice: 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltdé. 2025 Chongqing Medical University
DBID 6I.
AAFTH
AAYXX
CITATION
NPM
7X8
5PM
DOA
DOI 10.1016/j.gendis.2025.101678
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Open Access Full Text
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 2352-3042
ExternalDocumentID oai_doaj_org_article_be1b16c5ce534c55846da7f5f2dc7b1b
PMC12354820
40821110
10_1016_j_gendis_2025_101678
S2352304225001679
Genre Journal Article
Review
GroupedDBID 0R~
4.4
457
53G
5VS
6I.
AAEDW
AAFTH
AAIKJ
AALRI
AAXUO
AAYWO
ABMAC
ACGFS
ACVFH
ADBBV
ADCNI
ADEZE
ADVLN
AEUPX
AEXQZ
AFPUW
AFTJW
AGHFR
AIGII
AITUG
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
AOIJS
BAWUL
BCNDV
DIK
EBS
EJD
FDB
GROUPED_DOAJ
HYE
IPNFZ
IXB
KQ8
M41
O9-
OK1
RIG
ROL
RPM
SSZ
AAYXX
CITATION
NPM
7X8
5PM
ID FETCH-LOGICAL-c3968-622f4e67e89351a73b60c475e9de049d3a246d7b068b91056c4fa0a82d5741fa3
IEDL.DBID DOA
ISSN 2352-3042
2352-4820
IngestDate Wed Aug 27 00:47:37 EDT 2025
Thu Aug 21 18:25:34 EDT 2025
Mon Aug 18 16:31:15 EDT 2025
Thu Aug 28 04:36:49 EDT 2025
Wed Aug 27 16:39:06 EDT 2025
Sat Aug 30 17:16:43 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords Drug target
Ferroptosis
Iron metabolism
Cancer stemcells (CSCs)
Cell signaling
Language English
License This is an open access article under the CC BY license.
2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltdé.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3968-622f4e67e89351a73b60c475e9de049d3a246d7b068b91056c4fa0a82d5741fa3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
These authors contributed equally to this work.
ORCID 0000-0002-2709-0101
OpenAccessLink https://doaj.org/article/be1b16c5ce534c55846da7f5f2dc7b1b
PMID 40821110
PQID 3240480889
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_be1b16c5ce534c55846da7f5f2dc7b1b
pubmedcentral_primary_oai_pubmedcentral_nih_gov_12354820
proquest_miscellaneous_3240480889
pubmed_primary_40821110
crossref_primary_10_1016_j_gendis_2025_101678
elsevier_sciencedirect_doi_10_1016_j_gendis_2025_101678
PublicationCentury 2000
PublicationDate 2025-11-01
PublicationDateYYYYMMDD 2025-11-01
PublicationDate_xml – month: 11
  year: 2025
  text: 2025-11-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Genes & diseases
PublicationTitleAlternate Genes Dis
PublicationYear 2025
Publisher Elsevier B.V
Chongqing Medical University
KeAi Communications Co., Ltd
Publisher_xml – name: Elsevier B.V
– name: Chongqing Medical University
– name: KeAi Communications Co., Ltd
References Hasegawa, Takahashi, Rajabi (bib188) 2016; 7
Vasan, Werner, Chandel (bib107) 2020; 32
Liu, Li, Yu (bib7) 2013; 144
Müller, Lim, Bebber (bib97) 2023; 30
Wu, Zhang, Chen (bib173) 2023; 160
Li, Yuan, Chen, Guo (bib42) 2023; 3
Wang, Chen, Yang (bib62) 2022; 13
Xue, Yan, Chen (bib94) 2023; 19
Conrad, Proneth (bib106) 2020; 27
Chen, Kang, Kroemer, Tang (bib78) 2021; 28
Wu, Minikes, Gao (bib192) 2019; 572
Feng, Cai, Pook (bib34) 2024; 166
Aquilano, Baldelli, Ciriolo (bib90) 2014; 5
Chanvorachote, Luanpitpong (bib126) 2016; 310
Wang, Chen, Wang (bib140) 2021; 81
Ninomiya, Ohara, Noma (bib130) 2017; 8
Giustacchini, Thongjuea, Barkas (bib19) 2017; 23
Zhou, Xu, Bao (bib148) 2019; 10
Morikawa, Mabuchi, Kubota (bib200) 2009; 206
Maiorino, Scapin, Ursini, Biasolo, Bosello, Flohé (bib87) 2003; 278
Thoma, Zimmermann, Agarkova, Kelm, Krek (bib212) 2014; 69
Bonnet, Dick (bib8) 1997; 3
Yang, Shi, Zhao (bib194) 2020; 5
Johnston, Cox (bib66) 2001; 20
Hao, Song, Shang, Jiang, Qiao, Li (bib120) 2016; 21
Pal, Garg, Pandey (bib196) 2020; 9
Zhang, Wu, Zhen, Li, Jiang (bib111) 2022; 2
Liang, Yoo, Na, Walter, Richardson, Ran (bib109) 2009; 284
Yuan, Stewart, Yang (bib6) 2022; 612
Recalcati, Gammella, Cairo (bib139) 2019; 133
Dixon, Lemberg, Lamprecht (bib50) 2012; 149
Du, Xu, Sasada (bib15) 2020; 10
Kamble, Mahajan, Dhat, Sitasawad (bib150) 2021; 10
Homma, Ishii, Morishima (bib158) 2009; 15
Vira, Basak, Veena, Wang, Batra, Srivatsan (bib27) 2012; 31
Jiang, Zhao, Li (bib103) 2022; 41
Calle, Nair, Oo (bib16) 2016; 6
Lu, Zhou, Zhang (bib54) 2024; 5
Shen, Geng, Nie, Liu (bib63) 2023; 14
Clarke (bib12) 2019; 380
Diehn, Cho, Lobo (bib134) 2009; 458
Paradisi, Creveaux, Gibert (bib207) 2013; 5
Moreno, Laux, Brielmeier, Bornkamm, Conrad (bib86) 2003; 384
Qu, Xu, Yi (bib214) 2024; 5
Li, Condello, Thomes-Pepin (bib176) 2017; 20
Han, Zhang, Pan (bib205) 2023; 83
Bachoo, Maher, Ligon (bib13) 2024; 42
Zhu, Liu, Meng (bib52) 2024; 43
Cao, Traer, Zimmerman, McIntyre, Prescott (bib58) 1998; 49
Khan, Rayees, Sharma, Malik (bib144) 2023; 23
Long, Zhu, Wei, Zhao (bib119) 2023; 4
Bisht, Nigam, Kunjwal, Sergey, Mishra, Sharifi-Rad (bib9) 2022; 2022
Hong, Lei, Chen (bib210) 2021; 42
Manz, Blanchette, Paul, Torti, Torti (bib129) 2016; 1368
de Jong, Pramana, van der Wal (bib20) 2010; 16
Chen, Wang, Li, Budai, Wang (bib61) 2022; 11
Brewer (bib77) 2011; 10
Liu, Suo, Peng (bib172) 2019; 8
Kansara, Pandey, Lobie, Sethi, Garg, Pandey (bib193) 2020; 9
O'Connor, Feldman, Arora (bib24) 2021; 17
Watterson, Douglas (bib55) 2022; 12
Liu, Sun, Hou (bib178) 2021; 14
Kindrat, Tryndyak, de Conti (bib67) 2016; 7
Zhang, Wang, He (bib185) 2021; 12
Schneider, Forster, Boersma (bib88) 2009; 23
Mai, Hamaï, Hienzsch (bib48) 2017; 9
Wang, Zhang, Liu, Cui, Gao, Jiang (bib124) 2023; 42
Wang, Wu, Yang (bib125) 2022; 6
Doll, Freitas, Shah (bib96) 2019; 575
Chen, Benthani, Wu, Liang, Bian, Jiang (bib198) 2020; 27
Hentze, Muckenthaler, Galy, Camaschella (bib118) 2010; 142
Lagadinou, Sach, Callahan (bib116) 2013; 12
Feng, Fang, Guo, Hu, Shi (bib128) 2023; 145
Bystrom, Guzman, Rivella (bib132) 2014; 20
Luo, Bao, Xue (bib137) 2024; 134
Li, Yang, Zheng (bib53) 2023; 42
Jung, Mertens, Tomat, Brüne (bib127) 2019; 20
Yu, Liu, Duan, Zhang, Li, Wang (bib175) 2015; 360
Yan, Xie, Li (bib91) 2022; 32
Jiang, Maret, Vallee (bib82) 1998; 95
Cao, Wu, Gao, Chen, Feng, Wang (bib95) 2023; 14
Tang, Long, Hu (bib165) 2023; 10
Ding, Jin, Chen, Shao, Wu (bib22) 2012; 7
Xu, Zhang, Wei (bib163) 2020; 152
Okazaki, Matsunaga, Okazaki (bib68) 2010; 70
Bachhawat, Yadav (bib81) 2018; 70
Yu, Lu, Su (bib182) 2021; 8
Alemany-Ribes, Semino (bib213) 2014; 79
Zhu, Wang, Deng (bib2) 2023; 14
Fanet, Capuron, Castanon, Calon, Vancassel (bib104) 2021; 19
Torti, Torti (bib117) 2013; 13
Mao, Liu, Zhang (bib44) 2021; 593
Cui, Wong, Kai (bib203) 2017; 66
Ju, Lu, Chen (bib147) 2016; 6
Zhang, Deng, Zhang (bib161) 2022; 9
Saigusa, Tanaka, Toiyama (bib21) 2009; 16
Shimizu, Murao, Nofi, Wang, Aziz (bib93) 2022; 13
Chen, Kasai, Li (bib14) 2012; 7
Altamimi, AlFaris, Aljabryn (bib153) 2021; 28
Holmström, Gåfvels, Eriksson (bib69) 2006; 26
Bruedigam, Porter, Song (bib211) 2024; 5
Forcina, Dixon (bib110) 2019; 19
Kraft, Bezjian, Pfeiffer (bib101) 2020; 6
Xie, Chen, Zhao (bib38) 2023; 4
Ichikawa, Ghanefar, Bayeva (bib73) 2014; 124
Sung, Ferlay, Siegel (bib4) 2021; 71
Toledo, González-Titos, Hernández-Camarero, Perán (bib145) 2023; 24
Wang, Xu, Zhao (bib180) 2020; 11
Cheng, Yang, Lyu (bib72) 2018; 84
Xuan, Lu, Yang, Li, Jin, Li (bib60) 2022; 72
De Francesco, Sotgia, Lisanti (bib123) 2018; 475
Wang, Deng, Hatcher (bib70) 2014; 74
Seibt, Proneth, Conrad (bib84) 2019; 133
Soula, Weber, Zilka (bib102) 2020; 16
Petronek, Tomanek-Chalkley, Monga (bib121) 2022; 42
Samhan-Arias, Tyurina, Kagan (bib56) 2010; 48
Guo, Zhao, Zhang, Li, Teng, Liu (bib162) 2023; 2023
Liu, Lin, Huang (bib190) 2020; 122
Luo, Li, Yang (bib30) 2020; 12
Ji, Wang, Chen (bib187) 2024; 224
Bindhya, Sidhanth, Shabna, Krishnapriya, Garg, Ganesan (bib195) 2019; 107
Feng, Tang, Wang (bib41) 2023; 4
Wang, Xu, Huang, Qu (bib40) 2023; 2
Wang, Xu, Huang (bib39) 2023; 36
Xu, Li, Chen (bib149) 2023; 356
Ascenzi, Esposito, Bruschini (bib114) 2024; 15
Jiang, Jiang, Li (bib1) 2022; 22
Cui, Xu, Wang (bib168) 2024; 2
Malhi, Gu (bib199) 2015; 12
Zhu, Gong, Wang (bib57) 2023; 62
Ma, Chen, Zhao (bib46) 2024; 9
Batlle, Clevers (bib11) 2017; 23
Ishimoto, Nagano, Yae (bib135) 2011; 19
Wang, Sun, Villeneuve (bib160) 2008; 29
Chu, Tian, Ning (bib10) 2024; 9
Singal, Lampertico, Nahon (bib3) 2020; 72
Hamaï, Cañeque, Müller (bib49) 2017; 13
Hu, Iyer, Sataur, Covello, Chodosh, Simon (bib202) 2006; 26
Yan, Guo, Wang (bib37) 2023; 4
Li, Xu, Chen (bib45) 2024; 20
Wang, Gong, Chen (bib5) 2021; 8
Eling, Reuter, Hazin, Hamacher-Brady, Brady (bib197) 2015; 2
Badgley, Kremer, Maurer (bib186) 2020; 368
Stockwell, Friedmann Angeli, Bayir (bib43) 2017; 171
Thapa, Wilson (bib206) 2016; 2016
Skouta, Dixon, Wang (bib76) 2014; 136
Baudouin-Cornu, Lagniel, Kumar, Huang, Labarre (bib80) 2012; 287
Beziaud, Young, Alonso, Norkin, Minafra, Huelsken (bib32) 2023; 30
Sun, Lin, Wang (bib51) 2022; 41
Hreusova, Novohradsky, Markova (bib71) 2022; 2022
Kim, Leung (bib25) 2023; 14
He, Zhou, Su (bib152) 2023; 158
Liu, Du, Chao (bib181) 2022; 9
Sies (bib79) 1999; 27
Igarashi, Shoji, Sekine-Suzuki (bib65) 2022; 14
Wu, Zhang, Liu (bib170) 2023; 1
Schonberg, Miller, Wu (bib47) 2015; 28
Bersuker, Peterson, To (bib98) 2018; 44
Zheng, Pomyen, Hernandez (bib18) 2018; 68
Philip, Roland, Daniluk (bib174) 2013; 145
Kuwata, Hara (bib59) 2019; 144
Solis, Behrens, Dong (bib156) 2010; 16
Wu, Zhang, Zhang (bib23) 2022; 13
Daher, Parks, Durivault (bib74) 2019; 79
Ruivo, Bastos, Adem (bib31) 2022; 71
Xu, Wang, Qu (bib36) 2023; 4
Ye, Li, Wang (bib136) 2011; 129
Luo, Li, Li (bib171) 2023; 17
Kahroba, Shirmohamadi, Hejazi, Samadi (bib189) 2019; 239
Fang, Uchiumi, Yagi (bib108) 2013; 33
Imai, Hakkaku, Iwamoto (bib89) 2009; 284
Sun, Cai, Liu (bib204) 2023; 8
Ubellacker, Tasdogan, Ramesh (bib143) 2020; 585
Ding, Li, Cheng, Cui, Xu, Zhou (bib133) 2015; 2015
Qu, Qi, Zhang (bib35) 2023; 42
Zhu, Wan, Xu (bib183) 2022; 12
Friedmann-Morvinski, Bushong, Ke (bib17) 2012; 338
Lytle, Ferguson, Rajbhandari (bib29) 2019; 177
Bersuker, Hendricks, Li (bib99) 2019; 575
Luis, Godfroid, Nishiumi (bib184) 2021; 43
Qi, Li, Xia (bib75) 2019; 9
Aggarwal, Gross, Sharma, Fineman, Black (bib105) 2013; 3
Tu, Timashev, Chen, Liang (bib169) 2023; 1
Chen, Song, Zhan (bib151) 2022; 543
Yang, Huang, Wu, Ding, Murphy, Chi (bib191) 2020; 18
Yao, Liu, Yang (bib28) 2022; 13
Hadziahmetovic, Dentchev, Song (bib122) 2008; 49
Lei, Mao, Yan, Zhuang, Gan (bib208) 2021; 12
Hallis, Kim, Lee, Kwak (bib154) 2023; 60
Schmidt-Kittler, Ragg, Daskalakis (bib26) 2003; 100
Ursini, Maiorino, Valente, Ferri, Gregolin (bib85) 1982; 710
Glorieux, Enríquez, González, Aguirre-Martínez, Buc Calderon (bib155) 2024; 13
Huang, Liu, Xiao (bib33) 2023; 41
Brigelius-Flohé, Flohé (bib83) 2020; 33
Xu, Sun, Zhang, Xu, Miyamoto, Zheng (bib146) 2020; 10
Jiang, Chen, Zhao (bib159) 2010; 70
Ohta, Iijima, Miyamoto (bib157) 2008; 68
Henning, Blind, Larafa, Matschke, Fandrey (bib64) 2022; 13
Li, Zhang, Sun (bib112) 2023
Bisaro, Mandili, Poli (bib166) 2015; 3
Okawa, Sol (bib201) 2015; 15
Zhu, Deng, Dai (bib167) 2024; 24
Cheng, Alexander, Zhang (bib209) 2011; 11
Polewski, Reveron-Thornton, Cherryholmes, Marinov, Aboody (bib164) 2017; 26
Zhang, Yu, Yang (bib113) 2022; 1
Gan (bib92) 2023; 14
Nozaki, Motomura, Tamori (bib131) 2020; 15
Visweswaran, Arfuso, Warrier, Dharmarajan (bib177) 2020; 38
Ramosaj, Madsen, Maillard (bib179) 2021; 12
Wang, Ouyang, Liu (bib141) 2023; 42
Hashimoto, Tsunedomi, Yoshimura, Watanabe, Hazama, Oka (bib115) 2014; 14
Somasundaram, Hemalatha, Pal (bib138) 2016; 16
Liu, Chakraborty, Safi, Kazmin, Chang, McDonnell (bib142) 2021; 12
Zeng, Chen, Deng (bib100) 2022; 3
Sun (10.1016/j.gendis.2025.101678_bib51) 2022; 41
Bachhawat (10.1016/j.gendis.2025.101678_bib81) 2018; 70
Altamimi (10.1016/j.gendis.2025.101678_bib153) 2021; 28
Qu (10.1016/j.gendis.2025.101678_bib214) 2024; 5
Chen (10.1016/j.gendis.2025.101678_bib78) 2021; 28
Yan (10.1016/j.gendis.2025.101678_bib37) 2023; 4
Zhang (10.1016/j.gendis.2025.101678_bib113) 2022; 1
Solis (10.1016/j.gendis.2025.101678_bib156) 2010; 16
Baudouin-Cornu (10.1016/j.gendis.2025.101678_bib80) 2012; 287
Igarashi (10.1016/j.gendis.2025.101678_bib65) 2022; 14
Liu (10.1016/j.gendis.2025.101678_bib178) 2021; 14
