The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA - Dyakonova, Elena S.; Koval, Vladimir V.; Lomzov, Alexander A.; Ishchenko, Alexander A.; Fedorova, Olga S. (Biochimica et biophysica acta, 2015)
Keywords: 2-Aminopurine; Abasic site; active sites; Amino Acid Sequence; amino acids; antimalarials; AP endonuclease; Base excision repair; Catalysis; catalytic activity; Catalytic Domain; crystal structure; DNA; DNA damage; DNA Repair; DNA Repair Enzymes - chemistry; DNA Repair Enzymes - genetics; DNA Repair Enzymes - metabolism; DNA, Fungal - chemistry; DNA, Fungal - metabolism; Endodeoxyribonucleases - chemistry; Endodeoxyribonucleases - genetics; Endodeoxyribonucleases - metabolism; enzyme activity; Escherichia coli; fluorescence; guidelines; Histidine; ions; Kinetics; mammals; MD simulation; Molecular Dynamics Simulation; Molecular Sequence Data; mutants; Mutation; Nucleic Acid Conformation; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae - enzymology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; yeasts; zinc; Zinc - metabolism; Abasic site; MD simulation; 2-Aminopurine; F; MD; ODN; AP endonuclease; 2-aPu; DNA repair; Base excision repair; BER; AP