Genetic Dissection of Mouse Distal Chromosome 1 Reveals Three Linked BMD QTLs With Sex‐Dependent Regulation of Bone Phenotypes

• Published in: Journal of bone and mineral research Vol. 22; no. 8; pp. 1187 - 1196
• Main Authors: Beamer, Wesley G, Shultz, Kathryn L, Ackert‐Bicknell, Cheryl L, Horton, Lindsay G, Delahunty, Krista M, Coombs, Harold F, Donahue, Leah R, Canalis, Ernesto, Rosen, Clifford J
• Format: Journal Article
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.08.2007; American Society for Bone and Mineral Research
• Subjects: Animals; Biological and medical sciences; BMD; Bone Density - genetics; Chromosomes, Mammalian - genetics; Dissection; distal chromosome 1; Female; Femur - metabolism; Fundamental and applied biological sciences. Psychology; Haplotypes - genetics; Male; Mice; mouse congenic strains; Phenotype; quantitative trait loci; Quantitative Trait Loci - genetics; sex; Sex Characteristics; Skeleton and joints; Vertebrates: osteoarticular system, musculoskeletal system; distal chromosome 1; mouse congenic strains; Rodentia; Sex; quantitative trait loci; Chromosome 1; Osteoarticular system; Vertebrata; Phenotype; Mammalia; Mouse; BMD; Genetics; Bone

Genetic analyses with mouse congenic strains for distal Chr1 have identified three closely linked QTLs regulating femoral vBMD, mid‐diaphyseal cortical thickness, and trabecular microstructure in a sex‐dependent fashion. The homologous relationship between distal mouse Chr 1 and human 1q21–24 offers...