Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis - Sen, Zhang; Weida, Wang; Jie, Ma; Li, Sheng; Dongming, Zhang; Xiaoguang, Chen (Phytomedicine (Stuttgart), 2019)
Keywords: albumins; animal disease models; Animals; blood serum; collagen; coumarin; Coumarin glycoside; Coumarins - chemistry; Coumarins - pharmacology; creatinine; Diabetes Mellitus, Experimental - complications; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic nephropathy; excretion; fibronectins; Fibrosis - drug therapy; Fibrosis - pathology; flow cytometry; gene expression; glucose; Glycosides - chemistry; Glycosides - pharmacology; herbal medicines; histopathology; Hydrangea - chemistry; Hydrangea paniculata; immunohistochemistry; in vitro studies; insulin-dependent diabetes mellitus; interleukin-6; intraperitoneal injection; Kidney - drug effects; Kidney - metabolism; Kidney - physiology; kidneys; messenger RNA; metabolites; Molecular Targeted Therapy - methods; mothers against decapentaplegic homolog proteins; NF-E2-Related Factor 2 - metabolism; Nrf2; oral administration; pharmacokinetics; phosphorylation; Plant Extracts - chemistry; Plant Extracts - pharmacokinetics; Plant Extracts - pharmacology; protective effect; Rats; Rats, Wistar; Reactive oxygen species; renoprotective effect; reverse transcriptase polymerase chain reaction; secretion; Smad2 Protein - metabolism; Smad2/3; Smad3 Protein - metabolism; staining; Streptozocin; streptozotocin; transforming growth factor beta 1; umbelliferones; Umbelliferones - pharmacokinetics; urea nitrogen; urine; vacuoles; Western blotting; Reactive oxygen species; SCR; PAS-M; HP; Hydrangea paniculata; DN; MRT; AUC; GFR; CCr; GBM; Nrf2; ANOVA; STZ; Diabetic nephropathy; BUN; HPLC; TBS; Coumarin glycoside; EMT; ECM; IL-6; Smad2/3; TGFβ1; ROS; HG; TCM