Astaxanthin protects against renal fibrosis through inhibiting myofibroblast activation and promoting CD8+ T cell recruitment - Diao, Wenli; Chen, Wei; Cao, Wenmin; Yuan, Hui; Ji, Hao; Wang, Tianwei; Chen, Wei; Zhu, Xingxing; Zhou, Hong; Guo, Hongqian; Zhao, Xiaozhi (Biochimica et biophysica acta. General subjects, 2019)
Keywords: Animals; Astaxanthin; beta catenin; beta Catenin - metabolism; CD8-positive T-lymphocytes; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - metabolism; chemokine CCL5; epithelial cells; Epithelial-Mesenchymal Transition - drug effects; fibroblasts; fibrosis; Fibrosis - metabolism; Fibrosis - pathology; Fibrosis - prevention & control; flow cytometry; fluorescent antibody technique; histopathology; immunohistochemistry; interferon-gamma; Interferon-gamma - metabolism; kidney diseases; Kidney Diseases - metabolism; Kidney Diseases - pathology; Kidney Diseases - prevention & control; kidneys; Male; Mice; Mice, Inbred C57BL; Myofibroblasts - cytology; protective effect; Proto-Oncogene Proteins c-akt - metabolism; quantitative polymerase chain reaction; Renal fibrosis; Smad2 Protein - metabolism; Snail Family Transcription Factors - metabolism; snails; STAT3 Transcription Factor - metabolism; therapeutics; Unilateral ureteral obstruction; Western blotting; Xanthophylls - pharmacology; Unilateral ureteral obstruction; Renal fibrosis; Astaxanthin