Combinatorial anticancer effects of curcumin and 5-fluorouracil loaded thiolated chitosan nanoparticles towards colon cancer treatment

• Published in: Biochimica et biophysica acta Vol. 1840; no. 9; pp. 2730 - 2743
• Main Authors: Anitha, A., Deepa, N., Chennazhi, K.P., Lakshmanan, Vinoth-Kumar, Jayakumar, R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2014
• Subjects: 5-Fluorouracil; Animals; antineoplastic activity; bioavailability; Biological Availability; blood; cell cycle; Cell Cycle - drug effects; Cell Line, Tumor; chitosan; Chitosan - pharmacokinetics; Chitosan - pharmacology; Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; colorectal neoplasms; Combinatorial nanomedicine; crosslinking; Curcumin; Curcumin - pharmacokinetics; Curcumin - pharmacology; Delayed-Action Preparations - pharmacokinetics; Delayed-Action Preparations - pharmacology; drug therapy; fluorouracil; Fluorouracil - pharmacokinetics; Fluorouracil - pharmacology; Humans; membrane potential; Membrane Potential, Mitochondrial - drug effects; Mice; mitochondrial membrane; nanomedicine; Nanoparticles; neoplasm cells; patient compliance; Pharmacokinetics; Thiolated chitosan; zeta potential; DDA; H and E; PT; RNA; COX-2; 5-Fluorouracil; TCS; EPR; CO2; FT-IR; DLS; Mw; MTT; AUC; RPM I; BSA; PPP; FdUMP; Colon cancer; TPP; OD; FBS; pH; IEC 6; Thiolated chitosan; Hb; Curcumin; HPLC; Rh 123; RNase; PBS; aPTT; ACD; 5-FU-TCS-NPs; CRC-TCS-NPs; FUTP; EDTA; NPs; HT29; CRC; DNA; PI; SEM; FdUTP; Pharmacokinetics; 5-FU; JC-1; Combinatorial nanomedicine

Evaluation of the combinatorial anticancer effects of curcumin/5-fluorouracil loaded thiolated chitosan nanoparticles (CRC-TCS-NPs/5-FU-TCS-NPs) on colon cancer cells and the analysis of pharmacokinetics and biodistribution of CRC-TCS-NPs/5-FU-TCS-NPs in a mouse model. CRC-TCS-NPs/5-FU-TCS-NPs were...