Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of hand, foot and mouth disease

• Published in: Journal of general virology Vol. 98; no. 4; pp. 643 - 651
• Main Authors: Nakata, Keiko, Takeda, Satoshi, Tanaka, Atsushi, Kwang, Jimmy, Komano, Jun
• Format: Journal Article
• Language: English
• Published: England 01.04.2017
• Subjects: Antiviral Agents - pharmacology; Cell Line; Enterovirus A, Human - immunology; Enterovirus A, Human - physiology; Glucosylceramidase - pharmacology; Hand, Foot and Mouth Disease - virology; Humans; Lysosomal Membrane Proteins - metabolism; Receptors, Scavenger - metabolism; Receptors, Virus - metabolism; Virus Attachment

Enterovirus 71 (EV71) is a causative agent of hand, foot and mouth disease (HFMD). EV71 causes fever, rash, diarrhoea and, in some cases, acute encephalopathy/encephalitis, which can be fatal. No specific treatment is currently available for EV71 infection. Here, we conducted a cDNA library screen a...