G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1414 - 1428
• Main Authors: Bates, Paula J., Reyes-Reyes, Elsa M., Malik, Mohammad T., Murphy, Emily M., O'Toole, Martin G., Trent, John O.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: animal models; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - therapeutic use; Aptamer; Aptamers, Nucleotide; AS1411; Binding Sites; Cancer; Cell Proliferation - drug effects; Cell Survival - drug effects; Contrast agent; Contrast Media - chemistry; Contrast Media - metabolism; Diagnostic Imaging - methods; DNA; Drug Carriers; Drug delivery; endocytosis; G-Quadruplexes; Guanosine - chemistry; Guanosine - metabolism; Humans; image analysis; Imaging; Ligands; Nanoparticles; neoplasm cells; neoplasms; Neoplasms - diagnostic imaging; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Nucleolin; Oligodeoxyribonucleotides - chemistry; Oligodeoxyribonucleotides - metabolism; Oligodeoxyribonucleotides - therapeutic use; oligonucleotides; patients; Phosphoproteins - metabolism; Quadruplex; Radiopharmaceuticals - chemistry; Radiopharmaceuticals - metabolism; Radiosensitizer; RNA-Binding Proteins - metabolism; Structure-Activity Relationship; therapeutics; Nanoparticles; AS1411; Imaging; Contrast agent; Radiosensitizer; Aptamer; Drug delivery; Quadruplex; Nucleolin; Cancer

AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic...