Reduced neutralizing antibody titer against genotype I virus in swine immunized with a live-attenuated genotype III Japanese encephalitis virus vaccine

• Published in: Veterinary microbiology Vol. 163; no. 3-4; pp. 248 - 256
• Main Authors: Fan, Yi-Chin, Chen, Jo-Mei, Chen, Yi-Ying, Lin, Jen-Wei, Chiou, Shyan-Song
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 03.05.2013
• Subjects: amino acids; Animals; antibodies; Antibodies, Neutralizing; Antibodies, Neutralizing - immunology; Antibodies, Viral; Antibodies, Viral - blood; blood; chemistry; Cross Protection; Cross Protection - immunology; Encephalitis Virus, Japanese; Encephalitis Virus, Japanese - chemistry; Encephalitis Virus, Japanese - genetics; Encephalitis Virus, Japanese - immunology; Encephalitis, Japanese; Encephalitis, Japanese - prevention & control; Encephalitis, Japanese - veterinary; genetics; Genotype; Genotype replacement; immunology; Japanese encephalitis; Japanese Encephalitis Vaccines; Japanese Encephalitis Vaccines - immunology; Japanese encephalitis virus; Live-attenuated vaccine; neutralization; piglets; prevention & control; Protective threshold; seroprevalence; structural proteins; Swine; Swine Diseases; Swine Diseases - immunology; Swine Diseases - prevention & control; Swine Diseases - virology; Taiwan; Vaccination; Vaccination - veterinary; vaccines; Vaccines, Attenuated; Vaccines, Attenuated - immunology; veterinary; Viral Envelope Proteins; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Viral Envelope Proteins - immunology; virology; viruses; Taiwan; Protective threshold; Live-attenuated vaccine; Genotype replacement; Japanese encephalitis

A shift in prevalence from Japanese encephalitis virus (JEV) genotype III (GIII) to GI virus has been observed in several Asian countries. Genotype I virus was first detected in Taiwan in 2008, and became the dominant JEV island-wide within a year. We conducted a serosurvey using swine serum specime...