The protective effect of natural compounds against rotenone‐induced neurotoxicity

Rotenone is a widely used organic pesticide; its serious side effect for off‐target species is neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial complex I. Oxidative stress, apoptosis, and reduction of autophagy are key outcomes of the inhibition of complex...

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Bibliographic Details
Published inJournal of biochemical and molecular toxicology Vol. 34; no. 12
Main Authors Yarmohammadi, Fatemeh, Wallace Hayes, A., Najafi, Nahid, Karimi, Gholamreza
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 01.12.2020
Subjects
Antioxidants
Apoptosis
Autophagy
Biocompatibility
Electron transport chain
In vivo methods and tests
Mitochondria
mitochondrial dysfunction
NADH-ubiquinone oxidoreductase
natural compounds
neuroprotective
Neurotoxicity
Organic pesticides
Oxidative stress
Pesticides
Phagocytosis
Rotenone
Toxicity
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Summary:Rotenone is a widely used organic pesticide; its serious side effect for off‐target species is neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial complex I. Oxidative stress, apoptosis, and reduction of autophagy are key outcomes of the inhibition of complex I. Numerous in vitro and in vivo studies have shown antioxidant, anti‐apoptotic, and autophagy enhancement of a variety of natural compounds (NCs). In this manuscript, we reviewed several NCs, which have protective effects against rotenone‐induced neurotoxicity.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22605