Lectins of the Araceae family: Insights, distinctions, and future avenues—A three-decade investigation

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 9; p. 130667
• Main Authors: Konozy, Emadeldin Hassan E., Dirar, Amina I., Osman, Makarim Elfadil M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2024
• Subjects: Animals; Araceae; Characterization; dimerization; erythrocytes; family; glycomics; GNA-related lectins; Humans; Lectins; Monocot; Plant Lectins - chemistry; Plant Lectins - metabolism; species; Structure; sugars; Characterization; Lectins; GNA-related lectins; Araceae; Structure; Monocot
• DOI: 10.1016/j.bbagen.2024.130667
• ISSN: 0304-4165; 1872-8006

The Araceae family boasts >3000 species of flowering plants that thrive across the tropics. Among the focal points of study within this family are lectins, proteins with affinity for binding carbohydrates. This review endeavors to gather data gleaned from numerous studies conducted over the past three decades on lectins extracted from Araceae plants. Our examination spans their extraction and purification methods, their specific interactions with carbohydrates, their molecular structures, and various physicochemical characteristics. Furthermore, we investigated the biological activities of these lectins and investigated the outcomes of cloning their genes. Despite their apparent similarities, these lectins exhibit notable distinctions, particularly regarding their unique preferences in interacting with erythrocytes from animals and humans, their sugar affinities, the critical amino acids for their functionality, the molecular weights of their subunits and their respective topologies, and ultimately, their dimerization and 3D β-prism-II structure, which reportedly diverge from those observed in other GNA-related lectins. These discrepancies not only deepen our understanding of monocot lectins but also render these proteins inherently captivating. This review marks the inaugural attempt at consolidating almost all published reports on lectins from the Araceae family, with the aim of furnishing glycobiology scientists with essential insights into potential laboratory challenges, the characteristics of these lectins, and avenues for future research. [Display omitted] •Reviews three decades of Araceae lectin research.•Covers extraction, purification, structures, and properties.•Investigates biological activities and gene cloning.•Examines unique interactions and 3D structures.•First comprehensive review for glycobiology.•Provides insights into challenges and future research.