COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 118; no. 43; pp. 1 - 9
• Main Authors: Urano, Emiko, Okamura, Tomotaka, Ono, Chikako, Ueno, Shiori, Nagata, Satoshi, Kamada, Haruhiko, Higuchi, Mahoko, Furukawa, Mugi, Kamitani, Wataru, Matsuura, Yoshiharu, Kawaoka, Yoshihiro, Yasutomi, Yasuhiro
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.10.2021
• Subjects: Animals; Antibodies, Viral - blood; Antibodies, Viral - immunology; Biological Sciences; COVID-19 - immunology; COVID-19 - virology; Disease Models, Animal; Female; Humans; Immunoglobulin G - blood; Immunoglobulin G - immunology; Lung - diagnostic imaging; Lung - immunology; Lung - virology; Macaca fascicularis - immunology; Macaca fascicularis - virology; Male; Primate Diseases - immunology; Primate Diseases - virology; SARS-CoV-2 - immunology; SARS-CoV-2 - physiology; Tomography, X-Ray Computed - methods; Virus Shedding - immunology; Virus Shedding - physiology; COVID-19; underlying disease; SARS-CoV-2; nonhuman primate; elderly

The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global threat to human health and life. A useful pathological animal model accurately reflecting human pathology is needed to overcome the COVID-19 crisis. In the present study, COVID-19 cynomolgus monkey models includ...