Spread of OXA-23-producing Acinetobacter baumannii ST2 and ST246 in a hospital in Japan

A total of 1085 strains of Acinetobacter sp. obtained from 280 medical institutions in the Chugoku and Shikoku areas of Japan were investigated between 2011 and 2013. Among these strains, 20 (1.84 %) showing meropenem or imipenem resistance with a MIC of >4 μg ml- 1 were detected. Of these 20 str...

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Published inJournal of medical microbiology Vol. 64; no. 7; pp. 739 - 744
Main Authors Kubo, Yumi, Komatsu, Masaru, Tanimoto, Emi, Sugimoto, Keiichi, Tanaka, Satoru, Migita, Shiho, Kondo, Yoko, Yano, Sawa, Maehara, Kuniho, Murata, Ryoko, Nakamura, Akihiro, Fujita, Toshikazu, Kawata, Yoichi
Format Journal Article
LanguageEnglish
Published England 01.07.2015
Subjects
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - drug therapy
Acinetobacter Infections - epidemiology
Anti-Bacterial Agents - therapeutic use
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
Cross Infection - microbiology
Drug Resistance, Multiple, Bacterial - genetics
Hospitals
Humans
Imipenem - therapeutic use
Japan - epidemiology
Meropenem
Microbial Sensitivity Tests
Multilocus Sequence Typing
Thienamycins - therapeutic use
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Abstract A total of 1085 strains of Acinetobacter sp. obtained from 280 medical institutions in the Chugoku and Shikoku areas of Japan were investigated between 2011 and 2013. Among these strains, 20 (1.84 %) showing meropenem or imipenem resistance with a MIC of >4 μg ml- 1 were detected. Of these 20 strains, the bla(OXA-23) gene was detected in 17 strains isolated from the same institution. The PFGE patterns of the 17 strains were separated into two clusters, and multi-locus sequence typing showed the sequence types (STs) to be ST2 and ST246. This investigation demonstrated that A. baumannii ST2 of international clone II, which has rarely been isolated in Japan, has not yet spread nationwide.
AbstractList A total of 1085 strains of Acinetobacter sp. obtained from 280 medical institutions in the Chugoku and Shikoku areas of Japan were investigated between 2011 and 2013. Among these strains, 20 (1.84 %) showing meropenem or imipenem resistance with a MIC of >4 μg ml- 1 were detected. Of these 20 strains, the bla(OXA-23) gene was detected in 17 strains isolated from the same institution. The PFGE patterns of the 17 strains were separated into two clusters, and multi-locus sequence typing showed the sequence types (STs) to be ST2 and ST246. This investigation demonstrated that A. baumannii ST2 of international clone II, which has rarely been isolated in Japan, has not yet spread nationwide.
Author Sugimoto, Keiichi
Tanaka, Satoru
Kondo, Yoko
Komatsu, Masaru
Kawata, Yoichi
Migita, Shiho
Nakamura, Akihiro
Maehara, Kuniho
Fujita, Toshikazu
Murata, Ryoko
Kubo, Yumi
Tanimoto, Emi
Yano, Sawa
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SubjectTerms Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - drug therapy
Acinetobacter Infections - epidemiology
Anti-Bacterial Agents - therapeutic use
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
Cross Infection - microbiology
Drug Resistance, Multiple, Bacterial - genetics
Hospitals
Humans
Imipenem - therapeutic use
Japan - epidemiology
Meropenem
Microbial Sensitivity Tests
Multilocus Sequence Typing
Thienamycins - therapeutic use
Title Spread of OXA-23-producing Acinetobacter baumannii ST2 and ST246 in a hospital in Japan
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