Chain-mediating effect of interaction between telomeres and mitochondria under oxidative stress in coke oven workers

• Published in: Environmental pollution (1987) Vol. 331; no. Pt 1; p. 121855
• Main Authors: Gu, Zhiguang, Niu, Zeming, Yan, Zhaofan, Fan, Yahui, Sun, Jing, Zhao, Xiangkai, Duan, Xiaoran, Yao, Wu, Yang, Yongli, Wang, Wei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.08.2023
• Subjects: antioxidant activity; blood; Chain-mediating effect; Coke oven emissions; computer software; dose response; fluorescence; linear models; mitochondria; mitochondrial DNA; Mitochondrial DNA copy Number; ovens; oxidants; Oxidative stress; pollution; quantitative polymerase chain reaction; Relative telomere length; telomeres; Oxidative stress; Coke oven emissions; Relative telomere length; Mitochondrial DNA copy Number; Chain-mediating effect

Coke oven emissions (COEs) exposure leads to oxidative stress, an imbalance between oxidant production and antioxidant defence in the body, which then leads to shortened relative telomere length (RTL) and reduced mitochondrial DNA copy number (mtDNAcn), ultimately leading to ageing and disease. By a...