O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function

• Published in: Frontiers in endocrinology (Lausanne) Vol. 12; p. 659733
• Main Authors: Ning, Jie, Yang, Huixia
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.06.2021
• Subjects: Acetylglucosamine - chemistry; Acetylglucosamine - metabolism; beta-N-Acetylhexosaminidases - genetics; beta-N-Acetylhexosaminidases - metabolism; Endocrinology; Female; Humans; Hyperglycemia - enzymology; Hyperglycemia - genetics; Hyperglycemia - metabolism; hyperglycemia in pregnancy; N-Acetylglucosaminyltransferases - genetics; N-Acetylglucosaminyltransferases - metabolism; O-GlcNAc transferase; O-GlcNAcylation; O-GlNAcase; Placenta - enzymology; Placenta - metabolism; placental function; Pregnancy; Pregnancy Complications - genetics; Pregnancy Complications - metabolism; Proteins - genetics; Proteins - metabolism; placental function; O-GlcNAcylation; O-GlcNAc transferase; O-GlNAcase; hyperglycemia in pregnancy

The dynamic cycling of N -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a m...