Fang (10.1016/j.gendis.2025.101678_bib108) 2013; 33
Kim (10.1016/j.gendis.2025.101678_bib25) 2023; 14
Cui (10.1016/j.gendis.2025.101678_bib203) 2017; 66
Bonnet (10.1016/j.gendis.2025.101678_bib8) 1997; 3
Ichikawa (10.1016/j.gendis.2025.101678_bib73) 2014; 124
Jung (10.1016/j.gendis.2025.101678_bib127) 2019; 20
Zhang (10.1016/j.gendis.2025.101678_bib185) 2021; 12
Cao (10.1016/j.gendis.2025.101678_bib58) 1998; 49
Tang (10.1016/j.gendis.2025.101678_bib165) 2023; 10
Cui (10.1016/j.gendis.2025.101678_bib168) 2024; 2
Badgley (10.1016/j.gendis.2025.101678_bib186) 2020; 368
Doll (10.1016/j.gendis.2025.101678_bib96) 2019; 575
Sun (10.1016/j.gendis.2025.101678_bib204) 2023; 8
Liu (10.1016/j.gendis.2025.101678_bib142) 2021; 12
O'Connor (10.1016/j.gendis.2025.101678_bib24) 2021; 17
Ding (10.1016/j.gendis.2025.101678_bib133) 2015; 2015
Calle (10.1016/j.gendis.2025.101678_bib16) 2016; 6
Ji (10.1016/j.gendis.2025.101678_bib187) 2024; 224
Wang (10.1016/j.gendis.2025.101678_bib70) 2014; 74
Zeng (10.1016/j.gendis.2025.101678_bib100) 2022; 3
Petronek (10.1016/j.gendis.2025.101678_bib121) 2022; 42
Zhang (10.1016/j.gendis.2025.101678_bib161) 2022; 9
Diehn (10.1016/j.gendis.2025.101678_bib134) 2009; 458
Tu (10.1016/j.gendis.2025.101678_bib169) 2023; 1
Schneider (10.1016/j.gendis.2025.101678_bib88) 2009; 23
Chen (10.1016/j.gendis.2025.101678_bib151) 2022; 543
Du (10.1016/j.gendis.2025.101678_bib15) 2020; 10
Wu (10.1016/j.gendis.2025.101678_bib170) 2023; 1
Maiorino (10.1016/j.gendis.2025.101678_bib87) 2003; 278
Recalcati (10.1016/j.gendis.2025.101678_bib139) 2019; 133
Wang (10.1016/j.gendis.2025.101678_bib140) 2021; 81
Bisht (10.1016/j.gendis.2025.101678_bib9) 2022; 2022
Wang (10.1016/j.gendis.2025.101678_bib62) 2022; 13
Hong (10.1016/j.gendis.2025.101678_bib210) 2021; 42
Hashimoto (10.1016/j.gendis.2025.101678_bib115) 2014; 14
Chanvorachote (10.1016/j.gendis.2025.101678_bib126) 2016; 310
Singal (10.1016/j.gendis.2025.101678_bib3) 2020; 72
Ding (10.1016/j.gendis.2025.101678_bib22) 2012; 7
Xu (10.1016/j.gendis.2025.101678_bib36) 2023; 4
Chen (10.1016/j.gendis.2025.101678_bib14) 2012; 7
Henning (10.1016/j.gendis.2025.101678_bib64) 2022; 13
Wu (10.1016/j.gendis.2025.101678_bib192) 2019; 572
Ramosaj (10.1016/j.gendis.2025.101678_bib179) 2021; 12
Hamaï (10.1016/j.gendis.2025.101678_bib49) 2017; 13
Aquilano (10.1016/j.gendis.2025.101678_bib90) 2014; 5
Moreno (10.1016/j.gendis.2025.101678_bib86) 2003; 384
Zhu (10.1016/j.gendis.2025.101678_bib52) 2024; 43
Li (10.1016/j.gendis.2025.101678_bib45) 2024; 20
Bruedigam (10.1016/j.gendis.2025.101678_bib211) 2024; 5
Vira (10.1016/j.gendis.2025.101678_bib27) 2012; 31
Batlle (10.1016/j.gendis.2025.101678_bib11) 2017; 23
Hu (10.1016/j.gendis.2025.101678_bib202) 2006; 26
Wang (10.1016/j.gendis.2025.101678_bib180) 2020; 11
Li (10.1016/j.gendis.2025.101678_bib42) 2023; 3
Qu (10.1016/j.gendis.2025.101678_bib35) 2023; 42
Wang (10.1016/j.gendis.2025.101678_bib124) 2023; 42
Yao (10.1016/j.gendis.2025.101678_bib28) 2022; 13
Shimizu (10.1016/j.gendis.2025.101678_bib93) 2022; 13
Hreusova (10.1016/j.gendis.2025.101678_bib71) 2022; 2022
Bersuker (10.1016/j.gendis.2025.101678_bib99) 2019; 575
Zhang (10.1016/j.gendis.2025.101678_bib111) 2022; 2
Skouta (10.1016/j.gendis.2025.101678_bib76) 2014; 136
Brigelius-Flohé (10.1016/j.gendis.2025.101678_bib83) 2020; 33
Conrad (10.1016/j.gendis.2025.101678_bib106) 2020; 27
Jiang (10.1016/j.gendis.2025.101678_bib103) 2022; 41
Cheng (10.1016/j.gendis.2025.101678_bib72) 2018; 84
Hadziahmetovic (10.1016/j.gendis.2025.101678_bib122) 2008; 49
Yang (10.1016/j.gendis.2025.101678_bib191) 2020; 18
Bindhya (10.1016/j.gendis.2025.101678_bib195) 2019; 107
Zhou (10.1016/j.gendis.2025.101678_bib148) 2019; 10
Visweswaran (10.1016/j.gendis.2025.101678_bib177) 2020; 38
Aggarwal (10.1016/j.gendis.2025.101678_bib105) 2013; 3
Qi (10.1016/j.gendis.2025.101678_bib75) 2019; 9
Xuan (10.1016/j.gendis.2025.101678_bib60) 2022; 72
Jiang (10.1016/j.gendis.2025.101678_bib1) 2022; 22
Giustacchini (10.1016/j.gendis.2025.101678_bib19) 2017; 23
Ishimoto (10.1016/j.gendis.2025.101678_bib135) 2011; 19
Wu (10.1016/j.gendis.2025.101678_bib23) 2022; 13
Yan (10.1016/j.gendis.2025.101678_bib91) 2022; 32
Yu (10.1016/j.gendis.2025.101678_bib175) 2015; 360
Jiang (10.1016/j.gendis.2025.101678_bib159) 2010; 70
Ascenzi (10.1016/j.gendis.2025.101678_bib114) 2024; 15
Nozaki (10.1016/j.gendis.2025.101678_bib131) 2020; 15
Li (10.1016/j.gendis.2025.101678_bib53) 2023; 42
Stockwell (10.1016/j.gendis.2025.101678_bib43) 2017; 171
Liu (10.1016/j.gendis.2025.101678_bib172) 2019; 8
Imai (10.1016/j.gendis.2025.101678_bib89) 2009; 284
Feng (10.1016/j.gendis.2025.101678_bib128) 2023; 145
Khan (10.1016/j.gendis.2025.101678_bib144) 2023; 23
Schonberg (10.1016/j.gendis.2025.101678_bib47) 2015; 28
Chen (10.1016/j.gendis.2025.101678_bib61) 2022; 11
Hallis (10.1016/j.gendis.2025.101678_bib154) 2023; 60
Mao (10.1016/j.gendis.2025.101678_bib44) 2021; 593
Xu (10.1016/j.gendis.2025.101678_bib163) 2020; 152
Daher (10.1016/j.gendis.2025.101678_bib74) 2019; 79
Holmström (10.1016/j.gendis.2025.101678_bib69) 2006; 26
Brewer (10.1016/j.gendis.2025.101678_bib77) 2011; 10
Cao (10.1016/j.gendis.2025.101678_bib95) 2023; 14
Ruivo (10.1016/j.gendis.2025.101678_bib31) 2022; 71
Mai (10.1016/j.gendis.2025.101678_bib48) 2017; 9
Cheng (10.1016/j.gendis.2025.101678_bib209) 2011; 11
Homma (10.1016/j.gendis.2025.101678_bib158) 2009; 15
Forcina (10.1016/j.gendis.2025.101678_bib110) 2019; 19
Jiang (10.1016/j.gendis.2025.101678_bib82) 1998; 95
Wu (10.1016/j.gendis.2025.101678_bib173) 2023; 160
Shen (10.1016/j.gendis.2025.101678_bib63) 2023; 14
Seibt (10.1016/j.gendis.2025.101678_bib84) 2019; 133
Zhu (10.1016/j.gendis.2025.101678_bib167) 2024; 24
Watterson (10.1016/j.gendis.2025.101678_bib55) 2022; 12
Lytle (10.1016/j.gendis.2025.101678_bib29) 2019; 177
Ninomiya (10.1016/j.gendis.2025.101678_bib130) 2017; 8
Pal (10.1016/j.gendis.2025.101678_bib196) 2020; 9
Kuwata (10.1016/j.gendis.2025.101678_bib59) 2019; 144
Eling (10.1016/j.gendis.2025.101678_bib197) 2015; 2
Huang (10.1016/j.gendis.2025.101678_bib33) 2023; 41
Ju (10.1016/j.gendis.2025.101678_bib147) 2016; 6
Ma (10.1016/j.gendis.2025.101678_bib46) 2024; 9
Paradisi (10.1016/j.gendis.2025.101678_bib207) 2013; 5
Luo (10.1016/j.gendis.2025.101678_bib30) 2020; 12
Wang (10.1016/j.gendis.2025.101678_bib160) 2008; 29
He (10.1016/j.gendis.2025.101678_bib152) 2023; 158
Kahroba (10.1016/j.gendis.2025.101678_bib189) 2019; 239
Hasegawa (10.1016/j.gendis.2025.101678_bib188) 2016; 7
Li (10.1016/j.gendis.2025.101678_bib112) 2023
Yu (10.1016/j.gendis.2025.101678_bib182) 2021; 8
Yang (10.1016/j.gendis.2025.101678_bib194) 2020; 5
Xue (10.1016/j.gendis.2025.101678_bib94) 2023; 19
Kindrat (10.1016/j.gendis.2025.101678_bib67) 2016; 7
Lu (10.1016/j.gendis.2025.101678_bib54) 2024; 5
Luis (10.1016/j.gendis.2025.101678_bib184) 2021; 43
Ohta (10.1016/j.gendis.2025.101678_bib157) 2008; 68
Wang (10.1016/j.gendis.2025.101678_bib39) 2023; 36
Luo (10.1016/j.gendis.2025.101678_bib137) 2024; 134
Bystrom (10.1016/j.gendis.2025.101678_bib132) 2014; 20
Manz (10.1016/j.gendis.2025.101678_bib129) 2016; 1368
Friedmann-Morvinski (10.1016/j.gendis.2025.101678_bib17) 2012; 338
De Francesco (10.1016/j.gendis.2025.101678_bib123) 2018; 475
Wang (10.1016/j.gendis.2025.101678_bib125) 2022; 6
Alemany-Ribes (10.1016/j.gendis.2025.101678_bib213) 2014; 79
de Jong (10.1016/j.gendis.2025.101678_bib20) 2010; 16
Liu (10.1016/j.gendis.2025.101678_bib190) 2020; 122
Polewski (10.1016/j.gendis.2025.101678_bib164) 2017; 26
Thoma (10.1016/j.gendis.2025.101678_bib212) 2014; 69
Ubellacker (10.1016/j.gendis.2025.101678_bib143) 2020; 585
Luo (10.1016/j.gendis.2025.101678_bib171) 2023; 17
Glorieux (10.1016/j.gendis.2025.101678_bib155) 2024; 13
Kansara (10.1016/j.gendis.2025.101678_bib193) 2020; 9
Okazaki (10.1016/j.gendis.2025.101678_bib68) 2010; 70
Johnston (10.1016/j.gendis.2025.101678_bib66) 2001; 20
Somasundaram (10.1016/j.gendis.2025.101678_bib138) 2016; 16
Kraft (10.1016/j.gendis.2025.101678_bib101) 2020; 6
Xu (10.1016/j.gendis.2025.101678_bib146) 2020; 10
Zhu (10.1016/j.gendis.2025.101678_bib2) 2023; 14
Gan (10.1016/j.gendis.2025.101678_bib92) 2023; 14
Lagadinou (10.1016/j.gendis.2025.101678_bib116) 2013; 12
Philip (10.1016/j.gendis.2025.101678_bib174) 2013; 145
Clarke (10.1016/j.gendis.2025.101678_bib12) 2019; 380
Bachoo (10.1016/j.gendis.2025.101678_bib13) 2024; 42
Dixon (10.1016/j.gendis.2025.101678_bib50) 2012; 149
Beziaud (10.1016/j.gendis.2025.101678_bib32) 2023; 30
Xie (10.1016/j.gendis.2025.101678_bib38) 2023; 4
Chen (10.1016/j.gendis.2025.101678_bib198) 2020; 27
Sung (10.1016/j.gendis.2025.101678_bib4) 2021; 71
Liu (10.1016/j.gendis.2025.101678_bib181) 2022; 9
Zheng (10.1016/j.gendis.2025.101678_bib18) 2018; 68
Ursini (10.1016/j.gendis.2025.101678_bib85) 1982; 710
Hentze (10.1016/j.gendis.2025.101678_bib118) 2010; 142
Liu (10.1016/j.gendis.2025.101678_bib7) 2013; 144
Chu (10.1016/j.gendis.2025.101678_bib10) 2024; 9
Wang (10.1016/j.gendis.2025.101678_bib141) 2023; 42
Han (10.1016/j.gendis.2025.101678_bib205) 2023; 83
Saigusa (10.1016/j.gendis.2025.101678_bib21) 2009; 16
Müller (10.1016/j.gendis.2025.101678_bib97) 2023; 30
Guo (10.1016/j.gendis.2025.101678_bib162) 2023; 2023
Lei (10.1016/j.gendis.2025.101678_bib208) 2021; 12
Kamble (10.1016/j.gendis.2025.101678_bib150) 2021; 10
Feng (10.1016/j.gendis.2025.101678_bib41) 2023; 4
Wang (10.1016/j.gendis.2025.101678_bib40) 2023; 2
Feng (10.1016/j.gendis.2025.101678_bib34) 2024; 166
Soula (10.1016/j.gendis.2025.101678_bib102) 2020; 16
Morikawa (10.1016/j.gendis.2025.101678_bib200) 2009; 206
Wang (10.1016/j.gendis.2025.101678_bib5) 2021; 8
Okawa
References_xml – volume: 24
  start-page: 8179
  year: 2024
  end-page: 8188
  ident: bib167
  article-title: A “ferroptosis-amplifier” hydrogel for eliminating refractory cancer stem cells post-lumpectomy
  publication-title: Nano Lett
– volume: 171
  start-page: 273
  year: 2017
  end-page: 285
  ident: bib43
  article-title: Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
  publication-title: Cell
– volume: 70
  start-page: 585
  year: 2018
  end-page: 592
  ident: bib81
  article-title: The glutathione cycle: glutathione metabolism beyond the γ-glutamyl cycle
  publication-title: IUBMB Life
– volume: 107
  start-page: 62
  year: 2019
  end-page: 68
  ident: bib195
  article-title: Induced pluripotent stem cells: a new strategy to model human cancer
  publication-title: Int J Biochem Cell Biol
– volume: 144
  start-page: 1031
  year: 2013
  end-page: 1041.e10
  ident: bib7
  article-title: Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells
  publication-title: Gastroenterology
– volume: 7
  year: 2012
  ident: bib14
  article-title: A model of cancer stem cells derived from mouse induced pluripotent stem cells
  publication-title: PLoS One
– volume: 26
  start-page: 3514
  year: 2006
  end-page: 3526
  ident: bib202
  article-title: Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1α) and HIF-2α in stem cells
  publication-title: Mol Cell Biol
– volume: 380
  start-page: 2237
  year: 2019
  end-page: 2245
  ident: bib12
  article-title: Clinical and therapeutic implications of cancer stem cells
  publication-title: N Engl J Med
– volume: 20
  start-page: 1917
  year: 2014
  end-page: 1924
  ident: bib132
  article-title: Iron and reactive oxygen species: friends or foes of cancer cells?
  publication-title: Antioxidants Redox Signal
– volume: 10
  start-page: 3427
  year: 2019
  end-page: 3434
  ident: bib148
  article-title: Nuclear Nrf2 activity in laryngeal carcinoma is regulated by SENP3 after cisplatin-induced reactive oxygen species stress
  publication-title: J Cancer
– volume: 66
  start-page: 2149
  year: 2017
  end-page: 2159
  ident: bib203
  article-title: SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
  publication-title: Gut
– volume: 12
  start-page: 1116
  year: 2021
  ident: bib185
  article-title: Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells
