Peptide-induced HLA-E expression in human PBMCs is dependent on peptide sequence and the HLA-E genotype

• Published in: Tissue antigens Vol. 85; no. 4; pp. 242 - 251
• Main Authors: Lauterbach, N., Wieten, L., Popeijus, H. E., Vanderlocht, J., van Zon, P. M. H., Voorter, C. E. M., Tilanus, M. G. J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2015
• Subjects: Amino Acid Sequence; Chaperonin 60 - chemistry; Chaperonin 60 - immunology; Cytomegalovirus; cytomegalovirus (CMV); Cytomegalovirus - chemistry; Cytomegalovirus - immunology; Cytotoxicity, Immunologic; Gene Expression Regulation; Genotype; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; HLA-B Antigens - chemistry; HLA-B Antigens - immunology; HLA-C Antigens - chemistry; HLA-C Antigens - immunology; HLA-E Antigens; Homozygote; human leukocyte antigen (HLA)-E expression; human leukocyte antigen (HLA)-E polymorphism; Humans; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - immunology; Mitochondrial Proteins - chemistry; Mitochondrial Proteins - immunology; Molecular Sequence Data; peptide; Peptides - chemistry; Peptides - immunology; Peptides - pharmacology; Primary Cell Culture; RNA, Messenger - genetics; RNA, Messenger - immunology; Signal Transduction; Structure-Activity Relationship; transplantation; peptide; cytomegalovirus (CMV); human leukocyte antigen (HLA)-E polymorphism; human leukocyte antigen (HLA)-E expression; transplantation

Human Leukocyte Antigen (HLA)‐E is a low‐polymorphic non‐classical HLA class I molecule which plays a crucial role in immune surveillance by presentation of peptides to T and natural killer (NK) cells. HLA‐E polymorphism is related to HLA‐E surface expression and is associated with patient outcome a...