Cardiac Fas Receptor‐dependent Apoptotic Pathway in Obese Zucker Rats

• Published in: Obesity (Silver Spring, Md.) Vol. 15; no. 10; pp. 2407 - 2415
• Main Authors: Lee, Shin‐Da, Tzang, Bor‐Show, Kuo, Wei‐Wen, Lin, Yueh‐Min, Yang, Ai‐Lan, Chen, Szu‐Hua, Tsai, Fuu‐Jen, Wu, Fong‐Li, Lu, Min‐Chi, Huang, Chih‐Yang
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2007
• Subjects: Adapter proteins; animal models; Animals; Apoptosis; Biotechnology; Body Weight; Cardiomyocytes; Cardiomyopathies - etiology; Cardiomyopathies - metabolism; Cardiomyopathies - pathology; Cardiomyopathy; Caspase 3 - analysis; Caspase 3 - metabolism; Caspase 8 - analysis; Caspase 8 - metabolism; fas Receptor - agonists; fas Receptor - metabolism; Fibrosis; Heart failure; Hospitals; Hypertension; Ligands; Male; Myocardium - metabolism; Myocardium - pathology; Obesity; Obesity - complications; Obesity - metabolism; Organ Size; Physical therapy; Rats; Rats, Zucker; Receptors, Death Domain - agonists; Receptors, Death Domain - metabolism; Research methodology; Science; Zucker rats; China; Taiwan

Objective: Very limited information regarding the cardiac molecular mechanism in obesity is available. The purpose of this study was to evaluate the cardiac Fas receptor‐dependent (type I) apoptotic pathway in obese Zucker rats. Research Methods and Procedures: Sixteen obese Zucker rats were studied...