A novel Pseudolaric acid B derivative, Hexahydropseudolaric acid B, exterts an immunomodulatory effect in vitro/in vivo evaluation

• Published in: European journal of pharmacology Vol. 745; pp. 10 - 18
• Main Authors: Li, Tan, Chen, Hong, Yang, Zhen, Wang, Wei, Wang, Yi-teng, Zhang, Li-ming, Zhao, Ji-hong, Zhou, Xin, Li, Yu-ming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2014
• Subjects: Animals; Cell Proliferation - drug effects; Delayed-type hypersensitivity; Diterpenes - chemistry; Diterpenes - pharmacology; Diterpenes - toxicity; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - toxicity; Female; Hexahydropseudolaric acid B; Hypersensitivity, Delayed - prevention & control; Immunosuppression; Immunosuppressive Agents - chemistry; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - toxicity; In Vitro Techniques; Lymphocyte Activation - drug effects; MAP Kinase Signaling System - drug effects; MAPK; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pinaceae - chemistry; PPAR gamma - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Regulatory T cells; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Transforming Growth Factor beta - biosynthesis; Hexahydropseudolaric acid B; Immunosuppression; Delayed-type hypersensitivity; Regulatory T cells; MAPK

Identification of immunosuppressants from natural sources has a proven track record in immune mediated disorders. Pseudolaric acid B is a diterpenoid isolated from the roots of Pseudolarix amabilis, possessing potent immunomodulatory effect. However, the cytotoxicity limits its future clinical appli...