Mitochondrial UCP1: Potential thermogenic mechanistic switch for the treatment of obesity and neurodegenerative diseases using natural and epigenetic drug candidates
Brown fat is known to provide non-shivering thermogenesis through mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1). Non-shivering is not dependent on UCP2, UCP4, and BMCP1/UCP5 genes, which are distinct from UCP1 in a way that they are not constitutive uncouplers. Although they are s...
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| Published in | Phytomedicine (Stuttgart) Vol. 130; p. 155672 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
Elsevier GmbH
25.07.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0944-7113 1618-095X 1618-095X |
| DOI | 10.1016/j.phymed.2024.155672 |
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| Abstract | Brown fat is known to provide non-shivering thermogenesis through mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1). Non-shivering is not dependent on UCP2, UCP4, and BMCP1/UCP5 genes, which are distinct from UCP1 in a way that they are not constitutive uncouplers. Although they are susceptible to free fatty acid and free radical activation, their functioning has a significant impact on the performance of neurons.
Using subject-specific keywords (Adipose tissue; Adipocytes; Mitochondria; Obesity; Thermogenesis; UCP's in Neurodegeneration; Alzheimer's disease; Parkinson's disease), research articles and reviews were retrieved from Web of Science, ScienceDirect, Google Scholar, and PubMed. This article includespublications published between 2018 and 2023. The drugs that upregulate UCP1 are included in the study while the drugs that do not impact UCP1 are were not included.
Neuronal UCPs have a direct impact on synaptic plasticity, neurodegenerative processes, and neurotransmission, by modulating calcium flux, mitochondrial biogenesis, local temperature, and free radical generation. Numerous significant advances in the study of neuronal UCPs and neuroprotection are still to be made. Identification of the tissue-dependent effects of UCPs is essential first. Pharmacologically targeting neuronal UCPs is a key strategy for preventing both neurodegenerative diseases and physiological aging. Given that UCP2 has activities that are tissue-specific, it will be essential to develop treatments without harmful side effects. The triggering of UCPs by CoQ, an essential cofactor, produces nigral mitochondrial uncoupling, reduces MPTP-induced toxicity, and may even decrease the course of Parkinson's disease, according to early indications.
Herein, we explore the potential of UCP1 as a therapeutic target for treating obesity, neurodegenerative diseases as well as a potential activator of both synthetic and natural drugs. A deeper knowledge of synaptic signaling and neurodegeneration may pave the way to new discoveries regarding the functioning and controlling of these genes. |
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| AbstractList | Brown fat is known to provide non-shivering thermogenesis through mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1). Non-shivering is not dependent on UCP2, UCP4, and BMCP1/UCP5 genes, which are distinct from UCP1 in a way that they are not constitutive uncouplers. Although they are susceptible to free fatty acid and free radical activation, their functioning has a significant impact on the performance of neurons.
Using subject-specific keywords (Adipose tissue; Adipocytes; Mitochondria; Obesity; Thermogenesis; UCP's in Neurodegeneration; Alzheimer's disease; Parkinson's disease), research articles and reviews were retrieved from Web of Science, ScienceDirect, Google Scholar, and PubMed. This article includespublications published between 2018 and 2023. The drugs that upregulate UCP1 are included in the study while the drugs that do not impact UCP1 are were not included.
Neuronal UCPs have a direct impact on synaptic plasticity, neurodegenerative processes, and neurotransmission, by modulating calcium flux, mitochondrial biogenesis, local temperature, and free radical generation. Numerous significant advances in the study of neuronal UCPs and neuroprotection are still to be made. Identification of the tissue-dependent effects of UCPs is essential first. Pharmacologically targeting neuronal UCPs is a key strategy for preventing both neurodegenerative diseases and physiological aging. Given that UCP2 has activities that are tissue-specific, it will be essential to develop treatments without harmful side effects. The triggering of UCPs by CoQ, an essential cofactor, produces nigral mitochondrial uncoupling, reduces MPTP-induced toxicity, and may even decrease the course of Parkinson's disease, according to early indications.
Herein, we explore the potential of UCP1 as a therapeutic target for treating obesity, neurodegenerative diseases as well as a potential activator of both synthetic and natural drugs. A deeper knowledge of synaptic signaling and neurodegeneration may pave the way to new discoveries regarding the functioning and controlling of these genes. Brown fat is known to provide non-shivering thermogenesis through mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1). Non-shivering is not dependent on UCP2, UCP4, and BMCP1/UCP5 genes, which are distinct from UCP1 in a way that they are not constitutive uncouplers. Although they are susceptible to free fatty acid and free radical activation, their functioning has a significant impact on the performance of neurons. Using subject-specific keywords (Adipose tissue; Adipocytes; Mitochondria; Obesity; Thermogenesis; UCP's in Neurodegeneration; Alzheimer's disease; Parkinson's disease), research articles and reviews were retrieved from Web of Science, ScienceDirect, Google Scholar, and PubMed. This article includespublications published between 2018 and 2023. The drugs that upregulate UCP1 are included in the study while the drugs that do not impact UCP1 are were not included. Neuronal UCPs have a direct impact on synaptic plasticity, neurodegenerative processes, and neurotransmission, by modulating calcium flux, mitochondrial biogenesis, local temperature, and free radical generation. Numerous significant advances in the study of neuronal UCPs and neuroprotection are still to be made. Identification of the tissue-dependent effects of UCPs is essential first. Pharmacologically targeting neuronal UCPs is a key strategy for preventing both neurodegenerative diseases and physiological aging. Given that UCP2 has activities that are tissue-specific, it will be essential to develop treatments without harmful side effects. The triggering of UCPs by CoQ, an essential cofactor, produces nigral mitochondrial uncoupling, reduces MPTP-induced toxicity, and may even decrease the course of Parkinson's disease, according to early indications. Herein, we explore the potential of UCP1 as a therapeutic target for treating obesity, neurodegenerative diseases as well as a potential activator of both synthetic and natural drugs. A deeper knowledge of synaptic signaling and neurodegeneration may pave the way to new discoveries regarding the functioning and controlling of these genes. Brown fat is known to provide non-shivering thermogenesis through mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1). Non-shivering is not dependent on UCP2, UCP4, and BMCP1/UCP5 genes, which are distinct from UCP1 in a way that they are not constitutive uncouplers. Although they are susceptible to free fatty acid and free radical activation, their functioning has a significant impact on the performance of neurons.BACKGROUNDBrown fat is known to provide non-shivering thermogenesis through mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1). Non-shivering is not dependent on UCP2, UCP4, and BMCP1/UCP5 genes, which are distinct from UCP1 in a way that they are not constitutive uncouplers. Although they are susceptible to free fatty acid and free radical activation, their functioning has a significant impact on the performance of neurons.Using subject-specific keywords (Adipose tissue; Adipocytes; Mitochondria; Obesity; Thermogenesis; UCP's in Neurodegeneration; Alzheimer's disease; Parkinson's disease), research articles and reviews were retrieved from Web of Science, ScienceDirect, Google Scholar, and PubMed. This article includespublications published between 2018 and 2023. The drugs that upregulate UCP1 are included in the study while the drugs that do not impact UCP1 are were not included.METHODOLOGYUsing subject-specific keywords (Adipose tissue; Adipocytes; Mitochondria; Obesity; Thermogenesis; UCP's in Neurodegeneration; Alzheimer's disease; Parkinson's disease), research articles and reviews were retrieved from Web of Science, ScienceDirect, Google Scholar, and PubMed. This article includespublications published between 2018 and 2023. The drugs that upregulate UCP1 are included in the study while the drugs that do not impact UCP1 are were not included.Neuronal UCPs have a direct impact on synaptic plasticity, neurodegenerative processes, and neurotransmission, by modulating calcium flux, mitochondrial biogenesis, local temperature, and free radical generation. Numerous significant advances in the study of neuronal UCPs and neuroprotection are still to be made. Identification of the tissue-dependent effects of UCPs is essential first. Pharmacologically targeting neuronal UCPs is a key strategy for preventing both neurodegenerative diseases and physiological aging. Given that UCP2 has activities that are tissue-specific, it will be essential to develop treatments without harmful side effects. The triggering of UCPs by CoQ, an essential cofactor, produces nigral mitochondrial uncoupling, reduces MPTP-induced toxicity, and may even decrease the course of Parkinson's disease, according to early indications.RESULTSNeuronal UCPs have a direct impact on synaptic plasticity, neurodegenerative processes, and neurotransmission, by modulating calcium flux, mitochondrial biogenesis, local temperature, and free radical generation. Numerous significant advances in the study of neuronal UCPs and neuroprotection are still to be made. Identification of the tissue-dependent effects of UCPs is essential first. Pharmacologically targeting neuronal UCPs is a key strategy for preventing both neurodegenerative diseases and physiological aging. Given that UCP2 has activities that are tissue-specific, it will be essential to develop treatments without harmful side effects. The triggering of UCPs by CoQ, an essential cofactor, produces nigral mitochondrial uncoupling, reduces MPTP-induced toxicity, and may even decrease the course of Parkinson's disease, according to early indications.Herein, we explore the potential of UCP1 as a therapeutic target for treating obesity, neurodegenerative diseases as well as a potential activator of both synthetic and natural drugs. A deeper knowledge of synaptic signaling and neurodegeneration may pave the way to new discoveries regarding the functioning and controlling of these genes.CONCLUSIONHerein, we explore the potential of UCP1 as a therapeutic target for treating obesity, neurodegenerative diseases as well as a potential activator of both synthetic and natural drugs. A deeper knowledge of synaptic signaling and neurodegeneration may pave the way to new discoveries regarding the functioning and controlling of these genes. |
| ArticleNumber | 155672 |
| Author | Reyad-ul-Ferdous, Md Raheem, Muhammad Akmal Qin, Peiwu Gul, Ijaz Pandey, Vijay |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38810549$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_feduc_2025_1518602 crossref_primary_10_1016_j_ijbiomac_2024_134448 crossref_primary_10_1113_JP286955 |
| Cites_doi | 10.1155/2022/3062274 10.1080/15548627.2020.1753002 10.1016/j.jbc.2022.101606 10.1038/s41586-022-04747-5 10.1007/s13679-020-00422-w 10.1038/ncomms6493 10.1007/s12272-023-01432-7 10.1038/s41419-019-1706-y 10.1016/S0140-6736(22)02403-5 10.1124/jpet.116.237925 10.1038/s42003-022-03895-8 10.3389/fendo.2020.00633 10.1016/j.metabol.2017.09.008 10.1038/s41366-021-01019-6 10.3390/cells12050714 10.1038/s41598-022-10644-8 10.1038/nrm.2016.96 10.1038/s41556-023-01155-3 10.1016/j.jscs.2022.101454 10.1016/j.biopha.2022.113808 10.1038/s41586-021-04127-5 10.1016/j.pharmthera.2020.107705 10.1017/jns.2022.53 10.1210/en.2003-0163 10.1016/j.ijbiomac.2022.09.285 10.3390/nu15020444 10.1016/j.jnutbio.2021.108898 10.1016/j.canlet.2018.10.016 10.3390/ijms23020956 10.1038/s41586-022-05507-1 10.1016/j.jjcc.2021.09.013 10.1038/nature13816 10.1016/j.biochi.2016.09.003 10.3389/fonc.2023.1122789 10.1038/s42003-022-03531-5 10.3390/cells10051122 10.3389/fnmol.2019.00252 10.3389/fphys.2022.1066023 10.1007/s00360-021-01362-0 10.1155/2011/525094 10.1038/s41398-020-0709-x 10.1016/j.molmet.2021.101411 10.1016/j.jnutbio.2020.108532 10.1080/07391102.2021.2024255 10.1002/biof.1610 10.1038/s41585-023-00764-9 10.1111/bph.13514 10.1007/s11095-022-03377-w 10.1080/07391102.2021.1930168 10.1038/s41573-021-00337-8 10.1080/15548627.2020.1850008 10.1016/j.cmet.2020.07.005 10.1007/s10863-019-09798-4 10.1194/jlr.M091173 10.1016/j.bbrc.2022.01.059 10.1038/srep38579 10.1002/hep.27371 10.1074/jbc.M116.768820 10.33549/physiolres.934674 10.3390/biomedicines11041208 10.1096/fj.202101905RR 10.2147/JEP.S265626 10.1038/nrn1767 10.1016/j.ebiom.2022.103969 10.1124/dmd.121.000453 10.1016/j.drudis.2018.09.013 10.4049/jimmunol.2100901 10.4103/1673-5374.360279 10.1016/j.orcp.2021.08.003 10.1271/bbb.100850 10.1016/j.molmet.2022.101526 10.1007/s40199-023-00458-y 10.1016/j.biochi.2016.10.013 10.1152/ajpheart.00005.2022 10.1038/s41467-017-00948-z 10.1016/j.ebiom.2018.10.019 10.1186/s40035-022-00321-1 10.3389/fendo.2020.572981 10.3390/cells11132038 10.1016/j.molmet.2023.101714 10.1016/j.expneurol.2020.113309 10.1016/j.apsb.2018.09.007 10.3390/ijms22084180 10.1007/s12640-023-00647-2 10.1073/pnas.2218510120 |
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| Keywords | FFA Adipose tissue ATGL HFD UCP1 CNS WAT COVID-19 Mitochondria pufas TRP PPAR UCPs CAGR BMI WHO HSL Obesity lcfas GLP-1 TRPV ISO IMM DIO2 tags SIRT-1 MAG Thermogenesis TH BAT ETC AMPK Alzheimer's disease and Parkinson's disease FA MPTP DHA PL lxrs TZD |
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| References | John, Petersen, Gerstenberg, Torz, Pedersen, Christoffersen, Kuhre (bib0027) 2022; 5 Baskaran, Krishnan, Ren, Thyagarajan (bib0004) 2016; 173 Qiu, Sun, Xu, Yang, Liu, Wei, Chen, Feng, Li, Reyad-Ul Ferdous, Zhao, Xu, Lao, Ding (bib0061) 2018; 37 Mangrulkar, Wankhede, Kale, Upaganlawar, Taksande, Umekar, Anwer, Dailah, Mohan, Behl (bib0042) 2023 Pei, Otieno, Gu, Lee, Parks, Schimmel, Kang (bib0055) 2021; 88 Szymczak-Pajor, Miazek, Selmi, Balcerczyk, Śliwińska (bib0079) 2022; 23 Liskiewicz, Zhang, Barthem, Jastroch, Liskiewicz, Khajavi, Grandl, Coupland, Kleinert, Garcia-Caceres, Novikoff, Maity, Boehm, Tschöp, Müller (bib0036) 2023; 72 Mahboobifard, Pourgholami, Jorjani, Dargahi, Amiri, Sadeghi, Tehrani (bib0041) 2022; 156 Simons, Benkert, Deuter, Poetschke, Pongs, Schneider, Duda, Liss (bib0075) 2019; 12 Tak, Lee (bib0080) 2021; 10 Müller, Blüher, Tschöp, DiMarchi (bib0049) 2022; 21 Li, Tang (bib0033) 2021; 15 Ko, Yun, Baek, Jang, Hwang, Lee, Heo, Bader, Lee, Han, Moon, Lee, Hong, Lee, Kim, Park, Hartig, Kang, Moore, Koh, Lee (bib0028) 2021; 17 Calderon, Gonzalez-Izundegui, Shan, Garcia-Valencia, Cifuentes, Campos, Collazo-Clavell, Shah, Hurley, Abu Lebdeh, Sharma, Schmitz, Clark, Grothe, Mundi, Camilleri, Abu Dayyeh, Hurtado Andrade, Mokadem, Acosta (bib0008) 2022; 46 Sawano, Fukushima, Akasaka, Nakamura, Tatsumi, Ikeuchi, Mizunoya (bib0072) 2023 Horvath, Diano, Leranth, Garcia-Segura, Cowley, Shanabrough, Elsworth, Sotonyi, Roth, Dietrich, Matthews, Barnstable, Redmond (bib0022) 2003; 144 Reyad-Ul-Ferdous, Song (bib0066) 2022; 222 Li, Li, Xiang, Dong, Liu, Xiang (bib0034) 2018; 78 Matesanz, Bernardo, Acín-Pérez, Manieri, Pérez-Sieira, Hernández-Cosido, Montalvo-Romeral, Mora, Rodríguez, Leiva-Vega, Lechuga-Vieco, Ruiz-Cabello, Torres, Crespo-Ruiz, Centeno, Álvarez, Marcos, Enríquez, Nogueiras, Sabio (bib0044) 2017; 8 Jia, Guo, Yao (bib0026) 2019; 17 Wu, Xia, Duan, Zhang, Jiang, Hu, Yan, Zhang, Gu, Shi, Li, Gao, Li (bib0092) 2019; 10 Reyad-ul-Ferdous, Abdalla, Yang, Xiaoling, Bian, Xie, Song (bib0065) 2022; 26 Decourt, Noorda, Noorda, Shi, Sabbagh (bib0012) 2022; 14 McKie, Medak, Shamshoum, Wright (bib0046) 2022; 36 Bertholet, Natale, Bisignano, Suzuki, Fedorenko, Hamilton, Brustovetsky, Kazak, Garrity, Chouchani, Brustovetsky, Grabe, Kirichok (bib0006) 2022; 606 Tanaka, Nagoshi, Takahashi, Oi, Yoshii, Kimura, Ito, Kashiwagi, Tanaka, Yoshimura (bib0085) 2022; 55 Matsuyama, Komatsu, Lee, Tasaki, Miyata, Xu, Shuto, Kai, Li (bib0045) 2022; 209 Nishimoto, Nakajima, Tateya, Saito, Ogawa, Tamori (bib0051) 2017; 292 Dolgacheva, Berezhnov, Fedotova, Zinchenko, Abramov (bib0014) 2019; 51 Jastroch, Polymeropoulos, Gaudry (bib0025) 2021; 191 Mehta, Ratre, Soni, Shukla, Sonkar, Kumar, Vishvakarma (bib0047) 2023; 13 Liu, Wang, Lin (bib0039) 2019; 9 Tauriainen, Luostarinen, Martonen, Finckenberg, Kovalainen, Huotari, Herzig, Lecklin, Mervaala (bib0087) 2011 Xie, Liu, Liu, Chen, Wang, Zu, Ma, Wang, Wu, Zheng, Bode, Dong, Kim (bib0094) 2019; 442 Wang, Seale (bib0091) 2016; 17 Marsh, Oliveira, Vieira-Potter (bib0043) 2023; 15 S N C, Sengupta, Palawat, P S, George, Paul (bib0068) 2022; 40 Fu, Sun, Xue, Zhou, Wang, Guo, Chen, Zhou, Xu, Liu, Xiao, Mao, Yang, Yin, Zhang, Wan, Lu, Chen, Zhu, Scherer, Fang, Piao, Shao, Gan (bib0019) 2023 Saito, Yamaguchi, Kuroda, Kitai, Yonetsu, Kohsaka, Torii, Node, Matsumoto, Matsue, Kodama (bib0070) 2022; 79 Suksawad, Udompornpitak, Thawinpipat, Korwattanamongkol, Visitchanakun, Phuengmaung, Saisorn, Kueanjinda, Leelahavanichkul (bib0077) 2023; 11 Raj, Lofquist, Lee (bib0062) 2023; 40 Pendergrast, Lundell, Ehrlich, Ashcroft, Schönke, Basse, Krook, Treebak, Dollet, Zierath (bib0056) 2023; 120 Duggirala, Geary, Hasenmayer, Daghigh (bib0016) 2022; 2022 Miao, Su, Dai, Wu, Huang, Barros, Nguyen, Maneix, Guan, Warner, Gustafsson (bib0048) 2016; 6 Pan, Zhu, Maretich, Chen (bib0054) 2020; 11 Saha, Kolonin, DiGiovanni (bib0069) 2023; 20 Ferdous, Abdalla, Yang, Xiaoling, Song (bib0017) 2023; 41 Præstholm, Correia, Grøntved (bib0059) 2020; 11 Gnad, Scheibler, von Kügelgen, Scheele, Kilić, Glöde, Hoffmann, Reverte-Salisa, Horn, Mutlu, El-Tayeb, Kranz, Deuther-Conrad, Brust, Lidell, Betz, Enerbäck, Schrader, Yegutkin, Müller, Pfeifer (bib0020) 2014; 516 Reyad-ul-Ferdous, Abdalla, Song (bib0064) 2022; 26 Cavalieri, Hazebroek, Cotrim, Lee, Kunji, Jastroch, Keipert, Crichton (bib0010) 2022; 62 Liu, Li, Yang, Wang, Xu, Chen, Zhang, Shi, Li, Zhao, Gao, Chen, Ma, Zheng, Wu, Zhang, Chen, Qian, Bi, Gu, Tang, Ning, Liu, Wang, Hong, Wang (bib0040) 2022; 78 Takeda, Dai (bib0081) 2022; 12 Salatto, Miller, Cameron, Cokorinos, Reyes, Ward, Calabrese, Kurumbail, Rajamohan, Kalgutkar, Tess, Shavnya, Genung, Edmonds, Jatkar, Maciejewski, Amaro, Gandhok, Monetti, Cialdea, Bollinger, Kreeger, Coskran, Opsahl, Boucher, Birnbaum, DaSilva-Jardine, Rolph (bib0071) 2017; 361 Shamardl, Ibrahim, Merzeban, Elamir, Golam, Elsayed (bib0073) 2023; 31 Qian, Tol, Wu, Uchiyama, Xiao, Cui, Bedard, Weston, Rajendran, Vergnes, Shimanaka, Yin, Jami-Alahmadi, Cohn, Bajar, Lin, Jin, DeNardo, Black, Whitelegge, Wohlschlegel, Reue, Shivkumar, Chen, Young, Li, Tontonoz (bib0060) 2023; 613 Takeda, Dai (bib0082) 2022; 11 Perdomo, Cohen, Sumithran, Clément, Frühbeck (bib0057) 2023; 401 Wang, Li, Cao, Shi, Zhu, Zhang, Cheng, Wen, Xu, Zhu, Zhang, Perry, Spadaro, Yang, He, Chen, Wang, Li, Liu, Yang, Wu, Zhou, Zhou, Ju, Lu, Xin, Yang, Wang, Liu, Shulman, Dixit, Lu, Yang, Flavell, Yin (bib0090) 2021; 600 Liu, Ho, Leung, Pang, Chang, Choi, Kung, Ramsden, Ho (bib0037) 2021; 17 Zhang, He, Wu, Li, Lin, Gan, Chen, Zhao, Niu, Zhang, Li, Zhu, Shen (bib0096) 2022; 23 Zhou, Zhang, You, Wang, Wang, Wang, Kong, Gao, Sun (bib0098) 2022; 13 Kobayashi, Shimizu, Tanaka, Kuramochi, Nakai, Nakajima, Taguchi (bib0029) 2022; 298 Li, Yang, Sun, Ferdous, Gao, Zhao, Song (bib0035) 2022; 594 Xiang, Cheng, Zhou, Ma (bib0093) 2020; 46 Simmons, Scholpa, Schnellmann (bib0074) 2020; 329 Blondin, Nielsen, Kuipers, Severinsen, Jensen, Miard, Jespersen, Kooijman, Boon, Fortin, Phoenix, Frisch, Guérin, Turcotte É, Haman, Richard, Picard, Rensen, Scheele, Carpentier (bib0007) 2020; 32 Zhang, Zhang, Li, Meng, Wang, Zhang, Yao, Ma, Jin, Yang, Wang, Ning (bib0097) 2014; 5 Reyad-ul-Ferdous, Song, Zhang, Pandey (bib0067) 2022; 26 Bertholet, Kirichok (bib0005) 2017; 134 Iwasaki, Tamura, Inayoshi, Narukawa, Kobata, Chiba, Muraki, Tsunoda, Watanabe (bib0023) 2011; 75 Sirotkin, Kolesárová (bib0076) 2021; 70 Zhu, Steinberg (bib0099) 2022; 322 Lee, Benvie, Park, Spektor, Harlan, Brenna, Berry, Soloway (bib0032) 2022; 5 Oliveira, Bauer, Ribeiro, Pereira, Beserra, Wajner, Maia, Neves, Coelho, Amato (bib0052) 2021; 12 Čater, Križančić Bombek (bib0009) 2022 Tanaka, Mitani, Nakashima, Yonemoto, Fujii, Ashida (bib0084) 2022; 100 Wang, Zhang, Xia, Cui (bib0089) 2022; 50 Ray, Maloney, Sambamurti, Karnati, Nelson, Greig, Lahiri (bib0063) 2020; 10 Lee, Jash, Jones, Puri, Fried (bib0031) 2019; 60 Tan, Zhang, Wang, Haberer (bib0083) 2022; 11 Fu, Sun, Xue, Zhou, Wang, Guo, Chen, Zhou, Xu, Liu, Xiao, Mao, Yang, Yin, Zhang, Wan, Lu, Chen, Zhu, Scherer, Fang, Piao, Shao, Gan (bib0018) 2023; 25 Pessoa, Duarte (bib0058) 2023; 18 Szallasi (bib0078) 2022 Andrews, Diano, Horvath (bib0003) 2005; 6 Pacifici, Malatesta, Mammi, Pastore, Marzolla, Ricordi, Chiereghin, Infante, Donadel, Curcio, Noce, Rovella, Lauro, Tesauro, Di Daniele, Garaci, Caprio, Della-Morte (bib0053) 2023; 12 Akter, Afrose, Rahman, Chowdhury, Nirzhor, Khan, Kabir (bib0002) 2021; 22 Xu, Park, So, Lee (bib0095) 2015; 61 Jamwal, Blackburn, Elsworth (bib0024) 2021; 219 Lee, Heo, Song, Lee, Choi (bib0030) 2023; 46 Liu, Lin (bib0038) 2019; 24 van der Vaart, Boon, Houtkooper (bib0088) 2021; 10 Nicholls (bib0050) 2017; 134 Abdalla, Harb, Almasri, Bustanji (bib0001) 2022; 13 Hirschfeld, Risacher, Nho, Saykin (bib0021) 2022; 11 Xie (10.1016/j.phymed.2024.155672_bib0094) 2019; 442 Xu (10.1016/j.phymed.2024.155672_bib0095) 2015; 61 Xiang (10.1016/j.phymed.2024.155672_bib0093) 2020; 46 Tauriainen (10.1016/j.phymed.2024.155672_bib0087) 2011 Matesanz (10.1016/j.phymed.2024.155672_bib0044) 2017; 8 John (10.1016/j.phymed.2024.155672_bib0027) 2022; 5 Liu (10.1016/j.phymed.2024.155672_bib0037) 2021; 17 Akter (10.1016/j.phymed.2024.155672_bib0002) 2021; 22 Horvath (10.1016/j.phymed.2024.155672_bib0022) 2003; 144 Nicholls (10.1016/j.phymed.2024.155672_bib0050) 2017; 134 Lee (10.1016/j.phymed.2024.155672_bib0032) 2022; 5 Perdomo (10.1016/j.phymed.2024.155672_bib0057) 2023; 401 Fu (10.1016/j.phymed.2024.155672_bib0018) 2023; 25 Nishimoto (10.1016/j.phymed.2024.155672_bib0051) 2017; 292 Qian (10.1016/j.phymed.2024.155672_bib0060) 2023; 613 Reyad-ul-Ferdous (10.1016/j.phymed.2024.155672_bib0065) 2022; 26 Bertholet (10.1016/j.phymed.2024.155672_bib0006) 2022; 606 Cavalieri (10.1016/j.phymed.2024.155672_bib0010) 2022; 62 Baskaran (10.1016/j.phymed.2024.155672_bib0004) 2016; 173 Hirschfeld (10.1016/j.phymed.2024.155672_bib0021) 2022; 11 Li (10.1016/j.phymed.2024.155672_bib0034) 2018; 78 Jastroch (10.1016/j.phymed.2024.155672_bib0025) 2021; 191 Szallasi (10.1016/j.phymed.2024.155672_bib0078) 2022 Sirotkin (10.1016/j.phymed.2024.155672_bib0076) 2021; 70 Ko (10.1016/j.phymed.2024.155672_bib0028) 2021; 17 Tanaka (10.1016/j.phymed.2024.155672_bib0085) 2022; 55 Calderon (10.1016/j.phymed.2024.155672_bib0008) 2022; 46 Wang (10.1016/j.phymed.2024.155672_bib0089) 2022; 50 Pei (10.1016/j.phymed.2024.155672_bib0055) 2021; 88 Wu (10.1016/j.phymed.2024.155672_bib0092) 2019; 10 Qiu (10.1016/j.phymed.2024.155672_bib0061) 2018; 37 Pacifici (10.1016/j.phymed.2024.155672_bib0053) 2023; 12 Shamardl (10.1016/j.phymed.2024.155672_bib0073) 2023; 31 Li (10.1016/j.phymed.2024.155672_bib0033) 2021; 15 Dolgacheva (10.1016/j.phymed.2024.155672_bib0014) 2019; 51 Tan (10.1016/j.phymed.2024.155672_bib0083) 2022; 11 Müller (10.1016/j.phymed.2024.155672_bib0049) 2022; 21 McKie (10.1016/j.phymed.2024.155672_bib0046) 2022; 36 Ray (10.1016/j.phymed.2024.155672_bib0063) 2020; 10 Pessoa (10.1016/j.phymed.2024.155672_bib0058) 2023; 18 Abdalla (10.1016/j.phymed.2024.155672_bib0001) 2022; 13 Mehta (10.1016/j.phymed.2024.155672_bib0047) 2023; 13 Tanaka (10.1016/j.phymed.2024.155672_bib0084) 2022; 100 Suksawad (10.1016/j.phymed.2024.155672_bib0077) 2023; 11 Mangrulkar (10.1016/j.phymed.2024.155672_bib0042) 2023 Zhu (10.1016/j.phymed.2024.155672_bib0099) 2022; 322 Lee (10.1016/j.phymed.2024.155672_bib0030) 2023; 46 Zhou (10.1016/j.phymed.2024.155672_bib0098) 2022; 13 Blondin (10.1016/j.phymed.2024.155672_bib0007) 2020; 32 Decourt (10.1016/j.phymed.2024.155672_bib0012) 2022; 14 Zhang (10.1016/j.phymed.2024.155672_bib0096) 2022; 23 Kobayashi (10.1016/j.phymed.2024.155672_bib0029) 2022; 298 Reyad-ul-Ferdous (10.1016/j.phymed.2024.155672_bib0067) 2022; 26 Miao (10.1016/j.phymed.2024.155672_bib0048) 2016; 6 Marsh (10.1016/j.phymed.2024.155672_bib0043) 2023; 15 Jamwal (10.1016/j.phymed.2024.155672_bib0024) 2021; 219 Takeda (10.1016/j.phymed.2024.155672_bib0081) 2022; 12 Oliveira (10.1016/j.phymed.2024.155672_bib0052) 2021; 12 Matsuyama (10.1016/j.phymed.2024.155672_bib0045) 2022; 209 Szymczak-Pajor (10.1016/j.phymed.2024.155672_bib0079) 2022; 23 Bertholet (10.1016/j.phymed.2024.155672_bib0005) 2017; 134 Liu (10.1016/j.phymed.2024.155672_bib0040) 2022; 78 Pan (10.1016/j.phymed.2024.155672_bib0054) 2020; 11 Lee (10.1016/j.phymed.2024.155672_bib0031) 2019; 60 Ferdous (10.1016/j.phymed.2024.155672_bib0017) 2023; 41 Sawano (10.1016/j.phymed.2024.155672_bib0072) 2023 Čater (10.1016/j.phymed.2024.155672_bib0009) 2022 Fu (10.1016/j.phymed.2024.155672_bib0019) 2023 Jia (10.1016/j.phymed.2024.155672_bib0026) 2019; 17 van der Vaart (10.1016/j.phymed.2024.155672_bib0088) 2021; 10 Simmons (10.1016/j.phymed.2024.155672_bib0074) 2020; 329 Takeda (10.1016/j.phymed.2024.155672_bib0082) 2022; 11 Duggirala (10.1016/j.phymed.2024.155672_bib0016) 2022; 2022 S N C (10.1016/j.phymed.2024.155672_bib0068) 2022; 40 Tak (10.1016/j.phymed.2024.155672_bib0080) 2021; 10 Raj (10.1016/j.phymed.2024.155672_bib0062) 2023; 40 Mahboobifard (10.1016/j.phymed.2024.155672_bib0041) 2022; 156 Saha (10.1016/j.phymed.2024.155672_bib0069) 2023; 20 Reyad-Ul-Ferdous (10.1016/j.phymed.2024.155672_bib0066) 2022; 222 Præstholm (10.1016/j.phymed.2024.155672_bib0059) 2020; 11 Simons (10.1016/j.phymed.2024.155672_bib0075) 2019; 12 Wang (10.1016/j.phymed.2024.155672_bib0090) 2021; 600 Wang (10.1016/j.phymed.2024.155672_bib0091) 2016; 17 Saito (10.1016/j.phymed.2024.155672_bib0070) 2022; 79 Zhang (10.1016/j.phymed.2024.155672_bib0097) 2014; 5 Gnad (10.1016/j.phymed.2024.155672_bib0020) 2014; 516 Reyad-ul-Ferdous (10.1016/j.phymed.2024.155672_bib0064) 2022; 26 Salatto (10.1016/j.phymed.2024.155672_bib0071) 2017; 361 Pendergrast (10.1016/j.phymed.2024.155672_bib0056) 2023; 120 Iwasaki (10.1016/j.phymed.2024.155672_bib0023) 2011; 75 Andrews (10.1016/j.phymed.2024.155672_bib0003) 2005; 6 Li (10.1016/j.phymed.2024.155672_bib0035) 2022; 594 Liu (10.1016/j.phymed.2024.155672_bib0038) 2019; 24 Liu (10.1016/j.phymed.2024.155672_bib0039) 2019; 9 Liskiewicz (10.1016/j.phymed.2024.155672_bib0036) 2023; 72 |
| References_xml | – volume: 329 year: 2020 ident: bib0074 article-title: Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases publication-title: Exp. Neurol. – volume: 11 start-page: 633 year: 2020 ident: bib0054 article-title: Metabolic improvement via enhancing thermogenic fat-mediated non-shivering thermogenesis: from rodents to humans publication-title: Front. Endocrinol. (Lausanne) – volume: 6 start-page: 829 year: 2005 end-page: 840 ident: bib0003 article-title: Mitochondrial uncoupling proteins in the CNS: in support of function and survival publication-title: Nat. Rev. Neurosci. – volume: 46 start-page: 555 year: 2022 end-page: 563 ident: bib0008 article-title: Effectiveness of anti-obesity medications approved for long-term use in a multidisciplinary weight management program: a multi-center clinical experience publication-title: Int. J. Obes. (Lond.) – volume: 10 start-page: 47 year: 2020 ident: bib0063 article-title: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease publication-title: Transl. Psychiatry – volume: 5 start-page: 5493 year: 2014 ident: bib0097 article-title: Berberine activates thermogenesis in white and brown adipose tissue publication-title: Nat. Commun. – volume: 46 start-page: 943 year: 2020 end-page: 954 ident: bib0093 article-title: Effects of 1,25(OH)(2) D(3) on lipid droplet growth in adipocytes publication-title: Biofactors – volume: 11 year: 2020 ident: bib0059 article-title: Multifaceted control of GR signaling and its impact on hepatic transcriptional networks and metabolism publication-title: Front. Endocrinol. (Lausanne) – volume: 606 start-page: 180 year: 2022 end-page: 187 ident: bib0006 article-title: Mitochondrial uncouplers induce proton leak by activating AAC and UCP1 publication-title: Nature – volume: 75 start-page: 904 year: 2011 end-page: 909 ident: bib0023 article-title: TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet publication-title: Biosci. Biotechnol. Biochem. – volume: 17 start-page: 3196 year: 2021 end-page: 3220 ident: bib0037 article-title: Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2(R1441G) mice publication-title: Autophagy – volume: 22 year: 2021 ident: bib0002 article-title: A comprehensive analysis into the therapeutic application of natural products as SIRT6 modulators in Alzheimer's disease, aging, cancer, inflammation, and diabetes publication-title: Int. J. Mol. Sci. – volume: 37 start-page: 344 year: 2018 end-page: 355 ident: bib0061 article-title: Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue publication-title: EBioMedicine – volume: 600 start-page: 314 year: 2021 end-page: 318 ident: bib0090 article-title: IL-27 signalling promotes adipocyte thermogenesis and energy expenditure publication-title: Nature – volume: 144 start-page: 2757 year: 2003 end-page: 2760 ident: bib0022 article-title: Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease publication-title: Endocrinology – volume: 21 start-page: 201 year: 2022 end-page: 223 ident: bib0049 article-title: Anti-obesity drug discovery: advances and challenges publication-title: Nat. Rev. Drug Discov. – volume: 15 start-page: 485 year: 2021 end-page: 490 ident: bib0033 article-title: Baicalin attenuates diet-induced obesity partially through promoting thermogenesis in adipose tissue publication-title: Obes. Res. Clin. Pract. – volume: 594 start-page: 168 year: 2022 end-page: 176 ident: bib0035 article-title: Liver cyclophilin D deficiency inhibits the progression of early NASH by ameliorating steatosis and inflammation publication-title: Biochem. Biophys. Res. Commun. – volume: 442 start-page: 126 year: 2019 end-page: 136 ident: bib0094 article-title: Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo publication-title: Cancer Lett. – volume: 60 start-page: 856 year: 2019 end-page: 868 ident: bib0031 article-title: Rosiglitazone remodels the lipid droplet and britens human visceral and subcutaneous adipocytes ex vivo publication-title: J. Lipid Res. – volume: 24 start-page: 300 year: 2019 end-page: 306 ident: bib0038 article-title: Small molecules for fat combustion: targeting thermosensory and satiety signals in the central nervous system publication-title: Drug Discov. Today – volume: 219 year: 2021 ident: bib0024 article-title: PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders publication-title: Pharmacol. Ther. – volume: 18 start-page: 1486 year: 2023 end-page: 1488 ident: bib0058 article-title: Overcoming mitochondrial dysfunction in neurodegenerative diseases publication-title: Neural Regen. Res. – volume: 40 start-page: 467 year: 2023 end-page: 480 ident: bib0062 article-title: Remodeling of adipose tissues by fatty acids: mechanistic update on browning and thermogenesis by n-3 polyunsaturated fatty acids publication-title: Pharm. Res. – volume: 11 year: 2022 ident: bib0082 article-title: Chronic fatty acid depletion induces uncoupling protein 1 (UCP1) expression to coordinate mitochondrial inducible proton leak in a human-brown-adipocyte model publication-title: Cells – volume: 191 start-page: 1085 year: 2021 end-page: 1095 ident: bib0025 article-title: Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials publication-title: J. Comp. Physiol. B Biochem. Syst. Environ. Physiol. – volume: 613 start-page: 160 year: 2023 end-page: 168 ident: bib0060 article-title: CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization publication-title: Nature – volume: 13 year: 2022 ident: bib0001 article-title: The interaction of TRPV1 and lipids: insights into lipid metabolism publication-title: Front. Physiol. – volume: 173 start-page: 2369 year: 2016 end-page: 2389 ident: bib0004 article-title: Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms publication-title: Br. J. Pharmacol. – volume: 134 start-page: 9 year: 2017 end-page: 18 ident: bib0050 article-title: The hunt for the molecular mechanism of brown fat thermogenesis publication-title: Biochimie – volume: 11 start-page: e54 year: 2022 ident: bib0083 article-title: Retinoic acid promotes tissue vitamin A status and modulates adipose tissue metabolism of neonatal rats exposed to maternal high-fat diet-induced obesity publication-title: J. Nutr. Sci. – volume: 31 start-page: 13 year: 2023 end-page: 27 ident: bib0073 article-title: Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: role of SIRT-1 /adipokines / PPARγ and IGF-1 publication-title: Daru: J. Faculty Pharm. Tehran Univ. Med. Sci. – volume: 61 start-page: 857 year: 2015 end-page: 869 ident: bib0095 article-title: Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis publication-title: Hepatology – volume: 2022 year: 2022 ident: bib0016 article-title: Modulation of arginase-2 mRNA levels by ω-3 PUFAs and aspirin in asthmatic human lung fibroblasts publication-title: J. Lipids – start-page: 15 year: 2022 ident: bib0078 article-title: Capsaicin for weight control: "Exercise in a Pill" (or just another fad)? publication-title: Pharmaceuticals (Basel) – volume: 51 start-page: 175 year: 2019 end-page: 188 ident: bib0014 article-title: Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease publication-title: J. Bioenerg. Biomembr. – volume: 88 year: 2021 ident: bib0055 article-title: Effect of quercetin on nonshivering thermogenesis of brown adipose tissue in high-fat diet-induced obese mice publication-title: J. Nutr. Biochem. – volume: 17 start-page: 1205 