Pregnane X receptor mediates sorafenib resistance in advanced hepatocellular carcinoma - Feng, Fan; Jiang, Qiyu; Cao, Shuang; Cao, Yu; Li, Ruisheng; Shen, Lijun; Zhu, Hua; Wang, Tao; Sun, Lijun; Liang, Erguang; Sun, Huiwei; Chai, Yantao; et al. (Biochimica et biophysica acta. General subjects, 2018)
Keywords: Animals; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cell Line, Tumor; Cell Survival - drug effects; Cell Survival - genetics; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; drugs; enzyme inhibitors; Gene Expression Regulation, Neoplastic - drug effects; Hep G2 Cells; Hepatocellular carcinoma; hepatoma; Humans; immunohistochemistry; Kaplan-Meier Estimate; Liver Neoplasms - drug therapy; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; luciferase; Metabolism and clearance; metastasis; Mice, SCID; Multi-drug resistance; Niacinamide - analogs & derivatives; Niacinamide - metabolism; Niacinamide - therapeutic use; patients; Phenylurea Compounds - metabolism; Phenylurea Compounds - therapeutic use; Pregnane X receptor; prognosis; Protein Kinase Inhibitors - metabolism; Protein Kinase Inhibitors - therapeutic use; quantitative polymerase chain reaction; Receptors, Steroid - genetics; Receptors, Steroid - metabolism; reporter genes; RNA Interference; Sorafenib; Western blotting; Xenograft Model Antitumor Assays - methods; Hepatocellular carcinoma; Multi-drug resistance; Pregnane X receptor; Sorafenib; Metabolism and clearance