  publication-title: Cell Death Dis
– volume: 206
  start-page: 2483
  year: 2009
  end-page: 2496
  ident: bib200
  article-title: Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
  publication-title: J Exp Med
– volume: 6
  start-page: 2799
  year: 2016
  end-page: 2815
  ident: bib16
  article-title: A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm)
  publication-title: Am J Cancer Res
– volume: 31
  start-page: 733
  year: 2012
  end-page: 751
  ident: bib27
  article-title: Cancer stem cells, microRNAs, and therapeutic strategies including natural products
  publication-title: Cancer Metastasis Rev.
– volume: 33
  year: 2013
  ident: bib108
  article-title: Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction
  publication-title: Biosci Rep
– volume: 16
  start-page: 3743
  year: 2010
  end-page: 3753
  ident: bib156
  article-title: Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
  publication-title: Clin Cancer Res
– volume: 5
  start-page: 1821
  year: 2013
  end-page: 1834
  ident: bib207
  article-title: Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death
  publication-title: EMBO Mol Med
– volume: 14
  start-page: 722
  year: 2014
  ident: bib115
  article-title: Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs
  publication-title: BMC Cancer
– volume: 136
  start-page: 4551
  year: 2014
  end-page: 4556
  ident: bib76
  article-title: Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
  publication-title: J Am Chem Soc
– volume: 145
  start-page: 1449
  year: 2013
  end-page: 1458
  ident: bib174
  article-title: A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice
  publication-title: Gastroenterology
– volume: 70
  start-page: 5486
  year: 2010
  end-page: 5496
  ident: bib159
  article-title: High levels of Nrf2 determine chemoresistance in type II endometrial cancer
  publication-title: Cancer Res
– volume: 21
  start-page: 325
  year: 2016
  ident: bib120
  article-title: Phosphorylation of Akt by SC79 prevents iron accumulation and ameliorates early brain injury in a model of experimental subarachnoid hemorrhage
  publication-title: Molecules
– volume: 4
  start-page: 33
  year: 2023
  ident: bib41
  article-title: The mechanism of ferroptosis and its related diseases
  publication-title: Mol Biomed
– volume: 30
  start-page: 442
  year: 2023
  end-page: 456
  ident: bib97
  article-title: Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
  publication-title: Cell Death Differ
– volume: 284
  start-page: 32522
  year: 2009
  end-page: 32532
  ident: bib89
  article-title: Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice
  publication-title: J Biol Chem
– volume: 133
  start-page: 216
  year: 2019
  end-page: 220
  ident: bib139
  article-title: Dysregulation of iron metabolism in cancer stem cells
  publication-title: Free Radic Biol Med
– volume: 4
  year: 2023
  ident: bib37
  article-title: The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression
  publication-title: MedComm
– volume: 5
  start-page: 6
  year: 2024
  ident: bib214
  article-title: Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine
  publication-title: Mol Biomed
– volume: 149
  start-page: 1060
  year: 2012
  end-page: 1072
  ident: bib50
  article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death
  publication-title: Cell
– volume: 9
  start-page: 170
  year: 2024
  ident: bib10
  article-title: Cancer stem cells: advances in knowledge and implications for cancer therapy
  publication-title: Signal Transduct Targeted Ther
– volume: 13
  start-page: 1040
  year: 2022
  ident: bib62
  article-title: Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis
  publication-title: Cell Death Dis
– volume: 74
  start-page: 497
  year: 2014
  end-page: 507
  ident: bib70
  article-title: IRP2 regulates breast tumor growth
  publication-title: Cancer Res
– volume: 9
  start-page: 527
  year: 2020
  ident: bib196
  article-title: Deciphering the mounting complexity of the p53 regulatory network in correlation to long non-coding RNAs (lncRNAs) in ovarian cancer
  publication-title: Cells
– volume: 49
  start-page: 2728
  year: 2008
  ident: bib122
  article-title: Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD
  publication-title: Invest Ophthalmol Vis Sci.
– volume: 11
  start-page: 3053
  year: 2022
  ident: bib61
  article-title: Mitochondrion-mediated cell death through Erk1-Alox5 independent of caspase-9 signaling
  publication-title: Cells
– volume: 2
  year: 2024
  ident: bib168
  article-title: Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy
  publication-title: BMEMat
– volume: 12
  year: 2022
  ident: bib55
  article-title: Intracellular lipid surveillance: modulating protein dynamics through lipid sensing
  publication-title: Clin Transl Med
– volume: 10
  start-page: 9955
  year: 2020
  ident: bib15
  article-title: Signaling inhibitors accelerate the conversion of mouse iPS cells into cancer stem cells in the tumor microenvironment
  publication-title: Sci Rep
– volume: 17
  start-page: 25257
  year: 2023
  end-page: 25268
  ident: bib171
  article-title: Reversing ferroptosis resistance in breast cancer via tailored lipid and iron presentation
  publication-title: ACS Nano
– volume: 9
  year: 2019
  ident: bib75
  article-title: LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells
  publication-title: Sci Rep
– volume: 575
  start-page: 688
  year: 2019
  end-page: 692
  ident: bib99
  article-title: The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
  publication-title: Nature
– volume: 16
  start-page: 1351
  year: 2020
  end-page: 1360
  ident: bib102
  article-title: Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
  publication-title: Nat Chem Biol.
– volume: 12
  start-page: 1307
  year: 2020
  end-page: 1326
  ident: bib30
  article-title: Stem cell quiescence and its clinical relevance
  publication-title: World J Stem Cells
– volume: 7
  year: 2012
  ident: bib22
  article-title: Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer
  publication-title: PLoS One
– volume: 27
  start-page: 242
  year: 2020
  end-page: 254
  ident: bib198
  article-title: Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
  publication-title: Cell Death Differ.
– volume: 129
  start-page: 820
  year: 2011
  end-page: 831
  ident: bib136
  article-title: Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells
  publication-title: Int J Cancer
– volume: 13
  year: 2022
  ident: bib28
  article-title: Single-cell sequencing reveals that DBI is the key gene and potential therapeutic target in quiescent bladder cancer stem cells
  publication-title: Front Genet
– volume: 5
  start-page: 196
  year: 2014
  ident: bib90
  article-title: Glutathione: new roles in redox signaling for an old antioxidant
  publication-title: Front Pharmacol
– volume: 12
  start-page: 1177
  year: 2015
  end-page: 1201
  ident: bib199
  article-title: Nanocarrier-mediated drugs targeting cancer stem cells: an emerging delivery approach
  publication-title: Expet Opin Drug Deliv
– volume: 48
  start-page: 91
  year: 2010
  end-page: 95
  ident: bib56
  article-title: Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation
  publication-title: J Clin Biochem Nutr
– volume: 160
  start-page: 281
  year: 2023
  end-page: 296
  ident: bib173
  article-title: An iron oxyhydroxide-based nanosystem sensitizes ferroptosis by a “three-pronged” strategy in breast cancer stem cells
  publication-title: Acta Biomater
– volume: 42
  year: 2021
  ident: bib210
  article-title: PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer
  publication-title: Redox Biol
– volume: 42
  start-page: 2124
  year: 2024
  ident: bib13
  article-title: Epidermal growth factor receptor and Ink4a/arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
  publication-title: Cancer Cell
– volume: 145
  start-page: 24153
  year: 2023
  end-page: 24165
  ident: bib128
  article-title: Nebulized therapy of early orthotopic lung cancer by iron-based nanoparticles: macrophage-regulated ferroptosis of cancer stem cells
  publication-title: J Am Chem Soc.
– volume: 2
  start-page: 517
  year: 2015
  end-page: 532
  ident: bib197
  article-title: Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
  publication-title: Oncoscience
– volume: 23
  start-page: 3233
  year: 2009
  end-page: 3242
  ident: bib88
  article-title: Mitochondrial glutathione peroxidase 4 disruption causes male infertility
  publication-title: FASEB J
– volume: 60
  year: 2023
  ident: bib154
  article-title: Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition
  publication-title: Redox Biol
– volume: 5
  start-page: 8
  year: 2020
  ident: bib194
  article-title: Targeting cancer stem cell pathways for cancer therapy
  publication-title: Signal Transduct Targeted Ther
– volume: 2022
  year: 2022
  ident: bib9
  article-title: Cancer stem cells: from an insight into the basics to recent advances and therapeutic targeting
  publication-title: Stem Cell Int
– year: 2023
  ident: bib112
  article-title: Harmine ameliorates steroid-induced osteonecrosis of the femoral head by modulating metabolism and ferroptosis via HIF1-α
  publication-title: Fundam Res
– volume: 585
  start-page: 113
  year: 2020
  end-page: 118
  ident: bib143
  article-title: Lymph protects metastasizing melanoma cells from ferroptosis
  publication-title: Nature
– volume: 72
  start-page: 250
  year: 2020
  end-page: 261
  ident: bib3
  article-title: Epidemiology and surveillance for hepatocellular carcinoma: new trends
  publication-title: J Hepatol
– volume: 23
  start-page: 1124
  year: 2017
  end-page: 1134
  ident: bib11
  article-title: Cancer stem cells revisited
  publication-title: Nat Med
– volume: 12
  year: 2022
  ident: bib183
  article-title: Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression
  publication-title: Clin Transl Med
– volume: 15
  start-page: 3423
  year: 2009
  end-page: 3432
  ident: bib158
  article-title: Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
  publication-title: Clin Cancer Res
– volume: 8
  year: 2021
  ident: bib182
  article-title: A CD10-OGP membrane peptolytic signaling axis in fibroblasts regulates lipid metabolism of cancer stem cells via SCD1
  publication-title: Adv Sci
– volume: 224
  start-page: 707
  year: 2024
  end-page: 722
  ident: bib187
  article-title: Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis
  publication-title: Free Radic Biol Med
– volume: 2016
  year: 2016
  ident: bib206
  article-title: The importance of CD44 as a stem cell biomarker and therapeutic target in cancer
  publication-title: Stem Cell Int
– volume: 20
  start-page: 1341
  year: 2024
  end-page: 1352
  ident: bib45
  article-title: Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
  publication-title: Nat Chem Biol
– volume: 70
  start-page: 6238
  year: 2010
  end-page: 6246
  ident: bib68
  article-title: Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice
  publication-title: Cancer Res
– volume: 14
  start-page: 84
  year: 2023
  end-page: 86
  ident: bib92
  article-title: How erastin assassinates cells by ferroptosis revealed
  publication-title: Protein Cell
– volume: 28
  start-page: 441
  year: 2015
  end-page: 455
  ident: bib47
  article-title: Preferential iron trafficking characterizes glioblastoma stem-like cells
  publication-title: Cancer Cell
– volume: 32
  start-page: 341
  year: 2020
  end-page: 352
  ident: bib107
  article-title: Mitochondrial metabolism as a target for cancer therapy
  publication-title: Cell Metab
– volume: 71
  start-page: 209
  year: 2021
  end-page: 249
  ident: bib4
  article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J Clin
– volume: 3
  start-page: 730
  year: 1997
  end-page: 737
  ident: bib8
  article-title: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
  publication-title: Nat Med.