year: 2021 end-page: 1221 ident: bib0028 article-title: Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice publication-title: Autophagy – volume: 79 start-page: 476 year: 2022 end-page: 481 ident: bib0070 article-title: Impact of body mass index on the outcome of Japanese patients with cardiovascular diseases and/or risk factors hospitalized with COVID-19 infection publication-title: J. Cardiol. – year: 2023 ident: bib0042 article-title: Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease publication-title: Neurotox. Res. – volume: 20 start-page: 579 year: 2023 end-page: 596 ident: bib0069 article-title: Obesity and prostate cancer - microenvironmental roles of adipose tissue publication-title: Nat. Rev. Urol. – volume: 322 start-page: H486 year: 2022 end-page: h491 ident: bib0099 article-title: Trypsin cleavage of the β(1)-adrenergic receptor publication-title: Am. J. Physiol. Heart Circ. Physiol. – volume: 5 start-page: 946 year: 2022 ident: bib0027 article-title: Housing-temperature reveals energy intake counter-balances energy expenditure in normal-weight, but not diet-induced obese, male mice publication-title: Commun. Biol. – volume: 72 year: 2023 ident: bib0036 article-title: Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice publication-title: Mol. Metab. – volume: 11 year: 2023 ident: bib0077 article-title: Cyclic GMP-AMP synthase (cGAS) deletion reduces severity in bilateral nephrectomy mice through changes in neutrophil extracellular traps and mitochondrial respiration publication-title: Biomedicines – volume: 13 year: 2023 ident: bib0047 article-title: Orchestral role of lipid metabolic reprogramming in T-cell malignancy publication-title: Front. Oncol. – volume: 40 start-page: 9530 year: 2022 end-page: 9542 ident: bib0068 article-title: Synthesis, molecular modelling, in vitro and in vivo evaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors publication-title: J. Biomol. Struct. Dyn. – volume: 17 start-page: 691 year: 2016 end-page: 702 ident: bib0091 article-title: Control of brown and beige fat development publication-title: Nat. Rev. Mol. Cell Biol. – volume: 12 year: 2021 ident: bib0052 article-title: Liraglutide activates type 2 deiodinase and enhances β3-adrenergic-induced thermogenesis in mouse adipose tissue publication-title: Front. Endocrinol. (Lausanne) – volume: 9 start-page: 220 year: 2019 end-page: 236 ident: bib0039 article-title: Small molecules for fat combustion: targeting obesity publication-title: Acta Pharm. Sin. B – volume: 516 start-page: 395 year: 2014 end-page: 399 ident: bib0020 article-title: Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors publication-title: Nature – volume: 209 start-page: 1532 year: 2022 end-page: 1544 ident: bib0045 article-title: Negative cross-talk between TLR2/4-independent AMPKα1 and TLR2/4-dependent JNK regulates S. pneumoniae-induced mucosal innate immune response publication-title: J. Immunol. – volume: 23 year: 2022 ident: bib0096 article-title: Factors associated with white fat browning: new regulators of lipid metabolism publication-title: Int. J. Mol. Sci. – volume: 36 start-page: e22205 year: 2022 ident: bib0046 article-title: Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality publication-title: FASEB J. – volume: 100 year: 2022 ident: bib0084 article-title: Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner publication-title: J. Nutr. Biochem. – volume: 78 start-page: 106 year: 2018 end-page: 117 ident: bib0034 article-title: Sildenafil induces browning of subcutaneous white adipose tissue in overweight adults publication-title: Metabolism. – volume: 12 start-page: 6612 year: 2022 ident: bib0081 article-title: Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts publication-title: Sci. Rep. – volume: 32 start-page: 287 year: 2020 end-page: 300 ident: bib0007 article-title: Human brown adipocyte thermogenesis is driven by β2-AR stimulation publication-title: Cell Metab. – volume: 17 start-page: 199 year: 2019 end-page: 204 ident: bib0026 article-title: PDE5 inhibitor protects the mitochondrial function of hypoxic myocardial cells publication-title: Exp. Ther. Med. – volume: 120 year: 2023 ident: bib0056 article-title: Time of day determines postexercise metabolism in mouse adipose tissue publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 41 start-page: 1704 year: 2023 end-page: 1714 ident: bib0017 article-title: Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production publication-title: J. Biomol. Struct. Dyn. – volume: 26 year: 2022 ident: bib0064 article-title: Glycyrrhizin (Glycyrrhizic Acid) HMGB1 (high mobility group box 1) inhibitor upregulate mitochondrial function in adipocyte, cell viability and in-silico study publication-title: J. Saudi Chem. Soc. – volume: 26 year: 2022 ident: bib0067 article-title: Histone deacetylase (HDAC) inhibitor curcumin upregulates mitochondrial uncoupling protein1 (UCP1) and mitochondrial function in brown adipocytes, in-silico study and screening natural drug library publication-title: J. Saudi Chem. Soc. – volume: 12 start-page: 252 year: 2019 ident: bib0075 article-title: NCS-1 deficiency affects mRNA levels of genes involved in regulation of ATP synthesis and mitochondrial stress in highly vulnerable substantia nigra dopaminergic neurons publication-title: Front. Mol. Neurosci. – volume: 62 year: 2022 ident: bib0010 article-title: Activating ligands of uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis publication-title: Mol. Metab. – volume: 50 start-page: 1414 year: 2022 end-page: 1428 ident: bib0089 article-title: Effect of chronic cadmium exposure on brain and liver transporters and drug-metabolizing enzymes in male and female mice genetically predisposed to Alzheimer's disease publication-title: Drug Metab. Dispos. – volume: 6 start-page: 38579 year: 2016 ident: bib0048 article-title: An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice publication-title: Sci. Rep. – volume: 26 year: 2022 ident: bib0065 article-title: Epigenetic drug (XL019) JAK2 inhibitor increases mitochondrial function in brown adipocytes by upregulating mitochondrial uncoupling protein 1 (UCP1), screening of epigenetic drug libraries, cell viability, and in-silico studies publication-title: J. Saudi Chem. Soc. – volume: 134 start-page: 28 year: 2017 end-page: 34 ident: bib0005 article-title: UCP1: a transporter for H(+) and fatty acid anions publication-title: Biochimie – volume: 23 year: 2022 ident: bib0079 article-title: The action of vitamin D in adipose tissue: is there the link between vitamin D deficiency and adipose tissue-related metabolic disorders? publication-title: Int. J. Mol. Sci. – volume: 401 start-page: 1116 year: 2023 end-page: 1130 ident: bib0057 article-title: Contemporary medical, device, and surgical therapies for obesity in adults publication-title: Lancet – volume: 361 start-page: 303 year: 2017 end-page: 311 ident: bib0071 article-title: Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathy publication-title: J. Pharmacol. Exp. Ther. – volume: 78 year: 2022 ident: bib0040 article-title: GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning publication-title: EBioMedicine – volume: 46 start-page: 192 year: 2023 end-page: 205 ident: bib0030 article-title: Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes publication-title: Arch. Pharm. Res. – volume: 15 year: 2023 ident: bib0043 article-title: Adipocyte metabolism and health after the menopause: the role of exercise publication-title: Nutrients – volume: 12 year: 2023 ident: bib0053 article-title: A novel mix of polyphenols and micronutrients reduces adipogenesis and promotes white adipose tissue browning via UCP1 expression and AMPK activation publication-title: Cells – volume: 25 start-page: 848 year: 2023 end-page: 864 ident: bib0018 article-title: Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes publication-title: Nat. Cell Biol. – volume: 13 year: 2022 ident: bib0098 article-title: Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine publication-title: Front. Endocrinol. (Lausanne) – volume: 8 start-page: 856 year: 2017 ident: bib0044 article-title: MKK6 controls T3-mediated browning of white adipose tissue publication-title: Nat. Commun. – volume: 10 year: 2021 ident: bib0088 article-title: The role of AMPK signaling in brown adipose tissue activation publication-title: Cells – volume: 10 start-page: 14 year: 2021 end-page: 30 ident: bib0080 article-title: Long-term efficacy and safety of anti-obesity treatment: where do we stand? publication-title: Curr. Obes. Rep. – volume: 292 start-page: 10824 year: 2017 end-page: 10834 ident: bib0051 article-title: Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes