Intratumoral regulatory T cells with higher prevalence and more suppressive activity in hepatocellular carcinoma patients

• Published in: Journal of gastroenterology and hepatology Vol. 28; no. 9; pp. 1555 - 1564
• Main Authors: Wu, Han, Chen, Pei, Liao, Rui, Li, Yi-Wei, Yi, Yong, Wang, Jia-Xing, Cai, Xiao-Yan, He, Hong-Wei, Jin, Jian-Jun, Cheng, Yun-Feng, Fan, Jia, Sun, Jian, Qiu, Shuang-Jian
• Format: Journal Article
• Language: English
• Published: Australia Blackwell Publishing Ltd 01.09.2013
• Subjects: Adult; Antigens, Surface - analysis; B-Lymphocyte Subsets - immunology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Case-Control Studies; Female; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; gene microarray; hepatocellular carcinoma; Humans; Immune Tolerance - immunology; Immunophenotyping; immunosuppression; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Lymphocytes, Tumor-Infiltrating - immunology; Male; Middle Aged; Oligonucleotide Array Sequence Analysis - methods; regulatory T cell; T-Lymphocytes, Regulatory - immunology; Tumor Escape - immunology; tumor immuno-escape; gene microarray; immunosuppression; tumor immuno-escape; regulatory T cell; hepatocellular carcinoma

Background and Aim Regulatory T cells (Treg) play a vital role in immunosuppressive crosstalk; however, Tregs from different locations lead to different clinical outcomes. Our aim was, therefore, to compare the prevalences and suppressive phenotypes of Tregs in the peripheral blood, peritumor, and i...