– volume: 8
  year: 2021
  ident: bib5
  article-title: Colorectal cancer stem cell states uncovered by simultaneous single-cell analysis of transcriptome and telomeres
  publication-title: Adv Sci.
– volume: 79
  start-page: 40
  year: 2014
  end-page: 49
  ident: bib213
  article-title: Bioengineering 3D environments for cancer models
  publication-title: Adv Drug Deliv Rev
– volume: 1
  year: 2023
  ident: bib170
  article-title: External physical field-driven nanocatalytic cancer therapy
  publication-title: BMEMat
– volume: 13
  year: 2022
  ident: bib93
  article-title: Extracellular CIRP promotes GPX4-mediated ferroptosis in sepsis
  publication-title: Front Immunol
– volume: 13
  start-page: 1371
  year: 2022
  ident: bib23
  article-title: Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis
  publication-title: Nat Commun
– volume: 42
  start-page: 255
  year: 2022
  end-page: 262
  ident: bib121
  article-title: Detection of ferritin expression in soft tissue sarcomas with MRI: potential implications for iron metabolic therapy
  publication-title: Iowa Orthop J
– volume: 2022
  year: 2022
  ident: bib71
  article-title: Gallium(III) complex with cloxyquin ligands induces ferroptosis in cancer cells and is a potent agent against both differentiated and tumorigenic cancer stem rhabdomyosarcoma cells
  publication-title: Bioinorgan Chem Appl
– volume: 41
  start-page: 307
  year: 2022
  ident: bib103
  article-title: circLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis
  publication-title: J Exp Clin Cancer Res
– volume: 11
  start-page: 220
  year: 2020
  ident: bib180
  article-title: Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
  publication-title: Nat Commun
– volume: 475
  start-page: 1611
  year: 2018
  end-page: 1634
  ident: bib123
  article-title: Cancer stem cells (CSCs): Metabolic strategies for their identification and eradication
  publication-title: Biochem J
– volume: 72
  start-page: 1797
  year: 2022
  end-page: 1808
  ident: bib60
  article-title: Propofol protects against erastin-induced ferroptosis in HT-22 cells
  publication-title: J Mol Neurosci
– volume: 6
  start-page: 1160
  year: 2016
  end-page: 1175
  ident: bib147
  article-title: Redox regulation of stem-like cells though the CD44v-xCT axis in colorectal cancer: mechanisms and therapeutic implications
  publication-title: Theranostics
– volume: 3
  start-page: 37
  year: 2022
  ident: bib100
  article-title: The anti-ferroptotic role of FSP1: current molecular mechanism and therapeutic approach
  publication-title: Mol Biomed
– volume: 36
  year: 2023
  ident: bib39
  article-title: Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder
  publication-title: Gen Psychiatry
– volume: 18
  start-page: 79
  year: 2020
  end-page: 90
  ident: bib191
  article-title: A TAZ-ANGPTL4-NOX2 axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer
  publication-title: Mol Cancer Res
– volume: 14
  start-page: 178
  year: 2021
  ident: bib178
  article-title: A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties
  publication-title: J Hematol Oncol
– volume: 32
  start-page: 687
  year: 2022
  end-page: 690
  ident: bib91
  article-title: The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
  publication-title: Cell Res
– volume: 12
  start-page: 329
  year: 2013
  end-page: 341
  ident: bib116
  article-title: BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
  publication-title: Cell Stem Cell
– volume: 12
  start-page: 836
  year: 2021
  end-page: 857
  ident: bib208
  article-title: Ferroptosis, radiotherapy, and combination therapeutic strategies
  publication-title: Protein Cell
– volume: 166
  start-page: 139
  year: 2024
  end-page: 154
  ident: bib34
  article-title: BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma
  publication-title: Gastroenterology
– volume: 9
  start-page: 64
  year: 2024
  ident: bib46
  article-title: Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
  publication-title: Signal Transduct Targeted Ther
– volume: 62
  year: 2023
  ident: bib57
  article-title: Amplification of lipid peroxidation by regulating cell membrane unsaturation to enhance chemodynamic therapy
  publication-title: Angew Chem Int Ed
– volume: 9
  start-page: 1025
  year: 2017
  end-page: 1033
  ident: bib48
  article-title: Salinomycin kills cancer stem cells by sequestering iron in lysosomes
  publication-title: Nat Chem
– volume: 4
  start-page: 30
  year: 2023
  ident: bib36
  article-title: A novel mechanism of ferroptosis surveillance offers promising therapeutic avenues for breast and prostate cancers
  publication-title: Mol Biomed
– volume: 122
  start-page: 279
  year: 2020
  end-page: 292
  ident: bib190
  article-title: Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
  publication-title: Br J Cancer
– volume: 16
  start-page: 336
  year: 2016
  ident: bib138
  article-title: Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells
  publication-title: BMC Cancer
– volume: 12
  start-page: 7362
  year: 2021
  ident: bib179
  article-title: Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation
  publication-title: Nat Commun
– volume: 593
  start-page: 586
  year: 2021
  end-page: 590
  ident: bib44
  article-title: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
  publication-title: Nature
– volume: 13
  start-page: 342
  year: 2013
  end-page: 355
  ident: bib117
  article-title: Iron and cancer: more ore to be mined
  publication-title: Nat Rev Cancer
– volume: 42
  start-page: 285
  year: 2023
  ident: bib35
  article-title: Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
  publication-title: J Exp Clin Cancer Res
– volume: 10
  start-page: 221
  year: 2011
  end-page: 247
  ident: bib77
  article-title: Natural antioxidants: sources, compounds, mechanisms of action, and potential applications
  publication-title: Compr Rev Food Sci Food Saf
– volume: 20
  start-page: 273
  year: 2019
  ident: bib127
  article-title: Iron as a central player and promising target in cancer progression
  publication-title: Int J Mol Sci
– volume: 6
  start-page: 2914
  year: 2022
  end-page: 2924
  ident: bib125
  article-title: Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma
  publication-title: Hepatol Commun
– volume: 11
  start-page: 1133
  year: 2011
  end-page: 1145
  ident: bib209
  article-title: The clinical and therapeutic implications of cancer stem cell biology
  publication-title: Expert Rev Anticancer Ther
– volume: 5
  year: 2024
  ident: bib54
  article-title: Phospholipids with two polyunsaturated fatty acyl tails: an important driver of ferroptosis
  publication-title: MedComm
– volume: 26
  start-page: 976
  year: 2006
  end-page: 985
  ident: bib69
  article-title: Expression of iron regulatory genes in a rat model of hepatocellular carcinoma
  publication-title: Liver Int
– volume: 284
  start-page: 30836
  year: 2009
  end-page: 30844
  ident: bib109
  article-title: Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions
  publication-title: J Biol Chem
– volume: 41
  start-page: 1621
  year: 2023
  end-page: 1636.e8
  ident: bib33
  article-title: CD44
  publication-title: Cancer Cell
– volume: 2015
  year: 2015
  ident: bib133
  article-title: Redox regulation in cancer stem cells
  publication-title: Oxid Med Cell Longev
– volume: 29
  start-page: 1235
  year: 2008
  end-page: 1243
  ident: bib160
  article-title: Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
  publication-title: Carcinogenesis
– volume: 338
  start-page: 1080
  year: 2012
  end-page: 1084
  ident: bib17
  article-title: Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
  publication-title: Science
– volume: 384
  start-page: 635
  year: 2003
  end-page: 643
  ident: bib86
  article-title: Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)
  publication-title: Biol Chem
– volume: 3
  start-page: 8
  year: 2015
  ident: bib166
  article-title: Proteomic analysis of extracellular vesicles from medullospheres reveals a role for iron in the cancer progression of medulloblastoma
  publication-title: Mol Cell Ther
– volume: 287
  start-page: 4552
  year: 2012
  end-page: 4561
  ident: bib80
  article-title: Glutathione degradation is a key determinant of glutathione homeostasis
  publication-title: J Biol Chem
– volume: 95
  start-page: 3483
  year: 1998
  end-page: 3488
  ident: bib82
  article-title: The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase
  publication-title: Proc Natl Acad Sci U S A.
– volume: 10
  start-page: 83
  year: 2021
  ident: bib150
  article-title: Keap1-Nrf2 pathway regulates ALDH and contributes to radioresistance in breast cancer stem cells
  publication-title: Cells
– volume: 2
  start-page: 237
  year: 2023
  end-page: 239
  ident: bib40
  article-title: The antiferroptotic role of TRIM7: molecular mechanism and synergistic effect with temozolomide
  publication-title: Cancer Innov
– volume: 44
  start-page: 97
  year: 2018
  end-page: 112.e7
  ident: bib98
  article-title: A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes
  publication-title: Dev Cell
– volume: 360
  start-page: 187
  year: 2015
  end-page: 194
  ident: bib175
  article-title: Four types of fatty acids exert differential impact on pancreatic cancer growth
  publication-title: Cancer Lett
– volume: 9
  year: 2022
  ident: bib181
  article-title: promotes colorectal cancer cell to acquire stem cell-like features by manipulating lipid droplet-mediated numb degradation
  publication-title: Adv Sci.
– volume: 27
  start-page: 409
  year: 2020
  end-page: 419
  ident: bib106
  article-title: Selenium: tracing another essential element of ferroptotic cell death
  publication-title: Cell Chem Biol
– volume: 14
  start-page: 2236
  year: 2023
  end-page: 2245
  ident: bib95
  article-title: QiLing decoction promotes ferroptosis of castration-resistant prostate cancer cells by inhibiting FSP1
  publication-title: J Cancer
– volume: 27
  start-page: 916
  year: 1999
  end-page: 921
  ident: bib79
  article-title: Glutathione and its role in cellular functions
  publication-title: Free Radic Biol Med
– volume: 15
  start-page: 427
  year: 2015
  end-page: 434
  ident: bib201
  article-title: A computational strategy for predicting lineage specifiers in stem cell subpopulations
  publication-title: Stem Cell Res
– volume: 20
  start-page: 623
  year: 2001
  end-page: 627
  ident: bib66
  article-title: Plasma-saturating intakes of vitamin C confer maximal antioxidant protection to plasma
  publication-title: J Am Coll Nutr
– volume: 19
  year: 2019
  ident: bib110
  article-title: GPX4 at the crossroads of lipid homeostasis and ferroptosis
  publication-title: Proteomics
– volume: 33
  start-page: 498
  year: 2020
  end-page: 516
  ident: bib83
  article-title: Regulatory phenomena in the glutathione peroxidase superfamily
  publication-title: Antioxidants Redox Signal
– volume: 10
  start-page: 1332
  year: 2020
  ident: bib146
  article-title: Activation of glucocorticoid receptor inhibits the stem-like properties of bladder cancer via inactivating the β-catenin pathway
  publication-title: Front Oncol
– volume: 19
  start-page: 591
  year: 2021
  end-page: 609
  ident: bib104
  article-title: Tetrahydrobioterin (BH4) pathway: from metabolism to neuropsychiatry
  publication-title: Curr Neuropharmacol
– volume: 13
  start-page: 70
  year: 2024
  ident: bib155
  article-title: The multifaceted roles of NRF2 in cancer: friend or foe?
  publication-title: Antioxidants
– volume: 16
  start-page: 5329
  year: 2010
  end-page: 5338
  ident: bib20
  article-title: CD44 expression predicts local recurrence after radiotherapy in larynx cancer
  publication-title: Clin Cancer Res
– volume: 144
  year: 2019
  ident: bib59
  article-title: Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism
  publication-title: Prostag Other Lipid Mediat
– volume: 41
  start-page: 284
  year: 2022
  ident: bib51
  article-title: AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
  publication-title: J Exp Clin Cancer Res
– volume: 7
  start-page: 11756
  year: 2016
  end-page: 11769
  ident: bib188
  article-title: Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
  publication-title: Oncotarget
– volume: 84
  year: 2018
  ident: bib72
  article-title: IdeR, a DtxR family iron response regulator, controls iron homeostasis, morphological differentiation, secondary metabolism, and the oxidative stress response in
  publication-title: Appl Environ Microbiol
– volume: 612
  start-page: 555
  year: 2022
  end-page: 563
  ident: bib6
  article-title: Ras drives malignancy through stem cell crosstalk with the microenvironment
  publication-title: Nature
– volume: 20
  start-page: 303
  year: 2017
  end-page: 314.e5
  ident: bib176
  article-title: Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells
  publication-title: Cell Stem Cell
– volume: 23
  start-page: 1405
  year: 2023
  end-page: 1423
  ident: bib144
  article-title: Targeting redox regulation and autophagy systems in cancer stem cells
  publication-title: Clin Exp Med
– volume: 13
  start-page: 662
  year: 2022
  ident: bib64
  article-title: Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction
  publication-title: Cell Death Dis.
– volume: 575
  start-page: 693
  year: 2019
  end-page: 698
  ident: bib96
  article-title: FSP1 is a glutathione-independent ferroptosis suppressor
  publication-title: Nature
– volume: 2
  start-page: 66
  year: 2022
  end-page: 73
  ident: bib111
  article-title: Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in ferroptosis
  publication-title: Fundam Res
– volume: 83
  start-page: 1887
  year: 2023
  end-page: 1902.e8
  ident: bib205
  article-title: IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
  publication-title: Mol Cell
– volume: 6
  start-page: 41
  year: 2020
  end-page: 53
  ident: bib101
  article-title: GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling
  publication-title: ACS Cent Sci
– volume: 1
  start-page: 92
  year: 2022
  end-page: 113
  ident: bib113
  article-title: Crosstalk between ferroptosis and stress: implications in cancer therapeutic responses
  publication-title: Cancer Innov
– volume: 142
  start-page: 24
  year: 2010
  end-page: 38
  ident: bib118
  article-title: Two to tango: regulation of mammalian iron metabolism
  publication-title: Cell
– volume: 43
  year: 2021
  ident: bib184
  article-title: Tumor resistance to ferroptosis driven by stearoyl-CoA desaturase-1 (SCD1) in cancer cells and fatty acid binding protein-4 (FABP4) in tumor microenvironment promote tumor recurrence
  publication-title: Redox Biol
– volume: 24
  start-page: 4487
  year: 2023
  ident: bib145
  article-title: A brief review on chemoresistance; targeting cancer stem cells as an alternative approach
  publication-title: Int J Mol Sci.
