FoxO4 activity is regulated by phosphorylation and the cellular environment during dehydration in the African clawed frog, Xenopus laevis

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 8; pp. 1721 - 1728
• Main Authors: Zhang, Yichi, Luu, Bryan E., Storey, Kenneth B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2018
• Subjects: amphibians; Animals; antioxidant genes; Antioxidants - metabolism; binding capacity; Dehydration; Dehydration - physiopathology; DNA; DNA - metabolism; DPI-ELISA; Environment; environmental factors; Forkhead box O; Forkhead Transcription Factors - metabolism; gene expression; Gene Expression Regulation, Enzymologic; Myogenin; Phosphorylation; protein content; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction; skeletal muscle; temperature; transcription (genetics); transcription factors; Transcription, Genetic; urea; Western blotting; Xenopus laevis; Xenopus laevis - growth & development; Xenopus laevis - metabolism; Xenopus Proteins - metabolism; Myogenin; DPI-ELISA; Dehydration; Xenopus laevis; Western blotting; Forkhead box O

The African clawed frog, Xenopus laevis, is capable of enduring seasonal bouts of severe dehydration stress resulting from transcriptional regulation that facilitates a pro-survival response. Previous studies have shown that dehydration increases antioxidant gene expression in this amphibian. As Fox...