α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects - Fernández-Galilea, Marta; Pérez-Matute, Patricia; Prieto-Hontoria, Pedro L.; Houssier, Marianne; Burrell, María A.; Langin, Dominique; Martínez, J. Alfredo; Moreno-Aliaga, María J. (Biochimica et biophysica acta, 2015)
Keywords: acetylation; Acetylation - drug effects; acid treatment; adipocytes; Adipocytes, Brown - drug effects; Adipocytes, Brown - metabolism; Adipocytes, Brown - pathology; antioxidants; Antioxidants - pharmacology; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; beta oxidation; biogenesis; Brown adipose tissue; Carnitine O-Palmitoyltransferase - genetics; Carnitine O-Palmitoyltransferase - metabolism; carnitine palmitoyltransferase; Cell Differentiation; DNA Copy Number Variations - drug effects; DNA, Mitochondrial - agonists; DNA, Mitochondrial - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; electron microscopy; Female; Gene Expression Regulation; genes; Human adipocyte; Humans; lipoic acid; messenger RNA; mitochondria; Mitochondria - drug effects; Mitochondria - genetics; Mitochondrial biogenesis; mitochondrial DNA; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; Mitochondrial Turnover - drug effects; Nuclear Respiratory Factor 1 - genetics; Nuclear Respiratory Factor 1 - metabolism; Obesity; Obesity - metabolism; Obesity - pathology; overweight; Oxidoreductases - genetics; Oxidoreductases - metabolism; oxygen consumption; Oxygen Consumption - drug effects; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Primary Cell Culture; Signal Transduction; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Subcutaneous Fat - drug effects; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; T-Box Domain Proteins - genetics; T-Box Domain Proteins - metabolism; Thioctic Acid - pharmacology; transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; α-Lipoic acid; α-Lipoic acid; mtDNA; UCP1; Brown adipose tissue; Nrf1; α-Lip; LDH; BSA; Mitochondrial biogenesis; EFTEM; Tfam; CD36; ASM; MTCO2; BMI; TBX1; BCA; Obesity; Human adipocyte; CIDEA; Prdm16; PGC-1α; PVDF; PPARγ; Acox; AMPK; Sirt1; TEM; CPT-1