G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms
AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic...
Saved in:
| Published in | Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1414 - 1428 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.05.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences.
Recent developments related to AS1411 will be examined, with a focus on its use for targeted delivery of therapeutic and imaging agents.
Numerous research groups have used AS1411 as a targeting agent to deliver nanoparticles, oligonucleotides, and small molecules into cancer cells. Studies in animal models have demonstrated that AS1411-linked materials can accumulate selectively in tumors following systemic administration. The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.
Human trials have indicated that AS1411 is safe and can induce durable remissions in a few patients, but new strategies are needed to maximize its clinical impact. A better understanding of the mechanisms by which AS1411 targets and kills cancer cells may hasten the development of promising technologies using AS1411-linked nanoparticles or conjugates for cancer-targeted therapy and imaging. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio.
•AS1411 is a G-quadruplex DNA oligonucleotide that is also a nucleolin aptamer.•This review covers the structure, clinical status, uses, and mechanism of AS1411.•AS1411 is being widely used to deliver therapeutic and imaging agents to cancer cells.•Its cancer-targeting activity has been demonstrated in at least 30 animal studies.•Its targeting mechanism is not fully understood but may involve macropinocytosis. |
|---|---|
| AbstractList | AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences.
Recent developments related to AS1411 will be examined, with a focus on its use for targeted delivery of therapeutic and imaging agents.
Numerous research groups have used AS1411 as a targeting agent to deliver nanoparticles, oligonucleotides, and small molecules into cancer cells. Studies in animal models have demonstrated that AS1411-linked materials can accumulate selectively in tumors following systemic administration. The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.
Human trials have indicated that AS1411 is safe and can induce durable remissions in a few patients, but new strategies are needed to maximize its clinical impact. A better understanding of the mechanisms by which AS1411 targets and kills cancer cells may hasten the development of promising technologies using AS1411-linked nanoparticles or conjugates for cancer-targeted therapy and imaging. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio.
•AS1411 is a G-quadruplex DNA oligonucleotide that is also a nucleolin aptamer.•This review covers the structure, clinical status, uses, and mechanism of AS1411.•AS1411 is being widely used to deliver therapeutic and imaging agents to cancer cells.•Its cancer-targeting activity has been demonstrated in at least 30 animal studies.•Its targeting mechanism is not fully understood but may involve macropinocytosis. AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences. Recent developments related to AS1411 will be examined, with a focus on its use for targeted delivery of therapeutic and imaging agents. Numerous research groups have used AS1411 as a targeting agent to deliver nanoparticles, oligonucleotides, and small molecules into cancer cells. Studies in animal models have demonstrated that AS1411-linked materials can accumulate selectively in tumors following systemic administration. The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells. Human trials have indicated that AS1411 is safe and can induce durable remissions in a few patients, but new strategies are needed to maximize its clinical impact. A better understanding of the mechanisms by which AS1411 targets and kills cancer cells may hasten the development of promising technologies using AS1411-linked nanoparticles or conjugates for cancer-targeted therapy and imaging. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences.Recent developments related to AS1411 will be examined, with a focus on its use for targeted delivery of therapeutic and imaging agents.Numerous research groups have used AS1411 as a targeting agent to deliver nanoparticles, oligonucleotides, and small molecules into cancer cells. Studies in animal models have demonstrated that AS1411-linked materials can accumulate selectively in tumors following systemic administration. The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.Human trials have indicated that AS1411 is safe and can induce durable remissions in a few patients, but new strategies are needed to maximize its clinical impact. A better understanding of the mechanisms by which AS1411 targets and kills cancer cells may hasten the development of promising technologies using AS1411-linked nanoparticles or conjugates for cancer-targeted therapy and imaging. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences.BACKGROUNDAS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences.Recent developments related to AS1411 will be examined, with a focus on its use for targeted delivery of therapeutic and imaging agents.SCOPE OF REVIEWRecent developments related to AS1411 will be examined, with a focus on its use for targeted delivery of therapeutic and imaging agents.Numerous research groups have used AS1411 as a targeting agent to deliver nanoparticles, oligonucleotides, and small molecules into cancer cells. Studies in animal models have demonstrated that AS1411-linked materials can accumulate selectively in tumors following systemic administration. The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.MAJOR CONCLUSIONSNumerous research groups have used AS1411 as a targeting agent to deliver nanoparticles, oligonucleotides, and small molecules into cancer cells. Studies in animal models have demonstrated that AS1411-linked materials can accumulate selectively in tumors following systemic administration. The mechanism underlying the cancer-targeting ability of AS1411 is not completely understood, but recent studies suggest a model that involves: (1) initial uptake by macropinocytosis, a form of endocytosis prevalent in cancer cells; (2) stimulation of macropinocytosis by a nucleolin-dependent mechanism resulting in further uptake; and (3) disruption of nucleolin-mediated trafficking and efflux leading to cargoes becoming trapped inside cancer cells.Human trials have indicated that AS1411 is safe and can induce durable remissions in a few patients, but new strategies are needed to maximize its clinical impact. A better understanding of the mechanisms by which AS1411 targets and kills cancer cells may hasten the development of promising technologies using AS1411-linked nanoparticles or conjugates for cancer-targeted therapy and imaging. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio.SIGNIFICANCEHuman trials have indicated that AS1411 is safe and can induce durable remissions in a few patients, but new strategies are needed to maximize its clinical impact. A better understanding of the mechanisms by which AS1411 targets and kills cancer cells may hasten the development of promising technologies using AS1411-linked nanoparticles or conjugates for cancer-targeted therapy and imaging. This article is part of a Special Issue entitled "G-quadruplex" Guest Editor: Dr. Concetta Giancola and Dr. Daniela Montesarchio. |
| Author | O'Toole, Martin G. Reyes-Reyes, Elsa M. Murphy, Emily M. Bates, Paula J. Malik, Mohammad T. Trent, John O. |
| Author_xml | – sequence: 1 givenname: Paula J. surname: Bates fullname: Bates, Paula J. email: paula.bates@louisville.edu organization: Department of Medicine, University of Louisville, USA – sequence: 2 givenname: Elsa M. surname: Reyes-Reyes fullname: Reyes-Reyes, Elsa M. organization: Department of Medicine, University of Arizona, USA – sequence: 3 givenname: Mohammad T. surname: Malik fullname: Malik, Mohammad T. organization: Department of Medicine, University of Louisville, USA – sequence: 4 givenname: Emily M. surname: Murphy fullname: Murphy, Emily M. organization: Department of Biomedical Engineering, University of Louisville, USA – sequence: 5 givenname: Martin G. surname: O'Toole fullname: O'Toole, Martin G. organization: Department of Biomedical Engineering, University of Louisville, USA – sequence: 6 givenname: John O. surname: Trent fullname: Trent, John O. organization: Department of Medicine, University of Louisville, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28007579$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1P3DAQhi1EVRbaf1BVOfaS1B_xOuFQCaEClZB6KJytsT3ZepU4i-0g-Pf1aqGHHoov9sjPOyPNc0qOwxyQkE-MNoyy9ddtYwxsMDS8VA3jDWXyiKxYp3jdUbo-JisqaFu3bC1PyGlKW1qO7OV7csILoKTqV-Tuun5YwMVlN-JTNY9-M4fFjjhn77C6-MVaxipIFVQWgsVYZ4gbzD5sqv3wfF7dJyzfwVUT2t8QfJrSB_JugDHhx5f7jNxffb-7vKlvf17_uLy4ra3oZa4HMEM_CJAtOsFFZ501rbMKBuegA-ZAGVOe0LfMIhhsC94Dp6D6TlEjzsiXQ99dnB8WTFlPPlkcRwg4L0lz2sqOManEmyjrJFedEIoW9PMLupgJnd5FP0F81q9LK0B7AGycU4o4_EUY1Xs3eqsPbvTejWZcFzcldv5PzPoM2c8hR_DjW-FvhzCWfT56jDpZj8WI8xFt1m72_2_wBxUWrNk |
| CitedBy_id | crossref_primary_10_1002_cphc_202300264 crossref_primary_10_3390_cancers9060069 crossref_primary_10_1016_j_canlet_2019_01_045 crossref_primary_10_1111_cpr_13105 crossref_primary_10_1002_ange_202318665 crossref_primary_10_1016_j_aca_2024_343276 crossref_primary_10_1007_s12033_023_01030_4 crossref_primary_10_3390_ijms231911390 crossref_primary_10_1021_acsabm_8b00639 crossref_primary_10_1016_j_nano_2021_102429 crossref_primary_10_1039_D1CP05753G crossref_primary_10_1021_acs_jmedchem_2c01557 crossref_primary_10_1039_C9RA07974B crossref_primary_10_1039_C8NR07321J crossref_primary_10_1039_D4AY02183E crossref_primary_10_1016_j_jconrel_2018_10_018 crossref_primary_10_1021_acs_jmedchem_1c01567 crossref_primary_10_3390_nano9050709 crossref_primary_10_1038_s41598_020_67217_w crossref_primary_10_1016_j_jsb_2019_10_001 crossref_primary_10_1002_ange_202208451 crossref_primary_10_1007_s00216_021_03667_z crossref_primary_10_1016_j_colsurfb_2021_112047 crossref_primary_10_1093_nar_gkab039 crossref_primary_10_1016_j_talanta_2020_121037 crossref_primary_10_1021_acsabm_2c00907 crossref_primary_10_3390_pharmaceutics16040566 crossref_primary_10_1007_s00216_023_04629_3 crossref_primary_10_1038_s41598_018_33873_2 crossref_primary_10_1021_acsnano_4c09800 crossref_primary_10_15212_bioi_2024_0002 crossref_primary_10_1038_s41598_019_44388_9 crossref_primary_10_3390_ijms21207781 crossref_primary_10_1021_acssensors_2c00992 crossref_primary_10_3390_ph14020121 crossref_primary_10_1016_j_jddst_2023_104255 crossref_primary_10_1038_s41467_019_11728_2 crossref_primary_10_3389_fmolb_2022_1025313 crossref_primary_10_3390_ijms24119524 crossref_primary_10_2174_1381612828666220928105044 crossref_primary_10_3389_fcell_2022_1053984 crossref_primary_10_3390_pharmaceutics13101671 crossref_primary_10_1016_j_apsb_2022_02_022 crossref_primary_10_1016_j_biochi_2022_05_002 crossref_primary_10_1002_adhm_202401020 crossref_primary_10_1016_j_ejps_2021_106093 crossref_primary_10_1021_acs_molpharmaceut_8b00124 crossref_primary_10_1186_s13046_024_03133_5 crossref_primary_10_15392_2319_0612_2022_1933 crossref_primary_10_3390_pharmaceutics14112456 crossref_primary_10_2147_IJN_S254108 crossref_primary_10_3390_ijms241814344 crossref_primary_10_3390_catal10101153 crossref_primary_10_1111_cbdd_13910 crossref_primary_10_3390_mi13020315 crossref_primary_10_3390_ph14050473 crossref_primary_10_1002_adhm_202300561 crossref_primary_10_1038_s42004_025_01462_w crossref_primary_10_3390_molecules24193625 crossref_primary_10_1088_1361_6528_abed03 crossref_primary_10_3390_ijms232314921 crossref_primary_10_1016_j_ijbiomac_2018_06_137 crossref_primary_10_5812_tms_113773 crossref_primary_10_1002_cmdc_202400438 crossref_primary_10_3390_nano12213869 crossref_primary_10_1016_j_biopha_2024_117064 crossref_primary_10_1039_D0CC06347A crossref_primary_10_1039_D2RA06631A crossref_primary_10_1016_j_ijpharm_2022_121963 crossref_primary_10_1021_acs_biomac_1c01706 crossref_primary_10_1016_j_ica_2025_122585 crossref_primary_10_1016_j_carbpol_2023_121562 crossref_primary_10_1016_j_ymthe_2021_06_010 crossref_primary_10_2147_IJN_S243223 crossref_primary_10_3390_molecules25225227 crossref_primary_10_1016_j_ijpharm_2019_118511 crossref_primary_10_15252_embj_2020107158 crossref_primary_10_1039_D0TB02527E crossref_primary_10_1186_s12951_022_01240_z crossref_primary_10_1016_j_nano_2019_102060 crossref_primary_10_1021_acsabm_0c01009 crossref_primary_10_1038_s42003_025_07915_1 crossref_primary_10_1016_j_lfs_2017_07_025 crossref_primary_10_1088_1748_605X_ad2212 crossref_primary_10_1016_j_actbio_2023_12_013 crossref_primary_10_1039_D4CC00578C crossref_primary_10_1039_D1NR00611H crossref_primary_10_1111_jcmm_70077 crossref_primary_10_1021_acs_analchem_9b04868 crossref_primary_10_1021_acs_jmedchem_4c01228 crossref_primary_10_3390_ijms22073372 crossref_primary_10_1186_s12951_023_01941_z crossref_primary_10_1016_j_trac_2019_115759 crossref_primary_10_18632_oncotarget_25260 crossref_primary_10_1038_s41598_018_25816_8 crossref_primary_10_3390_cells9061412 crossref_primary_10_1021_acs_jpcb_2c08784 crossref_primary_10_1016_j_ejmech_2024_117027 crossref_primary_10_1016_j_xphs_2024_02_005 crossref_primary_10_3389_fmolb_2023_1217769 crossref_primary_10_3390_ijms22137040 crossref_primary_10_1039_D2OB01911F crossref_primary_10_1016_j_jddst_2022_103692 crossref_primary_10_1016_j_talanta_2020_122037 crossref_primary_10_1158_2326_6066_CIR_20_0020 crossref_primary_10_5812_tms_113991 crossref_primary_10_1016_j_chembiol_2024_03_011 crossref_primary_10_3390_molecules27020383 crossref_primary_10_1002_adhm_202300791 crossref_primary_10_1039_D4TB00909F crossref_primary_10_3389_fgene_2023_1170260 crossref_primary_10_1016_j_ijbiomac_2020_05_173 crossref_primary_10_1038_s41392_023_01536_y crossref_primary_10_1016_j_omtn_2018_06_003 crossref_primary_10_3390_pharmaceutics14122610 crossref_primary_10_1016_j_jbc_2021_100553 crossref_primary_10_1016_j_omtn_2020_01_034 crossref_primary_10_1016_j_ultramic_2024_113986 crossref_primary_10_1093_jb_mvaa095 crossref_primary_10_1186_s11671_019_3101_0 crossref_primary_10_1002_mabi_202100272 crossref_primary_10_1016_j_bioorg_2022_105827 crossref_primary_10_1016_j_jddst_2024_106214 crossref_primary_10_1007_s12010_024_05091_2 crossref_primary_10_1002_open_202400463 crossref_primary_10_3390_pharmaceutics13060888 crossref_primary_10_1016_j_omtn_2019_12_004 crossref_primary_10_2745_dds_36_360 crossref_primary_10_3390_ijms21124522 crossref_primary_10_1016_j_snb_2023_135172 crossref_primary_10_1080_17425247_2019_1575808 crossref_primary_10_1080_1061186X_2021_1892117 crossref_primary_10_1016_j_jconrel_2023_08_036 crossref_primary_10_1016_j_nano_2023_102710 crossref_primary_10_3390_cancers9120174 crossref_primary_10_3390_molecules27206781 crossref_primary_10_1038_s41375_021_01434_8 crossref_primary_10_1039_D1CC05924F crossref_primary_10_1208_s12249_020_1629_z crossref_primary_10_1039_D2CC03296A crossref_primary_10_2147_IJN_S240083 crossref_primary_10_1038_s41598_018_25720_1 crossref_primary_10_1039_D0TB00663G crossref_primary_10_1007_s13346_021_00972_z crossref_primary_10_1016_j_molmed_2017_10_004 crossref_primary_10_1089_jamp_2024_0016 crossref_primary_10_1016_j_carbpol_2020_116735 crossref_primary_10_1039_C9NJ06445A crossref_primary_10_1186_s12951_022_01586_4 crossref_primary_10_1039_C9OB00318E crossref_primary_10_3390_pharmaceutics16070864 crossref_primary_10_1039_D3CC02904B crossref_primary_10_3390_ph14070671 crossref_primary_10_4251_wjgo_v15_i7_1149 crossref_primary_10_3390_cancers13164038 crossref_primary_10_1016_j_drudis_2023_103550 crossref_primary_10_3390_cancers13163984 crossref_primary_10_1016_j_ijpharm_2024_124539 crossref_primary_10_1016_j_biomaterials_2018_09_016 crossref_primary_10_1002_anie_202318665 crossref_primary_10_3390_molecules27123944 crossref_primary_10_1021_acsami_3c16723 crossref_primary_10_1039_C8TB01563E crossref_primary_10_1016_j_biosx_2023_100318 crossref_primary_10_1016_j_isci_2022_105324 crossref_primary_10_1002_adma_202205746 crossref_primary_10_26599_NR_2025_94907030 crossref_primary_10_3390_ph12040146 crossref_primary_10_1016_j_ab_2019_03_016 crossref_primary_10_3390_ph16060849 crossref_primary_10_1002_med_21737 crossref_primary_10_3390_ijms22189948 crossref_primary_10_3389_fphar_2021_588306 crossref_primary_10_1002_adfm_202208797 crossref_primary_10_3390_cancers14194698 crossref_primary_10_1002_smll_202007391 crossref_primary_10_1021_jacs_4c15674 crossref_primary_10_1021_acs_analchem_8b02847 crossref_primary_10_1016_j_ejpb_2019_07_017 crossref_primary_10_3390_pathogens13010060 crossref_primary_10_1016_j_bbagen_2017_03_022 crossref_primary_10_3390_genes9020074 crossref_primary_10_1016_j_colsurfa_2022_128675 crossref_primary_10_1016_j_ejphar_2025_177310 crossref_primary_10_1038_s42004_024_01353_6 crossref_primary_10_1016_j_ijbiomac_2023_127703 crossref_primary_10_1016_j_microc_2021_106640 crossref_primary_10_1007_s00294_017_0773_9 crossref_primary_10_3390_cancers15072151 crossref_primary_10_37349_emed_2021_00039 crossref_primary_10_1039_C9BM01813A crossref_primary_10_1371_journal_pone_0233466 crossref_primary_10_1016_j_colsurfb_2024_114121 crossref_primary_10_3389_fcell_2021_662791 crossref_primary_10_3390_biomedicines10020486 crossref_primary_10_1007_s11095_020_02873_1 crossref_primary_10_1038_s41541_022_00541_6 crossref_primary_10_1080_1061186X_2020_1830407 crossref_primary_10_3390_ijms25126742 crossref_primary_10_1002_anie_202208451 crossref_primary_10_3390_pharmaceutics11020050 crossref_primary_10_1016_j_ijbiomac_2019_11_118 crossref_primary_10_3390_molecules24203781 crossref_primary_10_1039_C8NR01451E crossref_primary_10_3390_ijms21093252 crossref_primary_10_3390_ph11040093 crossref_primary_10_1016_j_molmed_2020_05_002 crossref_primary_10_1039_D3BM01116J crossref_primary_10_1088_1748_605X_ac8c75 crossref_primary_10_3390_molecules27113446 crossref_primary_10_1016_j_ab_2021_114262 crossref_primary_10_1021_acsnano_1c06667 crossref_primary_10_3390_bioengineering9120766 crossref_primary_10_1016_j_abb_2019_07_004 crossref_primary_10_2147_IJN_S248736 crossref_primary_10_3390_biom10040583 crossref_primary_10_1016_j_bbrc_2022_04_020 crossref_primary_10_3390_molecules26061741 crossref_primary_10_1016_j_carbpol_2020_117476 crossref_primary_10_1016_j_omtn_2023_01_007 crossref_primary_10_2147_IJN_S295598 crossref_primary_10_1016_j_trac_2021_116257 crossref_primary_10_1021_acs_chemrev_8b00629 |