publication-title: J. Biol. Chem. – start-page: 13 year: 2023 ident: bib0072 article-title: Up- and downregulated genes after long-term muscle atrophy induced by denervation in mice detected using RNA-seq publication-title: Life (Basel) – volume: 55 year: 2022 ident: bib0085 article-title: URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice publication-title: Mol. Metab. – year: 2023 ident: bib0019 article-title: Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes publication-title: Nat. Cell Biol. – volume: 11 start-page: 47 year: 2022 ident: bib0021 article-title: Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics publication-title: Transl. Neurodegener. – volume: 222 start-page: 1963 year: 2022 end-page: 1973 ident: bib0066 article-title: Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies publication-title: Int. J. Biol. Macromol. – volume: 10 start-page: 468 year: 2019 ident: bib0092 article-title: Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans publication-title: Cell Death. Dis. – volume: 298 year: 2022 ident: bib0029 article-title: Characterization and structural analyses of a novel glycosyltransferase acting on the β-1,2-glucosidic linkages publication-title: J. Biol. Chem. – start-page: 11 year: 2022 ident: bib0009 article-title: Protective role of mitochondrial uncoupling proteins against age-related oxidative stress in type 2 diabetes mellitus publication-title: Antioxidants (Basel, Switzerland) – volume: 70 start-page: 161 year: 2021 end-page: 168 ident: bib0076 article-title: The anti-obesity and health-promoting effects of tea and coffee publication-title: Physiol. Res. – volume: 14 start-page: 331 year: 2022 end-page: 352 ident: bib0012 article-title: Review of advanced drug trials focusing on the reduction of brain beta-amyloid to prevent and treat dementia publication-title: J. Exp. Pharmacol. – volume: 5 start-page: 584 year: 2022 ident: bib0032 article-title: Remodeling of gene regulatory networks underlying thermogenic stimuli-induced adipose beiging publication-title: Commun. Biol. – volume: 156 year: 2022 ident: bib0041 article-title: Estrogen as a key regulator of energy homeostasis and metabolic health publication-title: Biomed. PharmacOther – year: 2011 ident: bib0087 article-title: Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation publication-title: J. Nutr. Metab. – volume: 2022 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0016 article-title: Modulation of arginase-2 mRNA levels by ω-3 PUFAs and aspirin in asthmatic human lung fibroblasts publication-title: J. Lipids doi: 10.1155/2022/3062274 – volume: 17 start-page: 1205 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0028 article-title: Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice publication-title: Autophagy doi: 10.1080/15548627.2020.1753002 – volume: 298 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0029 article-title: Characterization and structural analyses of a novel glycosyltransferase acting on the β-1,2-glucosidic linkages publication-title: J. Biol. Chem. doi: 10.1016/j.jbc.2022.101606 – volume: 606 start-page: 180 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0006 article-title: Mitochondrial uncouplers induce proton leak by activating AAC and UCP1 publication-title: Nature doi: 10.1038/s41586-022-04747-5 – volume: 10 start-page: 14 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0080 article-title: Long-term efficacy and safety of anti-obesity treatment: where do we stand? publication-title: Curr. Obes. Rep. doi: 10.1007/s13679-020-00422-w – volume: 5 start-page: 5493 year: 2014 ident: 10.1016/j.phymed.2024.155672_bib0097 article-title: Berberine activates thermogenesis in white and brown adipose tissue publication-title: Nat. Commun. doi: 10.1038/ncomms6493 – volume: 46 start-page: 192 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0030 article-title: Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes publication-title: Arch. Pharm. Res. doi: 10.1007/s12272-023-01432-7 – volume: 10 start-page: 468 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0092 article-title: Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans publication-title: Cell Death. Dis. doi: 10.1038/s41419-019-1706-y – volume: 17 start-page: 199 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0026 article-title: PDE5 inhibitor protects the mitochondrial function of hypoxic myocardial cells publication-title: Exp. Ther. Med. – volume: 12 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0052 article-title: Liraglutide activates type 2 deiodinase and enhances β3-adrenergic-induced thermogenesis in mouse adipose tissue publication-title: Front. Endocrinol. (Lausanne) – volume: 401 start-page: 1116 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0057 article-title: Contemporary medical, device, and surgical therapies for obesity in adults publication-title: Lancet doi: 10.1016/S0140-6736(22)02403-5 – volume: 361 start-page: 303 year: 2017 ident: 10.1016/j.phymed.2024.155672_bib0071 article-title: Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathy publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.116.237925 – volume: 5 start-page: 946 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0027 article-title: Housing-temperature reveals energy intake counter-balances energy expenditure in normal-weight, but not diet-induced obese, male mice publication-title: Commun. Biol. doi: 10.1038/s42003-022-03895-8 – volume: 11 start-page: 633 year: 2020 ident: 10.1016/j.phymed.2024.155672_bib0054 article-title: Metabolic improvement via enhancing thermogenic fat-mediated non-shivering thermogenesis: from rodents to humans publication-title: Front. Endocrinol. (Lausanne) doi: 10.3389/fendo.2020.00633 – volume: 13 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0098 article-title: Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine publication-title: Front. Endocrinol. (Lausanne) – volume: 78 start-page: 106 year: 2018 ident: 10.1016/j.phymed.2024.155672_bib0034 article-title: Sildenafil induces browning of subcutaneous white adipose tissue in overweight adults publication-title: Metabolism. doi: 10.1016/j.metabol.2017.09.008 – volume: 46 start-page: 555 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0008 article-title: Effectiveness of anti-obesity medications approved for long-term use in a multidisciplinary weight management program: a multi-center clinical experience publication-title: Int. J. Obes. (Lond.) doi: 10.1038/s41366-021-01019-6 – volume: 12 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0053 article-title: A novel mix of polyphenols and micronutrients reduces adipogenesis and promotes white adipose tissue browning via UCP1 expression and AMPK activation publication-title: Cells doi: 10.3390/cells12050714 – volume: 12 start-page: 6612 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0081 article-title: Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts publication-title: Sci. Rep. doi: 10.1038/s41598-022-10644-8 – volume: 17 start-page: 691 year: 2016 ident: 10.1016/j.phymed.2024.155672_bib0091 article-title: Control of brown and beige fat development publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm.2016.96 – year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0019 article-title: Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes publication-title: Nat. Cell Biol. doi: 10.1038/s41556-023-01155-3 – volume: 26 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0064 article-title: Glycyrrhizin (Glycyrrhizic Acid) HMGB1 (high mobility group box 1) inhibitor upregulate mitochondrial function in adipocyte, cell viability and in-silico study publication-title: J. Saudi Chem. Soc. doi: 10.1016/j.jscs.2022.101454 – volume: 156 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0041 article-title: Estrogen as a key regulator of energy homeostasis and metabolic health publication-title: Biomed. PharmacOther doi: 10.1016/j.biopha.2022.113808 – volume: 600 start-page: 314 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0090 article-title: IL-27 signalling promotes adipocyte thermogenesis and energy expenditure publication-title: Nature doi: 10.1038/s41586-021-04127-5 – volume: 219 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0024 article-title: PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2020.107705 – volume: 11 start-page: e54 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0083 article-title: Retinoic acid promotes tissue vitamin A status and modulates adipose tissue metabolism of neonatal rats exposed to maternal high-fat diet-induced obesity publication-title: J. Nutr. Sci. doi: 