– volume: 14
  start-page: 367
  year: 2023
  end-page: 378
  ident: bib63
  article-title: Erianin induces ferroptosis of renal cancer stem cells via promoting
  publication-title: J Cancer
– volume: 42
  start-page: 6
  year: 2023
  ident: bib53
  article-title: Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis
  publication-title: J Exp Clin Cancer Res
– volume: 68
  start-page: 1303
  year: 2008
  end-page: 1309
  ident: bib157
  article-title: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
  publication-title: Cancer Res
– volume: 26
  start-page: 1236
  year: 2017
  end-page: 1246
  ident: bib164
  article-title: Overexpression in glioblastoma is associated with increased cancer stem cell-like properties
  publication-title: Stem Cell Dev
– volume: 69
  start-page: 29
  year: 2014
  end-page: 41
  ident: bib212
  article-title: 3D cell culture systems modeling tumor growth determinants in cancer target discovery
  publication-title: Adv Drug Deliv Rev
– volume: 14
  start-page: 3642
  year: 2022
  ident: bib65
  article-title: Importance of locations of iron ions to elicit cytotoxicity induced by a Fenton-type reaction
  publication-title: Cancers (Basel)
– volume: 43
  start-page: 245
  year: 2024
  ident: bib52
  article-title: CCT3/ACTN4/TFRC axis protects hepatocellular carcinoma cells from ferroptosis by inhibiting iron endocytosis
  publication-title: J Exp Clin Cancer Res
– volume: 8
  start-page: 98405
  year: 2017
  end-page: 98416
  ident: bib130
  article-title: Iron depletion is a novel therapeutic strategy to target cancer stem cells
  publication-title: Oncotarget
– volume: 134
  year: 2024
  ident: bib137
  article-title: ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2
  publication-title: J Clin Investig
– volume: 9
  start-page: 1511
  year: 2020
  ident: bib193
  article-title: Mechanistic involvement of long non-coding RNAs in oncotherapeutics resistance in triple-negative breast cancer
  publication-title: Cells
– volume: 49
  start-page: 327
  year: 1998
  end-page: 330
  ident: bib58
  article-title: Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)
  publication-title: Genomics
– volume: 42
  start-page: 2688
  year: 2023
  end-page: 2700
  ident: bib141
  article-title: The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis
  publication-title: Oncogene
– volume: 133
  start-page: 144
  year: 2019
  end-page: 152
  ident: bib84
  article-title: Role of GPX4 in ferroptosis and its pharmacological implication
  publication-title: Free Radic Biol Med
– volume: 3
  start-page: 1011
  year: 2013
  end-page: 1034
  ident: bib105
  article-title: Reactive oxygen species in pulmonary vascular remodeling
  publication-title: Compr Physiol
– volume: 3
  start-page: 525
  year: 2023
  end-page: 528
  ident: bib42
  article-title: Metal complexes induced ferroptosis for anticancer therapy
  publication-title: Fundam Res
– volume: 14
  start-page: 944
  year: 2023
  end-page: 945
  ident: bib25
  article-title: Therapeutic potentials and challenges of cytostatic persister cancer cells
  publication-title: Oncotarget
– volume: 458
  start-page: 780
  year: 2009
  end-page: 783
  ident: bib134
  article-title: Association of reactive oxygen species levels and radioresistance in cancer stem cells
  publication-title: Nature
– volume: 38
  start-page: 6
  year: 2020
  end-page: 14
  ident: bib177
  article-title: Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells
  publication-title: Stem Cells
– volume: 2023
  year: 2023
  ident: bib162
  article-title: Vitamin D promotes ferroptosis in colorectal cancer stem cells via SLC7A11 downregulation
  publication-title: Oxid Med Cell Longev
– volume: 30
  start-page: 818
  year: 2023
  end-page: 831.e6
  ident: bib32
  article-title: IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy
  publication-title: Cell Stem Cell.
– volume: 19
  start-page: 387
  year: 2011
  end-page: 400
  ident: bib135
  article-title: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc
  publication-title: Cancer Cell
– volume: 356
  start-page: 256
  year: 2023
  end-page: 271
  ident: bib149
  article-title: Doxorubicin and erastin co-loaded hydroxyethyl starch-polycaprolactone nanoparticles for synergistic cancer therapy
  publication-title: J Contr Release
– volume: 4
  year: 2023
  ident: bib119
  article-title: Iron homeostasis imbalance and ferroptosis in brain diseases
  publication-title: MedComm
– volume: 1368
  start-page: 149
  year: 2016
  end-page: 161
  ident: bib129
  article-title: Iron and cancer: recent insights
  publication-title: Ann N Y Acad Sci
– volume: 177
  start-page: 572
  year: 2019
  end-page: 586.e22
  ident: bib29
  article-title: A multiscale map of the stem cell state in pancreatic adenocarcinoma
  publication-title: Cell
– volume: 278
  start-page: 34286
  year: 2003
  end-page: 34290
  ident: bib87
  article-title: Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants
  publication-title: J Biol Chem.
– volume: 22
  start-page: 546
  year: 2022
  ident: bib1
  article-title: The epidemiological trends of biliary tract cancers in the United States of America
  publication-title: BMC Gastroenterol
– volume: 81
  start-page: 5217
  year: 2021
  end-page: 5229
  ident: bib140
  article-title: Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
  publication-title: Cancer Res
– volume: 8
  year: 2019
  ident: bib172
  article-title: Multifunctional magnetic nanoplatform eliminates cancer stem cells via inhibiting the secretion of extracellular heat shock protein 90
  publication-title: Adv Healthcare Mater
– volume: 17
  year: 2021
  ident: bib24
  article-title: Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma
  publication-title: Mol Syst Biol
– volume: 14
  start-page: 992
  year: 2023
  end-page: 1003
  ident: bib2
  article-title: Epidemiological landscape of esophageal cancer in Asia: results from GLOBOCAN 2020
  publication-title: Thorac Cancer
– volume: 368
  start-page: 85
  year: 2020
  end-page: 89
  ident: bib186
  article-title: Cysteine depletion induces pancreatic tumor ferroptosis in mice
  publication-title: Science
– volume: 7
  start-page: 1276
  year: 2016
  end-page: 1287
  ident: bib67
  article-title: MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
  publication-title: Oncotarget
– volume: 543
  year: 2022
  ident: bib151
  article-title: Fangchinoline inhibits non-small cell lung cancer metastasis by reversing epithelial-mesenchymal transition and suppressing the cytosolic ROS-related Akt-mTOR signaling pathway
  publication-title: Cancer Lett
– volume: 100
  start-page: 7737
  year: 2003
  end-page: 7742
  ident: bib26
  article-title: From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression
  publication-title: Proc Natl Acad Sci U S A
– volume: 68
  start-page: 127
  year: 2018
  end-page: 140
  ident: bib18
  article-title: Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma
  publication-title: Hepatology
– volume: 124
  start-page: 617
  year: 2014
  end-page: 630
  ident: bib73
  article-title: Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
  publication-title: J Clin Invest
– volume: 158
  year: 2023
  ident: bib152
  article-title: Brusatol: a potential sensitizing agent for cancer therapy from
  publication-title: Biomed Pharmacother
– volume: 310
  start-page: C728
  year: 2016
  end-page: C739
  ident: bib126
  article-title: Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells
  publication-title: Am J Physiol Cell Physiol
– volume: 19
  start-page: 1982
  year: 2023
  end-page: 1996
  ident: bib94
  article-title: Copper-dependent autophagic degradation of GPX4 drives ferroptosis
  publication-title: Autophagy
– volume: 1
  year: 2023
  ident: bib169
  article-title: Ferritin-based drug delivery system for tumor therapy
  publication-title: BMEmat
– volume: 42
  start-page: 242
  year: 2023
  ident: bib124
  article-title: circRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs
  publication-title: J Exp Clin Cancer Res
– volume: 572
  start-page: 402
  year: 2019
  end-page: 406
  ident: bib192
  article-title: Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
  publication-title: Nature
– volume: 79
  start-page: 3877
  year: 2019
  end-page: 3890
  ident: bib74
  article-title: Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival, and tumor formation via nutrient and oxidative stresses
  publication-title: Cancer Res
– volume: 710
  start-page: 197
  year: 1982
  end-page: 211
  ident: bib85
  article-title: Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides
  publication-title: Biochim Biophys Acta
– volume: 13
  start-page: 1465
  year: 2017
  end-page: 1466
  ident: bib49
  article-title: An iron hand over cancer stem cells
  publication-title: Autophagy
– volume: 16
  start-page: 3488
  year: 2009
  end-page: 3498
  ident: bib21
  article-title: Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
  publication-title: Ann Surg Oncol
– volume: 9
  year: 2022
  ident: bib161
  article-title: Adipocyte-derived exosomal MTTP suppresses ferroptosis and promotes chemoresistance in colorectal cancer
  publication-title: Adv Sci.
– volume: 239
  year: 2019
  ident: bib189
  article-title: The Role of Nrf2 signaling in cancer stem cells: from stemness and self-renewal to tumorigenesis and chemoresistance
  publication-title: Life Sci
– volume: 10
  year: 2023
  ident: bib165
  article-title: Targeting USP8 inhibits O-GlcNAcylation of SLC7A11 to promote ferroptosis of hepatocellular carcinoma via stabilization of OGT
  publication-title: Adv Sci.
– volume: 15
  year: 2020
  ident: bib131
  article-title: High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients
  publication-title: PLoS One
– volume: 71
  start-page: 2043
  year: 2022
  end-page: 2068
  ident: bib31
  article-title: Extracellular vesicles from pancreatic cancer stem cells lead an intratumor communication network (EVNet) to fuel tumour progression
  publication-title: Gut
– volume: 23
  start-page: 692
  year: 2017
  end-page: 702
  ident: bib19
  article-title: Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
  publication-title: Nat Med.
– volume: 8
  year: 2023
  ident: bib204
  article-title: BCL6 promotes a stem-like CD8
  publication-title: Sci Immunol
– volume: 28
  start-page: 2843
  year: 2021
  end-page: 2856
  ident: bib78
  article-title: Organelle-specific regulation of ferroptosis
  publication-title: Cell Death Differ
– volume: 4
  year: 2023
  ident: bib38
  article-title: promotes development and metastasis of breast cancer by regulating
  publication-title: MedComm
– volume: 5
  start-page: 47
  year: 2024
  end-page: 65
  ident: bib211
  article-title: Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
  publication-title: Nat Cancer
– volume: 15
  start-page: 303
  year: 2024
  ident: bib114
  article-title: Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
  publication-title: Cell Death Dis
– volume: 152
  year: 2020
  ident: bib163
  article-title: Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis
  publication-title: Eur J Pharmaceut Sci
– volume: 28
  start-page: 4300
  year: 2021
  end-page: 4310
  ident: bib153
  article-title: Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2
  publication-title: Saudi J Biol Sci
– volume: 12
  start-page: 5103
  year: 2021
  ident: bib142
  article-title: Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
  publication-title: Nat Commun
– volume: 9
  start-page: 527
  issue: 3
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib196
  article-title: Deciphering the mounting complexity of the p53 regulatory network in correlation to long non-coding RNAs (lncRNAs) in ovarian cancer
  publication-title: Cells
  doi: 10.3390/cells9030527
– volume: 5
  start-page: 6
  issue: 1
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib214
  article-title: Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine
  publication-title: Mol Biomed
  doi: 10.1186/s43556-023-00165-9
– volume: 171
  start-page: 273
  issue: 2
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib43
  article-title: Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease
  publication-title: Cell
  doi: 10.1016/j.cell.2017.09.021
– volume: 10
  start-page: 3427
  issue: 15
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib148
  article-title: Nuclear Nrf2 activity in laryngeal carcinoma is regulated by SENP3 after cisplatin-induced reactive oxygen species stress
  publication-title: J Cancer
  doi: 10.7150/jca.30318
– volume: 14
  start-page: 2236
  issue: 12
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib95
  article-title: QiLing decoction promotes ferroptosis of castration-resistant prostate cancer cells by inhibiting FSP1 in vitro and in vivo
  publication-title: J Cancer
  doi: 10.7150/jca.84363
– volume: 15
  start-page: 427
  issue: 2
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib201
  article-title: A computational strategy for predicting lineage specifiers in stem cell subpopulations
  publication-title: Stem Cell Res
  doi: 10.1016/j.scr.2015.08.006
– volume: 160
  start-page: 281
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib173
  article-title: An iron oxyhydroxide-based nanosystem sensitizes ferroptosis by a “three-pronged” strategy in breast cancer stem cells
  publication-title: Acta Biomater
  doi: 10.1016/j.actbio.2023.02.015
– volume: 13
  start-page: 1465
  issue: 8
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib49
  article-title: An iron hand over cancer stem cells
  publication-title: Autophagy
  doi: 10.1080/15548627.2017.1327104
– volume: 310
  start-page: C728
  issue: 9
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib126
  article-title: Iron induces cancer stem cells and aggressive phenotypes in human lung cancer cells
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00322.2015
– volume: 14
  start-page: 3642
  issue: 15
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib65
  article-title: Importance of locations of iron ions to elicit cytotoxicity induced by a Fenton-type reaction
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers14153642
– volume: 38
  start-page: 6
  issue: 1
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib177
  article-title: Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells
  publication-title: Stem Cells
  doi: 10.1002/stem.3101
– volume: 10
  start-page: 1332
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib146
  article-title: Activation of glucocorticoid receptor inhibits the stem-like properties of bladder cancer via inactivating the β-catenin pathway
  publication-title: Front Oncol
  doi: 10.3389/fonc.2020.01332
– volume: 356
  start-page: 256
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib149
  article-title: Doxorubicin and erastin co-loaded hydroxyethyl starch-polycaprolactone nanoparticles for synergistic cancer therapy
  publication-title: J Contr Release
  doi: 10.1016/j.jconrel.2023.03.001
– volume: 26
  start-page: 1236
  issue: 17
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib164
  article-title: SLC7A11Overexpression in glioblastoma is associated with increased cancer stem cell-like properties
  publication-title: Stem Cell Dev
  doi: 10.1089/scd.2017.0123
– volume: 107
  start-page: 62
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib195
  article-title: Induced pluripotent stem cells: a new strategy to model human cancer
  publication-title: Int J Biochem Cell Biol
  doi: 10.1016/j.biocel.2018.12.008
– volume: 12
  start-page: 329
  issue: 3
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib116
  article-title: BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.12.013
– volume: 70
  start-page: 585
  issue: 7
  year: 2018
  ident: 10.1016/j.gendis.2025.101678_bib81
  article-title: The glutathione cycle: glutathione metabolism beyond the γ-glutamyl cycle
  publication-title: IUBMB Life
  doi: 10.1002/iub.1756
– volume: 1
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib170
  article-title: External physical field-driven nanocatalytic cancer therapy
  publication-title: BMEMat
  doi: 10.1002/bmm2.12010
– volume: 10
  start-page: 9955
  issue: 1
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib15
  article-title: Signaling inhibitors accelerate the conversion of mouse iPS cells into cancer stem cells in the tumor microenvironment
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-66471-2
– volume: 12
  start-page: 836
  issue: 11
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib208
  article-title: Ferroptosis, radiotherapy, and combination therapeutic strategies
  publication-title: Protein Cell
  doi: 10.1007/s13238-021-00841-y
– volume: 8
  issue: 8
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib5
  article-title: Colorectal cancer stem cell states uncovered by simultaneous single-cell analysis of transcriptome and telomeres
  publication-title: Adv Sci.