| Cites_doi | 10.1371/journal.ppat.1002657 10.1016/j.ijrobp.2015.09.032 10.1371/journal.pone.0034795 10.1371/journal.pone.0002518 10.3109/1061186X.2015.1009075 10.1073/pnas.221467298 10.1021/bi0119520 10.1083/jcb.201504097 10.1016/j.talanta.2013.09.062 10.1371/journal.ppat.1001121 10.7150/thno.14184 10.2174/1574892808666131119095953 10.1128/JVI.06194-11 10.1093/nar/gkp1088 10.1016/j.yexmp.2009.01.004 10.1084/jem.179.2.601 10.1038/nm.3791 10.1002/0471142700.nc1707s61 10.1021/bi901265z 10.1016/j.cell.2015.06.017 10.18632/oncotarget.7073 10.1038/nm.2444 10.1016/j.celrep.2016.07.005 10.1007/s00432-014-1587-5 10.1186/1471-2091-14-2 10.1158/0008-5472.CAN-10-2887 10.1093/nar/gkv897 10.18632/oncotarget.2343 10.1182/blood-2007-01-064428 10.3389/fphys.2015.00038 10.1128/JVI.80.7.3332-3340.2006 10.1038/ncb0509-510 10.1038/srep25799 10.1016/j.jconrel.2015.05.232 10.1007/s10895-015-1612-3 10.1016/j.virol.2016.04.008 10.1038/srep15675 10.1038/sj.cr.7310024 10.1128/JVI.75.22.11166-11177.2001 10.1074/jbc.274.37.26369 10.1371/journal.pone.0164146 10.1371/journal.ppat.1001329 10.1002/anie.200901452 10.1016/j.biomaterials.2011.07.004 10.1016/j.jconrel.2004.10.018 10.1016/j.bbrc.2007.08.091 10.18632/oncotarget.11323 10.1038/mt.2010.214 10.1128/mBio.00301-11 10.1158/0008-5472.CAN-07-5723 10.1371/journal.pone.0002310 10.1021/mp900042p 10.1128/JVI.01510-09 10.18632/oncotarget.5990 10.1021/nn300296p 10.1002/smll.200801580 10.1186/1471-2407-6-197 10.1006/excr.2002.5522 10.1021/acsami.5b05065 10.1016/j.bbrc.2014.04.148 10.1128/JVI.00704-13 10.1371/journal.pone.0014193 10.4161/rna.19718 10.1111/j.1742-4658.2006.05143.x 10.1039/c3tb20412j 10.1002/anie.201205271 10.1021/bi00253a007 10.18632/oncotarget.3608 10.1002/smll.201601903 10.1128/JVI.76.13.6689-6700.2002 10.1084/jem.20120950 10.1158/1535-7163.MCT-06-0172 10.1371/journal.pone.0136673 10.1038/nm996 10.1128/jvi.69.11.6751-6757.1995 10.1021/acs.molpharmaceut.6b00277 10.1186/1471-2180-8-145 10.1039/C4SC03949A 10.1128/MCB.25.6.2463-2474.2005 10.1007/s12274-014-0420-4 10.1021/mp4005657 10.1016/j.molcel.2011.03.017 10.1182/blood-2012-12-471094 10.1016/j.exer.2015.09.005 10.1046/j.1432-1033.2003.03929.x 10.1016/j.molcel.2014.11.013 10.1002/path.2760 10.1007/s00417-016-3409-8 10.1016/j.ejpb.2016.03.013 10.1016/j.biochi.2010.10.015 10.1007/s12032-015-0530-1 10.1146/annurev.biochem.78.081307.110540 10.1128/JVI.01889-14 10.1002/smll.200801821 10.1021/nl500844m 10.1073/pnas.1321800111 10.1002/jnr.490420305 10.1182/blood-2005-07-2961 10.18632/oncotarget.2131 10.1007/s13277-014-2734-y 10.1158/0008-5472.CAN-14-2211 10.1155/2010/168306 10.1074/jbc.M112.387076 10.1021/nn901374b 10.1186/2045-824X-4-21 10.1371/journal.pone.0089141 10.1128/JVI.02007-09 10.1128/JVI.00077-08 10.1074/jbc.272.49.31130 10.1021/bc500562s 10.1074/jbc.273.34.21988 10.1002/eji.201141693 10.1039/c1ob05891f 10.1089/088922299311358 10.1016/j.biochi.2015.09.009 10.1016/j.nano.2014.08.013 10.1016/j.bbrc.2011.06.109 10.1074/jbc.M207629200 10.1371/journal.pone.0015787 10.1002/smll.201670168 10.1038/nature12138 10.1002/mabi.201300165 10.1158/0008-5472.CAN-10-3459 10.1016/j.bbrc.2009.07.055 10.1007/s12035-014-8955-7 10.4155/tde.12.107 10.1093/oxfordjournals.jbchem.a124628 10.1186/1471-2407-11-333 10.1073/pnas.1507087112 10.1093/jb/mvm102 10.1084/jem.20011053 10.1016/S0960-9822(00)80116-5 10.1074/jbc.M100874200 10.1016/j.biomaterials.2015.07.055 10.1039/c3nr03490a 10.1093/nar/gkg316 10.2174/1389201015666140408123710 10.1158/1541-7786.MCR-07-2036 10.1128/JVI.03498-14 10.1128/JVI.78.15.8146-8158.2004 10.2967/jnumed.109.069880 10.1083/jcb.200304132 10.1128/JVI.01802-12 10.1371/journal.ppat.1001110 10.1016/j.actbio.2016.02.012 10.1158/1538-7445.AM2016-1488 10.1007/s10059-013-0149-z 10.1016/j.biomaterials.2014.01.019 10.1007/s10456-012-9284-y 10.1038/ncomms5904 10.1126/science.1199484 10.1007/s00432-009-0733-y 10.1126/science.1199498 10.1158/1535-7163.MCT-05-0361 10.1158/0008-5472.CAN-10-0920 10.1042/CBI20100625 10.1124/mol.109.055947 10.1128/mBio.01340-14 10.1074/jbc.M104446200 10.3389/fphys.2016.00381 10.1006/excr.2000.5071 10.1007/BF00351168 10.1016/j.biomaterials.2016.05.017 10.1016/j.biomaterials.2011.09.023 10.1158/0008-5472.CAN-06-4206 10.1152/ajpcell.00036.2011 10.1016/j.nano.2014.10.005 10.18632/oncotarget.6334 10.1016/j.ymthe.2004.08.010 10.1016/j.biomaterials.2012.03.058 10.1074/jbc.M110230200 10.1371/journal.pone.0075269 10.1073/pnas.1407361111 10.1093/nar/gkq166 10.1128/JVI.05992-11 10.1038/nature13124 10.1016/j.jconrel.2015.01.032 10.1093/oxfordjournals.jbchem.a124840 10.1089/nat.2015.0592 10.1016/j.yexcr.2008.03.016 10.3109/1061186X.2014.886038 10.1371/journal.ppat.1003309 10.1128/JVI.03320-14 10.1089/nat.2012.0347 10.1002/jcp.20501 10.1039/c2ob26504d 10.1016/j.biomaterials.2013.12.054 10.1371/journal.pone.0160822 10.1158/0008-5472.CAN-16-0300 10.1038/nrg3899 10.1016/j.jconrel.2014.06.037 10.1073/pnas.1418718112 10.1038/srep29006 10.1128/JVI.03631-13 10.1007/s12031-014-0292-9 10.1111/j.1742-4658.2006.05471.x 10.1007/s10637-013-0045-6 10.1371/journal.pone.0090687 10.1038/mt.2009.192 10.1021/acs.molpharmaceut.5b00712 10.1002/0471142700.nc1703s45 10.1016/j.molonc.2015.03.012 10.18632/oncotarget.4207 10.1074/jbc.M112.362178 10.1074/jbc.M701611200 10.1016/j.nucmedbio.2013.10.008 10.1016/j.ijantimicag.2016.01.016 10.1093/nar/30.10.2251 |
| ContentType | Journal Article |
| Copyright | 2016 Copyright © 2016. Published by Elsevier B.V. |
| Copyright_xml | – notice: 2016 – notice: Copyright © 2016. Published by Elsevier B.V. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.bbagen.2016.12.015 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1872-8006 |
| EndPage | 1428 |
| ExternalDocumentID | 28007579 10_1016_j_bbagen_2016_12_015 S0304416516305098 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: R21 CA104230 – fundername: NCI NIH HHS grantid: R01 CA122383 – fundername: NCI NIH HHS grantid: R01 CA113735 |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABGSF ABMAC ABUDA ABXDB ABYKQ ACDAQ ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OHT OZT P-8 P-9 PC. Q38 R2- ROL RPZ SBG SCC SDF SDG SDP SES SEW SPCBC SSU SSZ T5K UQL WH7 WUQ XJT XPP ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 7S9 EFKBS L.6 |
| ID | FETCH-LOGICAL-c395t-fabf9f3a54ed3238cdcb4dc7afdda8a1da7bbddaa941ceabe4f9f9a20a79870b3 |
| IEDL.DBID | .~1 |
| ISSN | 0304-4165 |
| IngestDate | Tue Aug 05 09:55:38 EDT 2025 Thu Jul 10 22:16:53 EDT 2025 Thu Apr 03 07:07:14 EDT 2025 Tue Jul 01 00:22:08 EDT 2025 Thu Apr 24 23:01:06 EDT 2025 Fri Feb 23 02:34:16 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | Nanoparticles AS1411 Imaging Contrast agent Radiosensitizer Aptamer Drug delivery Quadruplex Nucleolin Cancer |
| Language | English |
| License | Copyright © 2016. Published by Elsevier B.V. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c395t-fabf9f3a54ed3238cdcb4dc7afdda8a1da7bbddaa941ceabe4f9f9a20a79870b3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 28007579 |
| PQID | 1852783370 |
| PQPubID | 23479 |
| PageCount | 15 |
| ParticipantIDs | proquest_miscellaneous_2045811573 proquest_miscellaneous_1852783370 pubmed_primary_28007579 crossref_primary_10_1016_j_bbagen_2016_12_015 crossref_citationtrail_10_1016_j_bbagen_2016_12_015 elsevier_sciencedirect_doi_10_1016_j_bbagen_2016_12_015 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | May 2017 2017-05-00 2017-May 20170501 |
| PublicationDateYYYYMMDD | 2017-05-01 |
| PublicationDate_xml | – month: 05 year: 2017 text: May 2017 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biochimica et biophysica acta. General subjects |
| PublicationTitleAlternate | Biochim Biophys Acta Gen Subj |
| PublicationYear | 2017 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Hirano, Kaneko, Yamashita, Luo, Qin, Shirota, Nomura, Kobayashi, Murakami (bb0380) 2003; 278 Chen, Hu, Huang, Kung, Chu, Yi, Huang, Chan, Chuang, Liu, Wu, Wu, Chang, Tai (bb0905) 2015; 6 Lai, Wang, Chang, Chang, Yang, Peck (bb0830) 2014; 35 Kim, Jung, Seo, Kim, Park, Bae, Kim (bb0765) 2015; 57 Alpuche-Aranda, Racoosin, Swanson, Miller (bb0585) 1994; 179 Greco, Arata, Soler, Gaume, Coute, Hacot, Calle, Monier, Epstein, Sanchez, Bouvet, Diaz (bb0415) 2012; 86 Huang, Shi, Zhou, Song, Yuan, Luo (bb0920) 2006; 107 Soundararajan, Wang, Sridharan, Chen, Courtenay-Luck, Jones, Spicer, Fernandes (bb0705) 2009; 76 Dam, Lee, Lee, Kim, Kelleher, Odom (bb0090) 2015; 26 Malik, O'Toole, Casson, Thomas, Bardi, Reyes-Reyes, Ng, Kang, Bates (bb0170) 2015; 6 Ai, Xu, Lou, Li, Wang (bb0065) 2014; 118 Rosenberg, Bambury, Van Allen, Drabkin, Lara, Harzstark, Wagle, Figlin, Smith, Garraway, Choueiri, Erlandsson, Laber (bb0140) 2014; 32 Murayama, Harada, Shibata, Kuroda, Hayakawa, Shimizu, Tanaka (bb0360) 2007; 362 Hu, Dai, Sun, Li, Gao, Wu, Fang, Yang, An, Wu (bb0875) 2013; 5 Schokoroy, Juster, Kloog, Pinkas-Kramarski (bb1035) 2013; 8 Ha, Bidlingmaier, Liu (bb0675) 2016; 7 Bates, Laber, Miller, Thomas, Trent (bb0005) 2009; 86 Cho, Lee, Lee, Lee, Cho, Yu, Kim, Kim, Im, Lee, Oh, Yoon (bb0145) 2016; 11 Nisole, Krust, Hovanessian (bb0340) 2002; 276 Pang, Braun, Friman, Aza-Blanc, Ruidiaz, Sugahara, Teesalu, Ruoslahti (bb0740) 2014; 5 Chan, Chu, Zhang, Leung, Sze, Kao, Chik, K.K. To, Chan, Chen, Jin, Liu, Yuen (bb0365) 2016; 494 Oksayan, Nikolic, David, Blondel, Jans, Moseley (bb0455) 2015; 89 Shi, Huang, Zhou, Song, Yuan, Fu, Luo (bb0950) 2007; 110 Fu, Chen, Luo, Liang, Shi, Gao, Zhan, Zhou, Luo (bb0945) 2009; 48 Bradburne, Verhoeven, Manyam, Chaudhry, Chang, Thach, Bailey, van Hoek (bb0630) 2013; 288 Kaplan, Wadia, Dowdy (bb0570) 2005; 102 Su, Wang, Huang, Lo, Wang, Wu, Shieh, Chen, Wang, Lai, Chang (bb0465) 2015; 89 Wadia, Stan, Dowdy (bb0575) 2004; 10 Song, Ding, Zhuo, He, Fu, Chen, Song, Fu, Luo (bb0955) 2012; 15 Li, You, Dai, Xu (bb0900) 2015; 56 Niu, Yang, Xu, Du, Wang (bb1005) 2015; 36 Kim, Dimitrova, Carta, Saxena, Daras, Borowiec (bb0285) 2005; 25 Freeman, Peek, Becker, Smith, Denison (bb0580) 2014; 5 Quiroz-Mercado, Ramirez-Velazquez, Partido, Zenteno, Chavez, Agundis-Mata, Jimenez-Martinez, Garfias (bb0315) 2016; 254 Sato, Kusumoto-Matsuo, Ishii, Mori, Nakahara, Shinkai-Ouchi, Kawana, Fujii, Taketani, Kanda, Kukimoto (bb0450) 2009; 387 Acton (bb0105) 2013 Moraes, Duan, Norris, Hegele, Mastrangelo (bb0400) 2016 Chen, Liu, Cheng, Zhao, Hsu, Shen, Chiu, Kieff, Peng (bb0440) 2014; 111 Saeed, Kolokoltsov, Albrecht, Davey (bb0605) 2010; 6 Koutsioumpa, Polytarchou, Courty, Zhang, Kieffer, Mikelis, Skandalis, Hellman, Iliopoulos, Papadimitriou (bb0995) 2013; 288 Dam, Culver, Odom (bb0180) 2014; 11 Schuemann, Berbeco, Chithrani, Cho, Kumar, McMahon, Sridhar, Krishnan (bb0200) 2016; 94 Tayyari, Marchant, Moraes, Duan, Mastrangelo, Hegele (bb0395) 2011; 17 Hsu, Kang, Rameseder, Zhang, Ottina, Lim, Peterson, Choi, Gray, Yaffe, Marto, Sabatini (bb0770) 2011; 332 Di Segni, Farin, Pinkas-Kramarski (bb1045) 2008; 3 Koutsioumpa, Papadimitriou (bb0265) 2014; 9 Miller, Le, Dean, Holt, Chaires, Trent (bb0050) 2011; 9 Barel, Hovanessian, Meibom, Briand, Dupuis, Charbit (bb0495) 2008; 8 Antisoma (bb0120) 2011 Mongelard, Bouvet (bb0100) 2010; 12 Wang, Mao, Xu (bb0485) 2011; 35 Christian, Pilch, Akerman, Porkka, Laakkonen, Ruoslahti (bb1055) 2003; 163 Laber, Choudry, Taft, Bhupalam, Sharma, Hendler, Barnhart (bb0110) 2004 Bose, Basu, Banerjee (bb0470) 2004; 78 Choi, Chen, Han, Chaffee, Strano (bb0085) 2009; 5 Li, Zheng, Bates, Malik, Li, Trent, Ng (bb0845) 2014; 41 Qi, Zhang, Gou, Lee, Wang, Chen, Zhou, Wu, Yang, Liang (bb0810) 2016 Strang, Boulant, Coen (bb0420) 2010; 84 Zhang, Luo, Liu, Ding, Li, Cai (bb0785) 2014; 192 Fujiki, Watanabe, Suganuma (bb0270) 2014; 140 Krust, Vienet, Cardona, Rougeot, Jacotot, Callebaut, Guichard, Briand, Grognet, Hovanessian, Edelman (bb0325) 2001; 98 Kocisova, Praus, Bok, Bonneau, Sureau (bb0700) 2015; 25 Dapic, Abdomerovic, Marrington, Peberdy, Rodger, Trent, Bates (bb0015) 2003; 31 Le, Miller, Buscaglia, Dean, Holt, Chaires, Trent (bb0055) 2012; 10 Scaggiante, Dapas, Grassi, Manzini (bb0720) 2006; 273 Kim, Choi, Lee, Jo, Kim (bb0865) 2012; 33 Li, Hou, Liu, Guo, Wu, Zhang, Yang (bb0835) 2014; 35 Commisso, Davidson, Soydaner-Azeloglu, Parker, Kamphorst, Hackett, Grabocka, Nofal, Drebin, Thompson, Rabinowitz, Metallo, Vander Heiden, Bar-Sagi (bb0680) 2013; 497 Bi, Wang, Zhang, Han, Ampah, Liu, Zeng (bb1000) 2013; 36 Benedetti, Antonosante, d'Angelo, Cristiano, Galzio, Destouches, Florio, Dhez, Astarita, Cinque, Fidoamore, Rosati, Cifone, Ippoliti, Giordano, Courty, Cimini (bb1085) 2015; 6 Krust, El Khoury, Nondier, Soundaramourty, Hovanessian (bb1060) 2011; 11 Miller, Ohrenberg, Kuttan, Trent (bb0045) 2015; 61 Goldshmit, Trangle, Kloog, Pinkas-Kramarski (bb1030) 2014; 5 Gao, Qian, Cao, Yang, Pang, Pan, Fan, Xi, Jiang, Zhang (bb0235) 2012; 33 Gao, Yang, Zhang, Pang, Jiang (bb0695) 2014; 22 Doherty, McMahon (bb0535) 2009; 78 Le Trinh, Zhu, Xiao, Puszyk, Sefah, Wu, Tan, Liu (bb0795) 2015; 10 Hwang, Ko, Lee, Kang, Ryu, Song, Lee, Kim (bb0220) 2010; 51 Maltese, Overmeyer (bb0715) 2015; 6 Laber, Sharma, Bhupalam, Taft, Hendler, Barnhart (bb0115) 2005 Nakase, Niwa, Takeuchi, Sonomura, Kawabata, Koike, Takehashi, Tanaka, Ueda, Simpson, Jones, Sugiura, Futaki (bb0595) 2004; 10 Soundararajan, Chen, Spicer, Courtenay-Luck, Fernandes (bb1120) 2008; 68 Zhang, Hou, Jiao, Yandan, Zhu, Hongji, Chen, Ren, Xia, Zhang (bb0780) 2014; 14 Xu, Hamhouyia, Thomas, Burke, Girvan, McGregor, Trent, Miller, Bates (bb0530) 2001; 276 Fan, Sun, Wu, Zhang, Yang (bb0150) 2016; 6 Dumler, Stepanova, Jerke, Mayboroda, Vogel, Bouvet, Tkachuk, Haller, Gulba (bb1050) 1999; 9 Tosoni, Frasson, Scalabrin, Perrone, Butovskaya, Nadai, Palu, Fabris, Richter (bb0350) 2015; 43 Konishi, Karasaki, Nomoto, Ohmori, Shibata, Abe, Shimizu, Itoh, Higashi (bb0290) 1995; 117 Watanabe, Tsuge, Imagawa, Kise, Hirano, Beppu, Takahashi, Yamaguchi, Fujiki, Suganuma (bb0480) 2010; 136 Leaderer, Cashman, Kumar-Singh (bb0510) 2015; 140 Dam, Culver, Sisco, Odom (bb0195) 2012; 3 Zhang, Bing, Liu, Qi, Shen, Wang, Shangguan (bb0060) 2015; 6 Ireson, Kelland (bb0095) 2006; 5 de Verdugo, Selinka, Huber, Kramer, Kellermann, Hofschneider, Kandolf (bb0460) 1995; 69 Wittrup, Sandgren, Lilja, Bratt, Gustavsson, Morgelin, Belting (bb0555) 2007; 282 Turck, Lefebvre, Gross, Gendry, Kedinger, Simon-Assmann, Launay (bb0980) 2006; 206 Kumar, Broor, Rajala (bb0370) 2016; 11 de Vries, Tscherne, Wienholts, Cobos-Jimenez, Scholte, Garcia-Sastre, Rottier, de Haan (bb0620) 2011; 7 Wolfson, Goldenberg, Solomon, Frishberg, Pinkas-Kramarski (bb1025) 2016 Farin, Schokoroy, Haklai, Cohen-Or, Elad-Sfadia, Reyes-Reyes, Bates, Cox, Kloog, Pinkas-Kramarski (bb1040) 2011; 71 Liao, Chuang, Lin, Ho, Lin, Cheng, Chen, Wei, Sung (bb0230) 2015; 208 Liang, Guo, Wu, Shao, Li, Liu, Dang, Wang, Li, Li, Lau, Cao, Yang, Lu, He, Au, Pan, Zhang, Lu, Zhang, Yue, Qian, Shang, Xu, Xiao, Bian, Tan, Liang, He, Zhang, Lu, Zhang (bb0545) 2015; 21 Bates, Kahlon, Thomas, Trent, Miller (bb0010) 1999; 274 Perry, Rishal, Doron-Mandel, Kalinski, Medzihradszky, Terenzio, Alber, Koley, Lin, Rozenbaum, Yudin, Sahoo, Gomes, Shinder, Geraisy, Huebner, Woolf, Yaron, Burlingame, Twiss, Fainzilber (bb0515) 2016; 16 Marechal, Prevost, Petit, Perret, Heard, Schwartz (bb0610) 2001; 75 Haeusler, Donnelly, Periz, Simko, Shaw, Kim, Maragakis, Troncoso, Pandey, Sattler, Rothstein, Wang (bb0520) 2014; 507 Destouches, Page, Hamma-Kourbali, Machi, Chaloin, Frechault, Birmpas, Katsoris, Beyrath, Albanese, Maurer, Carpentier, Strub, Van Dorsselaer, Muller, Bagnard, Briand, Courty (bb1080) 2011; 71 Metifiot, Amrane, Mergny, Andreola (bb0345) 2015; 118 Zhao, Xu, Sun, Ma, Wu, Kuang, Wang, Xu (bb0895) 2016 Devadas, Koithan, Diestel, Prank, Sodeik, Dohner (bb0670) 2014; 88 Choi, Nayak, Bates (bb0025) 2010; 38 Bremer, Klein, Sedlmaier, Abouzied, Gieselmann, Franken (bb0910) 2013; 14 Dam, Lee, Odom (bb0185) 2014; 14 Peng, Zhang, Han, Zhang, Wu, Wang, Gao, Mao (bb0245) 2015; 7 Shimakami, Honda, Kusakawa, Murata, Shimotohno, Kaneko, Murakami (bb0385) 2006; 80 Terrier, Carron, De Chassey, Dubois, Traversier, Julien, Cartet, Proust, Hacot, Ressnikoff, Lotteau, Lina, Diaz, Moules, Rosa-Calatrava (bb0375) 2016; 6 Seddiki, Nisole, Krust, Callebaut, Guichard, Muller, Briand, Hovanessian (bb0335) 1999; 15 Yu, Yoon, Poulogiannis, Yang, Ma, Villen, Kubica, Hoffman, Cantley, Gygi, Blenis (bb0755) 2011; 332 Xiao, Feng, Zhu, Dimitrov (bb0475) 2011; 411 Deng, Ballou, Hofmeister (bb1090) 1996; 23 Rizzieri, Stockerl-Goldstein, Wei, Herzig, Erlandsson, Stuart (bb0135) 2010 Ko, Kim, Kang, Lee, Kang, Moon, Hwang, Ko, Lee (bb0205) 2009; 5 Noaparast, Hosseinimehr, Piramoon, Abedi (bb0880) 2015; 23 Bello-Morales, Crespillo, Garcia, Dorado, Martin, Tabares, Krummenacher, de Castro, Lopez-Guerrero (bb0665) 2014; 9 Kotula, Pratico, Ming, Nakagawa, Juliano, Sullenger (bb0690) 2012; 22 Wang, Liu, Xu, Zhuang, Li, Yin, Cong, Xu, Lu (bb0800) 2016; 7 Dam, Lee, Sisco, Co, Zhang, Wasielewski, Odom (bb0075) 2012; 6 Chung, Heddi, Schmitt, Lim, Mechulam, Phan (bb0035) 2015; 112 Teng, Girvan, Casson, Pierce, Qian, Thomas, Bates (bb0305) 2007; 67 Taghdisi, Danesh, Ramezani, Lavaee, Jalalian, Robati, Abnous (bb0805) 2016; 102 Take, Tsutsui, Obama, Ozawa, Nakayama, Maruyama, Arima, Muramatsu (bb0940) 1994; 116 Gissberg, Zaghloul, Lundin, Nguyen, Landras-Guetta, Wengel, Zain, Smith (bb0155) 2016; 26 Shalem, Sanjana, Zhang (bb0725) 2015; 16 Guo, Gao, Su, Xia, Gu, Pang, Jiang, Yao, Chen, Chen (bb0225) 2011; 32 Li, Zhu, Qiu (bb0815) 2016; 35 Fumoto, Nishi, Ishii, Wang, Miyamoto, Yoshikawa, Nakashima, Nakamura, Nishida (bb0540) 2009; 6 Xing, Tang, Yang, Hwang, Wang, Yin, Wong, Dobrucki, Yasui, Katzenellenbogen, Helferich, Cheng, Lu (bb0775) 2013; 1 Calle, Ugrinova, Epstein, Bouvet, Diaz, Greco (bb0405) 2008; 82 Dailey, Miller, Bates, Lane, Trent (bb0030) 2010; 38 Legrand, Vigie, Said, Elass, Masson, Slomianny, Carpentier, Briand, Mazurier, Hovanessi Strang (10.1016/j.bbagen.2016.12.015_bb0420) 2010; 84 Renoux (10.1016/j.bbagen.2016.12.015_bb0650) 2011; 41 Taghdisi (10.1016/j.bbagen.2016.12.015_bb0805) 2016; 102 Dai (10.1016/j.bbagen.2016.12.015_bb1010) 2015; 52 Bose (10.1016/j.bbagen.2016.12.015_bb0470) 2004; 78 Soundararajan (10.1016/j.bbagen.2016.12.015_bb0705) 2009; 76 Goldshmit (10.1016/j.bbagen.2016.12.015_bb1030) 2014; 5 Dam (10.1016/j.bbagen.2016.12.015_bb0075) 2012; 6 Wittrup (10.1016/j.bbagen.2016.12.015_bb0555) 2007; 282 Barel (10.1016/j.bbagen.2016.12.015_bb0500) 2010; 5 Miller (10.1016/j.bbagen.2016.12.015_bb0040) 2011 Abdelmohsen (10.1016/j.bbagen.2016.12.015_bb0260) 2012; 9 Soundararajan (10.1016/j.bbagen.2016.12.015_bb1120) 2008; 68 Chen (10.1016/j.bbagen.2016.12.015_bb0905) 2015; 6 Farin (10.1016/j.bbagen.2016.12.015_bb1040) 2011; 71 Krust (10.1016/j.bbagen.2016.12.015_bb0325) 2001; 98 Xing (10.1016/j.bbagen.2016.12.015_bb0775) 2013; 1 Devadas (10.1016/j.bbagen.2016.12.015_bb0670) 2014; 88 Qiu (10.1016/j.bbagen.2016.12.015_bb1015) 2015; 32 Dam (10.1016/j.bbagen.2016.12.015_bb0185) 2014; 14 Kamphorst (10.1016/j.bbagen.2016.12.015_bb0685) 2015; 75 Perrone (10.1016/j.bbagen.2016.12.015_bb0355) 2016; 47 Miller (10.1016/j.bbagen.2016.12.015_bb0130) 2006 Dam (10.1016/j.bbagen.2016.12.015_bb0190) 2014 Ireson (10.1016/j.bbagen.2016.12.015_bb0095) 2006; 5 Reyes-Reyes (10.1016/j.bbagen.2016.12.015_bb0250) 2010; 70 Teng (10.1016/j.bbagen.2016.12.015_bb1115) 2007; 67 Overmeyer (10.1016/j.bbagen.2016.12.015_bb0710) 2008; 6 Li (10.1016/j.bbagen.2016.12.015_bb0815) 2016; 35 Girvan (10.1016/j.bbagen.2016.12.015_bb1110) 2006; 5 Zhang (10.1016/j.bbagen.2016.12.015_bb0060) 2015; 6 Le (10.1016/j.bbagen.2016.12.015_bb0055) 2012; 10 Birmpas (10.1016/j.bbagen.2016.12.015_bb1070) 2012; 4 Xu (10.1016/j.bbagen.2016.12.015_bb0825) 2016; 11 Reyes-Reyes (10.1016/j.bbagen.2016.12.015_bb0975) 2008; 314 Wang (10.1016/j.bbagen.2016.12.015_bb0295) 2001; 276 Li (10.1016/j.bbagen.2016.12.015_bb0835) 2014; 35 Mongelard (10.1016/j.bbagen.2016.12.015_bb0100) 2010; 12 Li (10.1016/j.bbagen.2016.12.015_bb0240) 2015; 11 Bender (10.1016/j.bbagen.2016.12.015_bb0430) 2014; 88 Di Segni (10.1016/j.bbagen.2016.12.015_bb1045) 2008; 3 Su (10.1016/j.bbagen.2016.12.015_bb0465) 2015; 89 Gobeil (10.1016/j.bbagen.2016.12.015_bb0635) 2013; 87 Shieh (10.1016/j.bbagen.2016.12.015_bb0215) 2010; 4 Ko (10.1016/j.bbagen.2016.12.015_bb0205) 2009; 5 Alpuche-Aranda (10.1016/j.bbagen.2016.12.015_bb0585) 1994; 179 Christian (10.1016/j.bbagen.2016.12.015_bb1055) 2003; 163 Lee (10.1016/j.bbagen.2016.12.015_bb0160) 2010; 2010 Li (10.1016/j.bbagen.2016.12.015_bb0845) 2014; 41 Strang (10.1016/j.bbagen.2016.12.015_bb0425) 2012; 3 Terrier (10.1016/j.bbagen.2016.12.015_bb0375) 2016; 6 Bates (10.1016/j.bbagen.2016.12.015_bb0010) 1999; 274 Chinen (10.1016/j.bbagen.2016.12.015_bb0070) 2014 Dam (10.1016/j.bbagen.2016.12.015_bb0175) 2015; 11 Palmieri (10.1016/j.bbagen.2016.12.015_bb1100) 2015; 112 Dam (10.1016/j.bbagen.2016.12.015_bb0195) 2012; 3 Take (10.1016/j.bbagen.2016.12.015_bb0940) 1994; 116 Song (10.1016/j.bbagen.2016.12.015_bb0955) 2012; 15 Pichiorri (10.1016/j.bbagen.2016.12.015_bb0505) 2013; 210 Chan (10.1016/j.bbagen.2016.12.015_bb0365) 2016; 494 Callebaut (10.1016/j.bbagen.2016.12.015_bb0330) 1998; 273 Bremer (10.1016/j.bbagen.2016.12.015_bb0910) 2013; 14 Quiroz-Mercado (10.1016/j.bbagen.2016.12.015_bb0315) 2016; 254 Liang (10.1016/j.bbagen.2016.12.015_bb0545) 2015; 21 Calle (10.1016/j.bbagen.2016.12.015_bb0405) 2008; 82 Le Trinh (10.1016/j.bbagen.2016.12.015_bb0795) 2015; 10 Sato (10.1016/j.bbagen.2016.12.015_bb0450) 2009; 387 Tate (10.1016/j.bbagen.2016.12.015_bb0915) 2006; 6 Kuo (10.1016/j.bbagen.2016.12.015_bb0885) 2014; 7 Nakase (10.1016/j.bbagen.2016.12.015_bb0595) 2004; 10 Dailey (10.1016/j.bbagen.2016.12.015_bb0030) 2010; 38 Choi (10.1016/j.bbagen.2016.12.015_bb0085) 2009; 5 Bi (10.1016/j.bbagen.2016.12.015_bb1000) 2013; 36 Haeusler (10.1016/j.bbagen.2016.12.015_bb0520) 2014; 507 Rossman (10.1016/j.bbagen.2016.12.015_bb0625) 2012; 86 Qi (10.1016/j.bbagen.2016.12.015_bb0810) 2016 Yoshida (10.1016/j.bbagen.2016.12.015_bb0730) 2015; 211 Ma (10.1016/j.bbagen.2016.12.015_bb0855) 2014; 449 Balinsky (10.1016/j.bbagen.2016.12.015_bb0435) 2013; 87 Dumler (10.1016/j.bbagen.2016.12.015_bb1050) 1999; 9 Miller (10.1016/j.bbagen.2016.12.015_bb0045) 2015; 61 Liao (10.1016/j.bbagen.2016.12.015_bb0230) 2015; 208 Commisso (10.1016/j.bbagen.2016.12.015_bb0680) 2013; 497 Krust (10.1016/j.bbagen.2016.12.015_bb0935) 2011; 93 Zhang (10.1016/j.bbagen.2016.12.015_bb0780) 2014; 14 Kaplan (10.1016/j.bbagen.2016.12.015_bb0570) 2005; 102 Wang (10.1016/j.bbagen.2016.12.015_bb0800) 2016; 7 de Verdugo (10.1016/j.bbagen.2016.12.015_bb0460) 1995; 69 Fu (10.1016/j.bbagen.2016.12.015_bb0945) 2009; 48 Teng (10.1016/j.bbagen.2016.12.015_bb0305) 2007; 67 Hwang (10.1016/j.bbagen.2016.12.015_bb0220) 2010; 51 Krust (10.1016/j.bbagen.2016.12.015_bb1060) 2011; 11 Laber (10.1016/j.bbagen.2016.12.015_bb0115) 2005 Ai (10.1016/j.bbagen.2016.12.015_bb0065) 2014; 118 Seddiki (10.1016/j.bbagen.2016.12.015_bb0335) 1999; 15 Hovanessian (10.1016/j.bbagen.2016.12.015_bb0280) 2000; 261 Chung (10.1016/j.bbagen.2016.12.015_bb0035) 2015; 112 Kusakawa (10.1016/j.bbagen.2016.12.015_bb0390) 2007; 141 Maltese (10.1016/j.bbagen.2016.12.015_bb0715) 2015; 6 Zhang (10.1016/j.bbagen.2016.12.015_bb0790) 2015; 213 Alete (10.1016/j.bbagen.2016.12.015_bb0310) 2006; 273 Chen (10.1016/j.bbagen.2016.12.015_bb0440) 2014; 111 Legrand (10.1016/j.bbagen.2016.12.015_bb0970) 2004; 271 Wolfson (10.1016/j.bbagen.2016.12.015_bb1025) 2016 Hu (10.1016/j.bbagen.2016.12.015_bb0875) 2013; 5 Hsu (10.1016/j.bbagen.2016.12.015_bb0770) 2011; 332 Xu (10.1016/j.bbagen.2016.12.015_bb0530) 2001; 276 Fujiki (10.1016/j.bbagen.2016.12.015_bb0270) 2014; 140 Grinstein (10.1016/j.bbagen.2016.12.015_bb0445) 2002; 196 Laber (10.1016/j.bbagen.2016.12.015_bb0125) 2007; 6 Perry (10.1016/j.bbagen.2016.12.015_bb0515) 2016; 16 Watanabe (10.1016/j.bbagen.2016.12.015_bb0480) 2010; 136 Zhao (10.1016/j.bbagen.2016.12.015_bb0895) 2016 Murayama (10.1016/j.bbagen.2016.12.015_bb0360) 2007; 362 Gao (10.1016/j.bbagen.2016.12.015_bb0695) 2014; 22 Zhou (10.1016/j.bbagen.2016.12.015_bb0925) 1997; 272 Yang (10.1016/j.bbagen.2016.12.015_bb0300) 2002; 30 Choi (10.1016/j.bbagen.2016.12.015_bb0025) 2010; 38 Yu (10.1016/j.bbagen.2016.12.015_bb0755) 2011; 332 Moraes (10.1016/j.bbagen.2016.12.015_bb0400) 2016 Bello-Morales (10.1016/j.bbagen.2016.12.015_bb0665) 2014; 9 Schelhaas (10.1016/j.bbagen.2016.12.015_bb0660) 2012; 8 Konishi (10.1016/j.bbagen.2016.12.015_bb0290) 1995; 117 Cao (10.1016/j.bbagen.2016.12.015_bb0210) 2009; 48 Bates (10.1016/j.bbagen.2016.12.015_bb0005) 2009; 86 Koutsioumpa (10.1016/j.bbagen.2016.12.015_bb0265) 2014; 9 Cho (10.1016/j.bbagen.2016.12.015_bb0145) 2016; 11 Malik (10.1016/j.bbagen.2016.12.015_bb0170) 2015; 6 Shen (10.1016/j.bbagen.2016.12.015_bb1125) 2014; 5 de Vries (10.1016/j.bbagen.2016.12.015_bb0620) 2011; 7 Destouches (10.1016/j.bbagen.2016.12.015_bb1065) 2008; 3 Dapic (10.1016/j.bbagen.2016.12.015_bb0015) 2003; 31 Nisole (10.1016/j.bbagen.2016.12.015_bb0340) 2002; 276 Sagou (10.1016/j.bbagen.2016.12.015_bb0410) 2010; 84 Pina (10.1016/j.bbagen.2016.12.015_bb0550) 2016; 13 Fan (10.1016/j.bbagen.2016.12.015_bb0150) 2016; 6 Shalem (10.1016/j.bbagen.2016.12.015_bb0725) 2015; 16 Jordan (10.1016/j.bbagen.2016.12.015_bb0985) 1994; 33 Lin (10.1016/j.bbagen.2016.12.015_bb0750) 2016 Huang (10.1016/j.bbagen.2016.12.015_bb0920) 2006; 107 Acton (10.1016/j.bbagen.2016.12.015_bb0105) 2013 Kotula (10.1016/j.bbagen.2016.12.015_bb0690) 2012; 22 Miller (10.1016/j.bbagen.2016.12.015_bb0050) 2011; 9 Noaparast (10.1016/j.bbagen.2016.12.015_bb0880) 2015; 23 Dapić (10.1016/j.bbagen.2016.12.015_bb0020) 2002; 41 Barel (10.1016/j.bbagen.2016.12.015_bb0495) 2008; 8 Scaggiante (10.1016/j.bbagen.2016.12.015_bb0720) 2006; 273 Hovanessian (10.1016/j.bbagen.2016.12.015_bb0275) 2010; 5 Pang (10.1016/j.bbagen.2016.12.015_bb0740) 2014; 5 Tang (10.1016/j.bbagen.2016.12.015_bb0870) 2012; 51 Bradburne (10.1016/j.bbagen.2016.12.015_bb0630) 2013; 288 Greco (10.1016/j.bbagen.2016.12.015_bb0415) 2012; 86 Kim (10.1016/j.bbagen.2016.12.015_bb0865) 2012; 33 Doherty (10.1016/j.bbagen.2016.12.015_bb0535) 2009; 78 Ha (10.1016/j.bbagen.2016.12.015_bb0675) 2016; 7 Palm (10.1016/j.bbagen.2016.12.015_bb0745) 2015; 162 Yu (10.1016/j.bbagen.2016.12.015_bb0560) 2013; 13 Saeed (10.1016/j.bbagen.2016.12.015_bb0605) 2010; 6 Liu (10.1016/j.bbagen.2016.12.015_bb0615) 2002; 76 Hovanessian (10.1016/j.bbagen.2016.12.015_bb0930) 2006; 16 Kim (10.1016/j.bbagen.2016.12.015_bb0765) 2015; 57 Fernandes (10.1016/j.bbagen.2016.12.015_bb1095) 2016; 76 Sung (10.1016/j.bbagen.2016.12.015_bb0735) 2015; 6 Wadia (10.1016/j.bbagen.2016.12.015_bb0575) 2004; 10 Sletten (10.1016/j.bbagen.2016.12.015_bb0965) 2014; 9 Zhuo (10.1016/j.bbagen.2016.12.015_bb0960) 2010; 222 Tao (10.1016/j.bbagen.2016.12.015_bb0820) 2016; 6 Peng (10.1016/j.bbagen.2016.12.015_bb0245) 2015; 7 Deng (10.1016/j.bbagen.2016.12.015_bb1090) 1996; 23 Destouches (10.1016/j.bbagen.2016.12.015_bb1080) 2011; 71 Saci (10.1016/j.bbagen.2016.12.015_bb0760) 2011; 42 Freeman (10.1016/j.bbagen.2016.12.015_bb0580) 2014; 5 Dam (10.1016/j.bbagen.2016.12.015_bb0180) 2014; 11 Guo (10.1016/j.bbagen.2016.12.015_bb0225) 2011; 32 Reyes-Reyes (10.1016/j.bbagen.2016.12.015_bb0255) 2015; 9 Haspot (10.1016/j.bbagen.2016.12.015_bb0655) 2012; 7 Laber (10.1016/j.bbagen.2016.12.015_bb0110) 2004 Antisoma (10.1016/j.bbagen.2016.12.015_bb0120) 2011 Gissberg (10.1016/j.bbagen.2016.12.015_bb0155) 2016; 26 Wise (10.1016/j.bbagen.2016.12.015_bb0990) 2013; 121 Kibbey (10.1016/j.bbagen.2016.12.015_bb0320) 1995; 42 Benedetti (10.1016/j.bbagen.2016.12.015_bb1085) 2015; 6 Lukyanenko (10.1016/j.bbagen.2016.12.015_bb0645) 2011; 301 Gilles (10.1016/j.bbagen.2016.12.015_bb1075) 2016 Chen (10.1016/j.bbagen.2016.12.015_bb0080) 2016; 100 Nakase (10.1016/j.bbagen.2016.12.015_bb0590) 2009; 17 Shimakami (10.1016/j.bbagen.2016.12.015_bb0385) 2006; 80 Li (10.1016/j.bbagen.2016.12.015_bb0900) 2015; 56 Hirano (10.1016/j.bbagen.2016.12.015_bb0380) 2003; 278 Roy (10.1016/j.bbagen.2016.12.015_bb0840) 2015; 71 Marechal (10.1016/j.bbagen.2016.12.015 |
| References_xml | – volume: 507 start-page: 195 year: 2014 end-page: 200 ident: bb0520 article-title: C9orf72 nucleotide repeat structures initiate molecular cascades of disease publication-title: Nature – volume: 33 start-page: 207 year: 2012 end-page: 217 ident: bb0865 article-title: Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle publication-title: Biomaterials – year: 2016 ident: bb0895 article-title: Gold-quantum dot core–satellite assemblies for lighting up microRNA in vitro and in vivo publication-title: Small – volume: 9 start-page: e89141 year: 2014 ident: bb0665 article-title: The effect of cellular differentiation on HSV-1 infection of oligodendrocytic cells publication-title: PLoS One – volume: 7 start-page: 658 year: 2014 end-page: 669 ident: bb0885 article-title: AS1411 aptamer-conjugated Gd publication-title: Nano Res. – volume: 69 start-page: 6751 year: 1995 end-page: 6757 ident: bb0460 article-title: Characterization of a 100-kilodalton binding protein for the six serotypes of coxsackie B viruses publication-title: J. Virol. – volume: 9 start-page: 1392 year: 2015 end-page: 1405 ident: bb0255 article-title: Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation publication-title: Mol. Oncol. – volume: 57 start-page: 207 year: 2015 end-page: 218 ident: bb0765 article-title: mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation publication-title: Mol. Cell – volume: 107 start-page: 3564 year: 2006 end-page: 3571 ident: bb0920 article-title: The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin publication-title: Blood – volume: 32 start-page: 178 year: 2014 end-page: 187 ident: bb0140 article-title: A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma publication-title: Investig. New Drugs – volume: 4 start-page: 21 year: 2012 ident: bb1070 article-title: The pseudopeptide HB-19 binds to cell surface nucleolin and inhibits angiogenesis publication-title: Vasc. Cell – volume: 76 start-page: 1488 year: 2016 ident: bb1095 article-title: Development of anti-nucleolin antibodies with broad spectrum anticancer activity and negligible toxicity to normal cells publication-title: Cancer Res. – year: 2014 ident: bb0190 article-title: Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars publication-title: Nanomed. Nanotechnol. Biol. Med. – volume: 3 start-page: e2310 year: 2008 ident: bb1045 article-title: Identification of nucleolin as new ErbB receptors- interacting protein publication-title: PLoS One – volume: 22 start-page: 187 year: 2012 end-page: 195 ident: bb0690 article-title: Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells publication-title: Nucleic Acid Ther. – volume: 6 start-page: 470 year: 2016 end-page: 484 ident: bb0820 article-title: Polydopamine-based surface modification of novel nanoparticle-aptamer bioconjugates for in vivo breast cancer targeting and enhanced therapeutic effects publication-title: Theranostics – start-page: 147 year: 2006 end-page: 148 ident: bb0130 article-title: Extended phase I study of AS1411 in renal and non-small cell lung cancers publication-title: Annals of Oncology – volume: 35 start-page: 3840 year: 2014 end-page: 3850 ident: bb0835 article-title: Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas publication-title: Biomaterials – volume: 19 start-page: 93 year: 2011 end-page: 102 ident: bb1105 article-title: Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid publication-title: Mol. Ther. – volume: 14 start-page: 2 year: 2013 ident: bb0910 article-title: Hepatoma-derived growth factor and nucleolin exist in the same ribonucleoprotein complex publication-title: BMC Biochem. – volume: 271 start-page: 303 year: 2004 end-page: 317 ident: bb0970 article-title: Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells publication-title: Eur. J. Biochem. – volume: 13 start-page: 795 year: 2016 end-page: 808 ident: bb0550 article-title: Biocompatible ELR-based polyplexes coated with MUC1 specific aptamers and targeted for breast cancer gene therapy publication-title: Mol. Pharm. – volume: 274 start-page: 26369 year: 1999 end-page: 26377 ident: bb0010 article-title: Antiproliferative activity of G-rich oligonucleotides correlates with protein binding publication-title: J. Biol. Chem. – volume: 82 start-page: 4762 year: 2008 end-page: 4773 ident: bb0405 article-title: Nucleolin is required for an efficient herpes simplex virus type 1 infection publication-title: J. Virol. – volume: 6 start-page: 16253 year: 2015 end-page: 16270 ident: bb0905 article-title: Hepatoma-derived growth factor/nucleolin axis as a novel oncogenic pathway in liver carcinogenesis publication-title: Oncotarget – volume: 13 start-page: 1413 year: 2013 end-page: 1421 ident: bb0560 article-title: Study of the selective uptake progress of aptamer-modified PLGA particles by liver cells publication-title: Macromol. Biosci. – volume: 55 start-page: 1 year: 2015 end-page: 6 ident: bb1020 article-title: Nucleolin promotes TGF-beta signaling initiation via TGF-beta receptor I in glioblastoma publication-title: J. Mol. Neurosci. – volume: 48 start-page: 6494 year: 2009 end-page: 6498 ident: bb0210 article-title: Reversible cell-specific drug delivery with aptamer-functionalized liposomes publication-title: Angew. Chem. Int. Ed. Eng. – volume: 51 start-page: 12721 year: 2012 end-page: 12726 ident: bb0870 article-title: Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors publication-title: Angew. Chem. Int. Ed. Eng. – volume: 494 start-page: 78 year: 2016 end-page: 88 ident: bb0365 article-title: Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization publication-title: Virology – volume: 118 start-page: 173 year: 2015 end-page: 175 ident: bb0345 article-title: Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1 publication-title: Biochimie – volume: 76 start-page: 6689 year: 2002 end-page: 6700 ident: bb0615 article-title: Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway publication-title: J. Virol. – volume: 22 start-page: 450 year: 2014 end-page: 459 ident: bb0695 article-title: Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles publication-title: J. Drug Target. – volume: 11 start-page: 671 year: 2015 end-page: 679 ident: bb0175 article-title: Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars publication-title: Nanomedicine – volume: 206 start-page: 545 year: 2006 end-page: 555 ident: bb0980 article-title: Effect of laminin-1 on intestinal cell differentiation involves inhibition of nuclear nucleolin publication-title: J. Cell. Physiol. – volume: 89 start-page: 4527 year: 2015 end-page: 4538 ident: bb0465 article-title: Cell surface nucleolin facilitates enterovirus 71 binding and infection publication-title: J. Virol. – volume: 8 start-page: 145 year: 2008 ident: bb0495 article-title: A novel receptor - ligand pathway for entry of publication-title: BMC Microbiol. – volume: 111 start-page: 18201 year: 2014 end-page: 18206 ident: bb0525 article-title: G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 6 start-page: 1170 year: 2009 end-page: 1179 ident: bb0540 article-title: Rac-mediated macropinocytosis is a critical route for naked plasmid DNA transfer in mice publication-title: Mol. Pharm. – volume: 497 start-page: 633 year: 