O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function

The dynamic cycling of N -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a m...

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Published inFrontiers in endocrinology (Lausanne) Vol. 12; p. 659733
Main Authors Ning, Jie, Yang, Huixia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.06.2021
Subjects
Acetylglucosamine - chemistry
Acetylglucosamine - metabolism
beta-N-Acetylhexosaminidases - genetics
beta-N-Acetylhexosaminidases - metabolism
Endocrinology
Female
Humans
Hyperglycemia - enzymology
Hyperglycemia - genetics
Hyperglycemia - metabolism
hyperglycemia in pregnancy
N-Acetylglucosaminyltransferases - genetics
N-Acetylglucosaminyltransferases - metabolism
O-GlcNAc transferase
O-GlcNAcylation
O-GlNAcase
Placenta - enzymology
Placenta - metabolism
placental function
Pregnancy
Pregnancy Complications - genetics
Pregnancy Complications - metabolism
Proteins - genetics
Proteins - metabolism
placental function
O-GlcNAcylation
O-GlcNAc transferase
O-GlNAcase
hyperglycemia in pregnancy
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Abstract The dynamic cycling of N -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a modulator in placental tissue; furthermore, increased levels of protein O-GlcNAcylation have been observed in women with hyperglycemia during pregnancy, which may affect the short-and long-term development of offspring. In this review, we focus on the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies. We discuss the following topics: effect of O-GlcNAcylation on placental development and its association with hyperglycemia; maternal-fetal nutrition transport, particularly glucose transport, via the mammalian target of rapamycin and AMP-activated protein kinase pathways; and the two-sided regulatory effect of O-GlcNAcylation on inflammation. As O-GlcNAcylation in the placental tissues of pregnant women with hyperglycemia influences near- and long-term development of offspring, research in this field has significant therapeutic relevance.
AbstractList The dynamic cycling of N-acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a modulator in placental tissue; furthermore, increased levels of protein O-GlcNAcylation have been observed in women with hyperglycemia during pregnancy, which may affect the short-and long-term development of offspring. In this review, we focus on the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies. We discuss the following topics: effect of O-GlcNAcylation on placental development and its association with hyperglycemia; maternal-fetal nutrition transport, particularly glucose transport, via the mammalian target of rapamycin and AMP-activated protein kinase pathways; and the two-sided regulatory effect of O-GlcNAcylation on inflammation. As O-GlcNAcylation in the placental tissues of pregnant women with hyperglycemia influences near- and long-term development of offspring, research in this field has significant therapeutic relevance.The dynamic cycling of N-acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a modulator in placental tissue; furthermore, increased levels of protein O-GlcNAcylation have been observed in women with hyperglycemia during pregnancy, which may affect the short-and long-term development of offspring. In this review, we focus on the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies. We discuss the following topics: effect of O-GlcNAcylation on placental development and its association with hyperglycemia; maternal-fetal nutrition transport, particularly glucose transport, via the mammalian target of rapamycin and AMP-activated protein kinase pathways; and the two-sided regulatory effect of O-GlcNAcylation on inflammation. As O-GlcNAcylation in the placental tissues of pregnant women with hyperglycemia influences near- and long-term development of offspring, research in this field has significant therapeutic relevance.
The dynamic cycling of N-acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a modulator in placental tissue; furthermore, increased levels of protein O-GlcNAcylation have been observed in women with hyperglycemia during pregnancy, which may affect the short-and long-term development of offspring. In this review, we focus on the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies. We discuss the following topics: effect of O-GlcNAcylation on placental development and its association with hyperglycemia; maternal-fetal nutrition transport, particularly glucose transport, via the mammalian target of rapamycin and AMP-activated protein kinase pathways; and the two-sided regulatory effect of O-GlcNAcylation on inflammation. As O-GlcNAcylation in the placental tissues of pregnant women with hyperglycemia influences near- and long-term development of offspring, research in this field has significant therapeutic relevance.
The dynamic cycling of -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a modulator in placental tissue; furthermore, increased levels of protein O-GlcNAcylation have been observed in women with hyperglycemia during pregnancy, which may affect the short-and long-term development of offspring. In this review, we focus on the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies. We discuss the following topics: effect of O-GlcNAcylation on placental development and its association with hyperglycemia; maternal-fetal nutrition transport, particularly glucose transport, the mammalian target of rapamycin and AMP-activated protein kinase pathways; and the two-sided regulatory effect of O-GlcNAcylation on inflammation. As O-GlcNAcylation in the placental tissues of pregnant women with hyperglycemia influences near- and long-term development of offspring, research in this field has significant therapeutic relevance.
The dynamic cycling of N -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of fundamental cellular processes. It is controlled by two essential enzymes, O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation serves as a modulator in placental tissue; furthermore, increased levels of protein O-GlcNAcylation have been observed in women with hyperglycemia during pregnancy, which may affect the short-and long-term development of offspring. In this review, we focus on the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies. We discuss the following topics: effect of O-GlcNAcylation on placental development and its association with hyperglycemia; maternal-fetal nutrition transport, particularly glucose transport, via the mammalian target of rapamycin and AMP-activated protein kinase pathways; and the two-sided regulatory effect of O-GlcNAcylation on inflammation. As O-GlcNAcylation in the placental tissues of pregnant women with hyperglycemia influences near- and long-term development of offspring, research in this field has significant therapeutic relevance.
Author Yang, Huixia
Ning, Jie
AuthorAffiliation 2 Beijing Key Laboratory of Maternal Foetal Medicine of Gestational Diabetes Mellitus , Beijing , China
3 Peking University , Beijing , China
1 Department of Obstetrics and Gynaecology, Peking University First Hospital , Beijing , China
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Keywords placental function
O-GlcNAcylation
O-GlcNAc transferase
O-GlNAcase
hyperglycemia in pregnancy
Language English
License Copyright © 2021 Ning and Yang.
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This article was submitted to Systems Endocrinology, a section of the journal Frontiers in Endocrinology
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Snippet The dynamic cycling of N -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of...
The dynamic cycling of -acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of...
The dynamic cycling of N-acetylglucosamine, termed as O-GlcNAcylation, is a post-translational modification of proteins and is involved in the regulation of...
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SubjectTerms Acetylglucosamine - chemistry
Acetylglucosamine - metabolism
beta-N-Acetylhexosaminidases - genetics
beta-N-Acetylhexosaminidases - metabolism
Endocrinology
Female
Humans
Hyperglycemia - enzymology
Hyperglycemia - genetics
Hyperglycemia - metabolism
hyperglycemia in pregnancy
N-Acetylglucosaminyltransferases - genetics
N-Acetylglucosaminyltransferases - metabolism
O-GlcNAc transferase
O-GlcNAcylation
O-GlNAcase
Placenta - enzymology
Placenta - metabolism
placental function
Pregnancy
Pregnancy Complications - genetics
Pregnancy Complications - metabolism
Proteins - genetics
Proteins - metabolism
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Title O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function
URI https://www.ncbi.nlm.nih.gov/pubmed/34140929
https://www.proquest.com/docview/2543454555
https://pubmed.ncbi.nlm.nih.gov/PMC8204080
https://doaj.org/article/e80ada017c2545ab83d074aed5fb3f06
Volume 12
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