Ca2+-dependent modulation of voltage-gated Ca2+ channels

• Published in: Biochimica et biophysica acta Vol. 1820; no. 8; pp. 1243 - 1252
• Main Authors: Christel, Carl, Lee, Amy
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2012
• Subjects: Animals; Calcium; Calcium - physiology; calcium channels; Calcium Channels - metabolism; Calcium Channels - physiology; Calcium Signaling; Calcium-Binding Proteins - metabolism; Cellular excitability; electrophysiology; Feedback, Physiological; heterologous gene expression; Humans; ions; Membrane Potentials; muscles; Neurons - metabolism; Neurons - physiology; Organ Specificity; Protein Isoforms - metabolism; Protein Isoforms - physiology; Protein Subunits - metabolism; Protein Subunits - physiology; transcription (genetics); Calcium; Cellular excitability
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/j.bbagen.2011.12.012

Voltage-gated (Cav) Ca2+ channels are multi-subunit complexes that play diverse roles in a wide variety of tissues. A fundamental mechanism controlling Cav channel function involves the Ca2+ ions that permeate the channel pore. Ca2+ influx through Cav channels mediates feedback regulation to the cha...