10.1017/jns.2022.53 – volume: 144 start-page: 2757 year: 2003 ident: 10.1016/j.phymed.2024.155672_bib0022 article-title: Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease publication-title: Endocrinology doi: 10.1210/en.2003-0163 – volume: 222 start-page: 1963 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0066 article-title: Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2022.09.285 – volume: 15 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0043 article-title: Adipocyte metabolism and health after the menopause: the role of exercise publication-title: Nutrients doi: 10.3390/nu15020444 – volume: 100 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0084 article-title: Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2021.108898 – volume: 442 start-page: 126 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0094 article-title: Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo publication-title: Cancer Lett. doi: 10.1016/j.canlet.2018.10.016 – volume: 23 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0079 article-title: The action of vitamin D in adipose tissue: is there the link between vitamin D deficiency and adipose tissue-related metabolic disorders? publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms23020956 – volume: 613 start-page: 160 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0060 article-title: CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization publication-title: Nature doi: 10.1038/s41586-022-05507-1 – volume: 25 start-page: 848 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0018 article-title: Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes publication-title: Nat. Cell Biol. doi: 10.1038/s41556-023-01155-3 – volume: 79 start-page: 476 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0070 article-title: Impact of body mass index on the outcome of Japanese patients with cardiovascular diseases and/or risk factors hospitalized with COVID-19 infection publication-title: J. Cardiol. doi: 10.1016/j.jjcc.2021.09.013 – volume: 516 start-page: 395 year: 2014 ident: 10.1016/j.phymed.2024.155672_bib0020 article-title: Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors publication-title: Nature doi: 10.1038/nature13816 – volume: 134 start-page: 9 year: 2017 ident: 10.1016/j.phymed.2024.155672_bib0050 article-title: The hunt for the molecular mechanism of brown fat thermogenesis publication-title: Biochimie doi: 10.1016/j.biochi.2016.09.003 – volume: 13 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0047 article-title: Orchestral role of lipid metabolic reprogramming in T-cell malignancy publication-title: Front. Oncol. doi: 10.3389/fonc.2023.1122789 – volume: 5 start-page: 584 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0032 article-title: Remodeling of gene regulatory networks underlying thermogenic stimuli-induced adipose beiging publication-title: Commun. Biol. doi: 10.1038/s42003-022-03531-5 – volume: 10 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0088 article-title: The role of AMPK signaling in brown adipose tissue activation publication-title: Cells doi: 10.3390/cells10051122 – volume: 12 start-page: 252 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0075 article-title: NCS-1 deficiency affects mRNA levels of genes involved in regulation of ATP synthesis and mitochondrial stress in highly vulnerable substantia nigra dopaminergic neurons publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2019.00252 – volume: 13 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0001 article-title: The interaction of TRPV1 and lipids: insights into lipid metabolism publication-title: Front. Physiol. doi: 10.3389/fphys.2022.1066023 – volume: 191 start-page: 1085 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0025 article-title: Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials publication-title: J. Comp. Physiol. B Biochem. Syst. Environ. Physiol. doi: 10.1007/s00360-021-01362-0 – year: 2011 ident: 10.1016/j.phymed.2024.155672_bib0087 article-title: Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation publication-title: J. Nutr. Metab. doi: 10.1155/2011/525094 – volume: 10 start-page: 47 year: 2020 ident: 10.1016/j.phymed.2024.155672_bib0063 article-title: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease publication-title: Transl. Psychiatry doi: 10.1038/s41398-020-0709-x – volume: 55 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0085 article-title: URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice publication-title: Mol. Metab. doi: 10.1016/j.molmet.2021.101411 – volume: 88 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0055 article-title: Effect of quercetin on nonshivering thermogenesis of brown adipose tissue in high-fat diet-induced obese mice publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2020.108532 – volume: 41 start-page: 1704 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0017 article-title: Berberine chloride (dual topoisomerase I and II inhibitor) modulate mitochondrial uncoupling protein (UCP1) in molecular docking and dynamic with in-vitro cytotoxic and mitochondrial ATP production publication-title: J. Biomol. Struct. Dyn. doi: 10.1080/07391102.2021.2024255 – volume: 46 start-page: 943 year: 2020 ident: 10.1016/j.phymed.2024.155672_bib0093 article-title: Effects of 1,25(OH)(2) D(3) on lipid droplet growth in adipocytes publication-title: Biofactors doi: 10.1002/biof.1610 – volume: 20 start-page: 579 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0069 article-title: Obesity and prostate cancer - microenvironmental roles of adipose tissue publication-title: Nat. Rev. Urol. doi: 10.1038/s41585-023-00764-9 – volume: 173 start-page: 2369 year: 2016 ident: 10.1016/j.phymed.2024.155672_bib0004 article-title: Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms publication-title: Br. J. Pharmacol. doi: 10.1111/bph.13514 – volume: 40 start-page: 467 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0062 article-title: Remodeling of adipose tissues by fatty acids: mechanistic update on browning and thermogenesis by n-3 polyunsaturated fatty acids publication-title: Pharm. Res. doi: 10.1007/s11095-022-03377-w – volume: 40 start-page: 9530 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0068 article-title: Synthesis, molecular modelling, in vitro and in vivo evaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors publication-title: J. Biomol. Struct. Dyn. doi: 10.1080/07391102.2021.1930168 – volume: 21 start-page: 201 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0049 article-title: Anti-obesity drug discovery: advances and challenges publication-title: Nat. Rev. Drug Discov. doi: 10.1038/s41573-021-00337-8 – volume: 17 start-page: 3196 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0037 article-title: Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2(R1441G) mice publication-title: Autophagy doi: 10.1080/15548627.2020.1850008 – volume: 32 start-page: 287 year: 2020 ident: 10.1016/j.phymed.2024.155672_bib0007 article-title: Human brown adipocyte thermogenesis is driven by β2-AR stimulation publication-title: Cell Metab. doi: 10.1016/j.cmet.2020.07.005 – volume: 23 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0096 article-title: Factors associated with white fat browning: new regulators of lipid metabolism publication-title: Int. J. Mol. Sci. – volume: 51 start-page: 175 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0014 article-title: Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease publication-title: J. Bioenerg. Biomembr. doi: 10.1007/s10863-019-09798-4 – volume: 60 start-page: 856 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0031 article-title: Rosiglitazone remodels the lipid droplet and britens human visceral and subcutaneous adipocytes ex vivo publication-title: J. Lipid Res. doi: 10.1194/jlr.M091173 – start-page: 13 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0072 article-title: Up- and downregulated genes after long-term muscle atrophy induced by denervation in mice detected using RNA-seq publication-title: Life (Basel) – volume: 594 start-page: 168 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0035 article-title: Liver cyclophilin D deficiency inhibits the progression of early NASH by ameliorating steatosis and inflammation publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2022.01.059 – volume: 6 start-page: 38579 year: 2016 ident: 10.1016/j.phymed.2024.155672_bib0048 article-title: An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice publication-title: Sci. Rep. doi: 10.1038/srep38579 – volume: 61 start-page: 857 year: 2015 ident: 10.1016/j.phymed.2024.155672_bib0095 