2013 end-page: 637 ident: bb0680 article-title: Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells publication-title: Nature – volume: 26 start-page: 183 year: 2016 end-page: 189 ident: bb0155 article-title: Delivery, effect on cell viability, and plasticity of modified aptamer constructs publication-title: Nucleic Acid Ther. – volume: 6 start-page: 38 year: 2015 ident: bb0715 article-title: Non-apoptotic cell death associated with perturbations of macropinocytosis publication-title: Front. Physiol. – volume: 67 start-page: 10491 year: 2007 end-page: 10500 ident: bb1115 article-title: AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin publication-title: Cancer Res. – volume: 15 start-page: 381 year: 1999 end-page: 390 ident: bb0335 article-title: The V3 loop-mimicking pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits HIV infection in primary macrophage cultures publication-title: AIDS Res. Hum. Retrovir. – volume: 36 start-page: 1099 year: 2015 end-page: 1104 ident: bb1005 article-title: Cell surface nucleolin interacts with CXCR4 receptor via the 212 c-terminal portion publication-title: Tumour Biol. – volume: 93 start-page: 426 year: 2011 end-page: 433 ident: bb0935 article-title: Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin publication-title: Biochimie – volume: 32 start-page: 75 year: 2015 ident: bb1015 article-title: The involvement of cell surface nucleolin in the initiation of CCR6 signaling in human hepatocellular carcinoma publication-title: Med. Oncol. (Northwood Lond. Engl.) – volume: 11 start-page: 333 year: 2011 ident: bb1060 article-title: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type publication-title: BMC Cancer – volume: 276 start-page: 20579 year: 2001 end-page: 20588 ident: bb0295 article-title: Regulation of DNA replication after heat shock by replication protein a-nucleolin interactions publication-title: J. Biol. Chem. – volume: 5 start-page: 2957 year: 2006 end-page: 2962 ident: bb0095 article-title: Discovery and development of anticancer aptamers publication-title: Mol. Cancer Ther. – volume: 254 start-page: 1753 year: 2016 end-page: 1763 ident: bb0315 article-title: Tissue and cellular characterisation of nucleolin in a murine model of corneal angiogenesis publication-title: Graefes Arch. Clin. Exp. Ophthalmol. – volume: 71 start-page: 2140 year: 2011 end-page: 2151 ident: bb1040 article-title: Oncogenic synergism between ErbB1, nucleolin, and mutant Ras publication-title: Cancer Res. – volume: 449 start-page: 44 year: 2014 end-page: 48 ident: bb0855 article-title: A dual functional fluorescent probe for glioma imaging mediated by blood-brain barrier penetration and glioma cell targeting publication-title: Biochem. Biophys. Res. Commun. – volume: 3 start-page: e2518 year: 2008 ident: bb1065 article-title: Suppression of tumor growth and angiogenesis by a specific antagonist of the cell-surface expressed nucleolin publication-title: PLoS One – volume: 35 start-page: 269 year: 2016 end-page: 279 ident: bb0815 article-title: Constructing aptamer anchored nanovesicles for enhanced tumor penetration and cellular uptake of water soluble chemotherapeutics publication-title: Acta Biomater. – volume: 9 start-page: 799 year: 2012 end-page: 808 ident: bb0260 article-title: RNA-binding protein nucleolin in disease publication-title: RNA Biol. – start-page: 3112 year: 2004 ident: bb0110 article-title: A phase I study of AGRO100 in advanced cancer publication-title: ASCO Annual Meeting Proceedings – volume: 301 start-page: C1140 year: 2011 end-page: C1149 ident: bb0645 article-title: Enterohemorrhagic publication-title: Am. J. Physiol. Cell Physiol. – volume: 33 start-page: 14696 year: 1994 end-page: 14706 ident: bb0985 article-title: Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins publication-title: Biochemistry – volume: 141 start-page: 917 year: 2007 end-page: 927 ident: bb0390 article-title: Functional interaction of hepatitis C virus NS5B with nucleolin GAR domain publication-title: J. Biochem. – volume: 1 start-page: 5288 year: 2013 end-page: 5297 ident: bb0775 article-title: Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells and publication-title: J. Mater. Chem. B Mater. Biol. Med. – volume: 3 start-page: 1263 year: 2012 end-page: 1267 ident: bb0195 article-title: Shining light on nuclear-targeted therapy using gold nanostar constructs publication-title: Ther. Deliv. – volume: 210 start-page: 951 year: 2013 end-page: 968 ident: bb0505 article-title: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation publication-title: J. Exp. Med. – volume: 78 start-page: 8146 year: 2004 end-page: 8158 ident: bb0470 article-title: Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells publication-title: J. Virol. – volume: 282 start-page: 27897 year: 2007 end-page: 27904 ident: bb0555 article-title: Identification of proteins released by mammalian cells that mediate DNA internalization through proteoglycan-dependent macropinocytosis publication-title: J. Biol. Chem. – volume: 110 start-page: 2899 year: 2007 end-page: 2906 ident: bb0950 article-title: Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin publication-title: Blood – volume: 7 start-page: 18628 year: 2015 end-page: 18637 ident: bb0245 article-title: Cell membrane capsules for encapsulation of chemotherapeutic and cancer cell targeting in vivo publication-title: ACS Appl. Mater. Interfaces – volume: 14 start-page: 1105 year: 2014 end-page: 1117 ident: bb0780 article-title: In vitro and in vivo evaluation of antitumor drug-loaded aptamer targeted single-walled carbon nanotubes system publication-title: Curr. Pharm. Biotechnol. – volume: 41 start-page: 3240 year: 2011 end-page: 3252 ident: bb0650 article-title: Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion publication-title: Eur. J. Immunol. – volume: 8 start-page: e1002657 year: 2012 ident: bb0660 article-title: Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis publication-title: PLoS Pathog. – volume: 100 start-page: 1 year: 2016 end-page: 16 ident: bb0080 article-title: Dual targeting luminescent gold nanoclusters for tumor imaging and deep tissue therapy publication-title: Biomaterials – volume: 5 start-page: 1790 year: 2006 end-page: 1799 ident: bb1110 article-title: AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin publication-title: Mol. Cancer Ther. – volume: 47 start-page: 311 year: 2016 end-page: 316 ident: bb0355 article-title: The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell publication-title: Int. J. Antimicrob. Agents – volume: 192 start-page: 192 year: 2014 end-page: 201 ident: bb0785 article-title: Cytochrome publication-title: J. Control. Release – volume: 6 start-page: 3831 year: 2015 end-page: 3838 ident: bb0060 article-title: Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides publication-title: Chem. Sci. – volume: 6 start-page: 22270 year: 2015 end-page: 22281 ident: bb0170 article-title: AS1411-conjugated gold nanospheres and their potential for breast cancer therapy publication-title: Oncotarget – volume: 78 start-page: 857 year: 2009 end-page: 902 ident: bb0535 article-title: Mechanisms of endocytosis publication-title: Annu. Rev. Biochem. – volume: 88 start-page: 13378 year: 2014 end-page: 13395 ident: bb0670 article-title: Herpes simplex virus internalization into epithelial cells requires Na publication-title: J. Virol. – volume: 11 start-page: e0160822 year: 2016 ident: bb0145 article-title: Modified AS1411 aptamer suppresses hepatocellular carcinoma by up-regulating galectin-14 publication-title: PLoS One – volume: 30 start-page: 2251 year: 2002 end-page: 2260 ident: bb0300 article-title: Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins publication-title: Nucleic Acids Res. – volume: 3 year: 2012 ident: bb0425 article-title: Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments publication-title: MBio – volume: 41 start-page: 179 year: 2014 end-page: 185 ident: bb0845 article-title: Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancer publication-title: Nucl. Med. Biol. – volume: 22 start-page: 1179 year: 2011 end-page: 1195 ident: bb0165 article-title: Simple PEG, modification of DNA aptamer based on copper ion coordination for tumor targeting publication-title: J. Biomater. Sci. Polym. Ed. – volume: 80 start-page: 3332 year: 2006 end-page: 3340 ident: bb0385 article-title: Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon publication-title: J. Virol. – volume: 2010 start-page: 168306 year: 2010 ident: bb0160 article-title: Bioimaging of nucleolin aptamer-containing 5-( publication-title: J. Biomed. Biotechnol. – volume: 10 start-page: 1011 year: 2004 end-page: 1022 ident: bb0595 article-title: Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement publication-title: Mol. Ther. – year: 2016 ident: bb1075 article-title: Nucleolin targeting impairs the progression of pancreatic cancer and promotes the normalization of tumor vasculature publication-title: Cancer Res. – volume: 16 start-page: 174 year: 2006 end-page: 181 ident: bb0930 article-title: Midkine, a cytokine that inhibits HIV infection by binding to the cell surface expressed nucleolin publication-title: Cell Res. – volume: 6 start-page: C147 year: 2007 ident: bb0125 article-title: Pharmacokinetics of the anti-nucleolin aptamer AS1411 in a phase I study publication-title: Mol. Cancer Ther. – volume: 6 start-page: 42091 year: 2015 end-page: 42104 ident: bb1085 article-title: Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model publication-title: Oncotarget – volume: 23 start-page: 497 year: 2015 end-page: 505 ident: bb0880 article-title: Tumor targeting with a 99mTc-labeled AS1411 aptamer in prostate tumor cells publication-title: J. Drug Target. – volume: 9 start-page: e1003309 year: 2013 ident: bb0640 article-title: Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein publication-title: PLoS Pathog. – volume: 9 start-page: 7633 year: 2011 end-page: 7637 ident: bb0050 article-title: Polymorphism and resolution of oncogene promoter quadruplex-forming sequences publication-title: Org. Biomol. Chem. – volume: 273 start-page: 21988 year: 1998 end-page: 21997 ident: bb0330 article-title: Identification of V3 loop-binding proteins as potential receptors implicated in the binding of HIV particles to CD4(+) cells publication-title: J. Biol. Chem. – volume: 9 start-page: 137 year: 2014 end-page: 152 ident: bb0265 article-title: Cell surface nucleolin as a target for anti-cancer therapies publication-title: Recent Pat. Anticancer Drug Discov. – volume: 102 start-page: 247 year: 2005 end-page: 253 ident: bb0570 article-title: Cationic TAT peptide transduction domain enters cells by macropinocytosis publication-title: J. Control. Release – volume: 7 start-page: 381 year: 2016 ident: bb0675 article-title: Macropinocytosis exploitation by cancers and cancer therapeutics publication-title: Front. Physiol. – volume: 52 start-page: 1521 year: 2015 end-page: 1526 ident: bb1010 article-title: Nuclear protein C23 on the cell surface plays an important role in activation of CXCR4 signaling in glioblastoma publication-title: Mol. Neurobiol. – volume: 8 start-page: e75269 year: 2013 ident: bb1035 article-title: Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death publication-title: PLoS One – volume: 17 start-page: 1868 year: 2009 end-page: 1876 ident: bb0590 article-title: Cell-surface accumulation of flock house virus-derived peptide leads to efficient internalization via macropinocytosis publication-title: Mol. Ther. – year: 2016 ident: bb1025 article-title: Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer publication-title: Oncotarget – volume: 11 start-page: 580 year: 2014 end-page: 587 ident: bb0180 article-title: Grafting aptamers onto gold nanostars increases in vitro efficacy in a wide range of cancer cell types publication-title: Mol. Pharm. – volume: 68 start-page: 2358 year: 2008 end-page: 2365 ident: bb1120 article-title: The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells publication-title: Cancer Res. – volume: 26 start-page: 279 year: 2015 end-page: 285 ident: bb0090 article-title: Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method publication-title: Bioconjug. Chem. – volume: 87 start-page: 735 year: 2013 end-page: 745 ident: bb0635 article-title: Macropinocytosis-like HIV-1 internalization in macrophages is CCR5 dependent and leads to efficient but delayed degradation in endosomal compartments publication-title: J. Virol. – volume: 222 start-page: 249 year: 2010 end-page: 260 ident: bb0960 article-title: Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells publication-title: J. Pathol. – volume: 272 start-page: 31130 year: 1997 end-page: 31137 ident: bb0925 article-title: Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells publication-title: J. Biol. Chem. – volume: 196 start-page: 1067 year: 2002 end-page: 1078 ident: bb0445 article-title: Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer publication-title: J. Exp. Med. – volume: 6 start-page: 197 year: 2006 ident: bb0915 article-title: Met-independent hepatocyte growth factor-mediated regulation of cell adhesion in human prostate cancer cells publication-title: BMC Cancer – volume: 4 start-page: 1433 year: 2010 end-page: 1442 ident: bb0215 article-title: Aptamer-based tumor-targeted drug delivery for photodynamic therapy publication-title: ACS Nano – volume: 67 start-page: 10491 year: 2007 end-page: 10500 ident: bb0305 article-title: AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin publication-title: Cancer Res. – volume: 288 start-page: 343 year: 2013 end-page: 354 ident: bb0995 article-title: Interplay between alphavbeta3 integrin and nucleolin regulates human endothelial and glioma cell migration publication-title: J. Biol. Chem. – volume: 213 start-page: e137 year: 2015 end-page: e138 ident: bb0790 article-title: Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles: a dual-functional strategy for paclitaxel delivery publication-title: J. Control. Release – year: 2011 ident: bb0120 article-title: Annual Report and Accounts – volume: 208 start-page: 42 year: 2015 end-page: 51 ident: bb0230 article-title: An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance publication-title: J. Control. Release – volume: 75 start-page: 544 year: 2015 end-page: 553 ident: bb0685 article-title: Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein publication-title: Cancer Res. – volume: 86 start-page: 1449 year: 2012 end-page: 1457 ident: bb0415 article-title: Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its trafficking publication-title: J. Virol. – volume: 41 start-page: 3676 year: 2002 end-page: 3685 ident: bb0020 article-title: Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications publication-title: Biochemistry – volume: 140 start-page: 171 year: 2015 end-page: 178 ident: bb0510 article-title: Topical application of a G-quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration publication-title: Exp. Eye Res. – volume: 48 start-page: 11655 year: 2009 end-page: 11663 ident: bb0945 article-title: The heparin binding motif of endostatin mediates its interaction with receptor nucleolin publication-title: Biochemistry – volume: 261 start-page: 312 year: 2000 end-page: 328 ident: bb0280 article-title: The cell-surface-expressed nucleolin is associated with the actin cytoskeleton publication-title: Exp. Cell Res. – start-page: A3027 year: 2016 ident: bb0400 article-title: Repurposing of a cancer drug in clinical trials for RSV prophylaxis publication-title: B26. Updates in Pediatric Lung Infections – volume: 9 start-page: e90687 year: 2014 ident: bb0965 article-title: Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1) publication-title: PLoS One – volume: 75 start-page: 11166 year: 2001 end-page: 11177 ident: bb0610 article-title: Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis publication-title: J. Virol. – volume: 14 start-page: 2843 year: 2014 end-page: 2848 ident: bb0185 article-title: Improved in vitro efficacy of gold nanoconstructs by increased loading of G-quadruplex aptamer publication-title: Nano Lett. – volume: 6 start-page: e1001110 year: 2010 ident: bb0605 article-title: Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes publication-title: PLoS Pathog. – volume: 6 start-page: 3318 year: 2012 end-page: 3326 ident: bb0075 article-title: Direct observation of nanoparticle-cancer cell nucleus interactions publication-title: ACS Nano – volume: 61 start-page: 17 year: 2015 ident: bb0045 article-title: Separation of quadruplex polymorphism in DNA sequences by reversed-phase chromatography publication-title: Curr. Protoc. Nucleic Acid Chem. – volume: 35 start-page: 677 year: 2011 end-page: 685 ident: bb0485 article-title: Cell-surface nucleolin is involved in lipopolysaccharide internalization and signalling in alveolar macrophages publication-title: Cell Biol. Int. – volume: 23 start-page: 191 year: 1996 end-page: 195 ident: bb1090 article-title: Internalization of anti-nucleolin antibody into viable HEp-2 cells publication-title: Mol. Biol. Rep. – start-page: 3064 year: 2005 ident: bb0115 article-title: Update on the first phase I study of AGRO100 in advanced cancer publication-title: ASCO Annual Meeting Proceedings – volume: 16 start-page: 299 year: 2015 end-page: 311 ident: bb0725 article-title: High-throughput functional genomics using CRISPR-Cas9 publication-title: Nat. Rev. Genet. – volume: 7 start-page: e1001329 year: 2011 ident: bb0620 article-title: Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway publication-title: PLoS Pathog. – volume: 163 start-page: 871 year: 2003 end-page: 878 ident: bb1055 article-title: Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels publication-title: J. Cell Biol. – volume: 87 start-page: 13094 year: 2013 end-page: 13106 ident: bb0435 article-title: Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles