Amadori and Heyns rearrangement products of bioactive peptides as potential new ligands of galectin-3

• Published in: Carbohydrate research Vol. 542; p. 109195
• Main Authors: Jakas, Andreja, Ayyalasomayajula, Ramya, Cudic, Mare
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2024
• Subjects: AlphaScreen; Amadori compounds; amino acid sequences; Blood Proteins; enkephalin; Enkephalin, Leucine - chemistry; Enkephalin, Leucine - metabolism; Enkephalins - chemistry; Enkephalins - metabolism; Galectin 3 - chemistry; Galectin 3 - metabolism; Galectin-3; galectins; Galectins - chemistry; Galectins - metabolism; Heyns compounds; Humans; Leu-enkephalin; Ligands; Maillard reaction; moieties; pathogenesis; Peptides - chemistry; Protein Binding; sugars; Maillard reaction; Amadori compounds; Galectin-3; Leu-enkephalin; AlphaScreen; Heyns compounds

Non-enzymatic cascade reactions between amines and reducing sugars are known as Maillard reaction. The late phase of these reactions consists of advanced glycation end products (AGEs), which have been implicated in the pathogenesis of numerous human diseases. Recent evidence suggests that galectin-3...