Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson's disease models - Zhang, Qian; Zhang, Pei; Qi, Guang-Jian; Zhang, Zheng; He, Feng; Lv, Ze-Xi; Peng, Xiang; Cai, Hong-Wei; Li, Tong-Xia; Wang, Xue-Min; Tian, Bo (Biochimica et biophysica acta. General subjects, 2018)
Keywords: Alzheimer disease; amyotrophic lateral sclerosis; animal models; Animals; Behavior, Animal; cell lines; Cells, Cultured; cyclin-dependent kinase; Cyclin-Dependent Kinase 5 - genetics; Cyclin-Dependent Kinase 5 - metabolism; Degradation; disease models; Disease Models, Animal; environmental factors; gene overexpression; genetic factors; Humans; Male; Mice; Mice, Inbred C57BL; neurons; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents; neuroprotective effect; neurotoxins; Parkinson disease; Parkinson Disease - etiology; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; protein synthesis; Rats, Sprague-Dawley; SIRT1; Sirtuin 1 - physiology; transgenic animals; Ubiquitin-proteasome pathway; Ubiquitins - metabolism; Degradation; Parkinson's disease; SIRT1; Ubiquitin-proteasome pathway