publication-title: J. Virol. – volume: 11 start-page: 175 year: 2015 end-page: 184 ident: bb0240 article-title: Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles publication-title: Nanomedicine – volume: 6 start-page: 25799 year: 2016 ident: bb0150 article-title: Bioactivity of 2′-deoxyinosine-incorporated aptamer AS1411 publication-title: Sci. Rep. – volume: 42 start-page: 314 year: 1995 end-page: 322 ident: bb0320 article-title: A 110-kD nuclear shuttling protein, nucleolin, binds to the neurite-promoting IKVAV site of laminin-1 publication-title: J. Neurosci. Res. – volume: 5 start-page: 672 year: 2009 end-page: 675 ident: bb0085 article-title: DNA aptamer-passivated nanocrystal synthesis: a facile approach for nanoparticle-based cancer cell growth inhibition publication-title: Small – year: 2013 ident: bb0105 article-title: Sympathy for the Devil – volume: 42 start-page: 50 year: 2011 end-page: 61 ident: bb0760 article-title: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size publication-title: Mol. Cell – volume: 288 start-page: 10780 year: 2013 end-page: 10791 ident: bb0630 article-title: Temporal transcriptional response during infection of type II alveolar epithelial cells with publication-title: J. Biol. Chem. – volume: 21 start-page: 288 year: 2015 end-page: 294 ident: bb0545 article-title: Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy publication-title: Nat. Med. – volume: 89 start-page: 1939 year: 2015 end-page: 1943 ident: bb0455 article-title: Identification of a role for nucleolin in rabies virus infection publication-title: J. Virol. – volume: 111 start-page: 243 year: 2014 end-page: 248 ident: bb0440 article-title: Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 38 start-page: 1623 year: 2010 end-page: 1635 ident: bb0025 article-title: Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides publication-title: Nucleic Acids Res. – volume: 7 start-page: e34795 year: 2012 ident: bb0655 article-title: Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner publication-title: PLoS One – volume: 84 start-page: 2110 year: 2010 end-page: 2121 ident: bb0410 article-title: Nucleolin is required for efficient nuclear egress of herpes simplex virus type 1 nucleocapsids publication-title: J. Virol. – volume: 112 start-page: 9418 year: 2015 end-page: 9423 ident: bb1100 article-title: Human anti-nucleolin recombinant immunoagent for cancer therapy publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 314 start-page: 2212 year: 2008 end-page: 2223 ident: bb0975 article-title: Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells publication-title: Exp. Cell Res. – volume: 31 start-page: 2097 year: 2003 end-page: 2107 ident: bb0015 article-title: Biophysical and biological properties of quadruplex oligodeoxyribonucleotides publication-title: Nucleic Acids Res. – volume: 88 start-page: 11738 year: 2014 end-page: 11747 ident: bb0430 article-title: Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli publication-title: J. Virol. – volume: 94 start-page: 189 year: 2016 end-page: 205 ident: bb0200 article-title: Roadmap to clinical use of gold nanoparticles for radiation sensitization publication-title: Int. J. Radiat. Oncol. Biol. Phys. – volume: 98 start-page: 14090 year: 2001 end-page: 14095 ident: bb0325 article-title: The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 278 start-page: 5109 year: 2003 end-page: 5115 ident: bb0380 article-title: Direct interaction between nucleolin and hepatitis C virus NS5B publication-title: J. Biol. Chem. – volume: 16 start-page: 1664 year: 2016 end-page: 1676 ident: bb0515 article-title: Nucleolin-mediated RNA, localization regulates neuron growth and cycling cell size publication-title: Cell Rep. – volume: 332 start-page: 1317 year: 2011 end-page: 1322 ident: bb0770 article-title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling publication-title: Science (New York, N.Y.) – volume: 5 start-page: 5494 year: 2014 end-page: 5509 ident: bb1125 article-title: A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis publication-title: Oncotarget – volume: 136 start-page: 911 year: 2010 end-page: 921 ident: bb0480 article-title: Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of publication-title: J. Cancer Res. Clin. Oncol. – volume: 32 start-page: 8010 year: 2011 end-page: 8020 ident: bb0225 article-title: Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery publication-title: Biomaterials – volume: 11 start-page: 2953 year: 2016 end-page: 2965 ident: bb0825 article-title: Robust aptamer-polydopamine-functionalized M-PLGA-TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy publication-title: Int. J. Nanomedicine – volume: 43 start-page: 8884 year: 2015 end-page: 8897 ident: bb0350 article-title: Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription publication-title: Nucleic Acids Res. – volume: 84 start-page: 1771 year: 2010 end-page: 1784 ident: bb0420 article-title: Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication publication-title: J. Virol. – volume: 7 start-page: 8360 year: 2016 end-page: 8372 ident: bb0800 article-title: Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine publication-title: Oncotarget – volume: 118 start-page: 54 year: 2014 end-page: 60 ident: bb0065 article-title: Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy publication-title: Talanta – volume: 277 start-page: 2876 year: 2002 end-page: 2885 ident: bb0490 article-title: Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic publication-title: J. Biol. Chem. – volume: 5 start-page: 1207 year: 2009 end-page: 1212 ident: bb0205 article-title: In vitro derby imaging of cancer biomarkers using quantum dots publication-title: Small – start-page: 6557 year: 2010 ident: bb0135 article-title: Long-term outcomes of responders in a randomized, controlled phase II trial of aptamer AS1411 in AML publication-title: ASCO Annual Meeting Proceedings – volume: 112 start-page: 2729 year: 2015 end-page: 2733 ident: bb0035 article-title: Structure of a left-handed DNA G-quadruplex publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 276 start-page: 43221 year: 2001 end-page: 43230 ident: bb0530 article-title: Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides publication-title: J. Biol. Chem. – volume: 6 start-page: 29006 year: 2016 ident: bb0375 article-title: Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication publication-title: Sci. Rep. – volume: 56 start-page: 1035 year: 2015 ident: bb0900 article-title: Preparation of GO/BSA-Gd publication-title: J. Nucl. Med. – volume: 33 start-page: 5115 year: 2012 end-page: 5123 ident: bb0235 article-title: Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles publication-title: Biomaterials – year: 2011 ident: bb0040 article-title: Resolution of quadruplex polymorphism by size-exclusion chromatography publication-title: Curr. Protoc. Nucleic Acid Chem. – volume: 273 start-page: 4668 year: 2006 end-page: 4681 ident: bb0310 article-title: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-sigma publication-title: FEBS J. – volume: 5 start-page: 15675 year: 2015 ident: bb0890 article-title: Fluorescence-guided probes of aptamer-targeted gold nanoparticles with computed tomography imaging accesses for in vivo tumor resection publication-title: Sci. Rep. – volume: 51 start-page: 98 year: 2010 end-page: 105 ident: bb0220 article-title: A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer publication-title: J. Nucl. Med. – volume: 121 start-page: 4729 year: 2013 end-page: 4739 ident: bb0990 article-title: Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex publication-title: Blood – volume: 35 start-page: 2905 year: 2014 end-page: 2914 ident: bb0830 article-title: Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras publication-title: Biomaterials – volume: 76 start-page: 984 year: 2009 end-page: 991 ident: bb0705 article-title: Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells publication-title: Mol. Pharmacol. – volume: 6 start-page: 40405 year: 2015 end-page: 40417 ident: bb0735 article-title: Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras publication-title: Oncotarget – year: 2014 ident: bb0070 article-title: Spherical nucleic acid nanoparticle conjugates enhance G-quadruplex formation and increase serum protein interactions publication-title: Angew. Chem. Int. Ed. Eng. – volume: 5 start-page: e15787 year: 2010 ident: bb0275 article-title: Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization publication-title: PLoS One – volume: 276 start-page: 155 year: 2002 end-page: 173 ident: bb0340 article-title: Anchorage of HIV on permissive cells leads to coaggregation of viral particles with surface nucleolin at membrane raft microdomains publication-title: Exp. Cell Res. – volume: 6 start-page: 965 year: 2008 end-page: 977 ident: bb0710 article-title: Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis publication-title: Mol. Cancer Res. – volume: 6 start-page: e1001121 year: 2010 ident: bb0600 article-title: Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner publication-title: PLoS Pathog. – volume: 411 start-page: 253 year: 2011 end-page: 258 ident: bb0475 article-title: Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor publication-title: Biochem. Biophys. Res. Commun. – volume: 71 start-page: 3296 year: 2011 end-page: 3305 ident: bb1080 article-title: A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins publication-title: Cancer Res. – volume: 12 start-page: 107 year: 2010 end-page: 114 ident: bb0100 article-title: AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia publication-title: Curr. Opin. Mol. Ther. – volume: 5 year: 2014 ident: bb0580 article-title: Coronaviruses induce entry-independent, continuous macropinocytosis publication-title: MBio – volume: 10 start-page: 310 year: 2004 end-page: 315 ident: bb0575 article-title: Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis publication-title: Nat. Med. – volume: 362 start-page: 880 year: 2007 end-page: 885 ident: bb0360 article-title: Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection publication-title: Biochem. Biophys. Res. Commun. – volume: 86 start-page: 10950 year: 2012 end-page: 10960 ident: bb0625 article-title: Filamentous influenza virus enters cells via macropinocytosis publication-title: J. Virol. – year: 2016 ident: bb0810 article-title: Multidrug delivery systems based on human serum albumin for combination therapy with three anticancer agents publication-title: Mol. Pharm. – volume: 70 start-page: 8617 year: 2010 end-page: 8629 ident: bb0250 article-title: A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism publication-title: Cancer Res. – volume: 211 start-page: 159 year: 2015 end-page: 172 ident: bb0730 article-title: Growth factor signaling to mTORC1 by amino acid-laden macropinosomes publication-title: J. Cell Biol. – volume: 10 start-page: e0136673 year: 2015 ident: bb0795 article-title: A synthetic aptamer-drug adduct for targeted liver cancer therapy publication-title: PLoS One – volume: 116 start-page: 1063 year: 1994 end-page: 1068 ident: bb0940 article-title: Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth associated molecule (HB-GAM) publication-title: J. Biochem. – volume: 15 start-page: 697 year: 2012 end-page: 711 ident: bb0955 article-title: The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells publication-title: Angiogenesis – volume: 5 start-page: 10447 year: 2013 end-page: 10454 ident: bb0875 article-title: Aptamer-conjugated Mn publication-title: Nanoscale – volume: 17 start-page: 1132 year: 2011 end-page: 1135 ident: bb0395 article-title: Identification of nucleolin as a cellular receptor for human respiratory syncytial virus publication-title: Nat. Med. – volume: 387 start-page: 525 year: 2009 end-page: 530 ident: bb0450 article-title: Identification of nucleolin as a protein that binds to human papillomavirus type 16 DNA publication-title: Biochem. Biophys. Res. Commun. – volume: 162 start-page: 259 year: 2015 end-page: 270 ident: bb0745 article-title: The utilization of extracellular proteins as nutrients is suppressed by mTORC1 publication-title: Cell – volume: 25 start-page: 1245 year: 2015 end-page: 1250 ident: bb0700 article-title: Intracellular monitoring of AS1411 aptamer by time-resolved microspectrofluorimetry and fluorescence imaging publication-title: J. Fluoresc. – volume: 332 start-page: 1322 year: 2011 end-page: 1326 ident: bb0755 article-title: Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling publication-title: Science (New York, N.Y.) – volume: 117 start-page: 1170 year: 1995 end-page: 1177 ident: bb0290 article-title: Induction of heat shock protein 70 and nucleolin and their intracellular distribution during early stage of liver regeneration publication-title: J. Biochem. – volume: 179 start-page: 601 year: 1994 end-page: 608 ident: bb0585 article-title: stimulate macrophage macropinocytosis and persist within spacious phagosomes publication-title: J. Exp. Med. – volume: 86 start-page: 151 year: 2009 end-page: 164 ident: bb0005 article-title: Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer publication-title: Exp. Mol. Pathol. – volume: 5 start-page: 8602 year: 2014 end-page: 8613 ident: bb1030 article-title: Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma publication-title: Oncotarget – volume: 38 start-page: 4877 year: 2010 end-page: 4888 ident: bb0030 article-title: Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence publication-title: Nucleic Acids Res. – volume: 10 start-page: 9393 year: 2012 end-page: 9404 ident: bb0055 article-title: Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4 publication-title: Org. Biomol. Chem. – volume: 5 start-page: e14193 year: 2010 ident: bb0500 article-title: Nucleolin, a shuttle protein promoting infection of human monocytes by publication-title: PLoS One – volume: 102 start-page: 152 year: 2016 end-page: 158 ident: bb0805 article-title: Double targeting and aptamer-assisted controlled release delivery of epirubicin to cancer cells by aptamers-based dendrimer in vitro and in vivo publication-title: Eur. J. Pharm. Biopharm. – volume: 273 start-page: 1350 year: 2006 end-page: 1361 ident: bb0720 article-title: Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines publication-title: FEBS J. – volume: 5 start-page: 4904 year: 2014 ident: bb0740 article-title: An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability publication-title: Nat. Commun. – volume: 140 start-page: 689 year: 2014 end-page: 699 ident: bb0270 article-title: Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands publication-title: J. Cancer Res. Clin. Oncol. – volume: 11 start-page: 510 year: 2009 end-page: 520 ident: bb0565 article-title: Virus entry by macropinocytosis publication-title: Nat. Cell Biol. – volume: 11 start-page: e0164146 year: 2016 ident: bb0370 article-title: Interaction of host nucleolin with influenza A virus nucleoprotein in the early phase of infection limits the late viral gene expression publication-title: PLoS One – volume: 9 start-page: 1468 year: 1999 end-page: 1476 ident: bb1050 article-title: Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin publication-title: Curr. Biol. – volume: 25 start-page: 2463 year: 2005 end-page: 2474 ident: bb0285 article-title: Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation publication-title: Mol. Cell. Biol. – volume: 36 start-page: 507 year: 2013 end-page: 517 ident: bb1000 article-title: Identification of nucleolin as a lipid-raft-dependent beta1-integrin-interacting protein in A375 cell migration publication-title: Mol. Cells – volume: 71 start-page: 84 year: 2015 end-page: 99 ident: bb0840 article-title: LNA aptamer based multi-modal, Fe publication-title: Biomaterials – year: 2016 ident: bb0750 article-title: Giant cellular vacuoles induced by rare earth oxide nanoparticles are abnormally enlarged endo/lysosomes and promote mTOR-dependent TFEB nucleus translocation publication-title: Small – volume: 8 start-page: e1002657 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0660 article-title: Entry of human papillomavirus type 16 by actin-dependent, clathrin- and lipid raft-independent endocytosis publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1002657 – volume: 94 start-page: 189 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0200 article-title: Roadmap to clinical use of gold nanoparticles for radiation sensitization publication-title: Int. J. Radiat. Oncol. Biol. Phys. doi: 10.1016/j.ijrobp.2015.09.032 – volume: 7 start-page: e34795 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0655 article-title: Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner publication-title: PLoS One doi: 10.1371/journal.pone.0034795 – volume: 3 start-page: e2518 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb1065 article-title: Suppression of tumor growth and angiogenesis by a specific antagonist of the cell-surface expressed nucleolin publication-title: PLoS One doi: 10.1371/journal.pone.0002518 – volume: 23 start-page: 497 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0880 article-title: Tumor targeting with a 99mTc-labeled AS1411 aptamer in prostate tumor cells publication-title: J. Drug Target. doi: 10.3109/1061186X.2015.1009075 – volume: 98 start-page: 14090 year: 2001 ident: 10.1016/j.bbagen.2016.12.015_bb0325 article-title: The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.221467298 – volume: 41 start-page: 3676 year: 2002 ident: 10.1016/j.bbagen.2016.12.015_bb0020 article-title: Antiproliferative activity of G-quartet-forming oligonucleotides with backbone and sugar modifications publication-title: Biochemistry doi: 10.1021/bi0119520 – volume: 211 start-page: 159 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0730 article-title: Growth factor signaling to mTORC1 by amino acid-laden macropinosomes publication-title: J. Cell Biol. doi: 