Oxidation of Thiols. IV. The Effect of Substituents on Ionization and Hexacyanoferrate (III) Oxidation of Monothiodiacylmethane

• Published in: Chemical & pharmaceutical bulletin Vol. 27; no. 3; pp. 620 - 624
• Main Authors: AL-HAJJAR, FAROUK H., KASSIM, AHMAD Y.
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1979; Japan Science and Technology Agency
• Subjects: linear free energy relationship

Ionization constants, pKa, for a set of six monothiodiacylmethanes have been determined in 50 vol% ethanol-water mixture at 25°±0.1. Excellent linear correlations are obtained when pKa values are plotted against the substituent constant, σx, and the polar substituent constant, σ*xC6H4, for substitut...