Growth differentiation factor 15: a promising biomarker in oral cancer

Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemother...

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Published inJournal of the Korean Association of Oral and Maxillofacial Surgeons Vol. 51; no. 2; pp. 123 - 125
Main Authors Oh, Hyun Jun, Lee, Jong-Ho, Kim, Soung Min
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Association of Oral and Maxillofacial Surgeons 30.04.2025
대한구강악안면외과학회
Subjects
Brief Communication
치의학
Biomarkers
Mouth neoplasms
Squamous cell carcinoma
Cachexia
Growth differentiation factor 15
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Abstract Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.
AbstractList KCI Citation Count: 0
Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.
Growth differentiation factor 15 (GDF-15), a cytokine within the transforming growth factor-β superfamily, is involved in various malignancies, with implications in oral squamous cell carcinoma (OSCC). Elevated GDF-15 levels are correlated with unfavorable prognosis, tumor progression, and chemotherapy resistance, and the protein has been identified as a potential diagnostic and prognostic biomarker for OSCC. Personalized treatment strategies based on GDF-15 expression could improve treatment outcomes.
Author Lee, Jong-Ho
Oh, Hyun Jun
Kim, Soung Min
AuthorAffiliation Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea
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Keywords Biomarkers
Mouth neoplasms
Squamous cell carcinoma
Cachexia
Growth differentiation factor 15
Language English
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치의학
Title Growth differentiation factor 15: a promising biomarker in oral cancer
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