10.1083/jcb.201504097 – volume: 118 start-page: 54 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0065 article-title: Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy publication-title: Talanta doi: 10.1016/j.talanta.2013.09.062 – volume: 6 start-page: e1001121 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0600 article-title: Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1001121 – volume: 6 start-page: 470 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0820 article-title: Polydopamine-based surface modification of novel nanoparticle-aptamer bioconjugates for in vivo breast cancer targeting and enhanced therapeutic effects publication-title: Theranostics doi: 10.7150/thno.14184 – volume: 9 start-page: 137 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0265 article-title: Cell surface nucleolin as a target for anti-cancer therapies publication-title: Recent Pat. Anticancer Drug Discov. doi: 10.2174/1574892808666131119095953 – volume: 86 start-page: 1449 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0415 article-title: Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its trafficking publication-title: J. Virol. doi: 10.1128/JVI.06194-11 – volume: 38 start-page: 1623 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0025 article-title: Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkp1088 – volume: 86 start-page: 151 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0005 article-title: Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer publication-title: Exp. Mol. Pathol. doi: 10.1016/j.yexmp.2009.01.004 – volume: 179 start-page: 601 year: 1994 ident: 10.1016/j.bbagen.2016.12.015_bb0585 article-title: Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes publication-title: J. Exp. Med. doi: 10.1084/jem.179.2.601 – volume: 21 start-page: 288 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0545 article-title: Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy publication-title: Nat. Med. doi: 10.1038/nm.3791 – volume: 61 start-page: 17 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0045 article-title: Separation of quadruplex polymorphism in DNA sequences by reversed-phase chromatography publication-title: Curr. Protoc. Nucleic Acid Chem. doi: 10.1002/0471142700.nc1707s61 – volume: 48 start-page: 11655 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0945 article-title: The heparin binding motif of endostatin mediates its interaction with receptor nucleolin publication-title: Biochemistry doi: 10.1021/bi901265z – volume: 162 start-page: 259 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0745 article-title: The utilization of extracellular proteins as nutrients is suppressed by mTORC1 publication-title: Cell doi: 10.1016/j.cell.2015.06.017 – volume: 7 start-page: 8360 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0800 article-title: Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine publication-title: Oncotarget doi: 10.18632/oncotarget.7073 – volume: 17 start-page: 1132 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0395 article-title: Identification of nucleolin as a cellular receptor for human respiratory syncytial virus publication-title: Nat. Med. doi: 10.1038/nm.2444 – volume: 16 start-page: 1664 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0515 article-title: Nucleolin-mediated RNA, localization regulates neuron growth and cycling cell size publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.07.005 – volume: 140 start-page: 689 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0270 article-title: Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-014-1587-5 – volume: 14 start-page: 2 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0910 article-title: Hepatoma-derived growth factor and nucleolin exist in the same ribonucleoprotein complex publication-title: BMC Biochem. doi: 10.1186/1471-2091-14-2 – volume: 71 start-page: 2140 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb1040 article-title: Oncogenic synergism between ErbB1, nucleolin, and mutant Ras publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-2887 – volume: 43 start-page: 8884 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0350 article-title: Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv897 – volume: 5 start-page: 8602 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb1030 article-title: Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma publication-title: Oncotarget doi: 10.18632/oncotarget.2343 – volume: 110 start-page: 2899 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb0950 article-title: Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin publication-title: Blood doi: 10.1182/blood-2007-01-064428 – volume: 6 start-page: 38 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0715 article-title: Non-apoptotic cell death associated with perturbations of macropinocytosis publication-title: Front. Physiol. doi: 10.3389/fphys.2015.00038 – volume: 80 start-page: 3332 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0385 article-title: Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon publication-title: J. Virol. doi: 10.1128/JVI.80.7.3332-3340.2006 – volume: 11 start-page: 510 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0565 article-title: Virus entry by macropinocytosis publication-title: Nat. Cell Biol. doi: 10.1038/ncb0509-510 – volume: 6 start-page: 25799 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0150 article-title: Bioactivity of 2′-deoxyinosine-incorporated aptamer AS1411 publication-title: Sci. Rep. doi: 10.1038/srep25799 – volume: 213 start-page: e137 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0790 article-title: Nucleolin targeting AS1411 aptamer modified pH-sensitive micelles: a dual-functional strategy for paclitaxel delivery publication-title: J. Control. Release doi: 10.1016/j.jconrel.2015.05.232 – volume: 25 start-page: 1245 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0700 article-title: Intracellular monitoring of AS1411 aptamer by time-resolved microspectrofluorimetry and fluorescence imaging publication-title: J. Fluoresc. doi: 10.1007/s10895-015-1612-3 – volume: 494 start-page: 78 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0365 article-title: Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization publication-title: Virology doi: 10.1016/j.virol.2016.04.008 – volume: 5 start-page: 15675 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0890 article-title: Fluorescence-guided probes of aptamer-targeted gold nanoparticles with computed tomography imaging accesses for in vivo tumor resection publication-title: Sci. Rep. doi: 10.1038/srep15675 – volume: 16 start-page: 174 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0930 article-title: Midkine, a cytokine that inhibits HIV infection by binding to the cell surface expressed nucleolin publication-title: Cell Res. doi: 10.1038/sj.cr.7310024 – volume: 75 start-page: 11166 year: 2001 ident: 10.1016/j.bbagen.2016.12.015_bb0610 article-title: Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis publication-title: J. Virol. doi: 10.1128/JVI.75.22.11166-11177.2001 – volume: 274 start-page: 26369 year: 1999 ident: 10.1016/j.bbagen.2016.12.015_bb0010 article-title: Antiproliferative activity of G-rich oligonucleotides correlates with protein binding publication-title: J. Biol. Chem. doi: 10.1074/jbc.274.37.26369 – volume: 11 start-page: e0164146 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0370 article-title: Interaction of host nucleolin with influenza A virus nucleoprotein in the early phase of infection limits the late viral gene expression publication-title: PLoS One doi: 10.1371/journal.pone.0164146 – volume: 7 start-page: e1001329 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0620 article-title: Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1001329 – volume: 48 start-page: 6494 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0210 article-title: Reversible cell-specific drug delivery with aptamer-functionalized liposomes publication-title: Angew. Chem. Int. Ed. Eng. doi: 10.1002/anie.200901452 – volume: 32 start-page: 8010 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0225 article-title: Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.07.004 – volume: 102 start-page: 247 year: 2005 ident: 10.1016/j.bbagen.2016.12.015_bb0570 article-title: Cationic TAT peptide transduction domain enters cells by macropinocytosis publication-title: J. Control. Release doi: 10.1016/j.jconrel.2004.10.018 – volume: 362 start-page: 880 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb0360 article-title: Influenza A virus non-structural protein 1 (NS1) interacts with cellular multifunctional protein nucleolin during infection publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2007.08.091 – year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb1025 article-title: Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer publication-title: Oncotarget doi: 10.18632/oncotarget.11323 – volume: 19 start-page: 93 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb1105 article-title: Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid publication-title: Mol. Ther. doi: 10.1038/mt.2010.214 – volume: 3 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0425 article-title: Host cell nucleolin is required to maintain the architecture of human cytomegalovirus replication compartments publication-title: MBio doi: 10.1128/mBio.00301-11 – year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0105 – volume: 68 start-page: 2358 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb1120 article-title: The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-5723 – volume: 3 start-page: e2310 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb1045 article-title: Identification of nucleolin as new ErbB receptors- interacting protein publication-title: PLoS One doi: 10.1371/journal.pone.0002310 – volume: 6 start-page: 1170 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0540 article-title: Rac-mediated macropinocytosis is a critical route for naked plasmid DNA transfer in mice publication-title: Mol. Pharm. doi: 10.1021/mp900042p – volume: 84 start-page: 1771 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0420 article-title: Nucleolin associates with the human cytomegalovirus DNA polymerase accessory subunit UL44 and is necessary for efficient viral replication publication-title: J. Virol. doi: 10.1128/JVI.01510-09 – volume: 6 start-page: 42091 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb1085 article-title: Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model publication-title: Oncotarget doi: 10.18632/oncotarget.5990 – volume: 6 start-page: 3318 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0075 article-title: Direct observation of nanoparticle-cancer cell nucleus interactions publication-title: ACS Nano doi: 10.1021/nn300296p – volume: 5 start-page: 1207 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0205 article-title: In vitro derby imaging of cancer biomarkers using quantum dots publication-title: Small doi: 10.1002/smll.200801580 – volume: 6 start-page: 197 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0915 article-title: Met-independent hepatocyte growth factor-mediated regulation of cell adhesion in human prostate cancer cells publication-title: BMC Cancer doi: 10.1186/1471-2407-6-197 – volume: 276 start-page: 155 year: 2002 ident: 10.1016/j.bbagen.2016.12.015_bb0340 article-title: Anchorage of HIV on permissive cells leads to coaggregation of viral particles with surface nucleolin at membrane raft microdomains publication-title: Exp. Cell Res. doi: 10.1006/excr.2002.5522 – volume: 7 start-page: 18628 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0245 article-title: Cell membrane capsules for encapsulation of chemotherapeutic and cancer cell targeting in vivo publication-title: ACS Appl. Mater. Interfaces doi: 10.1021/acsami.5b05065 – volume: 449 start-page: 44 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0855 article-title: A dual functional fluorescent probe for glioma imaging mediated by blood-brain barrier penetration and glioma cell targeting publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2014.04.148 – volume: 87 start-page: 13094 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0435 article-title: Nucleolin interacts with the dengue virus capsid protein and plays a role in formation of infectious virus particles publication-title: J. Virol. doi: 10.1128/JVI.00704-13 – volume: 5 start-page: e14193 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0500 article-title: Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis publication-title: PLoS One doi: 10.1371/journal.pone.0014193 – volume: 9 start-page: 799 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0260 article-title: RNA-binding protein nucleolin in disease publication-title: RNA Biol. doi: 10.4161/rna.19718 – volume: 273 start-page: 1350 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0720 article-title: Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines publication-title: FEBS J. doi: 10.1111/j.1742-4658.2006.05143.x – volume: 1 start-page: 5288 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0775 article-title: Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells and publication-title: J. Mater. Chem. B Mater. Biol. Med. doi: 10.1039/c3tb20412j – volume: 51 start-page: 12721 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0870 article-title: Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors publication-title: Angew. Chem. Int. Ed. Eng. doi: 10.1002/anie.201205271 – volume: 33 start-page: 14696 year: 1994 ident: 10.1016/j.bbagen.2016.12.015_bb0985 article-title: Major cell surface-located protein substrates of an ecto-protein kinase are homologs of known nuclear proteins publication-title: Biochemistry doi: 10.1021/bi00253a007 – volume: 6 start-page: 16253 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0905 article-title: Hepatoma-derived growth factor/nucleolin axis as a novel oncogenic pathway in liver carcinogenesis publication-title: Oncotarget doi: 10.18632/oncotarget.3608 – year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0750 article-title: Giant cellular vacuoles induced by rare earth oxide nanoparticles are abnormally enlarged endo/lysosomes and promote mTOR-dependent TFEB nucleus translocation publication-title: Small doi: 10.1002/smll.201601903 – volume: 76 start-page: 6689 year: 2002 ident: 10.1016/j.bbagen.2016.12.015_bb0615 article-title: Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway publication-title: J. Virol. doi: 10.1128/JVI.76.13.6689-6700.2002 – volume: 210 start-page: 951 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0505 article-title: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation publication-title: J. Exp. Med. doi: 10.1084/jem.20120950 – volume: 5 start-page: 2957 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0095 article-title: Discovery and development of anticancer aptamers publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-06-0172 – volume: 10 start-page: e0136673 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0795 article-title: A synthetic aptamer-drug adduct for targeted liver cancer therapy publication-title: PLoS One doi: 10.1371/journal.pone.0136673 – volume: 10 start-page: 310 year: 2004 ident: 10.1016/j.bbagen.2016.12.015_bb0575 article-title: Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis publication-title: Nat. Med. doi: 10.1038/nm996 – year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0120 – volume: 69 start-page: 6751 year: 1995 ident: 10.1016/j.bbagen.2016.12.015_bb0460 article-title: Characterization of a 100-kilodalton binding protein for the six serotypes of coxsackie B viruses publication-title: J. Virol. doi: 10.1128/jvi.69.11.6751-6757.1995 – year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0810 article-title: Multidrug delivery systems based on human serum albumin for combination therapy with three anticancer agents publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.6b00277 – volume: 8 start-page: 145 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb0495 article-title: A novel receptor - ligand pathway for entry of Francisella tularensis in monocyte-like THP-1 cells: interaction between surface nucleolin and bacterial elongation factor Tu publication-title: BMC Microbiol. doi: 10.1186/1471-2180-8-145 – volume: 6 start-page: 3831 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0060 article-title: Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides publication-title: Chem. Sci. doi: 10.1039/C4SC03949A – volume: 25 start-page: 2463 year: 2005 ident: 10.1016/j.bbagen.2016.12.015_bb0285 article-title: Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.6.2463-2474.2005 – volume: 7 start-page: 658 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0885 article-title: AS1411 aptamer-conjugated Gd2O3: Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging publication-title: Nano Res. doi: 10.1007/s12274-014-0420-4 – volume: 11 start-page: 580 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0180 article-title: Grafting aptamers onto gold nanostars increases in vitro efficacy in a wide range of cancer cell types publication-title: Mol. Pharm. doi: 10.1021/mp4005657 – volume: 42 start-page: 50 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0760 article-title: Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.03.017 – volume: 121 start-page: 4729 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0990 article-title: Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex publication-title: Blood doi: 10.1182/blood-2012-12-471094 – volume: 140 start-page: 171 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0510 article-title: Topical application of a G-quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2015.09.005 – volume: 271 start-page: 303 year: 2004 ident: 10.1016/j.bbagen.2016.12.015_bb0970 article-title: Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells publication-title: Eur. J. Biochem. doi: 10.1046/j.1432-1033.2003.03929.x – volume: 57 start-page: 207 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0765 article-title: mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.11.013 – volume: 222 start-page: 249 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0960 article-title: Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells publication-title: J. Pathol. doi: 10.1002/path.2760 – volume: 254 start-page: 1753 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0315 article-title: Tissue and cellular characterisation of nucleolin in a murine model of corneal angiogenesis publication-title: Graefes Arch. Clin. Exp. Ophthalmol. doi: 10.1007/s00417-016-3409-8 – volume: 102 start-page: 152 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0805 article-title: Double targeting and aptamer-assisted controlled release delivery of epirubicin to cancer cells by aptamers-based dendrimer in vitro and in vivo publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2016.03.013 – volume: 22 start-page: 1179 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0165 article-title: Simple PEG, modification of DNA aptamer based on copper ion coordination for tumor targeting publication-title: J. Biomater. Sci. Polym. Ed. – volume: 93 start-page: 426 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0935 article-title: Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin publication-title: Biochimie doi: 10.1016/j.biochi.2010.10.015 – volume: 32 start-page: 75 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb1015 article-title: The involvement of cell surface nucleolin in the initiation of CCR6 signaling in human hepatocellular carcinoma publication-title: Med. Oncol. (Northwood Lond. Engl.) doi: 10.1007/s12032-015-0530-1 – volume: 78 start-page: 857 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0535 article-title: Mechanisms of endocytosis publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.78.081307.110540 – volume: 88 start-page: 11738 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0430 article-title: Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli publication-title: J. Virol. doi: 10.1128/JVI.01889-14 – volume: 5 start-page: 672 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0085 article-title: DNA aptamer-passivated nanocrystal synthesis: a facile approach for nanoparticle-based cancer cell growth inhibition publication-title: Small doi: 10.1002/smll.200801821 – volume: 14 start-page: 2843 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0185 article-title: Improved in vitro efficacy of gold nanoconstructs by increased loading of G-quadruplex aptamer publication-title: Nano Lett. doi: 10.1021/nl500844m – volume: 111 start-page: 243 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0440 article-title: Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1321800111 – volume: 42 start-page: 314 year: 1995 ident: 10.1016/j.bbagen.2016.12.015_bb0320 article-title: A 110-kD nuclear shuttling protein, nucleolin, binds to the neurite-promoting IKVAV site of laminin-1 publication-title: J. Neurosci. Res. doi: 10.1002/jnr.490420305 – volume: 12 start-page: 107 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0100 article-title: AS-1411, a guanosine-rich oligonucleotide aptamer targeting nucleolin for the potential treatment of cancer, including acute myeloid leukemia publication-title: Curr. Opin. Mol. Ther. – volume: 107 start-page: 3564 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0920 article-title: The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin publication-title: Blood doi: 10.1182/blood-2005-07-2961 – volume: 5 start-page: 5494 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb1125 article-title: A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis publication-title: Oncotarget doi: 10.18632/oncotarget.2131 – volume: 36 start-page: 1099 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb1005 article-title: Cell surface nucleolin interacts with CXCR4 receptor via the 212 c-terminal portion publication-title: Tumour Biol. doi: 10.1007/s13277-014-2734-y – volume: 11 start-page: 2953 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0825 article-title: Robust aptamer-polydopamine-functionalized M-PLGA-TPGS nanoparticles for targeted delivery of docetaxel and enhanced cervical cancer therapy publication-title: Int. J. Nanomedicine – volume: 75 start-page: 544 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0685 article-title: Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-2211 – volume: 2010 start-page: 168306 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0160 article-title: Bioimaging of nucleolin aptamer-containing 5-(N-benzylcarboxyamide)-2′-deoxyuridine more capable of specific binding to targets in cancer cells publication-title: J. Biomed. Biotechnol. doi: 10.1155/2010/168306 – volume: 288 start-page: 343 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0995 article-title: Interplay between alphavbeta3 integrin and nucleolin regulates human endothelial and glioma cell migration publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.387076 – volume: 4 start-page: 1433 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0215 article-title: Aptamer-based tumor-targeted drug delivery for photodynamic therapy publication-title: ACS Nano doi: 10.1021/nn901374b – volume: 4 start-page: 21 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb1070 article-title: The pseudopeptide HB-19 binds to cell surface nucleolin and inhibits angiogenesis publication-title: Vasc. Cell doi: 10.1186/2045-824X-4-21 – volume: 9 start-page: e89141 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0665 article-title: The effect of cellular differentiation on HSV-1 infection of oligodendrocytic cells publication-title: PLoS One doi: 10.1371/journal.pone.0089141 – volume: 84 start-page: 2110 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0410 article-title: Nucleolin is required for efficient nuclear egress of herpes simplex virus type 1 nucleocapsids publication-title: J. Virol. doi: 10.1128/JVI.02007-09 – volume: 82 start-page: 4762 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb0405 article-title: Nucleolin is required for an efficient herpes simplex virus type 1 infection publication-title: J. Virol. doi: 10.1128/JVI.00077-08 – volume: 272 start-page: 31130 year: 1997 ident: 10.1016/j.bbagen.2016.12.015_bb0925 article-title: Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.49.31130 – volume: 26 start-page: 279 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0090 article-title: Tunable loading of oligonucleotides with secondary structure on gold nanoparticles through a pH-driven method publication-title: Bioconjug. Chem. doi: 10.1021/bc500562s – volume: 273 start-page: 21988 year: 1998 ident: 10.1016/j.bbagen.2016.12.015_bb0330 article-title: Identification of V3 loop-binding proteins as potential receptors implicated in the binding of HIV particles to CD4(+) cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.273.34.21988 – volume: 41 start-page: 3240 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0650 article-title: Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion publication-title: Eur. J. Immunol. doi: 10.1002/eji.201141693 – volume: 9 start-page: 7633 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0050 article-title: Polymorphism and resolution of oncogene promoter quadruplex-forming sequences publication-title: Org. Biomol. Chem. doi: 10.1039/c1ob05891f – volume: 15 start-page: 381 year: 1999 ident: 10.1016/j.bbagen.2016.12.015_bb0335 article-title: The V3 loop-mimicking pseudopeptide 5[Kpsi(CH2N)PR]-TASP inhibits HIV infection in primary macrophage cultures publication-title: AIDS Res. Hum. Retrovir. doi: 10.1089/088922299311358 – volume: 118 start-page: 173 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0345 article-title: Anticancer molecule AS1411 exhibits low nanomolar antiviral activity against HIV-1 publication-title: Biochimie doi: 10.1016/j.biochi.2015.09.009 – volume: 11 start-page: 175 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0240 article-title: Targeted delivery of anticancer drugs by aptamer AS1411 mediated Pluronic F127/cyclodextrin-linked polymer composite micelles publication-title: Nanomedicine doi: 10.1016/j.nano.2014.08.013 – volume: 411 start-page: 253 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0475 article-title: Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.06.109 – volume: 278 start-page: 5109 year: 2003 ident: 10.1016/j.bbagen.2016.12.015_bb0380 article-title: Direct interaction between nucleolin and hepatitis C virus NS5B publication-title: J. Biol. Chem. doi: 10.1074/jbc.M207629200 – volume: 5 start-page: e15787 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0275 article-title: Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization publication-title: PLoS One doi: 10.1371/journal.pone.0015787 – year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0895 article-title: Gold-quantum dot core–satellite assemblies for lighting up microRNA in vitro and in vivo publication-title: Small doi: 10.1002/smll.201670168 – volume: 497 start-page: 633 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0680 article-title: Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells publication-title: Nature doi: 10.1038/nature12138 – start-page: 147 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0130 article-title: Extended phase I study of AS1411 in renal and non-small cell lung cancers – volume: 13 start-page: 1413 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0560 article-title: Study of the selective uptake progress of aptamer-modified PLGA particles by liver cells publication-title: Macromol. Biosci. doi: 10.1002/mabi.201300165 – volume: 71 start-page: 3296 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb1080 article-title: A simple approach to cancer therapy afforded by multivalent pseudopeptides that target cell-surface nucleoproteins publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-3459 – volume: 387 start-page: 525 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0450 article-title: Identification of nucleolin as a protein that binds to human papillomavirus type 16 DNA publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2009.07.055 – volume: 52 start-page: 1521 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb1010 article-title: Nuclear protein C23 on the cell surface plays an important role in activation of CXCR4 signaling in glioblastoma publication-title: Mol. Neurobiol. doi: 10.1007/s12035-014-8955-7 – volume: 3 start-page: 1263 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0195 article-title: Shining light on nuclear-targeted therapy using gold nanostar constructs publication-title: Ther. Deliv. doi: 10.4155/tde.12.107 – volume: 116 start-page: 1063 year: 1994 ident: 10.1016/j.bbagen.2016.12.015_bb0940 article-title: Identification of nucleolin as a binding protein for midkine (MK) and heparin-binding growth associated molecule (HB-GAM) publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a124628 – volume: 11 start-page: 333 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb1060 article-title: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type publication-title: BMC Cancer doi: 10.1186/1471-2407-11-333 – volume: 112 start-page: 9418 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb1100 article-title: Human anti-nucleolin recombinant immunoagent for cancer therapy publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1507087112 – volume: 56 start-page: 1035 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0900 article-title: Preparation of GO/BSA-Gd2O3/AS1411-DOX theranostic nanocomplex and its application in MRI study of renal cell carcinoma publication-title: J. Nucl. Med. – volume: 141 start-page: 917 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb0390 article-title: Functional interaction of hepatitis C virus NS5B with nucleolin GAR domain publication-title: J. Biochem. doi: 10.1093/jb/mvm102 – volume: 196 start-page: 1067 year: 2002 ident: 10.1016/j.bbagen.2016.12.015_bb0445 article-title: Nucleolin as activator of human papillomavirus type 18 oncogene transcription in cervical cancer publication-title: J. Exp. Med. doi: 10.1084/jem.20011053 – volume: 9 start-page: 1468 year: 1999 ident: 10.1016/j.bbagen.2016.12.015_bb1050 article-title: Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin publication-title: Curr. Biol. doi: 10.1016/S0960-9822(00)80116-5 – volume: 276 start-page: 20579 year: 2001 ident: 10.1016/j.bbagen.2016.12.015_bb0295 article-title: Regulation of DNA replication after heat shock by replication protein a-nucleolin interactions publication-title: J. Biol. Chem. doi: 10.1074/jbc.M100874200 – volume: 71 start-page: 84 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0840 article-title: LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging publication-title: Biomaterials doi: 10.1016/j.biomaterials.2015.07.055 – volume: 5 start-page: 10447 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0875 article-title: Aptamer-conjugated Mn3O4@SiO2 core–shell nanoprobes for targeted magnetic resonance imaging publication-title: Nanoscale doi: 10.1039/c3nr03490a – volume: 31 start-page: 2097 year: 2003 ident: 10.1016/j.bbagen.2016.12.015_bb0015 article-title: Biophysical and biological properties of quadruplex oligodeoxyribonucleotides publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg316 – volume: 14 start-page: 1105 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0780 article-title: In vitro and in vivo evaluation of antitumor drug-loaded aptamer targeted single-walled carbon nanotubes system publication-title: Curr. Pharm. Biotechnol. doi: 10.2174/1389201015666140408123710 – volume: 6 start-page: C147 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb0125 article-title: Pharmacokinetics of the anti-nucleolin aptamer AS1411 in a phase I study publication-title: Mol. Cancer Ther. – volume: 6 start-page: 965 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb0710 article-title: Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis publication-title: Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-07-2036 – volume: 89 start-page: 4527 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0465 article-title: Cell surface nucleolin facilitates enterovirus 71 binding and infection publication-title: J. Virol. doi: 10.1128/JVI.03498-14 – volume: 78 start-page: 8146 year: 2004 ident: 10.1016/j.bbagen.2016.12.015_bb0470 article-title: Role of nucleolin in human parainfluenza virus type 3 infection of human lung epithelial cells publication-title: J. Virol. doi: 10.1128/JVI.78.15.8146-8158.2004 – volume: 51 start-page: 98 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0220 article-title: A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer publication-title: J. Nucl. Med. doi: 10.2967/jnumed.109.069880 – start-page: 6557 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0135 article-title: Long-term outcomes of responders in a randomized, controlled phase II trial of aptamer AS1411 in AML – volume: 163 start-page: 871 year: 2003 ident: 10.1016/j.bbagen.2016.12.015_bb1055 article-title: Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels publication-title: J. Cell Biol. doi: 10.1083/jcb.200304132 – start-page: 3112 year: 2004 ident: 10.1016/j.bbagen.2016.12.015_bb0110 article-title: A phase I study of AGRO100 in advanced cancer – volume: 87 start-page: 735 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0635 article-title: Macropinocytosis-like HIV-1 internalization in macrophages is CCR5 dependent and leads to efficient but delayed degradation in endosomal compartments publication-title: J. Virol. doi: 10.1128/JVI.01802-12 – volume: 6 start-page: e1001110 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0605 article-title: Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1001110 – volume: 35 start-page: 269 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0815 article-title: Constructing aptamer anchored nanovesicles for enhanced tumor penetration and cellular uptake of water soluble chemotherapeutics publication-title: Acta Biomater. doi: 10.1016/j.actbio.2016.02.012 – volume: 76 start-page: 1488 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb1095 article-title: Development of anti-nucleolin antibodies with broad spectrum anticancer activity and negligible toxicity to normal cells publication-title: Cancer Res. doi: 10.1158/1538-7445.AM2016-1488 – volume: 36 start-page: 507 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb1000 article-title: Identification of nucleolin as a lipid-raft-dependent beta1-integrin-interacting protein in A375 cell migration publication-title: Mol. Cells doi: 10.1007/s10059-013-0149-z – volume: 35 start-page: 3840 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0835 article-title: Nucleolin-targeting liposomes guided by aptamer AS1411 for the delivery of siRNA for the treatment of malignant melanomas publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.01.019 – volume: 15 start-page: 697 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0955 article-title: The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells publication-title: Angiogenesis doi: 10.1007/s10456-012-9284-y – volume: 5 start-page: 4904 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0740 article-title: An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability publication-title: Nat. Commun. doi: 10.1038/ncomms5904 – volume: 332 start-page: 1322 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0755 