Plasma Nitrosothiols Contribute to the Systemic Vasodilator Effects of Intravenously Applied NO: Experimental and Clinical Study on the Fate of NO in Human Blood

• Published in: Circulation research Vol. 91; no. 6; pp. 470 - 477
• Main Authors: Rassaf, Tienush, Kleinbongard, Petra, Preik, Michael, Dejam, André, Gharini, Putrika, Lauer, Thomas, Erckenbrecht, Julia, Duschin, Alexej, Schulz, Rainer, Heusch, Gerd, Feelisch, Martin, Kelm, Malte
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 20.09.2002; Lippincott; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; General aspects; Hemodynamics - drug effects; Humans; Infusions, Intravenous; Male; Nitrates - blood; Nitric Oxide - blood; Nitric Oxide - pharmacology; Nitrites - blood; Nitroso Compounds - blood; S-Nitrosoglutathione - blood; Time Factors; Vasodilation - drug effects; Vertebrates: cardiovascular system; Human; Nitroso compound; Intravenous administration; Biological transport; Metabolism; Biological activity; Vasodilation; Blood plasma; Vasomotricity; Nitric oxide; Blood vessel; Circulatory system; Hemodynamics

ABSTRACT—Higher doses of inhaled NO exert effects beyond the pulmonary circulation. How such extrapulmonary effects can be reconciled with the presumed short half-life of NO in the blood is unclear. Whereas erythrocytes have been suggested to participate in NO transport, the exact role of plasma in...