GAPDH with NAD+-binding site mutation competitively inhibits the wild-type and affects glucose metabolism in cancer - Kunjithapatham, Rani; Ganapathy-Kanniappan, Shanmugasundaram (Biochimica et biophysica acta. General subjects, 2018)
Keywords: Amino Acid Sequence; Animals; arginine; Binding Sites; bioinformatics; cancer metabolism; Catalysis; cell free system; Cell Line, Tumor; competitive inhibition; disease course; energy; energy metabolism; GAPDH; glucose; Glucose - metabolism; glutamine; glyceraldehyde-3-phosphate dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases - chemistry; Glyceraldehyde-3-Phosphate Dehydrogenases - genetics; Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism; glycolysis; Humans; isoleucine; Male; Mice; Mice, Nude; Mutation; NAD - metabolism; NAD+-binding; neoplasm cells; neoplasms; Neoplasms - metabolism; Neoplasms - pathology; phenotype; phenylalanine; site-directed mutagenesis; Stress, Physiological; therapeutics; cancer metabolism; GAPDH; NAD+-binding; glycolysis; competitive inhibition; NAD(+)-binding