  doi: 10.1002/advs.202004320
– volume: 18
  start-page: 79
  issue: 1
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib191
  article-title: A TAZ-ANGPTL4-NOX2 axis regulates ferroptotic cell death and chemoresistance in epithelial ovarian cancer
  publication-title: Mol Cancer Res
  doi: 10.1158/1541-7786.MCR-19-0691
– volume: 3
  start-page: 730
  issue: 7
  year: 1997
  ident: 10.1016/j.gendis.2025.101678_bib8
  article-title: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
  publication-title: Nat Med.
  doi: 10.1038/nm0797-730
– volume: 2022
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib71
  article-title: Gallium(III) complex with cloxyquin ligands induces ferroptosis in cancer cells and is a potent agent against both differentiated and tumorigenic cancer stem rhabdomyosarcoma cells
  publication-title: Bioinorgan Chem Appl
– volume: 42
  start-page: 2688
  issue: 36
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib141
  article-title: The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis
  publication-title: Oncogene
  doi: 10.1038/s41388-023-02744-0
– volume: 17
  issue: 6
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib24
  article-title: Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma
  publication-title: Mol Syst Biol
– volume: 12
  start-page: 1116
  issue: 12
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib185
  article-title: Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-021-04406-z
– volume: 14
  start-page: 367
  issue: 3
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib63
  article-title: Erianin induces ferroptosis of renal cancer stem cells via promoting ALOX12/P53 mRNA N6-methyladenosine modification
  publication-title: J Cancer
  doi: 10.7150/jca.81027
– volume: 19
  issue: 18
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib110
  article-title: GPX4 at the crossroads of lipid homeostasis and ferroptosis
  publication-title: Proteomics
  doi: 10.1002/pmic.201800311
– volume: 71
  start-page: 2043
  issue: 10
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib31
  article-title: Extracellular vesicles from pancreatic cancer stem cells lead an intratumor communication network (EVNet) to fuel tumour progression
  publication-title: Gut
  doi: 10.1136/gutjnl-2021-324994
– volume: 10
  start-page: 83
  issue: 1
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib150
  article-title: Keap1-Nrf2 pathway regulates ALDH and contributes to radioresistance in breast cancer stem cells
  publication-title: Cells
  doi: 10.3390/cells10010083
– volume: 593
  start-page: 586
  issue: 7860
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib44
  article-title: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
  publication-title: Nature
  doi: 10.1038/s41586-021-03539-7
– volume: 3
  start-page: 8
  issue: 1
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib166
  article-title: Proteomic analysis of extracellular vesicles from medullospheres reveals a role for iron in the cancer progression of medulloblastoma
  publication-title: Mol Cell Ther
  doi: 10.1186/s40591-015-0045-3
– volume: 6
  start-page: 1160
  issue: 8
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib147
  article-title: Redox regulation of stem-like cells though the CD44v-xCT axis in colorectal cancer: mechanisms and therapeutic implications
  publication-title: Theranostics
  doi: 10.7150/thno.14848
– volume: 12
  start-page: 5103
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib142
  article-title: Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-25354-4
– volume: 26
  start-page: 976
  issue: 8
  year: 2006
  ident: 10.1016/j.gendis.2025.101678_bib69
  article-title: Expression of iron regulatory genes in a rat model of hepatocellular carcinoma
  publication-title: Liver Int
  doi: 10.1111/j.1478-3231.2006.01316.x
– volume: 95
  start-page: 3483
  issue: 7
  year: 1998
  ident: 10.1016/j.gendis.2025.101678_bib82
  article-title: The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase
  publication-title: Proc Natl Acad Sci U S A.
  doi: 10.1073/pnas.95.7.3483
– volume: 2015
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib133
  article-title: Redox regulation in cancer stem cells
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2015/750798
– volume: 19
  start-page: 387
  issue: 3
  year: 2011
  ident: 10.1016/j.gendis.2025.101678_bib135
  article-title: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc− and thereby promotes tumor growth
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.01.038
– volume: 72
  start-page: 1797
  issue: 9
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib60
  article-title: Propofol protects against erastin-induced ferroptosis in HT-22 cells
  publication-title: J Mol Neurosci
  doi: 10.1007/s12031-022-02017-7
– volume: 575
  start-page: 693
  issue: 7784
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib96
  article-title: FSP1 is a glutathione-independent ferroptosis suppressor
  publication-title: Nature
  doi: 10.1038/s41586-019-1707-0
– volume: 60
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib154
  article-title: Association of NRF2 with HIF-2α-induced cancer stem cell phenotypes in chronic hypoxic condition
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2023.102632
– volume: 572
  start-page: 402
  issue: 7769
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib192
  article-title: Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling
  publication-title: Nature
  doi: 10.1038/s41586-019-1426-6
– volume: 166
  start-page: 139
  issue: 1
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib34
  article-title: BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2023.09.021
– volume: 27
  start-page: 242
  issue: 1
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib198
  article-title: Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-019-0352-3
– volume: 284
  start-page: 30836
  issue: 45
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib109
  article-title: Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.032839
– volume: 2023
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib162
  article-title: Vitamin D promotes ferroptosis in colorectal cancer stem cells via SLC7A11 downregulation
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2023/4772134
– volume: 206
  start-page: 2483
  issue: 11
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib200
  article-title: Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
  publication-title: J Exp Med
  doi: 10.1084/jem.20091046
– volume: 74
  start-page: 497
  issue: 2
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib70
  article-title: IRP2 regulates breast tumor growth
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-13-1224
– volume: 149
  start-page: 1060
  issue: 5
  year: 2012
  ident: 10.1016/j.gendis.2025.101678_bib50
  article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.042
– volume: 11
  start-page: 3053
  issue: 19
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib61
  article-title: Mitochondrion-mediated cell death through Erk1-Alox5 independent of caspase-9 signaling
  publication-title: Cells
  doi: 10.3390/cells11193053
– volume: 278
  start-page: 34286
  issue: 36
  year: 2003
  ident: 10.1016/j.gendis.2025.101678_bib87
  article-title: Distinct promoters determine alternative transcription of gpx-4 into phospholipid-hydroperoxide glutathione peroxidase variants
  publication-title: J Biol Chem.
  doi: 10.1074/jbc.M305327200
– volume: 68
  start-page: 127
  issue: 1
  year: 2018
  ident: 10.1016/j.gendis.2025.101678_bib18
  article-title: Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma
  publication-title: Hepatology
  doi: 10.1002/hep.29778
– volume: 32
  start-page: 341
  issue: 3
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib107
  article-title: Mitochondrial metabolism as a target for cancer therapy
  publication-title: Cell Metab
  doi: 10.1016/j.cmet.2020.06.019
– volume: 2
  start-page: 66
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib111
  article-title: Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in ferroptosis
  publication-title: Fundam Res
  doi: 10.1016/j.fmre.2021.07.008
– volume: 224
  start-page: 707
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib187
  article-title: Platycodin D ameliorates polycystic ovary syndrome-induced ovarian damage by upregulating CD44 to attenuate ferroptosis
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2024.09.033
– volume: 100
  start-page: 7737
  issue: 13
  year: 2003
  ident: 10.1016/j.gendis.2025.101678_bib26
  article-title: From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1331931100
– volume: 29
  start-page: 1235
  issue: 6
  year: 2008
  ident: 10.1016/j.gendis.2025.101678_bib160
  article-title: Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgn095
– volume: 1
  issue: 2
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib169
  article-title: Ferritin-based drug delivery system for tumor therapy
  publication-title: BMEmat
  doi: 10.1002/bmm2.12022
– volume: 10
  start-page: 221
  issue: 4
  year: 2011
  ident: 10.1016/j.gendis.2025.101678_bib77
  article-title: Natural antioxidants: sources, compounds, mechanisms of action, and potential applications
  publication-title: Compr Rev Food Sci Food Saf
  doi: 10.1111/j.1541-4337.2011.00156.x
– volume: 12
  issue: 9
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib183
  article-title: Positive epigenetic regulation loop between AR and NSUN2 promotes prostate cancer progression
  publication-title: Clin Transl Med
  doi: 10.1002/ctm2.1028
– volume: 3
  start-page: 525
  issue: 4
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib42
  article-title: Metal complexes induced ferroptosis for anticancer therapy
  publication-title: Fundam Res
  doi: 10.1016/j.fmre.2022.10.001
– volume: 23
  start-page: 1405
  issue: 5
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib144
  article-title: Targeting redox regulation and autophagy systems in cancer stem cells
  publication-title: Clin Exp Med
  doi: 10.1007/s10238-022-00955-5
– volume: 13
  start-page: 342
  issue: 5
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib117
  article-title: Iron and cancer: more ore to be mined
  publication-title: Nat Rev Cancer
  doi: 10.1038/nrc3495
– volume: 13
  start-page: 70
  issue: 1
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib155
  article-title: The multifaceted roles of NRF2 in cancer: friend or foe?
  publication-title: Antioxidants
  doi: 10.3390/antiox13010070
– volume: 4
  issue: 4
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib119
  article-title: Iron homeostasis imbalance and ferroptosis in brain diseases
  publication-title: MedComm
  doi: 10.1002/mco2.298
– volume: 19
  start-page: 591
  issue: 5
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib104
  article-title: Tetrahydrobioterin (BH4) pathway: from metabolism to neuropsychiatry
  publication-title: Curr Neuropharmacol
– volume: 15
  issue: 7
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib131
  article-title: High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0235747
– volume: 2
  start-page: 517
  issue: 5
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib197
  article-title: Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
  publication-title: Oncoscience
  doi: 10.18632/oncoscience.160
– volume: 30
  start-page: 442
  issue: 2
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib97
  article-title: Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-022-01096-8
– volume: 22
  start-page: 546
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib1
  article-title: The epidemiological trends of biliary tract cancers in the United States of America
  publication-title: BMC Gastroenterol
  doi: 10.1186/s12876-022-02637-8
– volume: 11
  start-page: 1133
  issue: 7
  year: 2011
  ident: 10.1016/j.gendis.2025.101678_bib209
  article-title: The clinical and therapeutic implications of cancer stem cell biology
  publication-title: Expert Rev Anticancer Ther
  doi: 10.1586/era.11.82
– volume: 12
  start-page: 1307
  issue: 11
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib30
  article-title: Stem cell quiescence and its clinical relevance
  publication-title: World J Stem Cells
  doi: 10.4252/wjsc.v12.i11.1307
– volume: 13
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib28
  article-title: Single-cell sequencing reveals that DBI is the key gene and potential therapeutic target in quiescent bladder cancer stem cells
  publication-title: Front Genet
  doi: 10.3389/fgene.2022.904536
– volume: 9
  issue: 12
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib181
  article-title: Fusobacterium nucleatum promotes colorectal cancer cell to acquire stem cell-like features by manipulating lipid droplet-mediated numb degradation
  publication-title: Adv Sci.
  doi: 10.1002/advs.202105222
– volume: 475
  start-page: 1611
  issue: 9
  year: 2018
  ident: 10.1016/j.gendis.2025.101678_bib123
  article-title: Cancer stem cells (CSCs): Metabolic strategies for their identification and eradication
  publication-title: Biochem J
  doi: 10.1042/BCJ20170164
– volume: 24
  start-page: 4487
  issue: 5
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib145
  article-title: A brief review on chemoresistance; targeting cancer stem cells as an alternative approach
  publication-title: Int J Mol Sci.
  doi: 10.3390/ijms24054487
– volume: 4
  start-page: 33
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib41
  article-title: The mechanism of ferroptosis and its related diseases
  publication-title: Mol Biomed
  doi: 10.1186/s43556-023-00142-2
– volume: 9
  start-page: 1025
  issue: 10
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib48
  article-title: Salinomycin kills cancer stem cells by sequestering iron in lysosomes
  publication-title: Nat Chem
  doi: 10.1038/nchem.2778
– volume: 33
  start-page: 498
  issue: 7
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib83
  article-title: Regulatory phenomena in the glutathione peroxidase superfamily
  publication-title: Antioxidants Redox Signal
  doi: 10.1089/ars.2019.7905
– volume: 14
  start-page: 992
  issue: 11
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib2
  article-title: Epidemiological landscape of esophageal cancer in Asia: results from GLOBOCAN 2020
  publication-title: Thorac Cancer
  doi: 10.1111/1759-7714.14835
– volume: 79
  start-page: 40
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib213
  article-title: Bioengineering 3D environments for cancer models
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2014.06.004
– volume: 8
  issue: 19
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib182
  article-title: A CD10-OGP membrane peptolytic signaling axis in fibroblasts regulates lipid metabolism of cancer stem cells via SCD1
  publication-title: Adv Sci
  doi: 10.1002/advs.202101848
– volume: 612
  start-page: 555
  issue: 7940
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib6
  article-title: Ras drives malignancy through stem cell crosstalk with the microenvironment
  publication-title: Nature
  doi: 10.1038/s41586-022-05475-6
– volume: 28
  start-page: 4300
  issue: 8
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib153
  article-title: Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2
  publication-title: Saudi J Biol Sci
  doi: 10.1016/j.sjbs.2021.04.005
– volume: 81
  start-page: 5217
  issue: 20
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib140
  article-title: Stem cell factor SOX2 confers ferroptosis resistance in lung cancer via upregulation of SLC7A11
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-21-0567
– volume: 20
  start-page: 623
  issue: 6
  year: 2001
  ident: 10.1016/j.gendis.2025.101678_bib66
  article-title: Plasma-saturating intakes of vitamin C confer maximal antioxidant protection to plasma
  publication-title: J Am Coll Nutr
  doi: 10.1080/07315724.2001.10719159
– volume: 368
  start-page: 85
  issue: 6486
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib186
  article-title: Cysteine depletion induces pancreatic tumor ferroptosis in mice
  publication-title: Science
  doi: 10.1126/science.aaw9872
– volume: 3
  start-page: 1011
  issue: 3
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib105
  article-title: Reactive oxygen species in pulmonary vascular remodeling
  publication-title: Compr Physiol
  doi: 10.1002/j.2040-4603.2013.tb00518.x
– volume: 20
  start-page: 1917
  issue: 12
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib132
  article-title: Iron and reactive oxygen species: friends or foes of cancer cells?