article-title: Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis publication-title: Hepatology doi: 10.1002/hep.27371 – volume: 292 start-page: 10824 year: 2017 ident: 10.1016/j.phymed.2024.155672_bib0051 article-title: Cell death-inducing DNA fragmentation factor A-like effector A and fat-specific protein 27β coordinately control lipid droplet size in brown adipocytes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M116.768820 – volume: 70 start-page: 161 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0076 article-title: The anti-obesity and health-promoting effects of tea and coffee publication-title: Physiol. Res. doi: 10.33549/physiolres.934674 – volume: 11 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0077 article-title: Cyclic GMP-AMP synthase (cGAS) deletion reduces severity in bilateral nephrectomy mice through changes in neutrophil extracellular traps and mitochondrial respiration publication-title: Biomedicines doi: 10.3390/biomedicines11041208 – volume: 36 start-page: e22205 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0046 article-title: Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality publication-title: FASEB J. doi: 10.1096/fj.202101905RR – volume: 14 start-page: 331 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0012 article-title: Review of advanced drug trials focusing on the reduction of brain beta-amyloid to prevent and treat dementia publication-title: J. Exp. Pharmacol. doi: 10.2147/JEP.S265626 – volume: 6 start-page: 829 year: 2005 ident: 10.1016/j.phymed.2024.155672_bib0003 article-title: Mitochondrial uncoupling proteins in the CNS: in support of function and survival publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn1767 – volume: 78 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0040 article-title: GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning publication-title: EBioMedicine doi: 10.1016/j.ebiom.2022.103969 – volume: 50 start-page: 1414 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0089 article-title: Effect of chronic cadmium exposure on brain and liver transporters and drug-metabolizing enzymes in male and female mice genetically predisposed to Alzheimer's disease publication-title: Drug Metab. Dispos. doi: 10.1124/dmd.121.000453 – volume: 24 start-page: 300 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0038 article-title: Small molecules for fat combustion: targeting thermosensory and satiety signals in the central nervous system publication-title: Drug Discov. Today doi: 10.1016/j.drudis.2018.09.013 – volume: 209 start-page: 1532 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0045 article-title: Negative cross-talk between TLR2/4-independent AMPKα1 and TLR2/4-dependent JNK regulates S. pneumoniae-induced mucosal innate immune response publication-title: J. Immunol. doi: 10.4049/jimmunol.2100901 – volume: 18 start-page: 1486 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0058 article-title: Overcoming mitochondrial dysfunction in neurodegenerative diseases publication-title: Neural Regen. Res. doi: 10.4103/1673-5374.360279 – start-page: 11 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0009 article-title: Protective role of mitochondrial uncoupling proteins against age-related oxidative stress in type 2 diabetes mellitus publication-title: Antioxidants (Basel, Switzerland) – volume: 15 start-page: 485 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0033 article-title: Baicalin attenuates diet-induced obesity partially through promoting thermogenesis in adipose tissue publication-title: Obes. Res. Clin. Pract. doi: 10.1016/j.orcp.2021.08.003 – start-page: 15 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0078 article-title: Capsaicin for weight control: "Exercise in a Pill" (or just another fad)? publication-title: Pharmaceuticals (Basel) – volume: 75 start-page: 904 year: 2011 ident: 10.1016/j.phymed.2024.155672_bib0023 article-title: TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet publication-title: Biosci. Biotechnol. Biochem. doi: 10.1271/bbb.100850 – volume: 62 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0010 article-title: Activating ligands of uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis publication-title: Mol. Metab. doi: 10.1016/j.molmet.2022.101526 – volume: 31 start-page: 13 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0073 article-title: Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: role of SIRT-1 /adipokines / PPARγ and IGF-1 publication-title: Daru: J. Faculty Pharm. Tehran Univ. Med. Sci. doi: 10.1007/s40199-023-00458-y – volume: 134 start-page: 28 year: 2017 ident: 10.1016/j.phymed.2024.155672_bib0005 article-title: UCP1: a transporter for H(+) and fatty acid anions publication-title: Biochimie doi: 10.1016/j.biochi.2016.10.013 – volume: 322 start-page: H486 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0099 article-title: Trypsin cleavage of the β(1)-adrenergic receptor publication-title: Am. J. Physiol. Heart Circ. Physiol. doi: 10.1152/ajpheart.00005.2022 – volume: 8 start-page: 856 year: 2017 ident: 10.1016/j.phymed.2024.155672_bib0044 article-title: MKK6 controls T3-mediated browning of white adipose tissue publication-title: Nat. Commun. doi: 10.1038/s41467-017-00948-z – volume: 37 start-page: 344 year: 2018 ident: 10.1016/j.phymed.2024.155672_bib0061 article-title: Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue publication-title: EBioMedicine doi: 10.1016/j.ebiom.2018.10.019 – volume: 11 start-page: 47 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0021 article-title: Myelin repair in Alzheimer's disease: a review of biological pathways and potential therapeutics publication-title: Transl. Neurodegener. doi: 10.1186/s40035-022-00321-1 – volume: 11 year: 2020 ident: 10.1016/j.phymed.2024.155672_bib0059 article-title: Multifaceted control of GR signaling and its impact on hepatic transcriptional networks and metabolism publication-title: Front. Endocrinol. (Lausanne) doi: 10.3389/fendo.2020.572981 – volume: 26 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0065 article-title: Epigenetic drug (XL019) JAK2 inhibitor increases mitochondrial function in brown adipocytes by upregulating mitochondrial uncoupling protein 1 (UCP1), screening of epigenetic drug libraries, cell viability, and in-silico studies publication-title: J. Saudi Chem. Soc. – volume: 11 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0082 article-title: Chronic fatty acid depletion induces uncoupling protein 1 (UCP1) expression to coordinate mitochondrial inducible proton leak in a human-brown-adipocyte model publication-title: Cells doi: 10.3390/cells11132038 – volume: 72 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0036 article-title: Neuronal loss of TRPM8 leads to obesity and glucose intolerance in male mice publication-title: Mol. Metab. doi: 10.1016/j.molmet.2023.101714 – volume: 329 year: 2020 ident: 10.1016/j.phymed.2024.155672_bib0074 article-title: Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2020.113309 – volume: 9 start-page: 220 year: 2019 ident: 10.1016/j.phymed.2024.155672_bib0039 article-title: Small molecules for fat combustion: targeting obesity publication-title: Acta Pharm. Sin. B doi: 10.1016/j.apsb.2018.09.007 – volume: 26 year: 2022 ident: 10.1016/j.phymed.2024.155672_bib0067 article-title: Histone deacetylase (HDAC) inhibitor curcumin upregulates mitochondrial uncoupling protein1 (UCP1) and mitochondrial function in brown adipocytes, in-silico study and screening natural drug library publication-title: J. Saudi Chem. Soc. – volume: 22 year: 2021 ident: 10.1016/j.phymed.2024.155672_bib0002 article-title: A comprehensive analysis into the therapeutic application of natural products as SIRT6 modulators in Alzheimer's disease, aging, cancer, inflammation, and diabetes publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms22084180 – year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0042 article-title: Mitochondrial dysfunction as a signaling target for therapeutic intervention in major neurodegenerative disease publication-title: Neurotox. Res. doi: 10.1007/s12640-023-00647-2 – volume: 120 year: 2023 ident: 10.1016/j.phymed.2024.155672_bib0056 article-title: Time of day determines postexercise metabolism in mouse adipose tissue publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.2218510120 |
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| Title | Mitochondrial UCP1: Potential thermogenic mechanistic switch for the treatment of obesity and neurodegenerative diseases using natural and epigenetic drug candidates |
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