Dopamine receptor D3 mRNA expression in human lymphocytes is negatively correlated with the personality trait of persistence

• Published in: Journal of neuroimmunology Vol. 150; no. 1; pp. 145 - 149
• Main Authors: Czermak, Christoph, Lehofer, Michael, Renger, Helmut, Wagner, Elke M, Lemonis, Leonidas, Rohrhofer, Alfred, Schauenstein, Konrad, Liebmann, Peter M
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2004
• Subjects: Adult; Analysis of Variance; Exploratory Behavior - physiology; Female; Genetic Markers; Human; Humans; Lymphocyte Subsets - metabolism; Lymphocytes; Male; Messenger; Personality; Personality - genetics; Personality Inventory - statistics & numerical data; Polymerase Chain Reaction; Receptors, dopamine; Receptors, Dopamine D2 - biosynthesis; Receptors, Dopamine D2 - blood; Receptors, Dopamine D2 - genetics; Receptors, Dopamine D3; Receptors, Dopamine D4; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger - biosynthesis; RNA, Messenger - blood; Statistics, Nonparametric; Human; RNA; Lymphocytes; Polymerase Chain Reaction; Receptors, dopamine; Personality; Messenger

It has been proposed that neurotransmitter receptor expression in peripheral immune cells reflects expression of these receptors in the brain. To test this “peripheral marker hypothesis”, we compared mRNA expression of the dopamine receptors D3 (DRD3) and D4 (DRD4) in peripheral blood lymphocytes (P...