  publication-title: Antioxidants Redox Signal
  doi: 10.1089/ars.2012.5014
– volume: 4
  issue: 3
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib38
  article-title: SNORA71C promotes development and metastasis of breast cancer by regulating RUNX1 and ferroptosis
  publication-title: MedComm
  doi: 10.1002/mco2.262
– volume: 20
  start-page: 273
  issue: 2
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib127
  article-title: Iron as a central player and promising target in cancer progression
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20020273
– volume: 79
  start-page: 3877
  issue: 15
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib74
  article-title: Genetic ablation of the cystine transporter xCT in PDAC cells inhibits mTORC1, growth, survival, and tumor formation via nutrient and oxidative stresses
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-3855
– volume: 33
  issue: 2
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib108
  article-title: Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction
  publication-title: Biosci Rep
  doi: 10.1042/BSR20120097
– volume: 15
  start-page: 3423
  issue: 10
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib158
  article-title: Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-08-2822
– volume: 5
  start-page: 47
  issue: 1
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib211
  article-title: Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
  publication-title: Nat Cancer
  doi: 10.1038/s43018-023-00653-5
– volume: 31
  start-page: 733
  issue: 3
  year: 2012
  ident: 10.1016/j.gendis.2025.101678_bib27
  article-title: Cancer stem cells, microRNAs, and therapeutic strategies including natural products
  publication-title: Cancer Metastasis Rev.
  doi: 10.1007/s10555-012-9382-8
– volume: 4
  start-page: 30
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib36
  article-title: A novel mechanism of ferroptosis surveillance offers promising therapeutic avenues for breast and prostate cancers
  publication-title: Mol Biomed
  doi: 10.1186/s43556-023-00140-4
– volume: 7
  start-page: 11756
  issue: 11
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib188
  article-title: Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7598
– volume: 12
  start-page: 1177
  issue: 7
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib199
  article-title: Nanocarrier-mediated drugs targeting cancer stem cells: an emerging delivery approach
  publication-title: Expet Opin Drug Deliv
  doi: 10.1517/17425247.2015.998648
– volume: 380
  start-page: 2237
  issue: 23
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib12
  article-title: Clinical and therapeutic implications of cancer stem cells
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1804280
– volume: 145
  start-page: 24153
  issue: 44
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib128
  article-title: Nebulized therapy of early orthotopic lung cancer by iron-based nanoparticles: macrophage-regulated ferroptosis of cancer stem cells
  publication-title: J Am Chem Soc.
  doi: 10.1021/jacs.3c08032
– volume: 23
  start-page: 1124
  issue: 10
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib11
  article-title: Cancer stem cells revisited
  publication-title: Nat Med
  doi: 10.1038/nm.4409
– volume: 42
  start-page: 2124
  issue: 12
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib13
  article-title: Epidermal growth factor receptor and Ink4a/arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2024.11.007
– volume: 5
  start-page: 1821
  issue: 12
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib207
  article-title: Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death
  publication-title: EMBO Mol Med
  doi: 10.1002/emmm.201302654
– volume: 20
  start-page: 303
  issue: 3
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib176
  article-title: Lipid desaturation is a metabolic marker and therapeutic target of ovarian cancer stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2016.11.004
– volume: 14
  start-page: 84
  issue: 2
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib92
  article-title: How erastin assassinates cells by ferroptosis revealed
  publication-title: Protein Cell
– volume: 6
  start-page: 2914
  issue: 10
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib125
  article-title: Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma
  publication-title: Hepatol Commun
  doi: 10.1002/hep4.2031
– volume: 20
  start-page: 1341
  issue: 10
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib45
  article-title: Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
  publication-title: Nat Chem Biol
  doi: 10.1038/s41589-024-01612-6
– volume: 7
  issue: 4
  year: 2012
  ident: 10.1016/j.gendis.2025.101678_bib14
  article-title: A model of cancer stem cells derived from mouse induced pluripotent stem cells
  publication-title: PLoS One
– volume: 284
  start-page: 32522
  issue: 47
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib89
  article-title: Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.016139
– volume: 12
  issue: 12
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib55
  article-title: Intracellular lipid surveillance: modulating protein dynamics through lipid sensing
  publication-title: Clin Transl Med
  doi: 10.1002/ctm2.1147
– volume: 3
  start-page: 37
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib100
  article-title: The anti-ferroptotic role of FSP1: current molecular mechanism and therapeutic approach
  publication-title: Mol Biomed
  doi: 10.1186/s43556-022-00105-z
– volume: 21
  start-page: 325
  issue: 3
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib120
  article-title: Phosphorylation of Akt by SC79 prevents iron accumulation and ameliorates early brain injury in a model of experimental subarachnoid hemorrhage
  publication-title: Molecules
  doi: 10.3390/molecules21030325
– volume: 42
  start-page: 255
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib121
  article-title: Detection of ferritin expression in soft tissue sarcomas with MRI: potential implications for iron metabolic therapy
  publication-title: Iowa Orthop J
– volume: 133
  start-page: 216
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib139
  article-title: Dysregulation of iron metabolism in cancer stem cells
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2018.07.015
– volume: 49
  start-page: 327
  issue: 2
  year: 1998
  ident: 10.1016/j.gendis.2025.101678_bib58
  article-title: Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)
  publication-title: Genomics
  doi: 10.1006/geno.1998.5268
– volume: 8
  start-page: 98405
  issue: 58
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib130
  article-title: Iron depletion is a novel therapeutic strategy to target cancer stem cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.21846
– volume: 26
  start-page: 3514
  issue: 9
  year: 2006
  ident: 10.1016/j.gendis.2025.101678_bib202
  article-title: Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1α) and HIF-2α in stem cells
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.26.9.3514-3526.2006
– volume: 2
  issue: 1
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib168
  article-title: Recent advances in multi-metallic-based nanozymes for enhanced catalytic cancer therapy
  publication-title: BMEMat
  doi: 10.1002/bmm2.12043
– volume: 43
  start-page: 245
  issue: 1
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib52
  article-title: CCT3/ACTN4/TFRC axis protects hepatocellular carcinoma cells from ferroptosis by inhibiting iron endocytosis
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-024-03169-7
– volume: 6
  start-page: 2799
  issue: 12
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib16
  article-title: A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm)
  publication-title: Am J Cancer Res
– volume: 16
  start-page: 3743
  issue: 14
  year: 2010
  ident: 10.1016/j.gendis.2025.101678_bib156
  article-title: Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-09-3352
– volume: 16
  start-page: 5329
  issue: 21
  year: 2010
  ident: 10.1016/j.gendis.2025.101678_bib20
  article-title: CD44 expression predicts local recurrence after radiotherapy in larynx cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-10-0799
– volume: 124
  start-page: 617
  issue: 2
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib73
  article-title: Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation
  publication-title: J Clin Invest
  doi: 10.1172/JCI72931
– volume: 129
  start-page: 820
  issue: 4
  year: 2011
  ident: 10.1016/j.gendis.2025.101678_bib136
  article-title: Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells
  publication-title: Int J Cancer
  doi: 10.1002/ijc.25944
– volume: 14
  start-page: 722
  issue: 1
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib115
  article-title: Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-14-722
– volume: 575
  start-page: 688
  issue: 7784
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib99
  article-title: The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
  publication-title: Nature
  doi: 10.1038/s41586-019-1705-2
– volume: 1
  start-page: 92
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib113
  article-title: Crosstalk between ferroptosis and stress: implications in cancer therapeutic responses
  publication-title: Cancer Innov
  doi: 10.1002/cai2.7
– volume: 49
  start-page: 2728
  issue: 6
  year: 2008
  ident: 10.1016/j.gendis.2025.101678_bib122
  article-title: Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD
  publication-title: Invest Ophthalmol Vis Sci.
  doi: 10.1167/iovs.07-1472
– volume: 32
  start-page: 687
  issue: 7
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib91
  article-title: The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis
  publication-title: Cell Res
  doi: 10.1038/s41422-022-00642-w
– volume: 48
  start-page: 91
  issue: 1
  year: 2010
  ident: 10.1016/j.gendis.2025.101678_bib56
  article-title: Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation
  publication-title: J Clin Biochem Nutr
  doi: 10.3164/jcbn.11-009FR
– volume: 23
  start-page: 3233
  issue: 9
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib88
  article-title: Mitochondrial glutathione peroxidase 4 disruption causes male infertility
  publication-title: FASEB J
  doi: 10.1096/fj.09-132795
– volume: 134
  issue: 6
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib137
  article-title: ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2
  publication-title: J Clin Investig
  doi: 10.1172/JCI171166
– volume: 7
  issue: 7
  year: 2012
  ident: 10.1016/j.gendis.2025.101678_bib22
  article-title: Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0041942
– volume: 71
  start-page: 209
  issue: 3
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib4
  article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA Cancer J Clin
– volume: 13
  start-page: 1371
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib23
  article-title: Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis
  publication-title: Nat Commun
  doi: 10.1038/s41467-022-29018-9
– volume: 14
  start-page: 178
  issue: 1
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib178
  article-title: A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-021-01194-z
– volume: 142
  start-page: 24
  issue: 1
  year: 2010
  ident: 10.1016/j.gendis.2025.101678_bib118
  article-title: Two to tango: regulation of mammalian iron metabolism
  publication-title: Cell
  doi: 10.1016/j.cell.2010.06.028
– volume: 5
  start-page: 8
  issue: 1
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib194
  article-title: Targeting cancer stem cell pathways for cancer therapy
  publication-title: Signal Transduct Targeted Ther
  doi: 10.1038/s41392-020-0110-5
– volume: 1368
  start-page: 149
  issue: 1
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib129
  article-title: Iron and cancer: recent insights
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/nyas.13008
– volume: 177
  start-page: 572
  issue: 3
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib29
  article-title: A multiscale map of the stem cell state in pancreatic adenocarcinoma
  publication-title: Cell
  doi: 10.1016/j.cell.2019.03.010
– volume: 9
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib75
  article-title: LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-52837-8
– volume: 12
  start-page: 7362
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib179
  article-title: Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-27365-7
– volume: 5
  issue: 7
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib54
  article-title: Phospholipids with two polyunsaturated fatty acyl tails: an important driver of ferroptosis
  publication-title: MedComm
  doi: 10.1002/mco2.606
– volume: 458
  start-page: 780
  issue: 7239
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib134
  article-title: Association of reactive oxygen species levels and radioresistance in cancer stem cells
  publication-title: Nature
  doi: 10.1038/nature07733
– volume: 2022
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib9
  article-title: Cancer stem cells: from an insight into the basics to recent advances and therapeutic targeting
  publication-title: Stem Cell Int
– volume: 42
  start-page: 285
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib35
  article-title: Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-023-02843-6
– volume: 144
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib59
  article-title: Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism
  publication-title: Prostag Other Lipid Mediat
  doi: 10.1016/j.prostaglandins.2019.106363
– volume: 145
  start-page: 1449
  issue: 6
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib174
  article-title: A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.08.018
– volume: 72
  start-page: 250
  issue: 2
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib3
  article-title: Epidemiology and surveillance for hepatocellular carcinoma: new trends
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2019.08.025
– volume: 27
  start-page: 916
  issue: 9–10
  year: 1999
  ident: 10.1016/j.gendis.2025.101678_bib79
  article-title: Glutathione and its role in cellular functions
  publication-title: Free Radic Biol Med
  doi: 10.1016/S0891-5849(99)00177-X
– volume: 360
  start-page: 187
  issue: 2
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib175
  article-title: Four types of fatty acids exert differential impact on pancreatic cancer growth
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2015.02.002
– volume: 36
  issue: 5
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib39
  article-title: Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder
  publication-title: Gen Psychiatry
– volume: 13
  start-page: 662
  issue: 7
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib64
  article-title: Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-022-05121-z
– volume: 84
  issue: 22
  year: 2018
  ident: 10.1016/j.gendis.2025.101678_bib72
  article-title: IdeR, a DtxR family iron response regulator, controls iron homeostasis, morphological differentiation, secondary metabolism, and the oxidative stress response in Streptomyces avermitilis
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.01503-18
– volume: 42
  start-page: 6
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib53
  article-title: Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-022-02567-z
– volume: 66
  start-page: 2149
  issue: 12
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib203
  article-title: SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
  publication-title: Gut
  doi: 10.1136/gutjnl-2016-313264
– volume: 6
  start-page: 41
  issue: 1
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib101
  article-title: GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling
  publication-title: ACS Cent Sci
  doi: 10.1021/acscentsci.9b01063
– volume: 8
  issue: 88
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib204
  article-title: BCL6 promotes a stem-like CD8+ T cell program in cancer via antagonizing BLIMP1
  publication-title: Sci Immunol
  doi: 10.1126/sciimmunol.adh1306
– volume: 24
  start-page: 8179
  issue: 26
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib167
  article-title: A “ferroptosis-amplifier” hydrogel for eliminating refractory cancer stem cells post-lumpectomy
  publication-title: Nano Lett
  doi: 10.1021/acs.nanolett.4c02192
– volume: 2
  start-page: 237
  issue: 4
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib40
  article-title: The antiferroptotic role of TRIM7: molecular mechanism and synergistic effect with temozolomide
  publication-title: Cancer Innov
  doi: 10.1002/cai2.77
– volume: 28
  start-page: 2843
  issue: 10
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib78
  article-title: Organelle-specific regulation of ferroptosis
  publication-title: Cell Death Differ
  doi: 10.1038/s41418-021-00859-z
– volume: 70
  start-page: 5486
  issue: 13
  year: 2010
  ident: 10.1016/j.gendis.2025.101678_bib159
  article-title: High levels of Nrf2 determine chemoresistance in type II endometrial cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-0713
– volume: 10
  issue: 33
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib165
  article-title: Targeting USP8 inhibits O-GlcNAcylation of SLC7A11 to promote ferroptosis of hepatocellular carcinoma via stabilization of OGT
  publication-title: Adv Sci.
  doi: 10.1002/advs.202302953
– volume: 16
  start-page: 1351
  issue: 12
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib102
  article-title: Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
  publication-title: Nat Chem Biol.
