Protective Effects of Baicalin on Aβ1–42-Induced Learning and Memory Deficit, Oxidative Stress, and Apoptosis in Rat

• Published in: Cellular and molecular neurobiology Vol. 35; no. 5; pp. 623 - 632
• Main Authors: Ding, Haitao, Wang, Haitao, Zhao, Yexia, Sun, Deke, Zhai, Xu
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2015
• Subjects: Amyloid beta-Peptides - toxicity; Animals; Antioxidants - metabolism; Apoptosis - drug effects; bcl-2-Associated X Protein - metabolism; Biomedical and Life Sciences; Biomedicine; Caspases - metabolism; Cell Biology; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Cytochromes c - metabolism; Enzyme Activation - drug effects; Flavonoids - chemistry; Flavonoids - pharmacology; Flavonoids - therapeutic use; Hippocampus - drug effects; Hippocampus - pathology; Male; Malondialdehyde - metabolism; Membrane Potential, Mitochondrial - drug effects; Memory Disorders - drug therapy; Memory Disorders - pathology; Neurobiology; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurosciences; NF-E2-Related Factor 2 - metabolism; Original Research; Oxidative Stress - drug effects; Rats, Wistar; Real-Time Polymerase Chain Reaction; Aβ; Oxidative stress; Learning and memory deficit; Alzheimer’s disease; Baicalin; Apoptosis

The accumulation and deposition of β-amyloid peptide (Aβ) in senile plaques and cerebral vasculature is believed to facilitate the progressive neurodegeneration that occurs in the Alzheimer’s disease (AD). The present study sought to elucidate possible effects of baicalin, a natural phytochemical, o...