Combined application of brain-derived neurotrophic factor and neurotrophin-3 and its impact on spiral ganglion neuron firing properties and hyperpolarization-activated currents

• Published in: Hearing research Vol. 291; no. 1-2; pp. 1 - 14
• Main Authors: Needham, Karina, Nayagam, Bryony A., Minter, Ricki L., O'Leary, Stephen J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2012
• Subjects: Action Potentials - drug effects; Animals; Brain-Derived Neurotrophic Factor - administration & dosage; Cells, Cultured; Drug Interactions; Electrophysiological Phenomena; Hearing Loss, Sensorineural - drug therapy; Hearing Loss, Sensorineural - physiopathology; Indexing in process; Membrane Potentials - drug effects; Models, Neurological; Neurons, Afferent - drug effects; Neurons, Afferent - physiology; Neurotrophin 3 - administration & dosage; Patch-Clamp Techniques; Rats; Spiral Ganglion - drug effects; Spiral Ganglion - physiology; p75NTR; RS; I770–790; Vpeak; NT; KCa; K; APMax; cAMP; Vh; IA; NBM; TTX; BDNF; ZD7288; IKL; KV; NT3; trk; 4-AP; DIV; TEA; HCN; Cap; TRIP8b; MEM; RMP; RIN; VSS; Iinst; Ntrk; SGN; Idiff; PIP2; Ih

Neurotrophins provide an effective tool for the rescue and regeneration of spiral ganglion neurons (SGNs) following sensorineural hearing loss. However, these nerve growth factors are also potent modulators of ion channel activity and expression, and in the peripheral auditory system brain-derived n...