Obesity-induced inflammatory miR-133a mediates apoptosis of granulosa cells and causes abnormal folliculogenesis

• Published in: Acta biochimica et biophysica Sinica Vol. 55; no. 8; pp. 1234 - 1246
• Main Authors: Chen, Ruizhi, Wu, Xueqing, Qiu, Han, Yang, Baiming, Chen, Yao, Chen, Xiang, Li, Yingshan, Yuan, Shaochun, Liu, Dan, Xiao, Luanjuan, Yu, Yanhong
• Format: Journal Article
• Language: English
• Published: China China Science Publishing & Media Ltd 01.08.2023
• Subjects: abnormal follicular development; inflammation; miR-133a; obesity; miR-133a; inflammation; abnormal follicular development; obesity

Obesity has been reported to promote disordered folliculogenesis, but the exact molecular mechanisms are still not fully understood. In this study, we find that miR-133a is involved in obesity-induced follicular development disorder. After feeding with a high-fat diet (HFD) and fructose water for ni...