Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis

• Published in: Phytomedicine (Stuttgart) Vol. 57; pp. 385 - 395
• Main Authors: Sen, Zhang, Weida, Wang, Jie, Ma, Li, Sheng, Dongming, Zhang, Xiaoguang, Chen
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.04.2019
• Subjects: albumins; animal disease models; Animals; blood serum; collagen; coumarin; Coumarin glycoside; Coumarins - chemistry; Coumarins - pharmacology; creatinine; Diabetes Mellitus, Experimental - complications; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic nephropathy; excretion; fibronectins; Fibrosis - drug therapy; Fibrosis - pathology; flow cytometry; gene expression; glucose; Glycosides - chemistry; Glycosides - pharmacology; herbal medicines; histopathology; Hydrangea - chemistry; Hydrangea paniculata; immunohistochemistry; in vitro studies; insulin-dependent diabetes mellitus; interleukin-6; intraperitoneal injection; Kidney - drug effects; Kidney - metabolism; Kidney - physiology; kidneys; messenger RNA; metabolites; Molecular Targeted Therapy - methods; mothers against decapentaplegic homolog proteins; NF-E2-Related Factor 2 - metabolism; Nrf2; oral administration; pharmacokinetics; phosphorylation; Plant Extracts - chemistry; Plant Extracts - pharmacokinetics; Plant Extracts - pharmacology; protective effect; Rats; Rats, Wistar; Reactive oxygen species; renoprotective effect; reverse transcriptase polymerase chain reaction; secretion; Smad2 Protein - metabolism; Smad2/3; Smad3 Protein - metabolism; staining; Streptozocin; streptozotocin; transforming growth factor beta 1; umbelliferones; Umbelliferones - pharmacokinetics; urea nitrogen; urine; vacuoles; Western blotting; Reactive oxygen species; SCR; PAS-M; HP; Hydrangea paniculata; DN; MRT; AUC; GFR; CCr; GBM; Nrf2; ANOVA; STZ; Diabetic nephropathy; BUN; HPLC; TBS; Coumarin glycoside; EMT; ECM; IL-6; Smad2/3; TGFβ1; ROS; HG; TCM

Water extract of Hydrangea paniculata (HP) stem, rich in coumarin glycosides, has been demonstrated to have renal protective effect in several experimental kidney injury animal models. Currently, it is under pre-clinical development as a class 5 herbal drug against membranous nephropathy. However, w...