In vitro tobramycin elution analysis from a novel β-tricalcium phosphate-silicate-xerogel biodegradable drug-delivery system

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Vol. 70B; no. 1; pp. 1 - 20
• Main Authors: DiCicco, Michael, Goldfinger, Aaron, Guirand, Felix, Abdullah, Aquill, Jansen, Susan A.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.07.2004
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - therapeutic use; Benzoates - chemistry; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Bone Substitutes - chemistry; Bone Substitutes - metabolism; Calcium Carbonate - chemistry; Calcium Carbonate - metabolism; Calcium Phosphates - chemistry; Calcium Phosphates - metabolism; Drug Delivery Systems; drug-delivery system; fluorescence; Gels - chemistry; Gels - metabolism; Humans; Hydroxyapatites - chemistry; Hydroxyapatites - metabolism; Materials Testing; Molecular Structure; Osteomyelitis - drug therapy; Quinolines - chemistry; Reproducibility of Results; silicate xerogel; Silicates - chemistry; Silicates - metabolism; tobramycin; Tobramycin - chemistry; Tobramycin - metabolism; Tobramycin - therapeutic use; β-tricalcium phosphate

This in vitro research analyzed local tobramycin elution characteristics from a novel, biodegradable drug delivery system, consisting of a β‐TCP bone substitute, VITOSS™, encapsulated with silicate xerogel prepared by the sol‐gel process. Tobramycin elution from silicate‐xerogel‐encapsulated VITOSS...