Biochemical and biophysical methodologies open the road for effective schistosomiasis therapy and vaccination

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 1; pp. 3613 - 3620
• Main Authors: El Ridi, Rashika, Tallima, Hatem, Migliardo, Federica
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2017
• Subjects: adults; Animals; antibodies; antigens; antiplatyhelmintic agents; Arachidonic acid; Biochemistry - methods; Biophysics - methods; biosynthesis; bleaching; children; cholesterol; Elastic incoherent and quasi-elastic neutron scattering; excretory-secretory products; flukes; Hydrogen bond barrier; hydrogen bonding; hydrolysis; Immune Evasion; laboratory animals; lipid bilayers; Middle East; Neutral sphingomyelinase; nutrients; permeability; Schistosoma; Schistosoma - growth & development; Schistosoma - immunology; Schistosoma haematobium; Schistosoma mansoni; schistosomiasis; Schistosomiasis - immunology; Schistosomiasis - therapy; South America; Sphingomyelin; sphingomyelins; Sub-Saharan Africa; toxicity; Vaccination; vaccines; viability; Middle East; South America; Sub-Saharan Africa; nSMase; ESP; PUFA; PZQ; Neutral sphingomyelinase; Hydrogen bond barrier; EINS; Schistosoma; Arachidonic acid; Elastic incoherent and quasi-elastic neutron scattering; ARA; MBCD; SG3PDH; Sphingomyelin; SM; QENS; IF

Schistosomiasis caused by blood-dwelling flukes, namely Schistosoma mansoni and Schistosoma haematobium is a severe debilitating disease, widespread in sub-Saharan Africa, the Middle East, and South America. Developing and adult worms are unscathed by the surrounding immune effectors and antibodies...