Mechanical overload decreases the thermal stability of collagen in an in vitro tensile overload tendon model

• Published in: Journal of orthopaedic research Vol. 26; no. 12; pp. 1605 - 1610
• Main Authors: Willett, Thomas L., Labow, Rosalind S., Lee, J. Michael
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2008
• Subjects: Animals; Biomechanical Phenomena; Cattle; collagen; Collagen - analysis; Collagen - chemistry; damage; denaturation; Hot Temperature; injury; Male; Models, Animal; Models, Chemical; Models, Structural; Protein Conformation; Protein Denaturation; Protein Stability; stability; Tendons - chemistry; Tensile Strength

Musculoskeletal soft tissue injuries are very common, yet poorly understood. We investigated molecular‐level changes in collagen caused by tensile overload of bovine tail tendons in vitro. Previous investigators concluded that tensile tendon rupture resulted in collagen denaturation, but our study s...