Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 9; pp. 1360 - 1370
• Main Authors: Diao, Wenli, Chen, Wei, Cao, Wenmin, Yuan, Hui, Ji, Hao, Wang, Tianwei, Zhu, Xingxing, Zhou, Hong, Guo, Hongqian, Zhao, Xiaozhi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2019
• Subjects: Animals; Astaxanthin; beta catenin; beta Catenin - metabolism; CD8-positive T-lymphocytes; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - metabolism; chemokine CCL5; epithelial cells; Epithelial-Mesenchymal Transition - drug effects; fibroblasts; fibrosis; Fibrosis - metabolism; Fibrosis - pathology; Fibrosis - prevention & control; flow cytometry; fluorescent antibody technique; histopathology; immunohistochemistry; interferon-gamma; Interferon-gamma - metabolism; kidney diseases; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; kidneys; Male; Mice; Mice, Inbred C57BL; Myofibroblasts - cytology; protective effect; Proto-Oncogene Proteins c-akt - metabolism; quantitative polymerase chain reaction; Renal fibrosis; Smad2 Protein - metabolism; Snail Family Transcription Factors - metabolism; snails; STAT3 Transcription Factor - metabolism; therapeutics; Unilateral ureteral obstruction; Western blotting; Xanthophylls - pharmacology; Unilateral ureteral obstruction; Renal fibrosis; Astaxanthin

Renal fibrosis is a common pathological hallmark of chronic kidney disease, and no effective treatment is clinically available to manage its progression. Astaxanthin was recently found to be anti-fibrotic, but its effect on renal fibrosis remains unclear. C57BL/6J mice were subjected to unilateral u...