  doi: 10.1038/s41589-020-0613-y
– volume: 16
  start-page: 3488
  issue: 12
  year: 2009
  ident: 10.1016/j.gendis.2025.101678_bib21
  article-title: Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
  publication-title: Ann Surg Oncol
  doi: 10.1245/s10434-009-0617-z
– volume: 70
  start-page: 6238
  issue: 15
  year: 2010
  ident: 10.1016/j.gendis.2025.101678_bib68
  article-title: Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-0184
– volume: 144
  start-page: 1031
  issue: 5
  year: 2013
  ident: 10.1016/j.gendis.2025.101678_bib7
  article-title: Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.01.046
– volume: 239
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib189
  article-title: The Role of Nrf2 signaling in cancer stem cells: from stemness and self-renewal to tumorigenesis and chemoresistance
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2019.116986
– volume: 384
  start-page: 635
  issue: 4
  year: 2003
  ident: 10.1016/j.gendis.2025.101678_bib86
  article-title: Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)
  publication-title: Biol Chem
  doi: 10.1515/BC.2003.070
– volume: 17
  start-page: 25257
  issue: 24
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib171
  article-title: Reversing ferroptosis resistance in breast cancer via tailored lipid and iron presentation
  publication-title: ACS Nano
  doi: 10.1021/acsnano.3c08485
– volume: 19
  start-page: 1982
  issue: 7
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib94
  article-title: Copper-dependent autophagic degradation of GPX4 drives ferroptosis
  publication-title: Autophagy
  doi: 10.1080/15548627.2023.2165323
– volume: 158
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib152
  article-title: Brusatol: a potential sensitizing agent for cancer therapy from Brucea javanica
  publication-title: Biomed Pharmacother
  doi: 10.1016/j.biopha.2022.114134
– volume: 27
  start-page: 409
  issue: 4
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib106
  article-title: Selenium: tracing another essential element of ferroptotic cell death
  publication-title: Cell Chem Biol
  doi: 10.1016/j.chembiol.2020.03.012
– volume: 23
  start-page: 692
  issue: 6
  year: 2017
  ident: 10.1016/j.gendis.2025.101678_bib19
  article-title: Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
  publication-title: Nat Med.
  doi: 10.1038/nm.4336
– volume: 133
  start-page: 144
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib84
  article-title: Role of GPX4 in ferroptosis and its pharmacological implication
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2018.09.014
– volume: 710
  start-page: 197
  issue: 2
  year: 1982
  ident: 10.1016/j.gendis.2025.101678_bib85
  article-title: Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides
  publication-title: Biochim Biophys Acta
  doi: 10.1016/0005-2760(82)90150-3
– volume: 42
  start-page: 242
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib124
  article-title: circRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-023-02816-9
– volume: 42
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib210
  article-title: PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2021.101928
– volume: 13
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib93
  article-title: Extracellular CIRP promotes GPX4-mediated ferroptosis in sepsis
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.903859
– volume: 2016
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib206
  article-title: The importance of CD44 as a stem cell biomarker and therapeutic target in cancer
  publication-title: Stem Cell Int
– volume: 4
  issue: 4
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib37
  article-title: The ubiquitin-specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression
  publication-title: MedComm
  doi: 10.1002/mco2.337
– volume: 69
  start-page: 29
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib212
  article-title: 3D cell culture systems modeling tumor growth determinants in cancer target discovery
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2014.03.001
– volume: 44
  start-page: 97
  issue: 1
  year: 2018
  ident: 10.1016/j.gendis.2025.101678_bib98
  article-title: A proximity labeling strategy provides insights into the composition and dynamics of lipid droplet proteomes
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2017.11.020
– volume: 68
  start-page: 1303
  issue: 5
  year: 2008
  ident: 10.1016/j.gendis.2025.101678_bib157
  article-title: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-5003
– volume: 11
  start-page: 220
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib180
  article-title: Arf1-mediated lipid metabolism sustains cancer cells and its ablation induces anti-tumor immune responses in mice
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-14046-9
– volume: 9
  start-page: 170
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib10
  article-title: Cancer stem cells: advances in knowledge and implications for cancer therapy
  publication-title: Signal Transduct Targeted Ther
  doi: 10.1038/s41392-024-01851-y
– volume: 9
  start-page: 1511
  issue: 6
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib193
  article-title: Mechanistic involvement of long non-coding RNAs in oncotherapeutics resistance in triple-negative breast cancer
  publication-title: Cells
  doi: 10.3390/cells9061511
– volume: 62
  issue: 12
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib57
  article-title: Amplification of lipid peroxidation by regulating cell membrane unsaturation to enhance chemodynamic therapy
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.202218407
– volume: 7
  start-page: 1276
  issue: 2
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib67
  article-title: MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6004
– volume: 9
  start-page: 64
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib46
  article-title: Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer
  publication-title: Signal Transduct Targeted Ther
  doi: 10.1038/s41392-024-01772-w
– volume: 41
  start-page: 307
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib103
  article-title: circLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-022-02518-8
– volume: 543
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib151
  article-title: Fangchinoline inhibits non-small cell lung cancer metastasis by reversing epithelial-mesenchymal transition and suppressing the cytosolic ROS-related Akt-mTOR signaling pathway
  publication-title: Cancer Lett
  doi: 10.1016/j.canlet.2022.215783
– year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib112
  article-title: Harmine ameliorates steroid-induced osteonecrosis of the femoral head by modulating metabolism and ferroptosis via HIF1-α
  publication-title: Fundam Res
  doi: 10.1016/j.fmre.2023.08.015
– volume: 13
  start-page: 1040
  issue: 12
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib62
  article-title: Activation of ALOX12 by a multi-organelle-orienting photosensitizer drives ACSL4-independent cell ferroptosis
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-022-05462-9
– volume: 152
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib163
  article-title: Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis
  publication-title: Eur J Pharmaceut Sci
  doi: 10.1016/j.ejps.2020.105450
– volume: 338
  start-page: 1080
  issue: 6110
  year: 2012
  ident: 10.1016/j.gendis.2025.101678_bib17
  article-title: Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
  publication-title: Science
  doi: 10.1126/science.1226929
– volume: 136
  start-page: 4551
  issue: 12
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib76
  article-title: Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
  publication-title: J Am Chem Soc
  doi: 10.1021/ja411006a
– volume: 5
  start-page: 196
  year: 2014
  ident: 10.1016/j.gendis.2025.101678_bib90
  article-title: Glutathione: new roles in redox signaling for an old antioxidant
  publication-title: Front Pharmacol
  doi: 10.3389/fphar.2014.00196
– volume: 15
  start-page: 303
  issue: 4
  year: 2024
  ident: 10.1016/j.gendis.2025.101678_bib114
  article-title: Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-024-06667-w
– volume: 14
  start-page: 944
  issue: 1
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib25
  article-title: Therapeutic potentials and challenges of cytostatic persister cancer cells
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.28488
– volume: 30
  start-page: 818
  issue: 6
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib32
  article-title: IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy
  publication-title: Cell Stem Cell.
  doi: 10.1016/j.stem.2023.05.007
– volume: 8
  issue: 13
  year: 2019
  ident: 10.1016/j.gendis.2025.101678_bib172
  article-title: Multifunctional magnetic nanoplatform eliminates cancer stem cells via inhibiting the secretion of extracellular heat shock protein 90
  publication-title: Adv Healthcare Mater
  doi: 10.1002/adhm.201900160
– volume: 16
  start-page: 336
  year: 2016
  ident: 10.1016/j.gendis.2025.101678_bib138
  article-title: Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2372-4
– volume: 41
  start-page: 1621
  issue: 9
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib33
  article-title: CD44+ lung cancer stem cell-derived pericyte-like cells cause brain metastases through GPR124-enhanced trans-endothelial migration
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2023.07.012
– volume: 28
  start-page: 441
  issue: 4
  year: 2015
  ident: 10.1016/j.gendis.2025.101678_bib47
  article-title: Preferential iron trafficking characterizes glioblastoma stem-like cells
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.09.002
– volume: 43
  year: 2021
  ident: 10.1016/j.gendis.2025.101678_bib184
  article-title: Tumor resistance to ferroptosis driven by stearoyl-CoA desaturase-1 (SCD1) in cancer cells and fatty acid binding protein-4 (FABP4) in tumor microenvironment promote tumor recurrence
  publication-title: Redox Biol
  doi: 10.1016/j.redox.2021.102006
– volume: 122
  start-page: 279
  issue: 2
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib190
  article-title: Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
  publication-title: Br J Cancer
  doi: 10.1038/s41416-019-0660-x
– volume: 41
  start-page: 284
  issue: 1
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib51
  article-title: AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/s13046-022-02493-0
– volume: 83
  start-page: 1887
  issue: 11
  year: 2023
  ident: 10.1016/j.gendis.2025.101678_bib205
  article-title: IL-1β-associated NNT acetylation orchestrates iron-sulfur cluster maintenance and cancer immunotherapy resistance
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2023.05.011
– volume: 9
  issue: 28
  year: 2022
  ident: 10.1016/j.gendis.2025.101678_bib161
  article-title: Adipocyte-derived exosomal MTTP suppresses ferroptosis and promotes chemoresistance in colorectal cancer
  publication-title: Adv Sci.
  doi: 10.1002/advs.202203357
– volume: 287
  start-page: 4552
  issue: 7
  year: 2012
  ident: 10.1016/j.gendis.2025.101678_bib80
  article-title: Glutathione degradation is a key determinant of glutathione homeostasis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.315705
– volume: 585
  start-page: 113
  issue: 7823
  year: 2020
  ident: 10.1016/j.gendis.2025.101678_bib143
  article-title: Lymph protects metastasizing melanoma cells from ferroptosis
  publication-title: Nature
  doi: 10.1038/s41586-020-2623-z
SSID ssj0001330549
ssib052855635
ssib044737542
Score 2.3320165
SecondaryResourceType review_article
Snippet Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 101678
SubjectTerms Cancer stemcells (CSCs)
Cell signaling
Drug target
Ferroptosis
Iron metabolism
Review
SummonAdditionalLinks – databaseName: ScienceDirect Open Access Journals (Elsevier)
  dbid: IXB
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELYQB8Sl6gPaQFu5Etdok_iV7Q0QCCHRS0Ham-VX2lRVskoWJP49M06yJe2hEkc7TuLMjD3fTGbGhJyACDjDGay0clmkXDGVWqZYmvPcVD7z3uWYnHzzTV7d8euVWO2Q8ykXBsMqx71_2NPjbj32LEZqLtZ1vfhesOjRBIGMsfSYxMd4GZP4Vmd__CxgsIuIgnF8ijdMGXQxzAvY5Gus212I2IXnrT3TULGQ_0xR_QtE_46nfKagLl-TVyOypKfD5N-QndC8JXs347_zd2R1G4O-QVXRKnRdu960fd3TuqEOOd9RLOlM0ZHff6WntGkfwm_aD8VrH-mmpXX0P4Rp-DZE_YDcXV7cnl-l47kKqWNLWaayKCoepAqAVURuFLMyc1yJsPQBDAbPTMGlVzaTpQU0IaTjlclMWXgB-KMy7JDsNm0TPhCaOyekVQBrwNAUmV-aDJq2MmDWSeZ9QtKJlno9lM_QU1zZLz3QXiPt9UD7hJwhwbdjsfh17Gi7H3rkvrYht7l0wgXBuBMIobxRlagK75TNbULUxC49kyV4VP2f13-ZuKthmSHJTRPa-15j3UJeYkxYQt4P3N5OEs_sBpWRJaScycHsK-ZXmvpnLOWNmcocQNjRi6d8TPaxNaRHfiS7m-4-fAKctLGf40J4ApxTEDo
  priority: 102
  providerName: Elsevier
Title Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
URI https://dx.doi.org/10.1016/j.gendis.2025.101678
https://www.ncbi.nlm.nih.gov/pubmed/40821110
https://www.proquest.com/docview/3240480889
https://pubmed.ncbi.nlm.nih.gov/PMC12354820
https://doaj.org/article/be1b16c5ce534c55846da7f5f2dc7b1b
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwELYQh4oLKoW2AVq5EteIJH5luQEqgkpwAmlvll9RU1UJ2ixI_Htm7GS1Sw9ceomUxErsGTvzjTPzDSEnMAWc4QxWWj2rcq6Yyi1TLC95aRpfeO9KTE6-vZPXD_zXXMzXSn1hTFiiB06CO7WhtKV0wgXBuBNoL71RjWgq75QtLX59weatOVNxdwXcdPB8ply5GNAFCvEtMnRXIl7CymprtihS9m-YpH8h59vIyTVTdPWR7I4Ykp6nvu-RrdB9Ih9ux7_k-2R-H8O7wSjRJiwW_eOyH9qBth11qOMFRfJmilv2wxk9p13_HP7SIdHUvtBlT9u40xCm5qtg9APycPXz_vI6Hyso5I7NZJ3Lqmp4kCoAKhGlUczKwnElwswHcA08MxWIU9lC1hZwg5CON6YwdeUFII3GsM9ku-u78JXQ0jkhrQIAAy6lKPzMFHBqGwMOnGTeZySfZKkfE1GGniLI_ugke42y10n2GblAga_aIs11vADK16Py9XvKz4ia1KVHxJCQADyqfef1PybtalhQKHLThf5p0MhQyGuM_srIl6TtVSexOjcYhyIj9cY82BjF5p2u_R1JuzEnmQPcOvwf4z4iOziWlBN5TLaXi6fwDcDR0n6P6wCON_OLV7WcD48
linkProvider Directory of Open Access Journals
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKkaAXxLvL00hwjDaJ7ThB4tAC1S7t9sJW2pvxKxCEktVmC-rv4g8y4yRLFw5ISD3GsRLn84znszMPQl6CCFjNGWhaXqQRl0xGhkkWJTzRpYudswkGJ89Os8kZ_7AQix3yc4iFQbfKfu3v1vSwWvct4x7N8bKqxh9TFk40QSCDL33Re1Ye-4sfsG9r30zfwSS_StOj9_O3k6gvLRBZVmR5lKVpyX0mPZhrkWjJTBZbLoUvnAfO7JhOeeakibPcFFic3vJSxzpPnQATXGoGz71GrgP7kLgaTBeHvw92GKhQoN04wAhHOITsBb8ykAtXYaLwVIQmLPB2ySSGygFblvFv5vunA-cli3h0m9zqqSw96NC6Q3Z8fZfcmPU_6--RxTx4mYNtpKVfrZrlummrllY1tShqK4o5pCn-OWhf0wNaN9_9N9p22XIv6LqhVTjw8EP3jU_8fXJ2JWg_ILt1U_t9QhNrRWYk8CjY2YrYFTqGS1Nq2EdmzLkRiQYs1bLL16EGR7avqsNeIfaqw35EDhHwTV_Mth0amtVn1YubMj4xSWaF9YJxK5CzOS1LUabOSpOYEZHDdKkt4YVHVf94_YthdhXoNUKua9-ctwoTJfIcndBG5GE325tBYpFwsFHxiORbcrD1Fdt36upLyB2OodEcWN-j_x7yc3JzMp-dqJPp6fFjsod3utjMJ2R3vTr3T4Gkrc2zoBSUfLpqLfwFeX1LsA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Targeting+ferroptosis+in+cancer+stem+cells%3A+A+novel+strategy+to+improve+cancer+treatment&rft.jtitle=Genes+%26+diseases&rft.au=Luyao+Wang&rft.au=Ye+Zhu&rft.au=Chengying+Huang&rft.au=Qiuming+Pan&rft.date=2025-11-01&rft.pub=KeAi+Communications+Co.%2C+Ltd&rft.eissn=2352-3042&rft.volume=12&rft.issue=6&rft.spage=101678&rft_id=info:doi/10.1016%2Fj.gendis.2025.101678&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_be1b16c5ce534c55846da7f5f2dc7b1b
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2352-3042&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2352-3042&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2352-3042&client=summon