article-title: Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling publication-title: Science (New York, N.Y.) doi: 10.1126/science.1199484 – volume: 136 start-page: 911 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0480 article-title: Nucleolin as cell surface receptor for tumor necrosis factor-alpha inducing protein: a carcinogenic factor of Helicobacter pylori publication-title: J. Cancer Res. Clin. Oncol. doi: 10.1007/s00432-009-0733-y – volume: 332 start-page: 1317 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0770 article-title: The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling publication-title: Science (New York, N.Y.) doi: 10.1126/science.1199498 – volume: 5 start-page: 1790 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb1110 article-title: AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-05-0361 – volume: 70 start-page: 8617 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0250 article-title: A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolin-dependent mechanism publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-0920 – volume: 35 start-page: 677 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0485 article-title: Cell-surface nucleolin is involved in lipopolysaccharide internalization and signalling in alveolar macrophages publication-title: Cell Biol. Int. doi: 10.1042/CBI20100625 – volume: 76 start-page: 984 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0705 article-title: Plasma membrane nucleolin is a receptor for the anticancer aptamer AS1411 in MV4-11 leukemia cells publication-title: Mol. Pharmacol. doi: 10.1124/mol.109.055947 – volume: 5 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0580 article-title: Coronaviruses induce entry-independent, continuous macropinocytosis publication-title: MBio doi: 10.1128/mBio.01340-14 – volume: 276 start-page: 43221 year: 2001 ident: 10.1016/j.bbagen.2016.12.015_bb0530 article-title: Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides publication-title: J. Biol. Chem. doi: 10.1074/jbc.M104446200 – volume: 7 start-page: 381 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0675 article-title: Macropinocytosis exploitation by cancers and cancer therapeutics publication-title: Front. Physiol. doi: 10.3389/fphys.2016.00381 – volume: 261 start-page: 312 year: 2000 ident: 10.1016/j.bbagen.2016.12.015_bb0280 article-title: The cell-surface-expressed nucleolin is associated with the actin cytoskeleton publication-title: Exp. Cell Res. doi: 10.1006/excr.2000.5071 – volume: 23 start-page: 191 year: 1996 ident: 10.1016/j.bbagen.2016.12.015_bb1090 article-title: Internalization of anti-nucleolin antibody into viable HEp-2 cells publication-title: Mol. Biol. Rep. doi: 10.1007/BF00351168 – volume: 100 start-page: 1 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0080 article-title: Dual targeting luminescent gold nanoclusters for tumor imaging and deep tissue therapy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2016.05.017 – year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0070 article-title: Spherical nucleic acid nanoparticle conjugates enhance G-quadruplex formation and increase serum protein interactions publication-title: Angew. Chem. Int. Ed. Eng. – volume: 33 start-page: 207 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0865 article-title: Molecular imaging of a cancer-targeting theragnostics probe using a nucleolin aptamer- and microRNA-221 molecular beacon-conjugated nanoparticle publication-title: Biomaterials doi: 10.1016/j.biomaterials.2011.09.023 – volume: 67 start-page: 10491 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb1115 article-title: AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-4206 – volume: 301 start-page: C1140 year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0645 article-title: Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00036.2011 – volume: 11 start-page: 671 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0175 article-title: Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars publication-title: Nanomedicine doi: 10.1016/j.nano.2014.10.005 – volume: 6 start-page: 40405 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0735 article-title: Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras publication-title: Oncotarget doi: 10.18632/oncotarget.6334 – volume: 10 start-page: 1011 year: 2004 ident: 10.1016/j.bbagen.2016.12.015_bb0595 article-title: Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement publication-title: Mol. Ther. doi: 10.1016/j.ymthe.2004.08.010 – volume: 33 start-page: 5115 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0235 article-title: Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles publication-title: Biomaterials doi: 10.1016/j.biomaterials.2012.03.058 – volume: 277 start-page: 2876 year: 2002 ident: 10.1016/j.bbagen.2016.12.015_bb0490 article-title: Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic Escherichia coli O157:H7 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110230200 – volume: 8 start-page: e75269 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb1035 article-title: Disrupting the oncogenic synergism between nucleolin and Ras results in cell growth inhibition and cell death publication-title: PLoS One doi: 10.1371/journal.pone.0075269 – start-page: A3027 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0400 article-title: Repurposing of a cancer drug in clinical trials for RSV prophylaxis – volume: 111 start-page: 18201 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0525 article-title: G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1407361111 – volume: 38 start-page: 4877 year: 2010 ident: 10.1016/j.bbagen.2016.12.015_bb0030 article-title: Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq166 – volume: 86 start-page: 10950 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0625 article-title: Filamentous influenza virus enters cells via macropinocytosis publication-title: J. Virol. doi: 10.1128/JVI.05992-11 – volume: 507 start-page: 195 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0520 article-title: C9orf72 nucleotide repeat structures initiate molecular cascades of disease publication-title: Nature doi: 10.1038/nature13124 – volume: 208 start-page: 42 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0230 article-title: An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance publication-title: J. Control. Release doi: 10.1016/j.jconrel.2015.01.032 – volume: 117 start-page: 1170 year: 1995 ident: 10.1016/j.bbagen.2016.12.015_bb0290 article-title: Induction of heat shock protein 70 and nucleolin and their intracellular distribution during early stage of liver regeneration publication-title: J. Biochem. doi: 10.1093/oxfordjournals.jbchem.a124840 – volume: 26 start-page: 183 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0155 article-title: Delivery, effect on cell viability, and plasticity of modified aptamer constructs publication-title: Nucleic Acid Ther. doi: 10.1089/nat.2015.0592 – volume: 314 start-page: 2212 year: 2008 ident: 10.1016/j.bbagen.2016.12.015_bb0975 article-title: Cell-surface nucleolin is a signal transducing P-selectin binding protein for human colon carcinoma cells publication-title: Exp. Cell Res. doi: 10.1016/j.yexcr.2008.03.016 – volume: 22 start-page: 450 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0695 article-title: Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles publication-title: J. Drug Target. doi: 10.3109/1061186X.2014.886038 – volume: 9 start-page: e1003309 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0640 article-title: Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1003309 – volume: 89 start-page: 1939 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0455 article-title: Identification of a role for nucleolin in rabies virus infection publication-title: J. Virol. doi: 10.1128/JVI.03320-14 – year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0190 article-title: Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars publication-title: Nanomed. Nanotechnol. Biol. Med. – volume: 22 start-page: 187 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0690 article-title: Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells publication-title: Nucleic Acid Ther. doi: 10.1089/nat.2012.0347 – volume: 206 start-page: 545 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0980 article-title: Effect of laminin-1 on intestinal cell differentiation involves inhibition of nuclear nucleolin publication-title: J. Cell. Physiol. doi: 10.1002/jcp.20501 – volume: 10 start-page: 9393 year: 2012 ident: 10.1016/j.bbagen.2016.12.015_bb0055 article-title: Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4 publication-title: Org. Biomol. Chem. doi: 10.1039/c2ob26504d – volume: 35 start-page: 2905 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0830 article-title: Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.12.054 – volume: 11 start-page: e0160822 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0145 article-title: Modified AS1411 aptamer suppresses hepatocellular carcinoma by up-regulating galectin-14 publication-title: PLoS One doi: 10.1371/journal.pone.0160822 – year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb1075 article-title: Nucleolin targeting impairs the progression of pancreatic cancer and promotes the normalization of tumor vasculature publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-16-0300 – volume: 16 start-page: 299 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0725 article-title: High-throughput functional genomics using CRISPR-Cas9 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3899 – volume: 192 start-page: 192 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0785 article-title: Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo publication-title: J. Control. Release doi: 10.1016/j.jconrel.2014.06.037 – volume: 112 start-page: 2729 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0035 article-title: Structure of a left-handed DNA G-quadruplex publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1418718112 – volume: 6 start-page: 29006 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0375 article-title: Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication publication-title: Sci. Rep. doi: 10.1038/srep29006 – volume: 88 start-page: 13378 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0670 article-title: Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis publication-title: J. Virol. doi: 10.1128/JVI.03631-13 – volume: 55 start-page: 1 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb1020 article-title: Nucleolin promotes TGF-beta signaling initiation via TGF-beta receptor I in glioblastoma publication-title: J. Mol. Neurosci. doi: 10.1007/s12031-014-0292-9 – volume: 273 start-page: 4668 year: 2006 ident: 10.1016/j.bbagen.2016.12.015_bb0310 article-title: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-sigma publication-title: FEBS J. doi: 10.1111/j.1742-4658.2006.05471.x – volume: 32 start-page: 178 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0140 article-title: A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma publication-title: Investig. New Drugs doi: 10.1007/s10637-013-0045-6 – start-page: 3064 year: 2005 ident: 10.1016/j.bbagen.2016.12.015_bb0115 article-title: Update on the first phase I study of AGRO100 in advanced cancer – volume: 9 start-page: e90687 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0965 article-title: Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1) publication-title: PLoS One doi: 10.1371/journal.pone.0090687 – volume: 17 start-page: 1868 year: 2009 ident: 10.1016/j.bbagen.2016.12.015_bb0590 article-title: Cell-surface accumulation of flock house virus-derived peptide leads to efficient internalization via macropinocytosis publication-title: Mol. Ther. doi: 10.1038/mt.2009.192 – volume: 13 start-page: 795 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0550 article-title: Biocompatible ELR-based polyplexes coated with MUC1 specific aptamers and targeted for breast cancer gene therapy publication-title: Mol. Pharm. doi: 10.1021/acs.molpharmaceut.5b00712 – year: 2011 ident: 10.1016/j.bbagen.2016.12.015_bb0040 article-title: Resolution of quadruplex polymorphism by size-exclusion chromatography publication-title: Curr. Protoc. Nucleic Acid Chem. doi: 10.1002/0471142700.nc1703s45 – volume: 9 start-page: 1392 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0255 article-title: Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation publication-title: Mol. Oncol. doi: 10.1016/j.molonc.2015.03.012 – volume: 6 start-page: 22270 year: 2015 ident: 10.1016/j.bbagen.2016.12.015_bb0170 article-title: AS1411-conjugated gold nanospheres and their potential for breast cancer therapy publication-title: Oncotarget doi: 10.18632/oncotarget.4207 – volume: 288 start-page: 10780 year: 2013 ident: 10.1016/j.bbagen.2016.12.015_bb0630 article-title: Temporal transcriptional response during infection of type II alveolar epithelial cells with Francisella tularensis live vaccine strain (LVS) supports a general host suppression and bacterial uptake by macropinocytosis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M112.362178 – volume: 67 start-page: 10491 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb0305 article-title: AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-4206 – volume: 282 start-page: 27897 year: 2007 ident: 10.1016/j.bbagen.2016.12.015_bb0555 article-title: Identification of proteins released by mammalian cells that mediate DNA internalization through proteoglycan-dependent macropinocytosis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M701611200 – volume: 41 start-page: 179 year: 2014 ident: 10.1016/j.bbagen.2016.12.015_bb0845 article-title: Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancer publication-title: Nucl. Med. Biol. doi: 10.1016/j.nucmedbio.2013.10.008 – volume: 47 start-page: 311 year: 2016 ident: 10.1016/j.bbagen.2016.12.015_bb0355 article-title: The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell publication-title: Int. J. Antimicrob. Agents doi: 10.1016/j.ijantimicag.2016.01.016 – volume: 30 start-page: 2251 year: 2002 ident: 10.1016/j.bbagen.2016.12.015_bb0300 article-title: Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins publication-title: Nucleic Acids Res. doi: 10.1093/nar/30.10.2251 |
| SSID | ssj0000595 |
| Score | 2.6121125 |
| SecondaryResourceType | review_article |
| Snippet | AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1414 |
| SubjectTerms | animal models Animals Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - therapeutic use Aptamer Aptamers, Nucleotide AS1411 Binding Sites Cancer Cell Proliferation - drug effects Cell Survival - drug effects Contrast agent Contrast Media - chemistry Contrast Media - metabolism Diagnostic Imaging - methods DNA Drug Carriers Drug delivery endocytosis G-Quadruplexes Guanosine - chemistry Guanosine - metabolism Humans image analysis Imaging Ligands Nanoparticles neoplasm cells neoplasms Neoplasms - diagnostic imaging Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Nucleolin Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Oligodeoxyribonucleotides - therapeutic use oligonucleotides patients Phosphoproteins - metabolism Quadruplex Radiopharmaceuticals - chemistry Radiopharmaceuticals - metabolism Radiosensitizer RNA-Binding Proteins - metabolism Structure-Activity Relationship therapeutics |
| Title | G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms |
| URI | https://dx.doi.org/10.1016/j.bbagen.2016.12.015 https://www.ncbi.nlm.nih.gov/pubmed/28007579 https://www.proquest.com/docview/1852783370 https://www.proquest.com/docview/2045811573 |
| Volume | 1861 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3daxQxEA-lIvoiWr9Oa4nga7zLJrvJ-nYcradiX9qDvoV8rWy57p63e6Av_ds7sx8VwVLwbclOYJiZZH5J5oOQD5lLlNKRM-e0ZTKojOVSZEzJGRwnPPj4iFcD30-z5Up-vUgv9shizIXBsMph7-_39G63HkamgzSnm7KcnuGjHsCJFBAFFjHBhF8pFVr5x-s_YR4AH9L-JUEypB7T57oYL-dg0WIVVJ51l4LYHPff7uku-Nm5oZOn5MmAH-m8Z_EZ2YvVAXnYd5T8fUAeLcYGbs_J-Wf2c2fDdrdZx1-0Xpc_6gqrF9dtGSKdn3HJObUNtdSj6resjwoHX0aR3_YTXTURfleBXkVMEC6bq-YFWZ0cny-WbGiiwLzI05YV1hV5IWwqYxDgn33wTgavbBGC1ZYHq5yDT5tL7qN1UQJ5bpOZVTmsZSdekv2qruJrQqXSXufaejg1ywKQTIhRxSRzUXjHkzAhYpSd8UOFcWx0sTZjKNml6SVuUOKGJwYkPiHsdtamr7BxD70a1WL-shQDTuCeme9HLRpQBb6M2CrWu8ZgBrnSQqjZ3TRYt19jaSIxIa96E7jlN9EIvVT-5r95e0seJwgYulDKQ7LfbnfxHcCd1h119nxEHsy_fFue3gDki_65 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKESoXBOW1PI3E1ew6dmKHW7WiLND20l2pN8uvoKBtsmyyElz47czkUYREVYlblIyl0Yzt-RzPfEPI28wlSunImXPaMhlUxnIpMqbkDI4THmJ8xF8Dp2fZYiU_X6QXe2Q-1sJgWuWw9_d7erdbD2-mgzWnm7KcnuOlHsCJFBAFkpjoW-S2hOWLbQze_fqT5wH4Ie2vEiRD8bF-rkvycg5WLdKg8qz7K4jdcf8dn67Dn10cOr5P7g0Akh71Oj4ge7E6JHf6lpI_D8nBfOzg9pAsP7LvOxu2u806_qD1uvxaV0hfXLdliPTonEvOqW2opR59v2V9WjgEM4r6tu_pqonwuQr0MmKFcNlcNo_I6vjDcr5gQxcF5kWetqywrsgLYVMZg4AA7YN3MnhlixCstjxY5Rw82lxyH62LEsRzm8ysymExO_GY7Fd1FZ8SKpX2OtfWw7FZFgBlQowqJpmLwjuehAkRo-2MHyjGsdPF2oy5ZN9Mb3GDFjc8MWDxCWFXozY9xcYN8mp0i_lrqhiIAjeMfDN60YAr8GrEVrHeNQZLyJUWQs2ul0Hifo3cRGJCnvRT4ErfRCP2Uvmz_9btNTlYLE9PzMmnsy_Pyd0E0UOXV_mC7LfbXXwJ2Kd1r7q5_RuotABW |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=G-quadruplex+oligonucleotide+AS1411+as+a+cancer-targeting+agent%3A+Uses+and+mechanisms&rft.jtitle=Biochimica+et+biophysica+acta.+General+subjects&rft.au=Bates%2C+Paula+J.&rft.au=Reyes-Reyes%2C+Elsa+M.&rft.au=Malik%2C+Mohammad+T.&rft.au=Murphy%2C+Emily+M.&rft.date=2017-05-01&rft.pub=Elsevier+B.V&rft.issn=0304-4165&rft.eissn=1872-8006&rft.volume=1861&rft.issue=5&rft.spage=1414&rft.epage=1428&rft_id=info:doi/10.1016%2Fj.bbagen.2016.12.015&rft.externalDocID=S0304416516305098 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-4165&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-4165&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-4165&client=summon |