Roles of ATP and cytoskeleton in the regulation of Na+/H+ exchanger along the nephron luminal membrane

• Published in: Journal of cellular physiology Vol. 187; no. 1; pp. 109 - 116
• Main Authors: Pellerin, Isabelle, Leclerc, Marie, Claveau, David, Mailloux, Johanne, Brunette, Michèle G.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.04.2001
• Subjects: 8-Bromo Cyclic Adenosine Monophosphate - analogs & derivatives; 8-Bromo Cyclic Adenosine Monophosphate - pharmacology; Adenosine Triphosphate - analogs & derivatives; Adenosine Triphosphate - pharmacology; Adenosine Triphosphate - physiology; Amiloride - analogs & derivatives; Amiloride - pharmacology; Animals; Cytochalasin B - pharmacology; Cytoskeleton - drug effects; Cytoskeleton - physiology; Cytosol - metabolism; Enzyme Inhibitors - pharmacology; Intracellular Membranes - drug effects; Intracellular Membranes - metabolism; Ion Transport - drug effects; Kidney Tubules, Distal - drug effects; Kidney Tubules, Distal - metabolism; Kidney Tubules, Proximal - drug effects; Kidney Tubules, Proximal - metabolism; Kinetics; Nephrons - metabolism; Phosphorylation; Protein Isoforms - metabolism; Rabbits; Sodium - metabolism; Sodium-Hydrogen Exchangers - metabolism; Thionucleotides - pharmacology

Although in LLC‐PK cells ATP depletion has been shown to result in alterations of cytoskeleton actin and an inhibition of Na+/H+ exchanger activity, there is little information concerning the regulation of this exchanger in the distal luminal membrane by ATP and actin filaments. The present study ex...